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At least 847 records · Page 47Linked to original sources
PubMed1993

Medical imaging databases. A National Institutes of Health workshop.

Development and implementation of a medical imaging database in a PACS-type environment that integrates all the patient data will impact directly on the quality of patient care. In addition, access to the wealth of information that is simply not accessible through the current technology, will contribute to improved disease detection and improved patient treatment, as well as produce significant new medical knowledge. Research and implementations must proceed in interdisciplinary environments which successfully combine the expertise and knowledge from the medical community with that of the database and computer science disciplines.

Database Management Systems↗
PubMed1999

Evaluation of telemedical services.

With the rapidly increasing development of telemedicine technology, the evaluation of telemedical services becomes more and more important. However, professional views of the aims and methods of evaluation are different from the perspective of computer science and engineering or from medicine and health policy. We propose that a continuous evaluation strategy should be chosen which guides the development and implementation of telemedicine technologies and applications. The evaluation strategy is divided into four phases in which the focus of evaluation is shifted from technical performance of the system in the early phases to medical outcome criteria and economical aspects in later phases. We review the study design methodology established for clinical trials assessing therapeutic effectiveness and diagnostic accuracy and discuss how it can be adapted to evaluation studies in telemedicine. As an example, we describe our approach to evaluation in a teleconsultation network in ophthalmology.

Evaluation Studies as Topic↗
PubMed2005

Assessing uncertainty in simulation-based maritime risk assessment.

Recent work in the assessment of risk in maritime transportation systems has used simulation-based probabilistic risk assessment techniques. In the Prince William Sound and Washington State Ferries risk assessments, the studies' recommendations were backed up by estimates of their impact made using such techniques and all recommendations were implemented. However, the level of uncertainty about these estimates was not available, leaving the decisionmakers unsure whether the evidence was sufficient to assess specific risks and benefits. The first step toward assessing the impact of uncertainty in maritime risk assessments is to model the uncertainty in the simulation models used. In this article, a study of the impact of proposed ferry service expansions in San Francisco Bay is used as a case study to demonstrate the use of Bayesian simulation techniques to propagate uncertainty throughout the analysis. The conclusions drawn in the original study are shown, in this case, to be robust to the inherent uncertainties. The main intellectual merit of this work is the development of Bayesian simulation technique to model uncertainty in the assessment of maritime risk. However, Bayesian simulations have been implemented only as theoretical demonstrations. Their use in a large, complex system may be considered state of the art in the field of computational sciences.

Journal Article↗
PubMed2006

Interoperator test for anatomical annotation of earprints.

As part of the Forensic Ear Identification (FearID) research project, which aims to obtain estimators for the strength of evidence of earmarks found on crime scenes, a large database of earprints (over 1200 donors) has been collected. Starting from a knowledge-based approach where experts add anatomical annotations of minutiae and landmarks present in prints, comparison of pairs of prints is done using the method of Vector Template Matching (VTM). As the annotation process is subjective, a validation experiment was performed to study its stability. Comparing prints on the basis of VTM, it appears that there are interoperator effects, individual operators yielding significantly more consistent results when annotating prints than different operators. The operators being well trained and educated, the observed variation on both clicking frequency and choice of annotation points suggests that implementation of the above is not the best way to go about objectifying earprint comparison. Processes like the above are relevant for any forensic science dealing with identification (e.g., of glass, tool marks, fibers, faces, fingers, handwriting, speakers) where manual (nonautomated) processes play a role. In these cases, results may be operator dependent and the dependencies need to be studied.

Data Collection↗
PubMed2006

National health education programs to promote healthy eating and physical activity.

The national education programs and campaigns described here are examples of the many unique kinds of federal efforts under way to promote the pillars of healthy eating and increased physical activity included in the "Healthier US Initiative." They are similar in that: 1) they are based on the best available science that a health problem exists, and 2) that healthy eating and physical active behaviors will improve health status. They are unique in their implementation, for example, in private/public partnerships, coordinating committees of professional associations, and congressionally mandated interventions. Most importantly, they provide the impetus to get a particular health issue on the public agenda.

Diet↗
PubMed1999

Approaching psychotherapy of the personality disorders from the Millon perspective.

Millon's integrative model for a clinical science begins with a theory that is consistent with current knowledge, establishes a taxonomy for classification, develops a coordinated assessment system, and develops and implements interventions with the guidance of the preceding elements of the model. In recent years, work on the last step of the model, clinical interventions, has accelerated rapidly, and the model now permits the therapist to directly extrapolate specific treatment goals, objective, and techniques to the practice of therapy with the individual patient. This article summarizes how treatment planning and implementation flows logically from the Millon model.

Humans↗
PubMed2002

Pharmacogenetic Development of Personalized Medicine: Multiple Sclerosis Treatment as a Model.

The goal of pharmacogenetics is to identify "genetic fingerprints" that may predict a patient's response to pharmaceutical treatment. The use of pharmacogenetics replaces the trial-and-error strategy, which governs much of our clinical decision-making regarding treatment allocation in current medical practice, with individually tailored therapy. We review a pharmacogenetic research model, which implements high-throughput single nucleotide polymorphism technology to establish the correlation between drug-responsiveness and genetic polymorphisms of Copaxone(R)-treated multiple sclerosis patients. Implementation of similar pharmacogenetic approaches may promote the development of personalized medicine in multiple sclerosis as well as in other diseases. (c) 2002 Prous Science. All rights reserved.

Journal Article↗
PubMedDate not supplied

The changing role of the medical technologist from technologist to information specialist.

Pathology laboratory services are dependent on the laboratory information system (LIS) to organize the work, manage the operation, and communicate the results for effective laboratory medicine. For maximum efficiency, staffing for the LIS should be an integral component of laboratory operations and is facilitated by a two-tier structure. A core LIS staff provides system support and continuous services. A group of bench medical technologists have multitasking responsibilities, including LIS support for a specific laboratory work area. The two components form a team that uses staff efficiently to provide ongoing operational services and flexibility for problem solving and new functionality implementation.

Clinical Laboratory Information Systems↗
PubMed1989

ITI-system. Basic and clinical procedures.

Future development in implant prosthodontics should be based on the fundamentals of sound research and reliable clinical implementation. The goals should be to research the safety and efficacy of implants with regard to materials, host receptor site and interfacial zone; to develop acceptable uniform standards of evaluation; and to submit findings to scientific methods of analysis in determining benefit-to-risk factors. This presentation will offer a glimpse at some current developments in basic and clinical research focusing on studies in biocompatibility and host acceptance; the implant-tissue interface; processes in osteogenesis related to vascularization of host sites; and bioengineering studies related to stress analysis and dimensional accuracy of impression systems for implants. The presentation will further describe future directions in research, training and implementation of services through development of an interdisciplinary team. A center is proposed to address the need for combined efforts in clinical++ and basic science research, the broad scope of implant utilization, and the teaching of implant procedures within an academic setting and to our colleagues.

Biocompatible Materials↗
PubMed1989

Future directions in the use of dental implants.

Future development in implant prosthodontics should be based on the fundamentals of sound research and reliable clinical implementation. The goals should be to research the safety and efficacy of implants with regard to materials, host receptor site and interfacial zone; to develop acceptable uniform standards of evaluation; and to submit findings to scientific methods of analysis in determining benefit-to-risk factors. This presentation will offer a glimpse at some current developments in basic and clinical research focusing on studies in biocompatability and host acceptance; the implant-tissue interface; processes in osteogenesis related to vascularization of host sites; and bioengineering studies related to stress analysis and dimensional accuracy of impression systems for implants. The presentation will further describe future direction in research, training and implementation of services through development of an interdisciplinary team. A center is proposed to address the need for combined efforts in clinical and basic science research, the broad scope of implant utilization, and the teaching of implant procedures within an academic setting and to our colleagues.

Dental Implantation↗
PubMed1989

End-user searching in a medical school curriculum: an evaluated modular approach.

Librarians at the Ohio State University Health Sciences Library developed and taught a four-week elective minimodule on database searching to second-year medical students. The behavioral objectives, design, implementation, and formal evaluation of the program are described. The authors point out the need for a systematic means of assisting all future physicians to develop information retrieval and management skills.

Computer User Training↗
PubMedDate not supplied

The 1995-1996 UP Pre-Dentistry Program: profile of students, problems and implications to dental proper admission.

The study focuses on the pre-dentistry program of the University of the Philippines Manila. It presents a demographic profile of its students and also the issues and problems they are confronted with. The results reveal that a typical pre-dentistry student is female who hails from Metro Manila and graduated with certain honors from a private high school. While in UP Manila, the pre-dentistry student is confronted with problems on career decisions and coping with the college's academic standard. Apparently, these problems stem from the fact that his/her preferred choice of course in the University of the Philippines College Admission Test (UPCAT) is Physical Therapy, and BS Biology. In UP Manila, the pre-dentistry student finds Mathematics, Chemistry, and Physics difficult to pass or obtain high grades. Admission into the dental proper program is perceived to be too competitive due to the limited slots available in the first year proper program. Moreover, the applicant has to meet the general weighted average (GWA), pass the dexterity test and interview by the Admission Committee of the college. The study further reveals the student's desire to move out from the college when the opportunity to shift comes along. The following are their reasons for shifting. Firstly, they do not want to be dentists. Secondly, even if they wanted to become dentists, they are not assured of slots in the Dentistry proper. Thirdly, they want to shift to their preferred courses as soon as possible. To deal with these issues, the study suggests that the administration should consider the following recommendations: (1) the DDM program should be turned to a quota course in the UPCAT in order to discourage applicants who are not interested in the course and to avoid the so-called "back-door-entry" to UP.; (2) the college should implement the selective admission process as early as first year pre-dentistry. (3) the college should consider lateral entry of qualified Bachelor of Science degree holders; and (4) increase the quota of more popular courses in UP Manila, like, BS Physical Therapy, BS Biology, and BS Public Health.

Education, Predental↗
PubMed2005

Re-envisioning the training and practice of clinical psychologists: preserving science and research orientations in the face of change.

We argue for preservation of an expectation of psychologists that approach human problems from an evidence-based perspective. Acquisition of the requisite knowledge, skills, and practical experience require access to resources outside of graduate psychology programs. Whether adhering to a scientist-practitioner or practitioner-scholar model, psychologists must be "scientifically literate." Deficiencies are noted in the training of scientist-practitioner psychologists for the conduct of clinical trials and the dissemination and sustained implementation of evidence-based interventions.

Curriculum↗
PubMed1998

The REACH Project of the Adolescent Medicine HIV/AIDS Research Network: design, methods, and selected characteristics of participants.

PURPOSE: To describe the Reaching for Excellence in Adolescent Care and Health (REACH) Project of the Adolescent Medicine Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) Research Network, a unique collaborative effort to conceive and implement a research design intended to examine HIV pathogenesis, pubertal hormonal variation, and the effects of sexually transmitted disease comorbidity in HIV-infected youth to improve their health care. METHODS: This multidisciplinary team has drawn on basic science and clinical experience to produce a study design with relevant and feasible study aims and testable hypotheses. Particular attention has been paid to centralized training and quality control practices. Standardized measurements include direct and computer interviews, physical examination, laboratory analysis, and medical chart abstraction. The protocol has been approved by local institutional review boards. RESULTS: A highly standardized and quality control monitored protocol has been implemented at 16 sites throughout the United States collecting historical, observational, and laboratory data in a group of HIV-infected adolescents and HIV-negative controls. Preliminary data collected on subjects are consistent with published reports of the sociodemographic and clinical characteristics of the HIV epidemic in sexually active youth, thus supporting the integrity of the protocol development process. The study population is, for the most part, in older adolescence, predominantly minority and female, and with publicly financed or no health insurance. CONCLUSIONS: The REACH Project is positioned to address questions about the clinical course, immunologic profile, and viral dynamics in HIV-positive youth, and thus is able to inform drug development and management strategies for this understudied population.

Acquired Immunodeficiency Syndrome↗
PubMed2002

Future improvements and implementation of animal care practices within the animal testing regulatory environment.

Animal welfare is an increasingly important concern when considering biomedical experimentation. Many of the emerging regulations and guidelines specifically address animal welfare in laboratory animal care and use. The current revision of the appendix of the European Convention, ETS123 (Council of Europe), updates and improves on the current animal care standardization in Europe. New guidelines from the Organisation for Economic Co-operation and Development and the European Federation of Pharmaceutical Industries Association focus specifically on safety testing. These guidelines will affect the way toxicity studies are conducted and therefore the global drug development process. With the 3Rs principles taken into account, consideration regarding animal welfare will demand changes in animal care practices in regulatory safety testing. The most significant future improvements in animal care and use practices are likely to be environmental enrichment, management of animal pain and distress, and improved application of the humane endpoints. Our challenge is to implement respective guidelines based on scientific data and animal welfare, through a complex interplay of regulatory objective and public opinion. The current goal is to work toward solutions that continue to provide relevant animal models for risk assessment in drug development and that are science based. In this way, future improvements in animal care and use practices can be founded on facts, scientific results, and analysis. Some of these improvements become common practice in some countries. International harmonization can facilitate the development and practical application of "best scientific practices" by the consensus development process that harmonization requires. Since the implementation of good laboratory practices (GLP) standards in safety testing, these new regulations and recommendations represent a new way forward for animal safety studies.

Animal Husbandry↗
PubMed2005

R(X) for recruitment and retention of veterinarian scientists: money, marketing, mentoring.

Veterinary medicine is failing both to sustain its academic base and to meet national needs for research in the fields of comparative medicine (translational research), public health, and food production. The basis for the shortage of veterinarians with research expertise is multi-factorial and related to the substantial commitment of time and money required to obtain both a DVM and advanced training, as well as the lack of motivation among veterinary students to engage in biomedical science. Effective strategies for increasing the number of veterinarian scientists must address these issues using a balanced combination of money, marketing, and mentoring. Success will require not only that we increase and improve opportunities for research training, but also that we create and sustain veterinary college environments that attract, foster, and reward dedication to research. The ''research pipeline'' needs to be transformed into a ''research manifold'' with multiple portals for entry and re-entry of trainees. Age-appropriate educational and mentoring programs should be implemented at K-14, baccalaureate, veterinary college, post-graduate, and junior faculty levels to promote recruitment, training, and retention of veterinarian scientists. New initiatives are especially needed to attract students with primary interests in science and biomedical research to the veterinary profession and to facilitate transition of motivated veterinary graduates from private practice to research careers. Specific examples of such programs are presented and future directions are discussed.

Animals↗