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Results for “spatial dependency”

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PubMed1997

The effect of spatial frequency and field size on the spread of exclusive visibility in binocular rivalry.

We measured binocular rivalry between dichoptic, orthogonal, sinusoidal gratings both having spatial frequencies of 0.5, 1, 2, 4, 8 or 16 c deg-1 in fields ranging from 0.5 to 8 deg of visual angle in diameter. Total time that one or the other grating was exclusively visible had an inverted U-shaped relationship with spatial frequency, with the peak shifting to coarser spatial frequencies as the field size increased. We computed for each spatial frequency the maximum field size over which a criterion duration of exclusive visibility would spread. When expressed as areas, these sizes were inversely proportional to spatial frequency. This dependence of rivalry on spatial frequency is similar to those for stereopsis and fusion, consistent with the notion that all three binocular phenomena have a common mechanism.

Analysis of Variance↗

PubMed2005

Generalized stokes parameters of random electromagnetic beams.

A generalization of the Stokes parameters of a random electromagnetic beam is introduced. Unlike the usual Stokes parameters, which depend on one spatial variable, the generalized Stokes parameters, depend on two spatial variables. They obey precise laws of propagation, both in free space and in any linear medium, whether deterministic or random. With the help of the generalized Stokes parameters, the changes in the ordinary Stokes parameters upon propagation can be determined. Numerical examples of such changes are presented. The generalized Stokes parameters contain information not only about the polarization properties of the beam but also about its coherence properties. We illustrate this fact by expressing the degree of coherence of the electromagnetic beam in terms of one of the generalized Stokes parameters.

Journal Article↗

PubMed1985

Simple- and complex-cell response dependences on stimulation parameters.

We studied the response time course and amplitude dependence on stimulation parameters in cat cortical visual neurons to determine their receptive-field spatial-summation characteristics. Response poststimulus time (PST) histograms of cortical simple cells to contrast-reversal grating stimulation generally have a single peak for each stimulus temporal cycle, though the responses appear rectified. In response to contrast-reversal grating stimulation the general PST histogram time course for complex cells is two peaks, though often these peaks are of different amplitudes. The time course of complex-cell responses, and the ratio of these two response peaks often varies with stimulation parameters. The appearance of a single response peak in simple cells is reflected in the dominance of the odd harmonic Fourier portion, whereas the half-wave rectification leads to a considerable even harmonic portion. Still, this even portion is never significantly greater than the odd portion. When complex cell PST histograms have two nearly equal peaks, Fourier transformation reveals almost only even harmonic components. When the histogram contains two peaks of unequal amplitude Fourier analysis reveals large odd and even components. An even:odd Fourier harmonic portion ratio larger than 1 may be seen as a defining characteristic of complex cells, differentiating them from simple cells. Histograms with two unequal peaks appear "mixed," containing something of the "pure" single-peaked response and something of the pure double-peaked response. The degree to which the response is mixed may be measured by the ratio of the even:odd portion amplitudes. There is a great degree of variability with stimulation parameters (both spatial phase and spatial frequency) of the time course of mixed responses as opposed to the case of responses that have two equal peaks independent of stimulation grating phase and frequency. In both simple and complex cells there is a close coincidence of the spatial frequency ranges over which the even and odd portions are substantial, though many complex cells show a periodic variation of the even:odd portions ratio. This spatial-frequency dependence differs from that of LGN Y-cells where the odd portion dominates at low spatial frequencies and the even portion at high spatial frequencies. The ratio of even-to-odd portion cut-off is close to 3:1 in all Y-cells, a characteristic we did not find in cortical simple or complex cells. We suggest, therefore, that the nonlinearity of these complex cells does not derive from that of Y-cells.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗

PubMed2003

Cross-modal perceptual integration of spatially and temporally disparate auditory and visual stimuli.

Under certain conditions, auditory and visual information are integrated into a single unified percept even when they originate in different locations in space. The present study shows how this illusion, known as the ventriloquism effect, depends on spatial, temporal and cognitive factors. A method of psychophysical scaling was employed in combination with simple auditory-visual stimuli (tone bursts and flashing light spots) that were presented with various spatiotemporal disparities. Participants either judged their impression of the likelihood of a common cause (Experiment 1) or spatial alignment (Experiment 2) or synchrony of sound and light (Experiment 3). In all three experiments the participants' judgements depended significantly on temporal disparity whereas influences of spatial disparity were significant in Experiments 1 and 2. Optimum scores were always obtained when auditory stimuli were presented with a delay of 50-100 ms after the visual stimuli. These results demonstrate that both temporal and spatial proximity of the two stimuli are critical for the experience of phenomenal causality. On the other hand, spatio-temporal ranges for optimal perception of phenomenal causality in Experiment 1 were significantly larger than predicted by simultaneous detection of spatial and temporal disparities. This finding suggests that auditory-visual binding was further facilitated by additional, cognitive, factors, associated with the specific instruction to judge the likelihood of a common cause. Obviously, these instructional influences may reflect similar perceptual effects, as have been shown previously by increasing the complexity or cognitive compellingness of auditory-visual stimuli.

Acoustic Stimulation↗

PubMed2005

Evaluation of normalization methods for cDNA microarray data by k-NN classification.

BACKGROUND: Non-biological factors give rise to unwanted variations in cDNA microarray data. There are many normalization methods designed to remove such variations. However, to date there have been few published systematic evaluations of these techniques for removing variations arising from dye biases in the context of downstream, higher-order analytical tasks such as classification. RESULTS: Ten location normalization methods that adjust spatial- and/or intensity-dependent dye biases, and three scale methods that adjust scale differences were applied, individually and in combination, to five distinct, published, cancer biology-related cDNA microarray data sets. Leave-one-out cross-validation (LOOCV) classification error was employed as the quantitative end-point for assessing the effectiveness of a normalization method. In particular, a known classifier, k-nearest neighbor (k-NN), was estimated from data normalized using a given technique, and the LOOCV error rate of the ensuing model was computed. We found that k-NN classifiers are sensitive to dye biases in the data. Using NONRM and GMEDIAN as baseline methods, our results show that single-bias-removal techniques which remove either spatial-dependent dye bias (referred later as spatial effect) or intensity-dependent dye bias (referred later as intensity effect) moderately reduce LOOCV classification errors; whereas double-bias-removal techniques which remove both spatial- and intensity effect reduce LOOCV classification errors even further. Of the 41 different strategies examined, three two-step processes, IGLOESS-SLFILTERW7, ISTSPLINE-SLLOESS and IGLOESS-SLLOESS, all of which removed intensity effect globally and spatial effect locally, appear to reduce LOOCV classification errors most consistently and effectively across all data sets. We also found that the investigated scale normalization methods do not reduce LOOCV classification error. CONCLUSION: Using LOOCV error of k-NNs as the evaluation criterion, three double-bias-removal normalization strategies, IGLOESS-SLFILTERW7, ISTSPLINE-SLLOESS and IGLOESS-SLLOESS, outperform other strategies for removing spatial effect, intensity effect and scale differences from cDNA microarray data. The apparent sensitivity of k-NN LOOCV classification error to dye biases suggests that this criterion provides an informative measure for evaluating normalization methods. All the computational tools used in this study were implemented using the R language for statistical computing and graphics.

Algorithms↗

PubMed1995

Anatomical specificity and time-dependence of chlordiazepoxide-induced spatial memory impairments.

Injection of the benzodiazepine (BDZ) chlordiazepoxide (CDP) into the medial septum (MS) produced a dose-dependent retrograde working memory deficit in a delayed non-match-to-sample radial-arm maze task. CDP (30 nmol; 10 micrograms) decreased the number of correct choices and increased the number of errors without altering latency to make arm choices. The effects of CDP were site specific; injection into regions proximate to the MS, including the lateral septum, the anterior cingulate, and the nucleus basalis magnocellularis, did not affect any index of performance. The second experiment demonstrated that CDP impaired working memory only when rats were injected either 0 or 60 min, but not 15, 30, or 45 min, following training. The MS appears (a) to contribute to both early (encoding/ maintenance) and late (retrieval/utilization) phases of working memory and (b) to be a critical site of action for BDZ-induced deficits in spatial working memory.

Animals↗

PubMed2006

General solution of the diffusion equation with a nonlocal diffusive term and a linear force term.

We obtain a formal solution for a large class of diffusion equations with a spatial kernel dependence in the diffusive term. The presence of this kernel represents a nonlocal dependence of the diffusive process and, by a suitable choice, it has the spatial fractional diffusion equations as a particular case. We also consider the presence of a linear external force and source terms. In addition, we show that a rich class of anomalous diffusion, e.g., the Lévy superdiffusion, can be obtained by an appropriated choice of kernel.

Journal Article↗

PubMed2006

Interpreting spatial terms involves simulating interactions.

Recent research in spatial language has demonstrated that the interpretation of a spatial term depends not only on the geometry of the configuration of the objects being spatially related, but also on extrageometric information, including information about the objects and their interaction. Such effects could emerge from activation of general knowledge of the association between the objects; thus, they should be widely observed. In contrast, they could be more restricted, emerging only in situations in which the spatial language task positions objects in a manner that is consistent with a simulation of their interaction. In two experiments, we test each of these ideas and demonstrate that extrageometric information augments geometric information in the interpretation of spatial terms only when the situation enables the interaction.

Cognition↗

PubMedDate not supplied

Short-term memory processes in delayed visual differentiation in rhesus macaques after bilateral removal of field 7 of the parietal cortex.

Monkeys (Macaca mulatta) with preliminary removal of field 7 of the lower parietal cortex and previously trained to differentiate images differing in shape, color, size, orientation, and spatial relationships were used to study the processes involved in short-term storage of different types of information required for a delayed (by 0-8 sec) visual differentiation task and the effects on these processes of the antioxidant Oxymetacil. Significant differences were found in comparison with intact animals. Removal of field 7 sharply worsened short-term storage processes during visual differentiation of different types of images, including those differing in terms of properties such as color, geometrical shape, and the spatial relationships between image elements. There were significant reductions in the level of correct responses for all delay periods with significant increases in the motor reaction time, indicating a sharp reduction in the duration of short-term information storage, which suggests that the monkeys' short-term memory mechanisms were disrupted. Oxymetacil had a correcting effect only in relation to stimuli differing in terms of color and shape, but had no effect at all on the short-term storage of spatial information. It is suggested that these data suggest that field 7 has at least two functions. These are, firstly, a role in processes underlying the evaluation, differentiation, and storage of spatial information depending on visual-vestibular interactions, and secondly, a role in the mechanisms underlying the attention system, which is disrupted by removal of field 7 and restored by treatment with the antioxidant when there is no need to differentiate spatial information, a process which depends on assessment of the body image and egocentric orientation based on visual-vestibular interactions.

Animals↗

PubMed1993

Dependence of plaid motion coherence on component grating directions.

We measured motion coherence for plaids composed of two different spatial frequency (SF) cosine grating components moving at various relative angles. The component SFs were in a ratio of 6:1, and several component motion directions were chosen to produce small to large angular differences. For angles of less than +/- 45 deg all subjects perceived rigid coherent motion, while for angles of +/- 45 deg or greater the components were perceived to slide transparently. The results were not altered when we changed the ratio of component contrasts or speeds over a factor of 2 and varied the SF ratio up to 9:1. These results show that transparency or coherence of moving plaids in different spatial scales depends on the relative component motion directions and is relatively independent of contrast, speed, and SF difference between the components. This angular dependence also explains recent data previously thought to be based on a visual computation of multiplicative transparency. A quantitative model in which the resultant motion on each scale provides a facilitative biasing signal to units tuned to similar directions (within +/- 30 deg) on other scales explains the experimental results.

Contrast Sensitivity↗

PubMed2005

Enhanced and diminished visuo-spatial information processing in autism depends on stimulus complexity.

Visuo-perceptual processing in autism is characterized by intact or enhanced performance on static spatial tasks and inferior performance on dynamic tasks, suggesting a deficit of dorsal visual stream processing in autism. However, previous findings by Bertone et al. indicate that neuro-integrative mechanisms used to detect complex motion, rather than motion perception per se, may be impaired in autism. We present here the first demonstration of concurrent enhanced and decreased performance in autism on the same visuo-spatial static task, wherein the only factor dichotomizing performance was the neural complexity required to discriminate grating orientation. The ability of persons with autism was found to be superior for identifying the orientation of simple, luminance-defined (or first-order) gratings but inferior for complex, texture-defined (or second-order) gratings. Using a flicker contrast sensitivity task, we demonstrated that this finding is probably not due to abnormal information processing at a sub-cortical level (magnocellular and parvocellular functioning). Together, these findings are interpreted as a clear indication of altered low-level perceptual information processing in autism, and confirm that the deficits and assets observed in autistic visual perception are contingent on the complexity of the neural network required to process a given type of visual stimulus. We suggest that atypical neural connectivity, resulting in enhanced lateral inhibition, may account for both enhanced and decreased low-level information processing in autism.

Adolescent↗

PubMed2006

Mislocalization of perceived saccade target position induced by perisaccadic visual stimulation.

The perceptual localization of objects flashed at the time of a saccade often shows large spatial distortions. These perisaccadic mislocalizations exhibit different spatial patterns depending on the experimental condition. In darkness, when only extraretinal information is available, mislocalization is spatially uniform. In light and when visual references are available, mislocalization is directed toward the saccade target, resembling a compression of visual space. These patterns are derived from measurements of the absolute perceived position of the flashed object in egocentric space. Here, we report that also the perceived location of the saccade target is altered when an object is flashed perisaccadically. The mislocalization of the target depends on the presentation time of the flashed object and is directed toward the position of the flash. The resulting compression of the relative distance between target and flash is similar in darkness and in light and can also be found during fixation. When the localization of the flashed object is described relative to the perceived location of the saccade target, spatial compression becomes similar in many experimental conditions. We therefore suggest that perisaccadic compression relies on an encoding of relative spatial locations of objects rather than on localizations in egocentric space.

Adult↗

PubMed2002

Cortical control of spatial memory in humans: the visuooculomotor model.

We review current knowledge of the cortical control of spatial memory, studied using visuooculomotor paradigms. Spatial memory is an essential cognitive process that can be involved in preparing motor responses. Our knowledge of spatial memory in humans recently has progressed thanks to the use of ocular saccades as a convenient model of motor behavior. Accuracy of memory-guided saccades, made to the remembered locations of visual targets, is a reflection of spatial memory. For the performance of memory-guided saccades with brief delays (up to 15-20 seconds), that is, involving short-term spatial memory, lesion studies have shown that the posterior parietal cortex, the dorsolateral prefrontal cortex, and the frontal eye field play significant roles. Studies of memory-guided saccades using transcranial magnetic stimulation have suggested that the right posterior parietal cortex is involved at the initial stage (<300 milliseconds) of visuospatial integration, whereas the dorsolateral prefrontal cortex in both hemispheres controls the following phase of short-term memorization, the frontal eye field mainly serving to trigger saccades. The new concept of a medium-term spatial memory has emerged from a behavioral study of memory-guided saccades in normal subjects, showing a paradoxical spontaneous improvement of spatial memory after delays of approximately 20 seconds. Lesion studies have shown that the parahippocampal cortex could specifically control this medium-term spatial memory. Last, different experimental and clinical arguments suggest that, after a few minutes, the hippocampal formation finally takes over the control of spatial memory for long-term spatial memorization. Therefore, spatial memory involved in the memorization of visual items could be successively controlled by the dorsolateral prefrontal cortex (short-term spatial memory), the parahippocampal cortex (medium-term spatial memory), and the hippocampal formation (long-term spatial memory), depending on specific periods of times. The applicability of this simple visuooculomotor model of spatial memory to other types of stimuli and general motoricity has yet to be confirmed.

Animals↗

PubMed2003

How much does an individual habitat fragment contribute to metapopulation dynamics and persistence?

We derive measures for assessing the value of an individual habitat fragment for the dynamics and persistence of a metapopulation living in a network of many fragments. We demonstrate that the most appropriate measure of fragment value depends on the question asked. Specifically, we analyse four alternative measures: the contribution of a fragment to the metapopulation capacity of the network, to the equilibrium metapopulation size, to the expected time to metapopulation extinction and the long-term contribution of a fragment to colonization events in the network. The latter measure is comparable to density-dependent measures in general matrix population theory, though some differences are introduced by the fact that "density dependence" is spatially localized in the metapopulation context. We show that the value of a fragment depends not only on the properties of the landscape but also on the properties of the species. Most importantly, variation in fragment values between the habitat fragments is greatest in the case of rare species that occur close to the extinction threshold, as these species are likely to be restricted to the most favorable parts of the landscape. We expect that the measures of habitat fragment value described and analysed here have applications in landscape ecology and in conservation biology.

Animals↗

PubMed2005

Attention-driven discrete sampling of motion perception.

In movies or on TV, a wheel can seem to rotate backwards, due to the temporal subsampling inherent in the recording process (the wagon wheel illusion). Surprisingly, this effect has also been reported under continuous light, suggesting that our visual system, too, might sample motion in discrete "snapshots." Recently, these results and their interpretation have been challenged. Here, we investigate the continuous wagon wheel illusion as a form of bistable percept. We observe a strong temporal frequency dependence: the illusion is maximal at alternation rates around 10 Hz but shows no spatial frequency dependence. We introduce an objective method, based on unbalanced counterphase gratings, for measuring this phenomenon and demonstrate that the effect critically depends on attention: the continuous wagon wheel illusion was almost abolished in the absence of focused attention. A motion-energy model, coupled with attention-dependent temporal subsampling of the perceptual stream at rates between 10 and 20 Hz, can quantitatively account for the observed data.

Attention↗

PubMed2005

How the spatial frequency of polarization influences the induction of reentry in cardiac tissue.

UNLABELLED: Influences of spatial frequency of polarization. INTRODUCTION: The mechanism by which an electric field induces a rotor during cross-field stimulation of cardiac tissue is not entirely known. Different heterogeneous aspects of cardiac tissue have been offered as possible theories, a prominent one being fiber curvature. The polarization produced when an electric field is applied to a sheet of tissue is varied over many spatial frequencies, depending upon the fiber angle. This article compares the effect of high and low spatial frequencies of polarization on reentry induction. METHODS AND RESULTS: We incorporate a randomized fiber angle geometry into a two-dimensional active cardiac tissue model with unequal anisotropy ratios already exhibiting smooth, curving fibers. We simulate cross-field stimulation to initiate reentry in the tissue model, and compare the electric field thresholds at different S1-S2 intervals for tissue with randomized fiber angles, tissue with a smooth fiber geometry, and tissue with randomized fiber angles plus smooth, curving fibers. The tissue with both small, random fiber angles and curving fibers has a significantly lower threshold for reentry at certain intervals on the strength-interval curve than for the two cases individually. CONCLUSION: Cardiac tissue exhibiting a random fiber geometry in conjunction with a smooth fiber geometry includes high and low spatial frequencies of polarization that may have an effect on the mechanism for reentry at certain S1-S2 intervals. Low spatial frequency regions of hyperpolarization carve out excitable pathways, and high spatial frequency regions provide the large gradient of transmembrane potential required to initiate break excitation.

Anisotropy↗

PubMed2005

Heterogeneous model of schistosomiasis transmission and long-term control: the combined influence of spatial variation and age-dependent factors on optimal allocation of drug therapy.

Prior field studies and modelling analyses have individually highlighted the importance of age-specific and spatial heterogeneities on the risk for schistosomiasis in human populations. As long-term, large-scale drug treatment programs for schistosomiasis are initiated in subSaharan Africa and elsewhere, optimal strategies for timing and distribution of therapy have yet to be fully defined on the working, district-level scale, where strong heterogeneities are often observed among sublocations. Based on transmission estimates from recent field studies, we develop an extended model of heterogeneous schistosome transmission for distributed human and snail population clusters and age-dependent behaviour, based on a 'mean worm burden + snail infection prevalence' formulation. We analyse its equilibria and basic reproduction patterns and their dependence on the underlying transmission parameters. Our model allows the exploration of chemotherapy-based control strategies targeted at high-risk behavioural groups and localities, and the approach to an optimal design in terms of cost. Efficacy of the approach is demonstrated for a model environment having linked, but spatially-distributed, populations and transmission sites.

Adolescent↗

PubMed2004

NMDA receptors and voltage-dependent calcium channels mediate different aspects of acquisition and retention of a spatial memory task.

Activity dependent calcium entry into neurons can initiate a form of synaptic plasticity called long-term potentiation (LTP). This phenomenon is considered by many to be one possible cellular mechanism underlying learning and memory. The calcium entry that induces this phenomenon can occur when N-methyl-D-aspartate receptors (NMDARs) and/or voltage-dependent calcium channels (VDCCs) are activated. While much is known about synaptic plasticity and the mechanisms that are triggered by activation of these two Ca(2+) channels, it is unclear what roles they play in learning. To better understand the role activation of these channels may play in learning we systemically administered pharmacological antagonists to block NMDARs, VDCCs, or both during training trials and retention tests in a radial arm maze task. Wistar rats injected with the NMDAR antagonist MK-801 (0.1mg/kg) were impaired in the acquisition of this task. In contrast, rats injected with verapamil (10mg/kg), an antagonist to VDCCs, acquired the task at the same rate as control animals, but were impaired on a 10-day retention test. A group of animals injected with both antagonists were unable to learn the task. The results suggest that each of the calcium channels and the processes they trigger are involved in a different stage of memory formation or expression.

Animals↗