SEARCH · PubMed Health

Results for “Avoidance Learning”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 865 records · Page 48Linked to original sources

PubMed2006

Elevated T-maze evaluation of anxiety and memory effects of NMDA/glycine-B site ligands injected into the dorsal periaqueductal gray matter and the superior colliculus of rats.

Rat behaviors in the elevated T-maze (ETM) were evaluated following tectum microinjections of either glycine (GLY, 1, 10, 80 and 120 nmol) or d-serine (D-SER, 160 and 320 nmol), the putative endogenous agonists of GLY-B site at NMDA receptor, or the respective antagonist 7-chloro-kynurenic acid (7CK, 8 nmol). ETM performance was appraised by two validated scores of anxiety, i.e., the inhibitory avoidance duration (AD) and risk assessment behavior, and two scores derived from a newly developed approach to inhibitory avoidance learning curves, i.e., the learning median number of trials (T50) and avoidance variability (standard deviation of learning curve). Effects on aversive memory consolidation were assessed through changes in the AD measured 48 h after the full-acquisition of inhibitory avoidance. Drug effects were compared to those of vehicle. In most cases, microinjection of GLY-B site agonists into the dorsal periaqueductal gray (dPAG) produced increases in AD, which were compatible with an increase in anxiety. However, neither the intra-periaqueductal injection of 80 nmol GLY, nor that of 160 nmol D-SER, increased the AD. On the other hand, these microinjections invariably produced a parallel left shift in avoidance learning curves, thereby reducing the T50 but not the variability. Effects of 120 nmol GLY on AD and T50 were both antagonized by a previous microinjection of 7CK into the dPAG. The inverse relationship of AD and T50 suggests that increases in the anxiety level reduce the number of trials required for the acquisition of inhibitory avoidance. The above data also suggest the higher consistency and drug sensitivity of T50 as compared to the AD. In turn, whereas the microinjection of 120 nmol GLY into the superior colliculus (SC) did not affect the T50, it increased the AD. On the other hand, there was an increase in avoidance variability following the microinjection of either 120 nmol GLY into the SC or 8 nmol 7CK into the dPAG. Therefore, the GLY-B receptors within these structures seem to play opposite roles on avoidance variability. In contrast, neither of these treatments changed T50. Finally, whereas the risk assessment was solely decreased by the microinjection of GLY into the SC, the aversive memory was only impaired by the microinjection of 7CK into the dPAG. Overall, these data suggest that NMDA/GLY-B receptors of dPAG mediate both anxiety and aversive memory, while those in the SC are most likely involved with attention and visuomotor components of risk assessment behavior.

Animals↗

PubMed2003

Perinatal hypothyroidism effects on neuromotor competence, novelty-directed exploratory and anxiety-related behaviour and learning in rats.

Thyroid hormone is essential for proper development of the mammalian CNS. Previous studies have documented a decrease in the ability of neonatal hypothyroid animals to learn and to habituate to maze tests and an increase in spontaneous activity. However, there is little information about the effects of perinatal (i.e. perinatal and postnatal) hypothyroidism on behaviour. The aim of the present work was to investigate the longitudinal effects of perinatal hypothyroidism on certain aspects of the behaviour in rats. Neuromotor competence was tested at 21, 40 and 60 days, novelty-directed exploratory behaviour and anxiety-related behaviour were evaluated at 40 and 60 days by means of the Boissier tests and associative learning ability was tested at 80 days by means of a step-through passive avoidance task. The persistence of the effects of perinatal hypothyroidism on psychomotor performance was highly dependent on the task examined. Perinatal hypothyroidism caused an increase of locomotor activity as revealed by the total distance travelled in the Boissier test and this increase also comprised a component of decreased anxiety-related behaviour. Methimazole-treated subjects also had higher head-dip scores than controls at 40 days while no differences were observed at 60 days. Finally, our results showed that methimazole-treated rats performed poorly in a passive avoidance learning task.

Animals↗

PubMed2006

The medial amygdala controls the coital access of female rats: a possible involvement of emotional responsiveness.

Partner preference and paced mating tests were accomplished in ovariectomized female rats following bilateral radiofrequency lesions in the medial amygdala. Open field behavior and passive avoidance learning were also examined to investigate the underlying behavioral mechanism. Partner preference was determined in a chamber located between castrated and sexually active males. Airborne olfactory cues were presented to the female through small holes on the partition. The lesion diminished preference for the odor of sexually active males over that of castrated males, even after injection with a high-dose of estrogen. On the other hand, in a paced mating test the lesioned females without estrogen treatment showed a significantly shorter latency for entering the male's compartment in a two-compartment apparatus, which allowed the females, but not the males, to cross the barrier through a narrow opening at the bottom. However, an administration of estrogen and progesterone reduced the effect. The lesion had no effect on emotionality or exploratory behavior in an open field test, but it impaired passive avoidance learning capability. We suggest that a male poses an inherent threat to a female. The seemingly incompatible results of partner preference and paced mating tests can be compromised if the male is inherently aversive to the female; this emotional response can be removed by the medial amygdala lesion.

Amygdala↗

PubMed1981

The effects of colchicine and vinblastine on memory in chicks.

Colchicine, injected bilaterally into the forebrain of day-old chicks at times before and after one-trial avoidance learning, produced transient amnesia for one to three hours after learning, that could not be accounted for as a perceptual or attentional defect. The amnesia was dose dependent and was produced only when injections occurred within a limited period before and after learning. No amnesia occurred when injections were given 120 min before or 60 min later than the learning trial, nor at times prior to the retrieval test. During the amnesic period, new learning could occur and be retrieved 15 min later. The amnesia could be overcome by retention-testing or by a new, related, learning experience before or up to 30 min after onset of amnesia. Control birds injected with saline or lumicolchicine, a biologically inactive derivative of colchicine, showed normal retention. Vinblastine sulphate, which also interrupts microtubular networks and hence axonal flow, had no amnesic properties. Colchicine injections had no effect on the levels of acetylcholinesterase, choline acetyltransferase, glutamic acid decarboxylase, and muscarinic acetylcholine receptors in the whole forebrain or in forebrain synaptosomes during the amnesic period. Nor did colchicine injections affect amino acid uptake and protein or glycoprotein synthesis before or during the amnesic period, although there was 10-20% inhibition of protein synthesis 5 h after injection. Thus over the amnesic period, there was no evidence of gross perturbation of brain function. Electron microscopy showed microtubules intact within 1 mm of the injection site 2.5 after injection. Oedema was found at this time in chicks injected with a high dose (100 micrograms) shown to disturb behaviour grossly, but not with a low dose (5 micrograms) which caused amnesia. Transient amnesia for one-trial avoidance learning is most probably caused by secondary effects of colchicine on nerve cell function. We suggest that the amnesic episode represents destruction of one of the stages of a multiple independent parallel process of memory consolidation.

Animals↗

PubMed2003

Activation of the phasic pontine-wave generator enhances improvement of learning performance: a mechanism for sleep-dependent plasticity.

The aim of this study was to test the hypothesis that supplementary activation of the phasic pontine wave (P-wave) generator during rapid eye movement (REM) sleep enhances consolidation and integration of memories, resulting in improved learning. To test this hypothesis, two groups of rats were trained on a two-way active avoidance learning task in the morning. Immediately after training, one group of rats received a carbachol microinjection into the P-wave generator and the other group was microinjected with control saline into the same target area. After training trials and microinjections, rats were allowed a 6-h period of undisturbed sleep in the polygraphic recording chamber. At the end of 6 h of undisturbed sleep-wake recordings, rats were retested in a session of avoidance learning trials. After learning trials, the total percentage of time spent in REM sleep was significantly increased in both saline (15.36%)- and carbachol (17.70%)-microinjected rats. After learning trials, REM sleep P-wave density was significantly greater throughout the 6-h period of recordings in carbachol treated rats than in the saline treated rats. In the retrial session, the improvement in learning task performance was 22.75% higher in the carbachol-microinjected rats than in the saline-microinjected rats. These findings show that the consolidation and integration of memories create a homeostatic demand for P-waves. In addition, these findings provide experimental evidence, for the first time, that activation of the P-wave generator may enhance consolidation and integration of memories, resulting in improved performance on a recently learned task.

Animals↗

PubMed1991

Effect of dihydroergotoxine, a cerebral vasodilator, on cognitive deficits induced by prenatal undernutrition and environmental impoverishment in young rats.

The study was conducted on 64 Charles Foster strain albino rats, which were equally distributed into 8 evenly matched groups, following a 2 x 2 x 2 factorial design, by varying three independent factors at two levels: nutrition--normal and undernutrition; environment--enrichment and impoverishment, and drug treatment--vehicle and dihydroergotoxine (3 mg/kg, i.p.). Prenatal undernutrition was induced by restricting the mother's food intake. The environmental enrichment/impoverishment and the vehicle/dihydroergotoxine treatments were given during the postweaning period of the pups. The rats were subjected to original and subsequent reversal brightness discrimination learning tests in a single unit T-maze at 8-9 weeks of age. Thereafter, the animals were tested for passive avoidance learning. The results indicate that undernutrition caused significant original and reversal discrimination learning, deficits whereas environmental deprivation attenuated only the original discrimination learning performance. Dihydroergotoxine treatment facilitated the learning performance of rats in both the original and reversal learning tests. Nutritional, environmental and dihydroergotoxine treatments had no effect on the retention of the passive avoidance learning, both at 24 hr and 1 week intervals. Dihydroergotoxine treatment attenuated the learning deficits induced by prenatal undernutrition. The results indicate that dihydroergotoxine is not likely to be useful in cognitive deficits, induced by malnutrition, though it facilitated learning acquisition, since it had no effect on retention.

Animals↗

PubMed2004

The roles of orbital frontal cortex in the modulation of antisocial behavior.

This article considers potential roles of orbital frontal cortex in the modulation of antisocial behavior. Two forms of aggression are distinguished: reactive aggression elicited in response to frustration/threat and goal directed, instrumental aggression. It is suggested that orbital frontal cortex is directly involved in the modulation of reactive aggression. It is argued that orbital frontal cortex does not "inhibit" reactive aggression but rather may both increase or decrease its probability as a function of social cues present in the environment. Early dysfunction in this function of orbital frontal cortex may be linked to the development of Borderline Personality Disorder. Instrumental aggression is linked to a fundamental failure in moral socialization. However, the available data suggest that the amygdala, but not orbital frontal cortex, is required for functions such as aversive conditioning and passive avoidance learning that are necessary for moral socialization. Psychopathic individuals who present with significant instrumental aggression, are impaired in aversive conditioning and passive avoidance learning and show evidence of amygdala dysfunction. Orbital frontal cortex and the amygdala are involved in response reversal where instrumental responses must be reversed following contingency change. Impairments in response reversal are also seen in psychopathic individuals. However, it remains unclear whether impairment in response reversal per se is associated with antisocial behavior.

Adult↗

PubMed2001

Strong antiapostatic selection against novel rare aposematic prey.

The evolution of aposematism, a phenomenon where prey species conspicuously advertise their unprofitability to predators, is puzzling. How did conspicuousness evolve, if it simultaneously increased the likelihood of an inexperienced predator to detect the prey and presumably kill it? Antiapostatic selection, where rare prey is predated relatively more often, is considered as another major difficulty for aposematism to evolve. However, the risk of being conspicuous in low frequencies has not been experimentally tested. We designed an experiment to test how frequency (4%, 12%, 32%) of conspicuous aposematic prey and its dispersion type (solitary vs. aggregated) affect an initial predation risk of the prey and in avoidance learning of predators. Wild great tits (Parus major) were predators on artificial prey in a "novel world." The relative mortality of aposematic prey was antiapostatic, thus the frequency-dependent predation was most severe at low frequencies. In all frequencies, aggregated aposematic prey survived better than solitary prey. Surprisingly, learning was not determined by a fixed number of unpalatable prey eaten, but at low frequencies fewer aposematic individuals eaten generated predators' avoidance learning. However, per-capita risk for the prey remained highest at low frequencies. Our results underscore the problems of initial evolution of rare conspicuous morphs. Aggregated prey suffered less from predation, indicating selective advantage of aggregation over solitary living for a conspicuous individual.

Animals↗

PubMed1985

Behavior and neurobehavioral teratology using the ferret.

A behavioral profile of the ferret is presented for those who would like to use this animal in behavioral teratology and toxicology, or other disciplines involving behavior. We have reviewed neurobehavioral teratology of lisencephalic ferrets and neuropsychology of ferrets sustaining frontal lesions, as well as most of the studies of "normal" ferret behavior that have appeared in the research literature. Emphasis is placed on discussion of the tests used and how ferrets behaved on them. The behaviors discussed include spatial (maze) learning, delayed response, visual discrimination learning, discrimination learning sets, schedule maintained behavior, shock avoidance learning and spontaneously occurring behaviors, such as ambulation in open field, spontaneous alternation and species specific behaviors. Although the use of the ferret in behavioral experiments is not yet extensive and large gaps exist in our knowledge about the basic functional capacities of this animal, the ferret is unquestionably well suited for behavioral studies.

Age Factors↗

PubMedDate not supplied

The molecular neurobiology of early learning, development, and sensitive periods, with emphasis on the avian brain.

The subcellular processes that correlate with early learning and memory formation in the chick and sensitive periods for this learning are discussed. Imprinting and passive avoidance learning are followed by a number of cellular processes, each of which persists for a characteristic time in certain brain regions, and may culminate in synaptic structure modification. In the chick brain, the NMDA subtype of glutamate receptor appears to play an important role in both memory formation and sensitive periods during development, similar to its demonstrated role in neural plasticity in the mammalian brain. Two important findings have emerged from the studies using chickens. First, memory formation appears to occur at multiple sites in the forebrain and, most importantly, it appears to "flow" from one site to another, leaving neurochemical traces in each as it moves on. Second, the memory is laid down either in different sites or in different subcellular events in the left and right forebrain hemispheres. Hence, we are alerted to the possibility of similar asymmetrical processes occurring in memory consolidation in the mammalian brain. The similarities between early memory formation and experience-dependent plasticity of the brain during development are discussed.

Animals↗

PubMed1994

Effects of fimbria-fornix lesions on avoidance tasks with temporal elements in rats.

Sidman schedule active avoidance, passive avoidance, and multiple avoidance (continuous alternation of active and passive avoidance) tasks were given to fimbria-fornix (FF)-lesioned (n = 10) and control (n = 10) rats to assess the effects of fimbria-fornix lesions on unsignaled avoidance learning with temporal cognition requirement. Active avoidance required subjects to make running responses, and passive avoidance required them to stop running and remain immobile on a running wheel. The tasks could be achieved purely by temporal cues, and no spatial elements were involved. Animals in the FF group performed the active, passive, and multiple avoidance tasks as well as control animals, showing no deficits by lesions in either the number of running responses nor the number of shocks received, although animals in the FF group displayed a greater negative transfer in passive avoidance when they received the active training before the passive training. The results indicate that fimbria-fornix lesions do not impair avoidance tasks when the tasks do not require spatial information, even if temporal information and/or inhibition are necessary to perform the tasks.

Animals↗

PubMed1977

Transections of stria medullaris or stria terminalis in the rat: effects on aversively controlled behavior.

Surgical transection of the stria medullaris (SM) reliably interfered with the acquisition of a one-way avoidance response but had no effect on two-way shuttle box avoidance, passive avoidance, intake of palatable fluids, or locomotor activity. Transection of the stria terminalis (ST) selectively interfered with the animals' reactions to punishment in a passive avoidance situation but had no effect on one-way or two-way active avoidance or on locomotor activity. This pattern of effects complements the results of earlier investigations from our laboratory that showed that two-way avoidance learning (but not one-way avoidance or passive aboidance behavior) was impaired after fornicotomy and after transection of the ventral connections of the septum with the lower brain stem. The latter cut, but not fornicotomy or transection of ST or SM, reproduced the effects of septal lesions on water intake, body weight, and preferential intake of palatable solutions. The results of this investigation provide support for the hypothesis that the septum exercises a number of separate functions that are mediated by different pathways.

Animals↗

PubMedDate not supplied

Autoimmunity and age-associated cognitive decline.

It is suggested that the immune system may play a role in the etiology of age-associated cognitive decline and/or Alzheimer's disease. The relationship between brain-reactive antibodies (BRA) and age-associated cognitive dysfunction is reviewed and discussed. A parallel relationship between BRA increases with age and decline of avoidance learning capacity is described in mouse models. Transfer of immunity from old to young mice was found to accelerate both age-related formation of brain-reactive antibodies and age-related decline of avoidance learning capacity. Short-lived mouse genotypes with accelerated autoimmunity were found to show accelerated age-related declines in their ability to acquire an avoidance response when compared with nonautoimmune mice. Overall, these findings suggest that the immune system could be an important target for development of intervention strategies aimed at extending the intellectually competent period of life. Mice in which autoimmunity is accelerated may be useful as models for the development of such interventions.

Aging↗

PubMed1997

Medial geniculate lesions block amygdalar and cingulothalamic learning-related neuronal activity.

This study assessed the role of the thalamic medial geniculate (MG) nucleus in discriminative avoidance learning, wherein rabbits acquire a locomotory response to a tone [conditioned stimulus (CS)+] to avoid a foot shock, and they learn to ignore a different tone (CS-) not predictive of foot shock. Limbic (anterior and medial dorsal) thalamic, cingulate cortical, or amygdalar lesions severely impair acquisition, and neurons in these areas develop training-induced activity (TIA): more firing to the CS+ than to the CS-. MG neurons exhibit TIA during learning and project to the amygdala. The MG neurons may supply afferents essential for amygdalar and cingulothalamic TIA and for avoidance learning. To test this hypothesis, bilateral electrolytic or excitotoxic ibotenic acid MG nuclear lesions were induced, and multiunit recording electrodes were chronically implanted into the anterior and posterior cingulate cortex, the anterior-ventral and medial-dorsal thalamic nuclei, and the basolateral nucleus of the amygdala before training. Learning was severely impaired and TIA was abolished in all areas in rabbits with lesions. Thus learning and TIA require the integrity of the MG nucleus. Only damage in the medial MG division was significantly correlated with the learning deficit. The lesions abolished the sensory response of amygdalar neurons, and they attenuated (but did not eliminate) the sensory response of cingulothalamic neurons, suggesting the existence of extra geniculate sources of auditory transmission to the cingulothalamic areas.

Acoustic Stimulation↗

PubMed2000

Acute exposure to saccharin reduces morphine analgesia in the the rat: evidence for involvement of N-methyl-D-aspartate and peripheral opioid receptors.

RATIONALE: Pairings of a sweet taste and injection of morphine result in a learned avoidance of that taste and learned analgesic tolerance. This avoidance is mediated by the drug's peripheral effect, while learned tolerance involves activation of N-methyl-D-aspartate (NMDA) receptors. Exposure to a sweet taste also reduces morphine analgesia. We studied whether this taste-mediated reduction was reversed by an NMDA or peripheral opioid receptor antagonist. OBJECTIVES: To determine whether an intraoral infusion of saccharin would modulate morphine analgesia in rats, and to study the contribution of NMDA as well as peripheral opioid receptors to this modulation. METHODS: Six experiments used the rat's tail-flick response to study the effect of an intraoral infusion of a sodium saccharin solution on morphine analgesia, and the effects of the quaternary opioid receptor antagonist methylnaltrexone as well as the noncompetitive NMDA receptor antagonist MK-801 on this modulation of analgesia. RESULTS: An intraoral infusion of saccharin reduced the analgesic effects of an intraperitoneal (i.p.) injection of morphine across a range of doses (experiment la), which was not attributable to an influence on tail-skin temperature (experiment 1b). This reduction was mediated by opioid receptors in the periphery and activation of NMDA receptors because morphine analgesia was reinstated by an i.p. injection of either methylnaltrexone (experiment 2a) or MK-801 (experiment 3a), which was not due to the effect of methylnaltrexone (experiment 2b) or MK-801 (experiment 3b) on morphine analgesia in the absence of saccharin. CONCLUSIONS: These results document evidence for an antagonism of morphine analgesia by actions of the drug at peripheral opioid receptors and excitatory amino-acid activity at NMDA receptors. They are discussed with reference to the aversive motivational effects of peripheral opioid receptors and pain facilitatory circuits.

Analgesia↗

PubMed1999

Striato-telencephalic and striato-tegmental circuits: relevance to learning in domestic chicks.

Memory formation for a passive avoidance task in the domestic chick is likely to involve a hyperstriatum ventrale (IMHV)-archistriatum-lobus parolfactorius (LPO) arc. The present study summarises previous findings, relevant to this neural system, and is also supplemented with some recent data from our laboratory. Projections from the IMHV on the archistriatum, as well as from the archistriatum on the LPO, have been characterised using a combination of anterograde pathway tracing (Phaseolus lectin), and post-embedding GABA and glutamate immunocytochemistry. The majority of IMHV efferents have been found to synapse with dendritic spine heads and necks of densely spiny projection neurons of the ventral archistriatum, and the ultrastructure of synapses suggested a potent excitatory input. Similar synaptic connections of the excitatory type were ultrastructurally verified between ventral archistriatal afferent terminals and dendrites or spines of the LPO, suggesting an involvement of the medium sized spiny neurons, which are typical of the striatum. Although some of the IMHV boutons terminating in the archistriatum were immunoreactive to glutamate, this was not observed in the archistriatal-LPO pathway. Tegmental connections of the basal ganglia, in particular LPO, are also likely to play a role in processing of the avoidance response. We have demonstrated reciprocal connections between the LPO and dopaminergic (TH-positive) neurons of the substantia nigra and ventral tegmentum. Dopamine D1 receptors were upregulated bilaterally in the LPO following avoidance learning and this response was not accompanied by significant changes in the level of dopamine or its metabolites (HVA, DOPAC), as revealed by HPLC chromatography of brain samples dissected from the LPO of control and trained chicks. The dopamine receptor-related phosphoprotein DARPP-32 was localised in dendritic elements of the LPO, often forming asymmetric synapses with glutamate immunoreactive axon terminals. The findings are consistent with a scenario in which the striatum acts as a suppressor of natural pecking behaviour. Learned visual association with the target (bead) occurs in the IMHV and is relayed to the basal ganglia via the limbic archistriatum (amygdala equivalent), the latter introducing a motivational element (aversion, fear). Suppression of a brainstem pecking centre is likely to involve activation of the nigrostriatal (tegmentostriatal) dopaminergic circuit.

Afferent Pathways↗

PubMedDate not supplied

Age-related changes of glutamate dehydrogenase in the rat hippocampus: an enzyme histochemical study.

Enzyme histochemical techniques associated with microphotometry were used to evaluate the reactivity of glutamate dehydrogenase (GDH) in the hippocampus of young (3 month) adult (12 month) and old (26 month) male Sprague-Dawley rats. In young rats the highest level of enzymatic reactivity was found in the stratum oriens of the CA-1-CA-4 fields followed in descending order by the molecular layer of fascia dentata, and by the layer of mossy fibers. In all the layers investigated GDH reactivity was higher in adult that in young rats. The older animals exhibited lower GDH reactivity than adult rats in almost all of the layers and higher enzymatic reactivity than in young rats in the stratum oriens of the CA-1-CA-4 fields. The hippocampus is known to be involved in the acquisition of two-way avoidance learning and is thought to utilize glutamate as one of its main neurotransmitters. These data suggest a possible relationship between hippocampal glutamatergic transmission and impairment of acquisition of avoidance learning occurring with age. Moreover, the possibility that a decreased glutamate catabolism occurring in old rats may contribute to the neuronal loss described in the hippocampus of aged rats is discussed.

Journal Article↗

PubMed1995

Cognitive function in rats with alcohol ingestion.

The effect of alcohol ingestion on learning disturbances was tested in rats. Rats were fed either an alcohol solution or a nonalcohol solution. The concentration of acetylcholine in the whole brain was significantly lower in rats fed with alcohol than rats fed without alcohol. Passive avoidance learning shows a lower tendency in rats with alcohol compared to rats without alcohol, but the alcohol and control groups did not differ in passive avoidance learning. We suggest that alcohol may disturb acetylcholine metabolism in the brain.

Animals↗