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[Quantitative model of human erythrocyte glycolysis. Relationship between erythrocyte energy metabolism and Na+, K+-ATPase activity].

The influence of the changes of the transport Na+, K+-ATPase activity on the human red blood cell (RBC) glycolysis was studied. Two different types of energetic regulation were found out under the strophanthin inhibition. A decrease of ATP comsumption results in a drop of glucose consumption and lactate production in the first type regulation of RBC. In the second type regulation of RBC the glucose consumption does not change after ATPase inhibition and the excess metabolic flux is directed through the hexosemonophosphate shunt. In both cases the resulting decrease of ATP production leads to the ATP level stabilization. An increase of potassium ions concentration in the external medium does not influence the RBC glycolysis. The valinomycin added increases the glucose consumption and the lactate production. The cell volume decreases under the effect of valinomycin.

Erythrocytes↗
PubMed1989

The erythrocyte density test (EDT) and erythrocyte creatine concentration (ECE) as laboratory indexes of perinatal hypoxia.

To study the influence of gestational age and asphyxia on the behaviour of EDT and ECE a group of cuban control and asphyxiated newborns was investigated. A total number of 203 newborns at the age of 0-3 days of life, all with adequate weight for gestational age, were classified into 4 groups according to their gestational age, the 1 min and 5 min Apgar score and the presence of meconium stained amniotic fluid and/or respiratory distress syndrome immediately after birth. In the group of asphyxiated newborns higher values for both parameters were found when they were compared with the respective control groups (p less than 0.05). These techniques could help the neonatologists to more precisely identify newborns with severe perinatal asphyxia and to improve the prognosis of the outcome.

Asphyxia Neonatorum↗