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At least 865 records · Page 48Linked to original sources
PubMed1990

[Immunogenetic analysis of delayed hypersensitivity to tuberculin in mice by the method of local adoptive transfer].

It has been demonstrated that a specific phase of DTH reaction to tuberculin is carried out (and in adoptive transfer-transferred) by T-lymphocytes with Lyt-1+, Lyt-2-, L3T4+ phenotype by a method of local adoptive transfer of this reaction from BCG-immunized mice to the pads of intact recipients. From genetic viewpoint, the above reaction is limited by 1-A beta, 1-A alpha genes. In a syngeneic apposition, monoclonal antibodies anti-1-A kappa beta (without complement) were blocking the reaction transfer to CBA mice A beta chain affected mutation bm12 failed to limit the reaction transfer in apposition B6----B6.C-H-2bm12.

Animals↗
PubMed1986

Macrophage transmission of suppressor signal for suppression of delayed hypersensitivity and humoral response in JEV-infected mice.

Japanese encephalitis virus (JEV) infection induces suppressor T-cells (Ts1) which suppress both the humoral (Ts-PFC) and cell mediated (Ts-DTH) immune response by producing soluble suppressor factors. This study shows that in the JEV model, both TS-PFC and Ts-DTH mediate suppression by recruiting a second subpopulation of suppressor T-cells, the Ts2-PFC and Ts2-DTH. The signal between Ts1 and Ts2 is transmitted by macrophages (M phi). The suppressor factors are adsorbed by peritoneal or splenic M phi. Both heat-killed and live M phi are capable of adsorbing suppressor factors but only live M phi are capable of presenting the signal to T-cells. Thus these are at least two generations of suppressor T-cells in the JEV-specific suppressor pathway and the presence of M phi is obligatory for transmission of the signal.

Adsorption↗
PubMed1987

Delayed hypersensitivity skin testing in nutritional assessment.

Skin testing is useful in nutritional assessment because decreased immunity is associated with malnutrition. Absence of positive reactions indicates anergy, reaction to one test shows some decreased immunity, and response to two or more tests is considered normal. Variation in number and type of test antigens could lead to contradictory results. Also, conventional intradermal injections vary in antigen strengths, injection techniques, and subjective evaluations, and are also uncomfortable. This study compared results from three, four, or seven antigens in relation to other nutritional indices. Fifty hospitalized men with cancer were assessed with a 23 item Protein Energy Malnutrition Scale and classified as well nourished (60%) or malnourished (40%). Number of tests did not differ in identifying the malnourished; however, the smaller battery misclassified the normal as malnourished twice as often as the seven tests. Misclassification of normal as abnormal could lead to unnecessary interventions, such as total parenteral nutrition, that increase complications and cost of care dramatically.

False Negative Reactions↗
PubMed1988

[Histone-like nature of bacterial allergens used in diagnosing delayed hypersensitivity reaction].

In this work new data are presented on the comparative quantitative amino acid analysis of allergens, isolated and purified from different bacteria. On the basis of a high content of basic amino acids, such as lysine, arginine and histidine, in Mycobacterium, Brucella and Francisella tularensis allergens, a suggestion is made to classify bacterial allergens with histone-like proteins.

Allergens↗