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PubMed1981

[The biological action of dithiocarbamates. Changes in serum leucine aminopeptidase induced in vitro by sodium diethyldithiocarbamate].

The Authors demonstrate that serum LAP activity in vitro is inhibited by NaDDTC. This may be related to the NaDDTC chelating-like action on the metallo-enzyme. The trend of the phenomenon follows an exponential pattern. The enzyme activity was completely restored after removal of NaDDTC from the medium by dialysis. The NaDDTC concentration able to inhibit the enzymatic activity in vitro was much higher than in vivo, in experimental animals. The Authors conclude pointing out the problem of a probable effect caused by repeated doses of dithiocarbamates more on enzyme synthesis than on metallic apoenzyme.

Animals↗
PubMed1981

[Histochemical demonstration of beta-glucuronidase and leucine aminopeptidase in cultivated aortic endothelial cells (author's transl)].

With the aid of histochemical techniques, the activity of beta-GD, LAP, NADH-D, and LDH of in vitro cultivated calf aortic endothelial cells were compared with the activity of these enzymes in different tumours in vivo. The relative high level of beta-GD, NADH-D, and LDH in the endothelial cells is comparable with the increased activity of these enzymes in invasive growing tumours. The results were discussed in connection with a possible enzymolytic effect during the invasive growth of capillary endothelial cells in course of neovascularization in vivo.

Animals↗