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Results for “RUTIN”

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At least 865 records · Page 48Linked to original sources

PubMed1975

A comparison of the effectiveness of some anti-inflammatory drugs on thermal oedema.

The efficacy of a group of anti-inflammatory drugs with similar modes of action was tested on thermal oedema. Of these, coumarin and sodiumrutin-sulphate were most effective. A combination of these, marketed as Venolot, although still beneficial, was not as effective as either given singly. The other drugs tested--levamisole, Reparil and Venoruton--although also of some benefit in treatment of this oedema, did not approach the overall effectiveness of coumarin of sodium-rutin-sulphate. Both drugs are characterized by a very wide safety margin between the therapeutic and the toxic dose. In addition, they are cheap, easy to obtain and can be taken orally. They work by stimulating phagocytosis, enzyme production and thus proteolysis and a subsequent removal of protein and oedema fluid from the injured tissues.

Animals↗

PubMed2000

[Studies on flavonoids from leave of Eucommia ulmoides Oliv].

OBJECTIVE: To separate the constituents from Eucommia ulmoides. METHOD: The constituents were separated by the repeated chromatography and identified by spectral methods. RESULT: The seven compounds were obtained, which were kaempferol(1), quercetin(2), astragalin(3), hirsutin(4), rutin(5), 3,4-dihydrobenzonic acid(6), ethyl glucopyranoside(7). CONCLUSION: Compounds 3-7 were obtained from leaves of E. ulmoides for the first time.

Alkaloids↗

PubMed2000

[Studies on chemical constituents of Phyllanthus urinaria L].

OBJECTIVE: To investigate the chemical constituents of Phyllanthus urinaria. METHOD: Various chromatographic techniques were employed for isolation and purification of the constituents. The structures were elucidated by chemical and spectral analyses. RESULT AND CONCLUSION: Fourteen compounds were isolated and seven of them were identified as corilagin(I), rutin(II), brevifolincarboxylic acid(VI), isostrictiniin(IX), geraniin (X), gallic acid(XI) and ellagic acid (XII). Compound VI was found from P. urinaria for the first time and compound IX was found from genus Phyllanthus for the first time.

Carboxylic Acids↗

PubMed2002

[Development of "Saules" tincture technology].

The article deals with the production of the "Saules" tincture in a way of selecting an extractive agent concentration, the size of particles of the raw material and the method of extraction. The experiment indicates that the optimum concentration of ethanol in the tincture is 70% V/V, the particles' size is in the range from 1 to 2 mm; the production method recommended for use is percolation. The quality of the tincture was evaluated by determining the quantity of flavonoids and dry residue, the concentration of the ethanol, the density and the microbial contamination. The presence of quercetin, rutin and hyperoside was confirmed using high-pressure liquid chromatography. The stability of the tincture was evaluated.

Aged↗

PubMed2002

[Analysis of flavonoids in the flowers and leaves of Monarda didyma L].

Monarda didyma L. is a herbaceous perennial with the square stems and opposite leaves characteristic of herbs in the Labiate family. Monarda didyma L. is often used as a domestic medicine, being particularly useful in the treatment of digestive disorders. The leaves and flowering stems are antihelmintic, carminative, diuretic, expectorant, febrifuge, rubefacient and stimulant. Monarda didyma L. has twenty-six compounds in the essential oil, of which thymol, with smaller amounts of para-cymene, d-limonene, carvacrol, linalool, and hydrothymoquinone. A new method was used for the determining of the amount of separate flavonols by high-performance liquid chromatography. The flavonoids (rutin, hyperoside, quercitrin, luteolin, quercetin) were found in leaves and flowers of beebalm. The quantity of flavonoids was higher in flowers than in leaves of Monarda didyma L.

Chromatography, High Pressure Liquid↗

PubMed2002

[Studies on chemical constituent of Solanum lyratum].

OBJECTIVE: To study chemical constituents of Solanum lyratum. METHOD: The constituens were isolated by polystyrene resin RA, sephadex LH-20 and silica gel column chormatography, their structures were identified by spectroscopic analysis. RESULT: Four compounds were identified as The constituens were caffeic acid, vanillic acid, rutin and N(p-hydropheneethyl) p-coumaramide. CONCLUSION: These compounds were isolated from this plant for the first time.

Caffeic Acids↗

PubMed1992

Inhibition of 11 beta-hydroxysteroid dehydrogenase by gossypol and bioflavonoids.

The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) oxidizes hydrocortisone to inactive cortisone in the kidney and is an important regulator of renal K+ clearance. Gossypol, in clinical trials as an antifertility drug for men in China, was associated with episodes of hypokalemia. To learn whether gossypol and other structurally similar compounds in plants can inhibit 11 beta-OHSD activity, purified enzyme from rat liver and in human renal cortical microsomes was studied. Rat liver enzyme was inhibited by glycyrrhetinic acid > gossypol >> morin > quercetin >> rutin. Glycyrrhetinic acid, gossypol, and morin inhibited activity of the human kidney enzyme. Enzyme in microsomes from five human kidneys had an IC50 (S.D.) of 1.5 (1.2) mumol/L for glycyrrhetinic acid; enzyme in microsomes from six human kidneys had a 50% inhibitory doses of 147 (25) mumol/L for gossypol. Our observations indicate that gossypol and other compounds in plants can inhibit 11 beta-OHSD activity and may thereby increase K+ excretion.

11-beta-Hydroxysteroid Dehydrogenases↗

PubMed1992

[Glycosides of phenolic acid and flavonoids from the leaves of Glycyrrhiza uralensis Ficsh].

Seven glycosidic constituents have been isolated from the dried leaves of Glycyrrhiza uralensis Ficsh. (Leguminosae). The Structures of these compounds have been identified as 1-O-protocatechuyl-beta-D-xylose (I), apigenin-6,8-di-C- beta-D-glucopyranoside (vicenin-2, II), isorhamnetin-3-O-rutinoside (narcissin, III) kaempferol-3-O-rutinoside (nicotiflorin, IV), kaempferol-3-O-beta-D- glucopyranoside (astragalin, V), quercetin-3-O-rutinoside (rutin, VI), and quercetin-3-O-beta- D-glucopyranoside (isoquercitrin, VII) by chemical method and spectroscopic analysis. Among these compounds, I is a new compound, named uralenneoside; III was reported for the first time in the genus; III to VII were isolated for the first time from the species. II to VII are known biologically active constituents.

Glycosides↗

PubMed1992

[HPLC analysis of the active ingredients of Forsythia suspensa].

Forsythia suspensa is a widely used traditional Chinese herb. Because of the need to evaluate its quality, a HPLC method was developed to analyze the active ingredients in its fruits and leaves. One g of powdered plant material was cold macerated over-night with 10 ml of methanol added then supersonic extracted for 20 min. Four ml of the extract were mixed with 1 ml of water, centrifuged (400 x g, 15 min), and then analyzed by HPLC with a Nucleosil C--18 column. The mobile phase for gradient elusion consisted of MeOH(containing 1% tetrahydrofuran) and H2O (containing 0.01 mol/L KH2PO4,pH 3.2) and monitored by UV absorption at 280 nm. The identity and purity of the peaks were checked by photodiode array detector and in comparison with standards. By this procedure, the active constituents caffeic acid, rutin, forsythoside A, forsythin, and forsythigenin were separated successfully, and the quantity of each compound was determined by peak area. Some fruit samples obtained from various sources and the leaf sample made as tea were analyzed by this method.

Caffeic Acids↗

PubMed2004

The medical management of idiopathic chylothorax in a domestic long-haired cat.

A 3-year-old, spayed female domestic long-hair was evaluated for a 2-week history of progressive tachypnea. Chylothorax was diagnosed through radiographic and pleural fluid evaluation. No primary cause was identified and the cat was managed medically. Thoracocentesis, dietary management, and oral rutin therapy resulted in substantial improvement of this idiopathic condition.

Administration, Oral↗

PubMed2003

[Studies on chemical constituents in herb of Lamium maculatum L. var Kansuense].

OBJECTIVE: To study the chemical constituents from Lamium maculatum L. var Kansuense. METHOD: The chemical constituents were isolated and repeatedly purified by silica gel column chromatography and the structures were elucidated by the NMR spectra and physico-chemical properties. RESULT: Ten compounds were obtained and they were identified as D-mannitol, beta-sitosterol, stigmasterol, rutin, 3'-methylquercetin-3-O-rutinoside, n-butyl-beta-D-fructopyranoside, daucosterol, acteoside, 20-hydroxyecdysone, allantoin. CONCLUSION: All the compounds were obtained from L. maculatum L. var Kansuense for the first time.

Allantoin↗

PubMedDate not supplied

Plant phenolics protect from bleomycin-induced oxidative stress and mutagenicity in Salmonella typhimurium TA102.

Antioxidants are deemed to be important against DNA damage and mutations induced by reactive oxygen species (ROS). An assay for the ability of plant phenolics to protect against mutations caused by bleomycin treatment in Salmonella typhimurium TA102 cells in concentrations up to 20 microM was developed. Caffeic acid, gallic acid, protocatechuic acid, ferulic acid and rutin hydrate in final concentrations of 0.5 to 20 microM were tested for their ability to protect TA102 cells from mutations caused by oxidative stress from bleomycin. The cut-off concentration of 20 microM was used because as a limit it is biologically meaningful, higher concentrations being unrealistic in vivo. Caffeic acid was very potent at a concentration of 0.5-20 microM. The other four antioxidants were not effective up to 20 microM. The above assay will be helpful to characterize antioxidant molecules.

Antimetabolites, Antineoplastic↗

PubMed2004

[Research of the amounts of flavonoids accumulated in the buds of single-styled hawthorn].

OBJECTIVE: To determine the amounts of flavonoids accumulated in the buds of single-styled hawthorn (Crataegus monogyna Jacq.); and to establish the possibility of usage of hawthorn buds in pharmacy practice. MATERIAL AND METHODS: Different examples of hawthorn buds collected in 2001, 2002 and 2003 from some Lithuanian regions: Akmene (V1, V2, V3), Kedainiai (S1, S2, S3), Klaipeda (M1), Lazdijai (D1, D2, D3) and Vilnius (VL1, VL2) from branches of lower storey. Examples were extracted with ethanol and flavonoids were measured by spectroscopic method and by high performance liquid chromatography. RESULTS: From 0.72 to 1.89% of flavonoids are found in the hawthorn buds. The dominating flavonoid is vitexin-2-O-rhamnosid (6.72-10.91 milligrams in one gram of dried crude drug). Other flavonoids are: vitexin: 0.88-6.53 milligrams/gram, hyperosid: 0.85-2.70 milligrams/gram, rutin: 0.72-2.10 milligrams/gram and quercitrin: 0.82-1.01 milligrams/gram. CONCLUSION: The marks of phytochemical compounds of Lithuanian single-styled hawthorn buds corroborated the theory of possibility to use hawthorn buds as pharmaceutical crude drug and form sufficient ground for planning phytochemical and pharmacological researches of new hawthorn crude drug.

Apigenin↗

PubMed2004

[Effect of soil preparation and fertilization on foliage and shoot growth of Ginkgo biloba and its medicine content].

The study showed that the efficiency of various treatments in improving the height growth of Ginkgo biloba was organic fertilizer plus intercropping > soil preparation by blasting plus intercropping > organic fertilizer > soil preparation by blasting > intercropping, and the height growth increased by 14.5%, 8.6%, 5.7%, 3.2% and 0, respectively. The efficiency of the treatments in improving new shoot growth was organic fertilizer plus intercropping > soil preparation by blasting plus intercropping > intercropping > organic fertilizer > soil preparation by blasting, and the new shoot growth increased by 58.1%, 36.6%, 33.1%, 30.2% and 14.0%, respectively. Soil preparation, organic fertilization and intercropping had no different effect on the number of long shoots, but their effect on the numbers of short shoots and leaves was significantly different. The most efficient treatment in improving the medicine content was organic fertilization plus intercropping. Compared with control, the content of quercetin and rutin in Ginkgo biloba leaves increased by 420% and 220%, respectively.

Fertilizers↗

PubMed2004

[Studies on chemical constituents from Eucommia ulmoides Oliv].

OBJECTIVE: To study the chemical constituents from Eucommia ulmoides Oliv. METHODS: The chemical constituents were isolated and repeatedly purified on silica gel column. They were identified and structurally elucidated by means of physio-chemical constants and spectral analysis. RESULTS: Seven compounds were obtained. They were (-)epicatechin (I), catechin (II), n-octacosanoic acid (III), tetracosanoic-2, 3-dihydroxypropylester (IV), rutin (V), chlorogenic acid (VI), and caffeic acid (VII), respectively. CONCLUSION: Four compounds (II, III, IV, V) were isolated from bark of Eucommia ulmoides Oliv for the first time.

Caffeic Acids↗

PubMed2005

[Applications of two-dimensional liquid chromatography coupled to mass spectrometry for the separation and identification of compounds in ginkgo biloba extracts].

A comprehensive two-dimensional liquid chromatographic separation system based on the combination of an immobilized liposome chromatographic (ILC) column and an ODS column was developed for the separation of components in Ginkgo biloba, a traditional Chinese medicine. Two columns were coupled by a two-position, eight-port valve equipped with two storage loops, and the system was controlled by a computer. The effluent was detected both by a diode array detector and by an atmospheric pressure chemical ionization (APCI) mass spectrometer. Under the optimization separation conditions with the separation system, more than 41 components in the methanol extract of Ginkgo biloba were resolved. According to their UV and mass spectra, 13 of them were preliminarily identified as ginkgolide B, ginkgolide C, bilobalide, rutin, quercetin, quercetin-3-O-beta-D-glucosyl (1-2)-alpha-L-rhamnoside, quercetin-3-O-beta-D-glucoside, isorhamnetin, kaempferol-3-O-beta-D-glucosyl (1-2)-alpha-L-rhamnoside, isohamnetin-3-O-beta-D-rutinoside, kaempferol-3-O-beta-D-glucoside, kaempferol, kaempferol-3-O-beta-D-rutinoside.

Chromatography, High Pressure Liquid↗

PubMed2005

[Studies on chemical constituents from Salvia roborowskii Maxim].

OBJECTIVE: To study the chemical constituents from Salvia roborowskii Maxim. METHODS: Chromatography and spectroscopic analysis were employed to isolate and elucidate the chemical constituents in the plant. RESULTS: Three compounds were isolated and elucidated as 1 beta-hydroxy-lupeol (I), quercetin-3-O-beta-D-glucoside (II), rutin (III). CONCLUSION: I - III were isolated from this plant for the first time.

Chromatography, Thin Layer↗

PubMed2005

[Study on the chemical constituents from Rumex japonicus Houtt].

OBJECTIVE: To study the chemical constituents in dried roots of Rumex japonicus Houtt. METHODS: Isolation and purification of chemical constituents from Runmex japonicus Houtt. were conducted by solvent extraction and chromatography. Their structures were identified by spectrum analysis. RESULTS: Two compounds were isolated from the acrtone extract of the roots and identified as emodin and rutin. CONCLUSION: Compound II is obtained from this plant for the first time. The task provided evidence for the exploitation and utilization of this plant resources.

Acetone↗