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Measurement of skin temperatures of active subjects by wireless telemetry.

A new sensor has been developed for measurement of skin temperatures of active human subjects that consists of a radio transmitter circuit incorporating a skin thermistor in a small epoxy slab or "tab." These tabs are reuseable, being large enough to permit battery replacement if required. They are glued to a subject's skin (thermistor side facing the skin) with a quick-setting adhesive and are easily removed after a 10-h period with an appropriate solvent. Thermal information is easily obtained from the sensor by a hand-held calibrated radio receiver accurate to +/- 0.1 degree C. This technique permits easy and rapid documentation of the thermal stress of active human subjects without interfering with their activity or clothing.

Body Temperature↗

[A system for biological pressure telemetry in conscious animals (author's transl)].

Cardiovascular studies on conscious laboratory animals are required for an accurate assessment in drug evaluations. However, attempts to define pharmacological significance of an agent in conscious and unrestrained animals have been limited by the techniques available for recording the cardiovascular parameters. We designed a system which can be applied to record biological pressure, such as the blood pressure, using a miniature FM-FM radio-transmitter and a receiver demodulator. The transmitter consists of a differential amplifier capable of an input signal up to 3 X 10(6) times, voltage controlled oscillator which triggers a 2-5 volts range and 76-90 MHz transmitting oscillator. The transmitter requires a 5.6 V mercury battery. Earphone output of a commercial FM radio-receiver serves for signals to the demodulator. The demodulator is based on the phase locked loop principle and is equipped with an independent output for instantaneous wave recording and the mean of this recording. Transmitting distance of the system may depend on the receiver, however, in most instances, the distance is over 39 meters, in an open field. Accuracy of the telemetering data is dependent on discharge characteristics of the mercury battery. After discharging 5%, the full capacity of the cell gives a sufficient zero stability and accurate pressure measurements.

Animals↗

Telemetry of cardiac left ventricular pressure in conscious dogs.

A fully implantable telemetric system for the measurement of cardiac left ventricular pressure and derived parameters in conscious dogs is presented. It provides the following advantages: ethical acceptability, scientific relevance, economical experimentation, avoidance of stress-induced situations for the animal, experiments without anaesthesia or sedation. The system has an operation time which allows the sequential pharmacological evaluation of a great number of drugs in individual dogs as has been shown by testing the effect of the positive inotropic agent, dobutamine, and the calcium antagonists, verapamil and nifedipine.

Animals↗

Intracranial pressure telemetry system. II. Animal testing.

A small, implantable, telemetric device for the long-term monitoring of intracranial pressure has been described in part I of this article. This portion of the study is designed to demonstrate the in vivo operational characteristics of that implant device in experimental animals. Results indicate that this system can provide long-term in vivo operation with rapid and accurate responses to acute changes in pressure. Data also indicate some drift in the baseline measurement of pressure. No signs of abnormal body reactions to the units were observed.

Animals↗

Telemetry of intracranial pressure.

In the care of patients with abnormal intracranial pressure, it is important to continuously and accurately measure the intracranial pressure so that treatment can be instituted. Strain gage pressure cells have successfully replaced the open-end manometer for chronic use but have lacked the stability for accurate long-term measurements. The system described uses a capacitive pressure transducer with excellent long-term stability. The transducer, electronics, and transmitter package can be implanted to telemeter the pressure transcutaneously, reducing the danger of infection by the elimination of transcutaneous leads. The pressure modulates the frequency of an oscillator in the 8-10 MHz region and provides an easily telemetered signal. To eliminate the problems of periodic battery replacement, the system is energized inductively by a coil placed externally over the implant device, so that the operating life is virtually unlimited.

Animals↗