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PubMed1985

Methods for measuring vascular and nonvascular alpha-receptor sensitivity in humans.

Since increased alpha-adrenergic reactivity may participate in the pathophysiology of essential hypertension, methods for accurately assessing in vivo alpha-receptor sensitivity in humans might be useful. The goals of this study were to employ previously used methods, namely pupillometry and local forearm intraarterial infusions, to assess alpha-receptor sensitivity, create an in vivo environment of decreased sympathetic drive (plasma norepinephrine) and increased alpha-receptor number (platelet alpha 2), in which increased alpha-receptor sensitivity to exogenous agonists might occur. Five patients with minimally elevated blood pressure (139 +/- 5/90 +/- 4 mm Hg) while on diuretic monotherapy completed assessment of biochemical and physiologic variables on diuretic alone and again on diuretic and guanadrel. Guanadrel plus diuretic compared with diuretic alone lowered the seated diastolic and standing systolic and diastolic blood pressure. Heart rate was decreased about 10 beats/min. Baseline supine norepinephrine was reduced an average of 40% (from 281 +/- 23 to 168 +/- 16 pg/ml, p = 0.03), and platelet alpha 2-receptors were increased roughly 40% (from 178 +/- 34 to 250 +/- 54 fmol/micrograms, p = 0.07). Despite the expected decrease in sympathetic drive and increase in alpha-receptors (platelet alpha 2), the pupillary mydriatic response to phenylephrine and the forearm vasoconstrictor response to intraarterial norepinephrine were not augmented. The failure to detect increased physiologic responsiveness in the presence of decreased norepinephrine and increased alpha 2-receptor number lends itself to multiple explanations which need to be tested in future research.(ABSTRACT TRUNCATED AT 250 WORDS)

Arm↗

PubMed1998

Comparison of discriminative properties among disease-specific questionnaires for measuring health-related quality of life in patients with chronic obstructive pulmonary disease.

Three disease-specific, health-related quality of life (HRQL) questionnaires have been introduced to assess patients with chronic obstructive pulmonary disease (COPD): the St. George's Respiratory Questionnaire (SGRQ), the Breathing Problems Questionnaire (BPQ), and the Chronic Respiratory Disease Questionnaire (CRQ). The purpose of the present study was to make comparisons between the SGRQ, the BPQ, and the CRQ in their discriminative properties, and to clarify the characteristics of each questionnaire. One hundred forty-three patients with mild to severe COPD completed pulmonary function tests, progressive cycle ergometer testing for exercise capacity, assessment of dyspnea, anxiety, and depression, and assessment of HRQL. The frequency distributions of the questionnaire scores showed that the SGRQ and the CRQ were normally distributed and that the BPQ was skewed toward low scores. Relationships between all dimensions of the three questionnaires were significant (correlation coefficients [Rs] = 0.74 to 0.86). The three questionnaires had significant but weak correlations (Rs = -0.24 to -0.36) with some physiologic variables (VC, FEV1, and DL(CO)/VA) and mild to moderate correlations with exercise capacity and assessment of dyspnea, anxiety, and depression. Stepwise multiple regression analyses revealed that the Baseline Dyspnea Index (BDI) score, anxiety by the Hospital Anxiety Depression Scale (HAD), and maximal oxygen uptake (VO2max) accounted for 61% of the variance in the SGRQ and that the BDI and anxiety of the HAD accounted for 53 and 49% of the variance in the BPQ and the CRQ, respectively. Dyspnea and psychologic status impacted the HRQL in patients with COPD. Although no substantial differences between the SGRQ, the BPQ, and the CRQ were evident in the correlations with physiologic parameters and the influential factors, the BPQ was found to be less discriminatory than the SGRQ and the CRQ in evaluating HRQL cross-sectionally.

Aged↗

PubMed1996

Artificial neural network prediction of ascites in broilers.

An artificial neural network was trained to predict the presence or absence of ascites in broiler chickens. The neural network was a three-layer back-propagation neural network with an input layer of 15 neurons (defining 15 physiological variables), a hidden layer of 16 neurons, and an output layer of 2 neurons (the presence or absence of ascites). Male by-products of a breeder pullet line were brooded at 32 and 30 C during Weeks 1 and 2, respectively. The training set for the neural network consisted of data from birds subjected to cool temperatures (18 C) to induce ascites. After training, the predictive ability of the neural network was verified with two new data sets. The second data set was from birds subjected to cool temperatures (18 C). The third data set was from birds subjected to clamping of the pulmonary artery to simulate the physiological processes involved in ascites (the temperature was 24 C). A comparison was made between laboratory diagnostic results and the neural network predicted ascites incidence. The neural network accurately identified the presence or absence of ascites in the first (training) set. Two false positives and one false positive were identified in the second and third verification sets, respectively. The birds identified as false positives were determined to be in the developmental stages of ascites before the occurrence of fluid accumulation. Artificial neural networks were found to effectively identify broilers with and without ascites.

Animals↗

PubMed2003

Chronomics of tree rings for chronoastrobiology and beyond.

Gliding spectral windows illustrate the changes as a function of time in the relative prominence of signals in a given frequency range, viewed in 3D or as surface charts. As an example, the method is applied to a 2,189-year series of averages of ring measurements on 11 sequoia trees published by Douglass. Analyses of the original data and after filtering reveal, among others, components with periods of about 10.5 and 21 years similar to the Schwabe and Hale solar activity cycles. An alignment of gliding spectra with a global spectrum serves to define, by minima, the ranges of variability around the anticipated Schwabe and Hale cycles. This procedure may have more general applicability when dealing with ranges of only transiently synchronized, wobbly, and perhaps sometimes free-running periodicities. Solar activity is known to affect climate and changes in climate are reflected to some extent in tree growth. The spectral structure in tree rings could serve not only to check any relations of climate with sunspots, auroras and more modern measures of solar activity, but also to check any purely mathematical extrapolations from the much shorter available actual data on solar activity. With such extrapolated series and the data analyzed herein, the task remains to align physical and physiological variables to further study the influence of natural environmental factors near and far on biota, including international battles, which cover an even longer span of 2,556 years.

Chronobiology Phenomena↗

PubMedDate not supplied

The experience of dyspnea during weaning.

OBJECTIVE: To compare the degree of dyspnea experienced by ventilator-dependent patients receiving synchronized intermittent mandatory ventilation (SIMV) versus T-piece or pressure support ventilation (PSV) weaning. The relationship between self-reported perceptions of dyspnea and physiologic variables observed during weaning trials was examined. Variables included heart rate, respiratory rate, minute ventilation, and oxygen saturation as measured by a pulse oximeter. DESIGN: Quasi-experimental, counterbalanced design with repeated measures. SETTING: Medical intensive care unit of a large university-affiliated medical center. PATIENTS: Nine mechanically ventilated patients diagnosed with chronic obstructive lung disease. The patients were admitted for respiratory failure between May 1990 to November 1990. Six tolerated SIMV 4 versus T-piece trials; three were placed in the SIMV 8 versus PSV trials. PROCEDURE: Each patient's perception of dyspnea was measured using a visual analog scale (VAS) at the initiation and at 5-minute intervals of 20-minute weaning trials. Physiologic indicators were noted simultaneously with VAS ratings of dyspnea. RESULTS: Findings indicated no difference in the degree of dyspnea experienced between weaning methods compared. Within-subject regression analysis on VAS scores revealed individual differences in the relationship between physiologic indicators and perceptions of dyspnea. CONCLUSIONS: The patient's experience of dyspnea during the weaning process can be a valuable guide to observe the patient's progress. The VAS serves as a reliable, easy-to-use tool for quantifying the patient's perception of dyspnea.

Aged↗

PubMed1992

Alteration of circadian rhythm in shift-working ambulance personnel. Monitoring of salivary cortisol rhythm.

In order to investigate the relationship between internal desynchronization and clinical intolerance to shift work, a set of circadian rhythms including salivary cortisol rhythm were monitored in seven shift-working ambulance personnel. Oral temperature, grip strength of both hands, subjective assessment of drowsiness, fatigue and attention were recorded approximately every four hours except during sleep, for seven days. Self-sampling of salivary cortisol, which was suitable evaluation of endocrine rhythm in field studies, was also tried in this study. cosinor (cosine curve fitting) method and power spectral analysis were used for time series data analysis. The internal desynchronizations between rhythms of physiological variables and sleep-wake cycle were observed in shift-working ambulance personnel. The incidence of internal desynchronization seemed to be higher in intolerant subjects, although the difference between tolerant and intolerant subjects did not reach a statistically significant level. The peak time of salivary cortisol rhythm during a twenty-four hour shift was phase-advanced as intolerant to shift work showed apparently an atypical circadian pattern of salivary cortisol with an abnormal peak at 21.00 h. In this subject, the clinical intolerance to shift work seemed to be associated with internal desynchronization of circadian rhythms. The present study confirmed the internal desynchronization of the circadian rhythm in physiological rhythms like oral temperature and grip strengths, and was in favour of the hypothesis of an internal desynchronization and clinical intolerance to shift work. The clinical implication of impairment of salivary cortisol rhythm remains to be further investigated.

Adult↗

PubMed1987

Variability of urinary sodium and potassium excretion in north Chinese men.

Variability of urine sodium (Na), potassium (K) and sodium/potassium (Na/K) excretion was studied in a sample of 50 employed normotensive male health professionals aged 27-50 in Beijing, China. Six 24-h urine specimens were collected from each participant during night-time (12-h) and daytime (12-h) fractions. The estimated ratio of intra- to inter-individual variances was 2.12 for night-time and 1.48 for 24-h urine Na, and 1.85 and 1.54, respectively, for urine K. Based on these values, six night-time and four 24-h urine specimens are necessary to reduce to 15% the diminution of a correlation between urine Na and another physiological variable. The corresponding numbers are five and four, respectively, for urinary K measurement. These data suggest that the ratio of within-person variation to between-person variation in Na excretion is smaller in these Chinese men than in Americans. The dietary Na intake of Chinese men can therefore be characterized with fewer urine specimens than are required for western populations. Night-time urinary Na and K showed good concordance with those from 24-h specimens in distinguishing high or low Na and K intake. These findings indicate that in large-scale epidemiological studies, overnight specimens may be adequate for classifying individuals with regard to Na and K intake.

Adult↗

PubMed2005

Gastrointestinal transit and disintegration of enteric coated magnetic tablets assessed by ac biosusceptometry.

The oral administration is a common route in the drug therapy and the solid pharmaceutical forms are widely used. Although much about the performance of these formulations can be learned from in vitro studies using conventional methods, evaluation in vivo is essential in product development. The knowledge of the gastrointestinal transit and how the physiological variables can interfere with the disintegration and drug absorption is a prerequisite for development of dosage forms. The aim of this work was to employing the ac biosusceptometry (ACB) to monitoring magnetic tablets in the human gastrointestinal tract and to obtain the magnetic images of the disintegration process in the colonic region. The ac biosusceptometry showed accuracy in the quantification of the gastric residence time, the intestinal transit time and the disintegration time (DT) of the magnetic formulations in the human gastrointestinal tract. Moreover, ac biosusceptometry is a non-invasive technique, radiation-free and harmless to the volunteers, as well as an important research tool in the pharmaceutical, pharmacological and physiological investigations.

Administration, Oral↗

PubMed1998

Recollections of Professor Henry Barcroft, F.R.S.

Professor Henry Barcroft, MD, FRS, Emeritus Professor of Physiology in St. Thomas' Hospital Medical School in London died on 11 January 1998, aged 93. He was born in Cambridge on 18 October 1904 where his father, Joseph Barcroft, a famous physiologist, worked with Foster and Langley and subsequently was appointed to the Chair of Physiology. Henry Barcroft followed in his father's footsteps. During his career as Professor of Physiology firstly at The Queen's University of Belfast and subsequently at St. Thomas's Hospital London, he made significant studies on the nervous and humoral control of human blood vessels. His success as a research scientist stemmed partly from his ability to simplify complex phenomena in a way that permitted them to be broken into component parts and tested and partly from his technical ingenuity that permitted simple, inexpensive measurements of difficult physiological variables. Perhaps the most important factor, however, was his ability to bring out and stimulate aptitudes and enthusiasms in others. Completely unselfish himself, he gave individuals every opportunity to develop their talents, and so make themselves known to a wide circle of interested medical scientists. In many ways, his life was a guidebook for young scientists on how to make the most of their opportunities.

England↗

PubMed1992

Cerebral blood flow, arteriovenous oxygen difference, and outcome in head injured patients.

Cerebral blood flow (CBF) and other physiological variables were measured repeatedly for up to 10 days after severe head injury in 102 patients, and CBF levels were related to outcome. Twenty five of the patients had a reduced CBF [mean (SD) 0.29 (0.05) ml/g/min]; 47 had a normal CBF, (0.41 (0.10) ml/g/min); and 30 had a raised CBF (0.62 (0.14) ml/g/min). Cerebral arteriovenous oxygen differences were inversely related to CBF and averaged 2.1 (0.7) mumol/ml in the group with reduced CBF, 1.9 (0.5) mumol/ml in the group with normal CBF, and 1.6 (0.4) mumol/ml in the group with raised CBF. Patients with a reduced CBF had a poorer outcome than patients with a normal or raised CBF. Mortality was highest in patients with a reduced CBF, and was 32% at three months after injury, whereas only 21% of the patients with a normal CBF and 20% of the patients with a raised CBF died. There were no differences in the type of injury, initial score on the Glasgow Coma Scale, mean intracranial pressure (ICP), highest ICP, or the amount of medical treatment required to keep the ICP less than 20 mm Hg in each group. Systemic factors did not significantly contribute to the differences in CBF among the three groups. A logistic regression model of the effect of CBF on neurological outcome was developed. When adjusted for variables which were found to be significant confounders, including age, initial Glasgow Coma Score, haemoglobin concentration, cerebral perfusion pressure and cerebral metabolic rate of oxygen, a reduced CBF remained significantly associated with an unfavourable neurological outcome.

Adult↗

PubMed2000

Blood chemistry, nutrient metabolism, and organ weights in fetal and newborn calves derived from in vitro-produced bovine embryos.

Calves born after in vitro production (IVP) of embryos often show reduced perinatal viability. The present experiment investigated a series of physiological variables in the immediate prenatal and postnatal period of IVP dairy calves. Fetal IVP and control calves (each n = 7) were prepared with vascular catheters at 248+/-1 day gestation (term = 280 days), and blood samples were taken for five days before premature delivery by cesarean section. IVP fetuses compared with controls had significantly elevated arterial hemoglobin and oxygen content (8.41 vs. 7.52% and 5.75 vs. 3.79%, respectively) whereas lactate level was lowered (1.89 vs. 2.26 mM). The umbilical venous-arterial concentration differences in oxygen, lactate, and glucose indicated that IVP fetuses relied more on lactate and less on glucose as oxidative substrates. The fetal glucose tolerance, and the basal and adrenocorticotropin-stimulated cortisol levels were similar between the groups. In the immediate postnatal period, IVP calves showed elevated venous blood pH (7.294 vs. 7.270), hemoglobin (9.06 vs. 8.25%), oxygen contents (6.33 vs. 4. 64%), K(+) levels (4.89 vs. 4.56 mM), and rectal temperature (38.9 vs. 37.4 degrees C), and lowered blood Na(+) (139.9 vs. 141.0 mM), Cl(-) (100.2 vs. 103.1 mM) and glucose levels (2.86 vs. 3.11 mM). There were no differences in body dimensions and organ weights, except that the fore legs and hind legs were slightly longer in the IVP group (76.1 vs. 72.4 cm and 93.4 vs. 88.8 cm, respectively). Although prenatal and neonatal IVP calves differed from control calves in a number of variables, the effects were relatively minor and provide no direct evidence for the hypothesis that IVP calves have an impaired capacity to adapt to life ex utero. In fact, several parameters indicated enhanced rather than retarded maturation of IVP calves when data from premature calves were compared with data from a group of control calves delivered at term.

Animal Nutritional Physiological Phenomena↗

PubMed2001

The influence of personality on nicotine craving: a hierarchical multivariate statistical prediction model.

The present study proposes a hierarchical multivariate statistical prediction model which enables to determine the most prominent variables (physiological, biochemical and personality factors) related to nicotine craving and dopaminergic activation. Based on animal studies reporting a reduction of the rewarding effects of psychotropic drugs after blockade or destruction of the mesolimbic dopamine (DA) system, changes in nicotine craving after pharmacological manipulation by means of a DA agonist (lisuride 0.2 mg) and a DA antagonist (fluphenazine 2 mg) were assessed in 36 healthy male heavy smokers. The major aim was the development of a multivariate prediction model which is applicable in samples lacking variance homogeneity or the prerequisite of a multivariate normal distribution. The model proposed is a combination of multivariate parametric and nonparametric methods taking advantage of their individual merits. Especially personality variables, such as sensation seeking, impulsivity, and neuroticism showed to be important predictors of craving in this responder approach.

Adult↗

PubMed2001

Use of medetomidine and ketamine for immobilization of free-ranging giraffes.

OBJECTIVE: To develop a dosage correlated with shoulder height (SH) in centimeters for effective immobilization of free-ranging giraffes, using a combination of medetomidine (MED) and ketamine (KET) and reversal with atipamezole (ATP). DESIGN: Prospective study. ANIMALS: 23 free-ranging giraffes. PROCEDURE: The drug combination (MED and KET) was administered by use of a projectile dart. Quality of induction, quality of immobilization, and time to recovery following injection of ATP were evaluated. Physiologic variables measured during immobilization included PaO2, PaCO2, oxygen saturation, end-tidal CO2, blood pH, indirect arterial blood pressure, heart and respiratory rates, and rectal temperature. RESULTS: Sixteen giraffes became recumbent with a dosage (mean +/- SD) of 143 +/- 29 microg of MED and 2.7 +/- 0.6 mg of KET/cm of SH. Initially, giraffes were atactic and progressed to lateral recumbency. Three giraffes required casting with ropes for data collection, with dosages of 166 +/- 5 microg of MED and 3.2 +/- 0.6 mg of KET/cm of SH. Four giraffes required administration of etorphine (n = 2) or were cast with ropes (2) for capture but remained dangerous to personnel once recumbent, precluding data collection. In giraffes successfully immobilized, physiologic monitoring revealed hypoxia and increased respiratory rates. Values for PaCO2, end-tidal CO2, and heart rate remained within reference ranges. All giraffes were hypertensive and had a slight increase in rectal temperature. Atipamezole was administered at 340 +/- 20 microg/cm of SH, resulting in rapid and smooth recoveries. CONCLUSIONS AND CLINICAL RELEVANCE: Medetomidine and KET was an effective immobilizing combination for free-ranging giraffes; however, at the dosages used, it does not induce adequate analgesia for major manipulative procedures. Quality of induction and immobilization were enhanced if the giraffe was calm. Reversal was rapid and complete following injection of ATP.

Adrenergic alpha-Agonists↗

PubMed2000

Dimension reduction for highdimensional online-monitoring data in intensive care.

Nowadays high dimensional data in intensive care medicine can be captured, stored, and retrieved with the help of clinical information systems. Intelligent alarm systems are needed for an adequate bedside decision support, in the course of which the detection of qualitative patterns in physiologic monitoring data such as outliers, level changes, or trends aims at a proper classification of the patients state. Statistical time series techniques have already been applied successfully to the analysis of single physiological variables. The simultaneous online analysis of the multivariate patient curve yields further challenges. We describe methods for reducing the dimension and for keeping the computational efforts necessary for monitoring low. We present preliminary results of an ongoing study on monitoring critically ill patients.

Adult↗

PubMed2003

Rationale for cardiovascular monitoring.

A primary aspect of cardiovascular support of the critically ill patient is the titration of cardiopulmonary therapies based on the baseline cardiopulmonary status and the subsequent physiologic response. Implicit in this paradigm is the monitoring of the processes being titrated. The degree to which a specific physiologic variable, such as mean arterial pressure or arterial oxygen saturation, needs to be assessed is a function of the therapy used, the stability of the patient, the relation among the variables defining the hemodynamic profile, and the ability of the support staff to remain in close attendance at the bedside. In an otherwise stable patient in heart failure being treated with mild afterload reduction and diuretics, periodic measures of heart rate, urine output, and daily measures of body weight are all that are reasonably needed to titrate therapy. However, in the management of a patient with cardiogenic shock with pulmonary edema and respiratory failure, continuous measures of mean arterial pressure, left ventricular filling pressure, cardiac output, arterial oxygen content, and end-organ function may be necessary as more potent and risky therapies are used. How, then, does one arrive at the correct formula to prescribe appropriate physiologic monitoring for the patient in the intensive care unit setting? To a large extent this is unknown, primarily because the utility of monitoring techniques to diagnose pathophysiologic processes and the resultant effect of therapy to reverse it is not known for most of the diseases treated in the intensive care unit. Few monitoring techniques have progressed through a logical progression of development to their present level of use. Thus, their use in the management of the critically ill patient cannot be vigorously defended, except under specific conditions.

Blood Pressure Determination↗

PubMed2000

[How does music affect the human body?].

Music therapy has developed its practice and research approaches within a qualitative framework more related to humanistic traditions than to medical science. Music medicine has therefore developed as a separate discipline, endeavouring to incorporate the legitimate therapeutic use of music within a medical framework. This paper argues that more extensive communication and collaboration between the methods developed within the music therapy community, and research based on medical science, could lead to a better understanding of the place of music as a therapeutic tool, both as regards its efficacy and its limits. Research has shown that music may influence central physiological variables like blood pressure, heart rate, respiration, EEG measurements, body temperature and galvanic skin response. Music influences immune and endocrine function. The existing research literature shows growing knowledge of how music can ameliorate pain, anxiety, nausea, fatigue and depression. There is less research done on how music, and what type of music, is utilized and administered specifically for optimum effect in specific clinical situations.

Acoustic Stimulation↗

PubMed1985

Hormonal modulation of responses to thymus-independent and thymus-dependent antigens in autoimmune NZB/W mice.

Previous work suggested that gonadal steroids influence immunity through the thymus, but the mechanisms were unclear. To investigate the effects of these hormones on immune responses to T1 and TD antigens in autoimmune mice, we studied hybrid NZB/W mice and the nonautoimmune DBA/2 strain. Mice castrated at 14 days of age were implanted with Silastic capsules releasing, in adults, physiologic levels of E2 in males or Te in females. Sham-operated controls received empty capsules. Splenic PFC were quantified 4 to 5 days after challenge with the TI2 antigen TNP-Ficoll, the TI1 antigen TNP-LPS, or the TD antigen SRBC. Young castrated NZB/W males implanted with E2 had striking enhancement of IgM responses to TNP-Ficoll when compared to castrated Te-treated females and comparable sham-operated controls of both sexes. E2 also stimulated responses to TNP-LPS. In response to challenge with SRBC, young E2-treated NZB/W males had a consistent trend to increased IgM PFC, and the stimulatory effect of E2 on IgG plaques was variable. Physiologic doses of Te had no consistent effect on responses in young mice. In old female NZB/W mice, Te caused PFC response after immunization with TNP-Ficoll to resemble age-matched NZB/W males. As sham-operated NZB/W females grew older, PFC responses to SRBC fell. This age-related phenomenon was delayed, however, in female castrates implanted with Te. In contrast, Te clearly suppressed responses to TNP-LPS. Implantation of E2 did not alter responses to TNP-Ficoll, TNP-LPS, or SRBC in nonautoimmune DBA/2 males. This finding suggested that exogenous E2 given in physiologic doses did not influence immunologic responsiveness in a normal strain to the degree seen in hormone-sensitive NZB/W mice. It was concluded that E2 enhanced responses to a variety of exogenous antigens in autoimmune NZB/W mice. The most consistent E2-induced increase in PFC response was observed with TI antigens, suggesting that E2 exerted its effects on B cells or Ts.

Animals↗

PubMed1999

Weight relapsers, maintainers, and controls: metabolic and behavioural differences.

The present investigation was undertaken to describe selected factors associated with the maintenance of body weight in three groups of women: relapsers (regained weight after losing weight), maintainers (maintained weight loss), and controls (weight stable). The following physiological variables were also assessed: resting energy expenditure (REE), serum glucose, insulin, leptin, triiodothyronine (T3), and body composition. As well, participants completed the interviewer-administered Weight Maintenance Questionnaire (WMQ). Overall, relapsers were older and heavier than maintainers and controls. As well, BMI, sum-of-four skinfolds, waist and arm circumference, serum leptin, and insulin levels were significantly greater for relapsers than for maintainers and controls. There were no differences between maintainers and controls in any of the parameters measured. Although relapsers revealed a history of weight cycling, the weight loss strategies and exercise habits of maintainers and relapsers did not differ. The data suggest that the higher body mass and fat mass in relapsers may explain the physiological differences between relapsers and maintainers.

Adipose Tissue↗