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Biological rhythms as organization and information.

While it is generally acknowledged that modern science began with the quantification of time in the measurement of linear physical processes in space by Galileo and Newton, the biological sciences have only recently developed appropriate experimental and mathematical methods for the description of living systems in terms of processes of non-linear, recursive dynamics. We now recognize that living organisms have patterns of exquisitely timed processes that are as intricate as their spatial structure and organization. Self-similarities of life processes in time and space have evolved to generate an ensemble of oscillators within which analogous functions may be discerned on many different time scales. The increasing complexity of periodic relationships on and between the many levels of biological organization are uncovered by current research. Recent efforts to reformulate the foundation of physics from the quantum to the cosmological level by using the concept of information as the common denominator integrating time, structure and energy remind us of an apparently analogous suggestion in the chronobiological literature which also describes the periodic dynamics of living systems as information processing. In this paper we review the periodic processes of living systems on all levels from the molecular, genetic and cellular to the neuroendocrinological, behavioural and social domains. Biological rhythms may be conceptualized as the evolution of ever more complex dynamics of information transduction that optimize the temporal integrity, development, and survival of the organism.

Animals↗

The victorian ethos of evolution.

The Victorian Age was the culmination of changes in the political, social, scientific, theological and cultural spheres throughout Europe. Darwin's newly elaborated evolutionary idea was the pivot for social Darwinism, a theory based on the gradual movement of the species toward greater self-awareness and strength. Shaw described this process in his play Man and Superman. Freud also utilized the concept in his libido theory. Horney interpreted the process as a psychic response to the intense societal pressures to succeed. A linkage of interdependence and progression of these ideas emerges as the world continues to evolve.

Biological Evolution↗

A health and social profile of the menopausal woman.

Data from Canada, Massachusetts, and Japan are combined to present a social and health profile of the menopausal woman. The paper examines the difference in perspective of the social scientist relative to the clinician or the medical epidemiologist. It also discusses the importance of a better understanding of the social context of women's lives for the further evolution of menopause research. Illustrative examples are taken from women's use of aspirin, the prescribing practices of physicians relative to hormone replacement therapy, the failure to collect occupational data in osteoporosis research, and the cost-benefit calculations to be made by women advised to take hormone replacement therapy. These examples are used as a way of showing that social data are not "frills" on the basic research of the medical scientist, but are essential to the future understanding of the menopausal experience of women.

Depression↗

Genetic architecture and evolutionary constraint when the environment contains genes.

The environment provided by conspecifics is often the most important component of the environment experienced by individuals, frequently having profound effects on fitness and trait expression. Although these social effects on fitness and trait expression may appear to be purely environmental, they differ from other sorts of environmental influences, because they can have a genetic basis and thus can contribute to evolution. Theory has shown that these effects modify the definition of genetic architecture by making the phenotype the property of the genotypes of multiple individuals and alter evolutionary dynamics by introducing additional heritable components contributing to trait evolution. These effects suggest that genetic and evolutionary analyses of traits influenced by social environments must incorporate the genetic components of variation contributed by these environments. However, empirical studies incorporating these effects are generally lacking. In this paper, I quantify the contribution of genetically based environmental effects arising from social interactions during group rearing to the quantitative genetics of body size in Drosophila melanogaster. The results demonstrate that the genetic architecture of body size contains an important component of variation contributed by the social environment, which is hidden to ordinary genetic analyses and opposes the direct effects of genes on body-size development within a population. Using a model of trait evolution, I show that these effects significantly alter evolutionary predictions by providing hidden constraints on phenotypic evolution. The importance of relatedness of interactants and the potential impact of kin selection on the evolution of body size are also examined.

Animals↗

Income change at retirement, neighbourhood-based social support, and ischaemic heart disease: results from the prospective cohort study "Men born in 1914".

Retirement from active life often leads to decreased finances and reduced social contact, which may increase ischaemic heart disease (IHD) risk in individuals. We examined whether income evolution during the decade before retirement has an impact on subsequent IHD, and explored the mediating effect of common risk factors and social support from different sources (marriage/cohabitation, support from friends/relatives, and neighbourhood-based social support). We analyzed data from the 1982-1983 prospective cohort study, "Men born in 1914" (n=498, follow-up period=10 years) conducted in Malmö, Sweden, merged with yearly income data for 14 years preceding baseline. Low income 10 years before retirement predicted both higher prevalence of IHD risk factors at retirement, and weaker neighbourhood-based social support. Income 10 years before retirement was a strong predictor of IHD incidence and mortality after retirement, but a significant downward income mobility at retirement did not increase IHD risk. After adjustment, low neighbourhood-based social support increased the risk of IHD incidence and mortality, and mediated 7-8% of the income effect. In conclusion, income 10 years before retirement, but not the subsequent income evolution, was a strong predictor of IHD post-retirement. This socioeconomic gradient was partly mediated by the protective effect of neighbourhood-based social support, which may be particularly important among the elderly in compensating for social disruptions related to retirement.

Aged↗

We-intentionality: an essential element in understanding human culture?

Culture is a powerful cause of human behavior, yet there have been few attempts to synthesize the biological and social sciences in order to provide an explanation of culture and hence to lay the foundations for a comprehensive human science. This essay explores one possible way of doing this by outlining the likely psychological mechanisms that give rise to the unique human capacity for creating social reality. The core assumption is that "we-intentionality," which is key to understanding social constructions, can and must be linked to specific evolved psychological traits, and hence placed within a neuroscience perspective.

Behavior↗

Olfactory evolution and behavioral ecology in primates.

Primates are usually thought of as "visual" mammals, and several comparative studies have emphasized the role of vision in primate neural and sociocognitive specialization. Here I explore the role of olfactory systems, using phylogenetic analysis of comparative volumetric data. The relative sizes of the main olfactory bulb (MOB) and accessory olfactory bulb (AOB) tend to show different evolutionary patterns in accordance with their different functions. Although there is some evidence of correlated evolution of the two systems, this is apparent in only one clade (the strepsirhines). As predicted, the MOBs correlate predominantly with ecological factors (activity period and diet), while the AOBs correlate with social and mating systems. Related olfactory structures (i.e., the piriform cortex and amygdala) exhibit correlated evolution with the AOBs but not with the MOBs, and the corticobasolateral part of the amygdala exhibits a correlation with social group size in platyrrhines similar to that observed for the AOB. These social system correlations support the idea that there is an olfactory dimension to the concept of the social brain.

Animal Communication↗

Evolution in group-structured populations can resolve the tragedy of the commons.

Public goods are the key features of all human societies and are also important in many animal societies. Collaborative hunting and collective defence are but two examples of public goods that have played a crucial role in the development of human societies and still play an important role in many animal societies. Public goods allow societies composed largely of cooperators to outperform societies composed mainly of non-cooperators. However, public goods also provide an incentive for individuals to be selfish by benefiting from the public good without contributing to it. This is the essential paradox of cooperation-known variously as the Tragedy of the Commons, Multi-person Prisoner's Dilemma or Social Dilemma. Here, we show that a new model for evolution in group-structured populations provides a simple and effective mechanism for the emergence and maintenance of cooperation in such a social dilemma. This model does not depend on kin selection, direct or indirect reciprocity, punishment, optional participation or trait-group selection. Since this mechanism depends only on population dynamics and requires no cognitive abilities on the part of the agents concerned, it potentially applies to organisms at all levels of complexity.

Animals↗

A view on the science: physical anthropology at the millennium.

EDITOR's NOTE The year 2000 marks the onset of the 21st century. Physical anthropologists will provide brief reflections on our discipline, including what attracted them to it, and their views on the directions our discipline may pursue as we enter, in January 2001, the third millennium.

Animals↗

The nature of living systems.

Living systems theory (LST) is concerned with eight levels of living systems, each of which is composed of 20 critical subsystems that carry out essential life processes. As a result of a continuous biosocial evolution involving progressive fray-out of components, the more recently developed levels in this hierarchy have become very complex. A brief summary of LST is presented in this article. Following this is a detailed analysis of current knowledge about the timer, which we have recently included in our list of subsystems.

Animals↗

Greater than the sum of its parts. II. Matter-energy processing subsystems.

Behavioral science theory has changed greatly since 1978, when Miller's Living Systems was published. Much of the change represents progress, particularly in the biological fields. During that time, living systems theory (LST) developed in many ways. Among the most significant developments have been the addition of another level, the community, to the seven levels previously included in LST and the addition of another subsystem, the timer, to become the 20th subsystem. The present article is the second to be published in this journal which describe relatively briefly and simply the current state of scientific knowledge about the subsystems of living systems. It deals with the first six matter-energy processing subsystems, the ingestor, distributor, convertor, producer, matter-energy storage, and extruder.

Adaptation, Physiological↗

Phylogenetic relationships of Iberian dung beetles (Coleoptera: scarabaeinae): insights on the evolution of nesting behavior.

A phylogeny of the main lineages of dung beetles (Coleoptera: Scarabaeinae) from the Iberian Peninsula was based on partial nucleotide sequences (about 1221 bp) of the mitochondrial cytochrome oxidase I and II genes of 33 taxa. Our phylogenetic analyses confirmed the validity and composition of most of the recognized tribes within the subfamily. Interestingly, the Onitini showed an evolutionary rate significantly higher than that of the other tribes. The molecular phylogeny supports a sister-group relationship of the tribes Onitini and Oniticellini + Onthophagini. A close relationship of Scarabaeini, Gymnopleurini, and Sisyphini is also suggested but lacks bootstrap support. Surprisingly, the Coprini, which had always been related to the Oniticellini and Onthophagini, were placed closer to the Scarabaeini, Gymnopleurini, and Sisyphini. The inferred molecular phylogeny was used to assess the main evolutionary trends of nesting behavior. Our results suggest tentative single origins for both the tunneling and the rolling behaviors, and the possibility that the rolling behavior could have been lost secondarily in Copris.

Animals↗

Epidemiology and the web of causation: has anyone seen the spider?

'Multiple causation' is the canon of contemporary epidemiology, and its metaphor and model is the 'web of causation.' First articulated in a 1960 U.S. epidemiology textbook, the 'web' remains a widely accepted but poorly elaborated model, reflecting in part the contemporary stress on epidemiologic methods over epidemiologic theories of disease causation. This essay discusses the origins, features, and problems of the 'web,' including its hidden reliance upon the framework of biomedical individualism to guide the choice of factors incorporated in the 'web.' Posing the question of the whereabouts of the putative 'spider,' the author examines several contemporary approaches to epidemiologic theory, including those which stress biological evolution and adaptation and those which emphasize the social production of disease. To better integrate biologic and social understandings of current and changing population patterns of health and disease, the essay proposes an ecosocial framework for developing epidemiologic theory. Features of this alternative approach are discussed, a preliminary image is offered, and debate is encouraged.

Causality↗

Anesthesiology in the Belgian health care environment.

This article focuses on anesthesiology practice in the context of Belgian health care. The first part describes the organization of Belgian health care, the role of private and public initiatives, the division of responsibilities between the different health authorities, the financing mechanisms, and the central role of the compulsory social health care insurance. Quantitative information on the evolution of expenditures, services, providers, and facilities is presented. The second part of the article deals more specifically with anesthesiology and contains information on current practice. The emphasis, however, concerns recent developments in training and accreditation.

Accreditation↗

Spite.

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Animals↗

Spotted hyenas.

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Africa South of the Sahara↗

From chemistry of life to chemistry of disease: the rise of clinical biochemistry.

Any young scientific discipline may experience difficulties in determining its position. For a young discipline placed at the juncture between potent branches of science with a long tradition, as is the case for Clinical Biochemistry, this is especially true. In such a situation, a look backwards to identify first origins and to follow trends of development can be helpful. Moreover, the close relationship between the history and the philosophy of science should provide insight into the nature of our present work and the potential for future work. Our discipline originated with the emergence of modern chemistry at the end of the 18th century. Methods for the chemical analysis of plant and animal material were developed first. The examination of chemical processes in living organisms followed. Only after these successes did chemical investigations of causes and mechanisms of human disease become possible. A few selected milestones in this evolution can illustrate the medical, philosophical, intellectual and social background which has shaped the rise of Clinical Biochemistry.

Biochemistry↗

Biological preparedness and evolutionary explanation.

It is commonly supposed that evolutionary explanations of cognitive phenomena involve the assumption that the capacities to be explained are both innate and modular. This is understandable: independent selection of a trait requires that it be both heritable and largely decoupled from other 'nearby' traits. Cognitive capacities realized as innate modules would certainly satisfy these contraints. A viable evolutionary cognitive psychology, however, requires neither extreme nativism nor modularity, though it is consistent with both. In this paper, we seek to show that rather weak assumptions about innateness and modularity are consistent with evolutionary explanations of cognitive capacities. Evolutionary pressures can affect the degree to which the development of a capacity is canalized by biasing acquisition/learning in ways that favor development of concepts and capacities that proved adaptive to an organism's ancestors.

Animals↗