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At least 883 records · Page 49Linked to original sources
PubMed2000

[Effects of vitamin K2 administration in the patients with severely motor and intellectual disabilities: assessment of bone metabolic marker and bone mineral density].

We studied the effects of vitamin K2 (menatetrenone) on the bone metabolic markers and bone mineral density (BMD) in 17 with low level of BMD cases of severely motor and intellectual disabilities (SMID). Markers of bone formation and resorption as well as BMD were determined before, and 16, 32, and 48 weeks after administration of vitamin K2. After 48 weeks of treatment, serum bone alkaline phosphatase and oseteocalcin levels of significantly increased (p < 0.05, p < 0.01, respectively), but urinary excretion of neither pyridinoline nor deoxypyridinoline decreased. BMD determined by the computed X-ray densitometer method tended to increase in cases with severe motor dysfunction (p = 0.07). There were no side effects. These data demonstrate that vitamin K2 may improve bone formation in patients with SMID.

Absorptiometry, Photon↗
PubMed1997

[Clinico-etiological study of forty-five cases of children with severe motor and intellectual disabilities of postnatal origin].

The aim of this study is to analyze causes of severe brain damages of postnatal origin in children and to search for strategies to prevent them. The patients group consists of forty-five children with severe motor and intellectual disabilities sampled at several hospitals and special schools in a part of Tokyo. Twenty-four out of 45 cases (53%) were due to infectious diseases of the central nervous system (meningitis, encephalitis, and acute encephalopathy including Reye syndrome). Nine cases (20%) were due to brain damage related to medical services (complications of heart surgery, hypoglycemic encephalopathy, and so on). Accident-related brain damages accounted for 8 cases (18%) and 4 out of 8 were anoxic encephalopathy due to asphyxia (hanging and near drowning in two cases each). We conclude that intensive prevention and treatment of infectious diseases and accidents in children can reduce large part of the incidence of postnatally acquired severe brain damages in children.

Adolescent↗
PubMed2025

Osteogenesis imperfecta, intellectual disability and recurrent infections in a male with a pathogenic SASH3 variant.

Src Homology 3 Domain-containing Adaptor Protein 3 (SASH3) deficiency is an X-linked immune disorder. Here we identified a male case with a pathogenic SASH3 variant (c.1039C>T [p.Arg347Cys]) who presented with osteogenesis imperfecta, intellectual disability and recurrent infections. While immunological features in this case were characterized, further studies are needed to determine the association between the SASH3 variant and the skeletal or neurological manifestations.

Journal Article↗
PubMed2001

Behavioural treatment for sleep problems in children with severe intellectual disabilities and daytime challenging behaviour: effect on mothers and fathers.

OBJECTIVES: The study aimed to assess the mental state of mothers and fathers following successful behavioural intervention for sleep problems in such children. DESIGN: A randomized controlled trial of behavioural interventions for sleep problems. METHODS: Parents of 15 children with severe intellectual disabilities, severe sleep problems, and challenging daytime behaviour received treatment for the child's sleep problem and were compared with 15 controls who received no treatment. Parental stress, sleepiness, locus of control, perceived control, and satisfaction with aspects of sleep were assessed. RESULTS: Successful treatment benefited the mothers, reducing stress, increasing perceived control and making them more satisfied with their sleep, their child's sleep, and their ability to cope with their child's sleep. Positive effects in the fathers were limited to increased satisfaction with their own sleep and their child's sleep; fathers tended to feel less control following treatment. Maternal sleepiness and perceived control, and aspects of parental satisfaction showed improvements in both the treatment and control groups. CONCLUSION: The effects of childhood sleep problems, and their resolution using behavioural interventions, may be different in mothers and fathers. This highlights the need to assess all family members in order to gain a greater understanding of how best to help families as a whole. The improvements in both control and treatment groups indicate that there may be non-specific effects of taking part in the study that played a therapeutic role.

Clinical Trial↗
PubMed2006

Motivators for children with severe intellectual disabilities in the self-contained classroom: a movement analysis.

The purpose of this study was to analyze the impact of the presence of a music therapist versus the use of switch-activated toys and recorded music in evoking physiological, affective, and vocal responses in school-aged children who are considered SID, or Severely Intellectually Disabled. Researchers studied movement responses to determine how these children might respond more readily to a music therapist interacting musically with them than to the toys and to the recorded music. Each of the 17 children participated in a videotaped session that included 5 trials. Other than the rest trial, motivators presented were: a switch-activated pig toy, switch-activated recorded music, the music therapist playing and singing to the child contingent upon his touching the guitar, and the therapist playing and singing to the child continually. A data collection sheet was developed by the researchers to assess positive responses by measuring limb and head movement, vocal sound, and facial expression change. The Kruskal-Wallis test was used to determine differences in means responses to music and nonmusic trials. At a 90% level of confidence, statistical significance was attained in comparing the responses to the pig toy, recorded music, and "activated guitar" trial to the trial during which the therapist played guitar and sang continually to the child. In addition, at a 95% level of confidence, statistically significant differences were found in comparing the pig and the recorded music trials with the therapist trial.

Activities of Daily Living↗
PubMed1989

Pregnancy and birth risk factors for intellectual disability in South Australia.

It is generally accepted that developmental handicaps can often be minimized through early detection and intervention. For this reason, it is normal practice in many hospitals to follow-up and screen infants who present at birth with established risk factors. Clinical judgement will always be important when selecting children for follow-up. However, as hospital data systems improve, automated systems could be developed for listing children potentially "at risk". Where initial clinical decisions not to follow-up individual children prove to be at odds with this automated output, the individual child could be re-assessed clinically. This process could increase the level of quality control. An initial risk-factor model for intellectual disability has been developed, based on the South Australian Perinatal Statistics Collection, for use in this context.

Australia↗
PubMed2002

A pilot study of the reliability and validity of the Caregiver Activity Survey - Intellectual Disability (CAS-ID).

BACKGROUND: People with Down's syndrome (DS) are at increased risk of Alzheimer-type dementia (AD) when compared to the general population. Despite AD being a serious progressive disorder, little attention has been paid to the impact of the illness on formal caregivers. In the general population, the Caregiver Activity Survey (CAS) is used to measure time spent by family caregivers assisting people with AD in their day-to-day activities of living. In order to plan appropriate models of health and social care effectively for people with AD and DS, it is imperative that the care requirements of individuals at different stages of dementia are realized. An amended version of this survey, the Caregiver Activity Survey - Intellectual Disability (CAS-ID), was developed and tested for use by professional caregivers in the present study. METHODS: The CAS-ID was administered to 30 people with DS and their caregivers. Convergent validity was tested by comparing the results of the CAS-ID to other validated tests for cognitive and functional impairment in individuals with DS. Test-retest and inter-rater reliability were investigated. RESULTS: The final version of the CAS-ID consists of eight items: dressing, bathing/showering, grooming, toileting, eating and drinking, housekeeping, nursing care-related activities, and supervision/ behaviour management. The scale had excellent test-retest reliability, and correlated strongly with the Down Syndrome Mental Status Examination (DSMSE; r = -0.770), the Test for Severe Impairment (TSI; r = -0.881) and the Daily Living Skills Questionnaire (DLSQ; r = -0.855). CONCLUSIONS: The present authors provide preliminary evidence for the validity and reliability of the CAS-ID. This instrument offers a means of identifying and measuring care and resources requirements as this population experiences symptoms of dementia. Such information may help assist healthcare professionals in planning supports and services to address the care challenges evidenced at different stages of the disease process.

Activities of Daily Living↗
PubMed2003

Associations between behavior disorders and health status among older adults with intellectual disability.

Few studies have examined the relationship of behavior and health status among aging persons with intellectual and developmental disabilities (I/DD). Behavioral disorders, which often are coincident with functional decline in older persons with I/DD, may be more related to medical morbidity than previously reported. This cross-sectional study examined the association between health status and behavior disorders with increasing age in a cohort of 60,752 adults with I/DD clustered into four adult-age groupings (21-44, 45-59, 60-74, and >74). Age grouping data suggested an association between morbidity and increased likelihood of behavior symptoms in all but the oldest age grouping. The magnitude of the association and trend varied by specific disease across age groupings compared to that found in healthy cohorts. About 25% of the adults with I/DD had psychiatric diagnoses and the frequency of such diagnoses did not decrease with age grouping. These results suggest that adverse health status may increase the likelihood of persistent behavioral disturbances in older persons with I/DD. Moreover, behavioral disorders may be sentinels for occult medical morbidity, which in turn may be responsive to intervention.

Adult↗