[The reality and future of susceptibility test].
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Useful results of microbiological examinations can only be expected, when the specimens submitted to the laboratory are taken correctly. This overview shows appropriate and inappropriate specimens. Hints are given for a 'calculated antimicrobial chemotherapy'. A brief outline shows which bacteria should be tested for susceptibility to antimicrobial agents due to variable sensitivity.
Eighteen captive, nonpoisonous snakes which suffered from bacterial infections were studied. The most usual bacteria found were gram-negative rods; especially Pseudomonas aeruginosa, Aeromonas hydrophila and Proteus spp. The most common disorders caused by them were stomatitis, septicaemia, bronchopneumonia and abscesses. The sensitivities of ten isolated bacteria to antimicrobial drugs were tested. Neomycin and gentamicin seemed to be effective, especially against P. aeruginosa.
Seventy-two patients with H. pylori infection in their antral mucosa took part in the study. Forty-three received metronidazole 400 mg t.d.s. for two weeks, plus De-Nol tabs 2 b.d. for four weeks, and the remaining 29 patients received metronidazole 400 mg t.d.s. for two weeks plus De-Nol liquid 5 ml q.d.s. for four weeks. Seven of 57 H. pylori isolates were found to have pre-treatment metronidazole resistance. Success, in terms of eradication of H. pylori, was assessed using a one-month post-treatment 14C urea breath test. Successful eradication of H. pylori was achieved in 72% and 79%, respectively, of the metronidazole/De-Nol tablet and metronidazole/De-Nol liquid groups. These figures increased to 87% and 84%, respectively, if the patients whose organisms were known to be metronidazole-sensitive were considered in isolation. H. pylori was successfully eradicated in only one of seven patients with a metronidazole-resistant organism.
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