PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “PROCAINE AND COMPOUNDS”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 883 records · Page 49Linked to original sources
PubMed1987

Effects of oxamniquine on chick isolated esophagus.

The effects of oxamniquine, a potent schistosomicide, on chick isolated esophagus have been examined. Oxamniquine (2.5 X 10(-8)-5 X 10(-5) M) caused rhythmic and tonic contractions of the chick isolated esophagus. The concentration of oxamniquine required to produce 50% of the maximal contractile response (EC50) was 4.2 X 10(-5) M. Pre-incubation of the muscle preparation with procaine (40-120, microM), scopolamine (0.40 microM) or indomethacin (10 microM) attenuated oxamniquine-induced myogenic contractions of the muscle preparation. It is suggested that inhibition of oxamniquine-induced contractions by indomethacin, scopolamine or procaine probably indicates that oxamniquine-induced contractions of the muscle preparation is due to the release of a prostaglandin-like substance and/or a yet unknown contractile compound from the muscle.

Animals↗
PubMed1980

[A procedure for recording electroretinogram (ERG) in conscious monkeys, and effects of some drugs (author's transl)].

Stable ERG was successfully recorded using a contact lens-type electrode in conscious cynomolgus monkeys restrained in a monkey-chair with a specially devised head-holder. After adaptation to darkness, single photostimulation evoked ERG consisting of an initial negative wave (a-wave), followed by a positive wave superimposed with oscillatory potentials (b-wave), and a late positive (c-wave). The former two waves were clearly recorded but c-wave was often mixed with artifacts probably due to eye movements. Amplitudes and peak latencies of a- and b-waves increased in progression of dark adaptation and attained to maximum within 20 min. The optimal intensity of photostimulus and time-constant for recording stable a- and b-waves with intermediate amplitudes were found to be 2 joule and 0.1 sec, respectively. The amplitudes and peak latencies (mean +/- s.d.) of a- and b-waves obtained by these conditions were 163.3 +/- 44.9 and 437.0 +/-37.9 microV, and 17.3 +/- 0.5 and 53.5 +/- 3.2 msec, respectively. These waves were reproducible within 25% variations change in a-wave: pentobarbital increased the amplitude of b-wave, whereas ketamine reduced this amplitude. A 3-day treatment with 1,5-di(p-aminophenoxy)pentane (200 mg/kg/day, p.o.), a retinal toxic and behavioral signs of visual dysfunction. Histological abnormality of the retina was also detected. The results indicate that this technique is useful for recording ERG in order to evaluate the effect of chronically treated drugs on visual perception in conscious monkeys.

Adaptation, Ocular↗
PubMed1984

Simultaneous determination of chloroprocaine hydrochloride and its degradation product 4-amino-2-chlorobenzoic acid in bulk drug and injection solutions by high-performance liquid chromatography.

A high-performance liquid chromatographic method has been developed for the simultaneous determination of chloroprocaine hydrochloride and its hydrolytic degradation product, 4-amino-2-chlorobenzoic acid. Separation is achieved using a mu-Bondapak C18 column and the eluant, water-acetonitrile-methanol-glacial acetic acid (74:20:5:1) containing 0.05-0.08% (w/v) sodium 1-heptanesulfonate, at a flow rate of 2 mL/min. Benzoic acid and p-nitroacetophenone were used as internal standards. A variable-wavelength UV detector (278 nm) was used for detection of the compounds. The method is simple, accurate, and precise.

Chromatography, High Pressure Liquid↗
PubMed1990

The effect of carbamate local anesthetics on artificial lipid membrane.

The influence of phenylcarbamic acid basic esters with local anesthetic activity on the phase transition temperature (Tc) of a model dipalmitoylphosphatidylcholine (DPPC) membrane from gel to liquid crystalline state was studied. It was found that (Tc) in the presence of carbamate anesthetics decreases. The decrease of Tc (delta Tc) correlated well with the biological activity of the compounds studied.

1,2-Dipalmitoylphosphatidylcholine↗
PubMed1986

A PCILO study of the pharmacologically active conformation of local anesthetics of the procaine type. Conformational analysis and complex formation of protonated 2-diethylaminoethyl-acetate with formate anion.

To rationalize and improve receptor selectivity of local anesthetics of the procaine type a dynamic two-center model of the pharmacon-receptor interaction is suggested. A quantum chemical study within the Perturbation Configuration Interaction using Localized Orbitals (PCILO) approximations is carried out to find indications for a conformational change of this flexible drug from its thermodynamically preferred conformation to its pharmacologically active one. For this purpose, the pharmacon-receptor interaction is simulated quantum chemically by the interaction of the local anesthetic model compound 2-diethylaminoethyl-acetate (acetylcaine) with the one-center receptor model formate anion and the two-center receptor model gamma-aminobutyric acid in its zwitterionic form. In the present study, the conformational behaviour of acetylcaine is investigated in detail, confirming this molecule to be an appropriate model for procaine. In its formate complex the preferred conformation of acetylcaine is still retained with regard to the torsional angle of the [OCCN] fragment. Artefacts of the in-vacuo condition of the calculation are discussed. In view of the proposed interaction model, the importance of the first interaction of acetylcaine with the anionic receptor site is found to be in the fixation of the local anesthetic at the receptor surface, due to the long-range character of this interaction. Furthermore, an increased polarity of the carbonyl group of acetylcaine due to this interaction may enhance the proposed second interaction with the receptor.

Anesthetics, Local↗