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At least 883 records · Page 49Linked to original sources
PubMed1991

[Effect of ammonium perchlorate on calcium currents in neurons and leukocyte mobility].

NH4ClO4 has been studied for its effect on the voltage-activated calcium current (ICa) in voltage-clamp experiments on intracellularly perfused snail neurons and on the chemokinesis of rat leukocytes. It has been found that NH4ClO4 enhances ICa amplitude 1.5-5 times (EC50 = 3 mmol/l), decreases the rate of ICa decay and stimulates mobility of leukocytes 3 times (EC50 = 2.5 mmol/l). It is suggested that these changes may be intermediated by similar mechanisms, e.g. by an increase in intracellular pH.

Animals↗
PubMed1990

Magnesium perchlorate and cis-platinum as radiosensitizers in in vitro radiolysis of nucleotides.

The mechanism of the gamma-radiolysis of the nucleotide guanosine-5'-monophosphate (5'-GMP) in the presence of Mg++ ions and cis-platinum was investigated. From high performance liquid chromatography and spectroscopy studies it was found that the OH radicals, produced in irradiated aqueous solutions, reacted with 5'-GMP by addition to the double bonds and that Mg++ as well as cis-Pt sensitized the nucleotide to radiation damage. Furthermore, an important finding was the fact that when the irradiation took place in aerated solutions, the Mg++ ions, contrary to cis-Pt, did not seem to have any effect on the decomposition yield G(-5'-GMP). This result together with the sensitization (100% increase) observed in deaerated solutions led to the conclusion that irradiation in the presence of Mg++ may result in a more effective gamma-radiation therapy for tumours.

Chromatography, High Pressure Liquid↗