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PubMed2005

[Evaluation of time resolution in cardiac synchronized image reconstruction using multi-slice CT].

One of the newest CT application technologies is cardiac synchronized image reconstruction. In this technology, evaluation of time-resolution is very important. We developed a method of measuring time-resolution in cardiac synchronized reconstruction, and evaluated various scanning protocols. In our experiment, ECG-gated scanning was done by multi-slice CT (Aquilion16 Super Heart Edition, Toshiba Medical Systems Co., Ltd., Japan). The nominal slice thickness was 0.5 mm, and rotation time was 0.5 sec. Input heart rate was set at 40, 45, 50, 55, 60, 70, 75, 80, and 90 bpm, and helical pitch at 3.2, 4.0, and 4.8 (beam-pitch: 0.200, 0.250 and 0.300). We measured FWTM of the obtained sensitivity distribution and compared at each scanning protocol. Time resolution improved as helical pitch decreased and heart rate increased. However, phase-time resolution deteriorated as heart rate increased. The results of our experiment indicated that a segment center was determined by X-ray tube rotation time and heart rate, and the number of segments was determined by heart rate, helical pitch, and reconstruction position. Time resolution changed with X-ray tube rotation time, heart rate, helical pitch, and reconstruction position. In this report, we provide a reference for an optimal scanning protocol in cardiac synchronized image reconstruction.

Electrocardiography↗

PubMed2005

[Effectiveness of deep breath-hold SPECT in torso area: examination concerning improvement of resolution].

Because SPECT images are acquired under normal respiration, the respiratory motion induces artifacts and decreases resolution. In this study we developed a novel method of acquiring SPECT data during deep inhalation breath-hold (BrST) and assessed its efficacy in reducing motion artifacts and improving resolution. Reproducibility studies found that variations in SPECT image homogeneity were reduced using the BrST method to within a clinically non-problematic range. An experiment using a custom-built respiration phantom showed almost complete elimination of motion artifacts and significant improvement in resolution using the BrST method. Clinical assessment confirmed a significant reduction in motion artifacts along with the improvement in resolution. The BrST method enabled visualization of lesions that previously had been impossible to detect by standard acquisition under normal respiration. The BrST method is expected to both significantly reduce motion artifacts and improve resolution.

Artifacts↗

PubMed1995

High resolution endoluminal ultrasonography in the staging of esophageal carcinoma.

Small catheters containing 20 MHz transducers have recently become available for high resolution endoluminal ultrasound. We report our early use of this technique to image and stage esophageal carcinoma. Fifteen patients undergoing high resolution endoluminal ultrasonography for suspected esophageal carcinoma were studied. Twelve of these patients also underwent computed tomography and pathologic correlation was available in seven. Satisfactory esophageal examination was possible in 14 of 15 patients. Of those with pathologic correlation, the depth of tumor invasion was correctly staged by high resolution endoluminal ultrasonography in six of seven patients and by computed tomography in only three of seven patients. Lymph node assessment correlated poorly with pathologic findings for both high resolution endoluminal ultrasound and computed tomography. With the increasing use of preoperative radiation therapy, we believe these early results predict a potential role for high resolution endoluminal ultrasonography in the staging of esophageal carcinoma.

Adenocarcinoma↗

PubMed1999

Non-contrast high resolution fast spin echo magnetic resonance imaging of acoustic schwannoma.

AIM OF STUDY: The current gold-standard of examination for the exclusion of acoustic schwannomas is contrast-enhanced magnetic resonance (MR) imaging. Many patients however, still cannot afford to pay for the cost of this examination. As a result, many clinicians still resort to contrast-enhanced computed tomography (CT) scan; an examination which could miss small intracanalicular acoustic schwannomas. The aim of this study was to report on our experience on the usage of the more affordable high-resolution fast spin-echo (FSE) MR imaging for the diagnosis of acoustic schwannoma. METHODOLOGY: A study involving 123 patients with symptoms of sensorineural hearing loss, vertigo and tinnitus was carried out between August 1996 and March 1997. All cases were scanned with a 1.5 T MR unit using a quadrate head coil. The section thickness was 1.5 mm, with TR/TE of 4000/96. Any mass arising from the vestibulocochlear nerve was considered to be an acoustic schwannoma, and most of these positive cases underwent further contrast-enhanced MR imaging to confirm the diagnosis. RESULTS: A total of 7 acoustic schwannomas were detected on high resolution FSE MR imaging and for 5 of these cases, the diagnosis was confirmed with contrast-enhanced MR imaging. Three of the 7 positive patients had contrast-enhanced CT scan done just prior to the MR study and the tumours were not detected on CT scan. The smallest acoustic schwannoma detected on high-resolution FSE MR imaging had a dimension of 0.5 x 0.4 x 0.5 cm. CONCLUSION: High resolution FSE MR imaging is more sensitive than contrast-enhanced CT scan in the diagnosis of acoustic schwannoma. Although the sensitivity is less than that of contrast-enhanced MR imaging, high resolution FSE MR is more affordable and therefore can play a role in the screening for acoustic schwannomas in selected groups of patients.

Adolescent↗

PubMed1975

Resolution of D-serine dehydratase by cysteine. An analytical treatment.

A general method is presented for analysis of the resolution of pyridoxal-P-requiring enzymes by carbonyl reagents. The method is useful for accurately determining the very small equilibrium constants (KP) which characterize the dissociation of cofactor from many pyridoxal-P-requiring enzymes. The analysis also establishes the minimum number and relative stabilities of distinct enzymic species involved in the resolution process. Analysis of the resolution of D-serine dehydratase by L-and D-cysteine resulted in the establishment of an enzyme bound thiazolidine derivative as an intermediate in the pathway for resolution. The over-all equilibrium constant (KR) for the reaction, D-serine dehydratase + cystein in equilibrium KR thiazolidine derivative +D-serine apodehydratase was determined. At pH 7.80, T/2 0.33, 25 degrees, KR equal to 1.08 times 10-minus 3. A value of 7.0 nM for the equilibrium constant for the dissociation of D-serine dehydratase to apoenzyme and free pyridoxal-P was determined from the ratio KR/KT, where KT is the equilibrium constant for the formation of a thiazolidine derivative from free pyridoxal-P and cysteine. An estimate of 14 nM for KP was also obtained from partial resolution of D-serine dehydratase by high dilution. The difficulties associated with this direct determination of KP from the dependence on the enzyme concentration of the activity of very dilute solutions of enzyme are discussed.

Cysteine↗

PubMed1975

Component resolution indices for scintillation camera systems.

From published overall resolution indices for three Anger camera systems, measured with three straight-bore collimators and 99mTc in air and with a water absorber present, the components due to inherent camera resolution, collimator geometry, and scatter are derived at various depths. Replacement of S-11 multiplier phototubes by bialkali phototubes improves calculated inherent Pho/Gamma III camera resolution by about 30% and by a further 33% upgrading to a high-performance model. At distances 2, 5, 8, and 10 cm from each collimator face with an intervening water absorber, mean scatter components of overall resolution indices are 6, 8, 9, and 10 mm, respectively. In typical clinical 99mm Tc imaging situations with a scattering medium present, the relative contributions of camera, collimator, and scatter to the total overall system resolution are presented.

Radionuclide Imaging↗

PubMed1999

High and intermediate resolution DNA typing systems for class I HLA-A, B, C genes by hybridization with sequence-specific oligonucleotide probes (SSOP).

DNA typing systems for alleles of the HLA class I loci A, B, C at intermediate (IR) and high resolution (HR) levels were developed. The approaches combine locus-specific amplification of genomic DNA by the polymerase chain reaction (PCR) and hybridization with sequence-specific oligonucleotide probes (SSOP). The SSOP were designed to match nucleotide sequences at all polymorphic sites of exons 2 and 3 at these loci. Alleles and genotypes for these loci are assigned by their unique hybridization patterns. Some genotypes with particular allele combinations resulted in the same hybridization pattern. These genotype ambiguities were resolved by performing additional group-specific amplifications with appropriate GSA primers and hybridization with informative SSOP. At intermediate resolution level, many groups of alleles of HLA-A and B with the same serologic equivalence resulted in the same hybridization pattern. Both HR and IR typing approaches required the design, validation and testing of locus- and group-specific primers and sequence-specific oligonucleotide probes (SSOP). Single locus-specific amplification and hybridization with sets of 67 SSOP for HLA-A, 99 for HLA-B and 57 for HLA-C allowed us to identify unequivocally the majority of A, B, C alleles at HR level. To resolve ambiguous genotypes at HLA-B, we performed 4 GSA with 5' primers at codon 45-46 and hybridization with selected sets of SSOP. About 22,415 high resolution typing results were obtained (4,953A, 6,621B, 10,841C). In these samples, 63 HLA-A, 170 HLA-B and 40 HLA-C alleles were observed. In the course of these studies, more than 30 new alleles have been identified. In IR testing, sets of 39 SSOP for HLA-A typing and 59 SSOP for HLA-B typing allowed us to obtain maximal resolution of the majority of common genotypes. To achieve IR level, the majority of SSOP selected were those that span codons encoding amino acid residues located in the alpha helical segments of the class I molecules. A total of 50,522 samples were typed for HLA-A and B at IR level. Approximately 2.0% of them carried ambiguous genotypes associated with alternative switches of Bw4/w6 related sequences. All these ambiguities were resolved by Bw4/Bw6 GSA by 2 primer pairs (77N-IALR-83/3B.1; 77S-DLRG-83/3B.1) and hybridization with 9 selected SSOP Testing was performed by individual hybridization of replicate dot blot membranes with the SSOP of the corresponding set. The approach was robust and cost-effective in large-scale HLA class I molecular typing. The resolution provided by HLA-A, B IR reached serologic split-level or higher. The description of primers and probes for HLA class I typing may be utilized as starting elements for development of second generation methods with a more rapid turn around time.

DNA↗

PubMed2002

Resolution of left atrial thrombi with anticoagulant therapy in candidates for percutaneous transvenous mitral commissurotomy.

BACKGROUND AND AIMS OF THE STUDY: Little is known of the fate of left atrial thrombus (LAT) among candidates for percutaneous transvenous mitral commissurotomy (PTMC) after oral anticoagulation (OA) therapy. The aim of this study was to estimate the resolution rate of documented LAT, and to determine its significant predictors among this population. METHODS: In this prospective cohort study all consecutive candidates for PTMC with documented LAT were followed between August 1996 and December 1999. All patients underwent both transthoracic (TTE) and transesophageal echocardiography (TEE) and received OA therapy (INR 2.0-3.0). The fate of LAT was studied serially using both TTE and TEE. RESULTS: A total of 75 patients was followed for six to 34 months (mean 12.2+/-6.2 months; total 914 patient-months). The LAT was completely resolved in 48 patients (5.25 per 100 pt-months; 95% CI 3.96-6.97). The overall resolution rate was 63.0 per 100 patients per year (95% CI 47.5-83.6). Patients with resolved LAT underwent uneventful PTMC. The median duration of LAT resolution was 16 months (95% CI 12.7-19.3). Significant predictors of LAT resolution were the size of the LAT (RR = 0.8 for each 1 cm2 increase in LAT; 95% CI 0.6-0.9; p = 0.012) and severity of the left atrial spontaneous echo contrast (LASEC) detected by TEE (RR = 0.6 for each 1 level increase of the LASEC severity score; 95% CI 0.4-0.9; p = 0.032). CONCLUSION: The smaller the LAT and the less severe the LASEC, the greater the likelihood of LAT resolution after OA therapy and the enhanced possibility of safely performing PTMC.

Adult↗

PubMed2002

[A novel resolution vector with Bacillus thuringiensis plasmid replicon ori44].

The resolution recognization sites of transposon Tn4430 of Bacillus thuringiensis was inserted into cloning vector pRSET B and pUC19, resulting recombinant plasmids pBMB1201 and pBMB1202. Both of the mini res fragments, BamHI/HindIII fragment in pBMB1201 and EcoRI/HindIII fragment in pBMB1202, were ligated to the 3.3 kb EcoRI/HindIII fragment of shuttle vector pHT3101, which contained the ori. Ec, ampr and emr antibiotic resistant genes, resulting recombinant plasmid pBMB1203. After deleted the BamHI and EcoRI sites which located ouside the two res sites, resolution vector pBMB1204 was resulted. There are multiple cloning sites between two copies of resolution sites which have the same direction. The plasmid replication origin ori44, which come from B. thuringiensis sub sp. kurstaki strain YBT-1520, was inserted into the multiple cloning sites of pBMB1204 and then resolution shuttle vector pBMB1205 was obtained. With spectinomycin resistant gene as target, it was found that the resolution rate is 100% and the stability of the resolved plasmid is 93%. Using this shuttle vector, antibiotic resistance markers and other non-B. thuringiensis DNA can be selectively eliminated after the selection of transformants by antibiotic resistance marker. This vector is very useful to solve the gene safety problem while has no effect on target gene expression.

Bacillus thuringiensis↗

PubMed1988

Resolution No. 2478/87-DM setting forth requirements to grant an entry permit or residency of a permanent or temporary nature, 15 September 1987.

This Resolution of Argentina sets forth the following categories of persons as those who may be granted an entry permit or residency of a permanent or temporary nature under Decree 1434/87: 1) professionals, technicians, or specialized personnel whose admission is required to undertake their specialized duties for businesses, or persons whose solvency or economic or social activity is publicly recognized; 2) business persons, artists, or athletes contracted by a person of known solvency to undertake their specialized duties; 3) scientists, professors, writers, journalists, or persons of special importance to the cultural, social, or political order; 4) students who, according to the laws of their own country, have reached the age of majority; 5) religious persons belonging to recognized religions; 6) foreigners who are of special interest to the country because of their talents or personal circumstances; 7) immigrants who have sufficient capital to undertake a commercial, industrial agricultural, mining, or fishing activity; persons who deposit US $30,000 for not less than 120 days are considered to have sufficient capital; 8) parents, unmarried children, or spouses of Argentine citizens, foreigners resident temporarily and permanently in Argentina, or persons mentioned in 1) to 7) above. Under Resolution 700/88-DNM (National Director of Migration) of 3 March 1988, foreigners of European origin are included within category 6) above. See Boletin Oficial de la Republica Argentina, No. 26.495, 27 October 1988, p. 95. Under Resolution 179/88-MI (Minister of the Interior) of 19 February 1988, Resolution No. 2479/87-DNM, which suspended temporarily the authorization of entry permits, settling, and visitation for foreigners of Taiwanese origin, is without effect and the National Directorate of Migration is instructed to establish a system of strict control of such persons. See Boletin Oficial de la Republica Argentina, No. 26.495, 27 October 1988, pp. 26-27. Resolution No. 2364 (National Director of Migration) of 2 September 1988 sets forth rules on the migration status of persons who entered Argentina before Decree No. 1434/87 came into effect. Those who entered the country in compliance with regulations applicable at the time are to be given permanent or temporary residency. Most of those who entered illegally will have to leave. See Boletin Official de la Republica Argentina, No. 26.304, 13 January 1988, p. 3.

Americas↗

PubMed2002

Thermodynamic study of the enantiomeric resolution of flurbiprofen by HPLC using Chiralpak AD-RH column.

The chiral resolution of (+/-)-flurbiprofen was achieved using water-acetonitrile (60:40, v/v) containing 0.1% acetic acid on a Chiralpak AD-RH column at 20 degrees C. The enantio-resolution was studied with different percentages of acetonitrile. Thermodynamic parameters (enthalpy, entropy and free energy) were calculated by carrying out the enantio-resolution experiments at 0 to 60 degrees C. The enantio-resolution was found to be exothermic in nature. Attempts have been made to explain the mechanism of chiral resolution of flurbiprofen on the Chiralpak AD-RH column.

Chromatography, High Pressure Liquid↗

PubMed2003

High-resolution profiling of an 11 Mb segment of human chromosome 22 in sporadic schwannoma using array-CGH.

Previous low-resolution schwannoma studies have reported diverse frequencies (30-80%) of 22q deletions, involving the neurofibromatosis-2 tumor suppressor (NF2) gene. We constructed an array spanning 11 million base pairs of 22q encompassing the NF2 gene, with 100% coverage and an average resolution of 58 kb. Moreover, the 220 kb genomic sequence encompassing the NF2 gene was covered by 13 cosmids to further enhance the resolution of analysis. The rationale of this array-CGH study was to map and size 22q deletions around the NF2 gene in sporadic schwannoma using a reliable method with maximal resolution. We studied tumor and constitutional DNA from 47 patients and detected heterozygous deletions in 21 (45%) tumors, which could be classified into three profiles. The predominant profile (12/21) was a continuous deletion of the 11 Mb segment, consistent with monosomy 22. The second profile, comprising five schwannomas, was also in agreement with a continuous 11 Mb heterozygous deletion. However, these displayed a distinctly different level of deletion when compared to the first profile, suggesting a considerable amount of normal tissue in the tumor samples. This is the first report demonstrating the sensitivity of array-CGH to discriminate such samples. The third profile was composed of four cases displaying interstitial deletions of various sizes. Two of these did not encompass the NF2 locus, which further emphasize the importance of other loci in schwannoma development. This is the first high-resolution study performed on a large series of tumors, using an array continuously covering 1/3 of a human chromosome. Our findings warrant further studies of an extended tumor series on a full 22q genomic array, to better define additional, putative 22q-located loci important for schwannoma development. Our array also provides a new diagnostic tool for analysis of NF2 gene deletions in patients affected with neurofibromatosis-2.

Adult↗

PubMed1992

Normal resolution of community-acquired pneumonia.

Resolution of pneumonia has to be considered as two different phases: resolution of the acute illness and resolution of radiographic opacities. Age, comorbidities, immunosuppression, and etiological agent(s) are all important in determining whether the acute illness resolves; there is a considerable mortality rate from pneumonia requiring hospitalization. The major concern when there is slow radiographic resolution of pneumonia is the possibility of an underlying malignancy. In 96% of patients whose pneumonia has not resolved in 30 days, an underlying disease is found; emphysema, chronic bronchitis, or bronchogenic carcinoma are the most common. Normal resolution of community-acquired pneumonia has to be defined in terms of the severity of the illness, comorbidity (ies), and infecting pathogen(s).

Adult↗

PubMed1992

[Fundamental study of helical scanning CT--evaluation of spatial resolution in the longitudinal axis].

We evaluated spatial resolution in the longitudinal axis with helical scanning CT using a fourth-generation fast CT scanner. We made a phantom by stringing acrylic balls (65 mm phi x 8 and 9 mm phi x 6). The acquired images were processed by MPR and assessed visually to evaluate axis resolution. With the conventional scanning method, the partial volume effect varied with the starting position, but helical scanning was able to reconstruct high-resolution images using continuous raw data. During helical scanning, axis resolution varied depending on the slice width and sliding speed of the couch top. Even if the sliding speed was kept constant at 4 mm/sec, axis resolution was superior with a slice width of 2 mm than with one of 5 mm.

Microcomputers↗

PubMed2003

[Wiener spectrum and relative electron density resolution in heavy ion CT based on measurement of residual range distribution].

The relative electron density resolution was discussed by the Wiener spectrum in the heavy ion CT image. The two-dimensional (2D) Wiener spectrum in the CT image was obtained from the one-dimensional (1D) Wiener spectrum of the measured residual range distribution of the water phantom for a single projection angle, and the relative electron density resolution in the CT image was calculated from the 2D Wiener spectrum. To examine the usefulness of this method, the relative electron density resolution was also estimated by other two methods; the calculation using the Wiener spectrum of the reconstructed image of the water phantom, and the estimation by the reconstructed image of the electron density resolution phantom. The result of the first method was similar to those of the other two methods. Therefore, it is useful to estimate the relative electron density resolution by the 1D Wiener spectrum of the measured residual range distribution of the water phantom for a single projection angle.

Electrons↗

PubMed2004

Rapid natural resolution of intracranial hematoma.

OBJECTIVE: To investigate the clinical characteristics of intracranial hematoma and the mechanism involved in its rapid natural resolution. METHODS: Seventeen cases of intracranial hematoma with typical clinical and CT manifestations were retrospectively studied. RESULTS: Intracranial hematoma was found obviously decreased in size within 72 h after its occurrence in 8 cases. The rest 9 cases presented complete resolution. CONCLUSIONS: Rapid natural resolution of acute epidural hematoma is mostly found in teenagers and the resolution is correlated with cranial fracture at the hematoma site. As for acute subdural hematoma, its rapid resolution is associated with the transfer of cerebrospinal fluid toward subdural space, the lavage effect, and the compression caused by the increased intracranial pressure or the space left resulting from redistribution of the hematoma in brain atrophy.

Adolescent↗

PubMed2004

Metabolic rates in small brain nuclei determined by high-resolution PET.

UNLABELLED: Identification of small nuclei in the brain by PET has been limited by the spatial resolution of conventional scanners. The new detector technology and advanced signal analysis of a high-resolution research tomograph (HRRT) has improved 3-dimensional spatial resolution to 2.2 mm at sufficient efficiency and permitted the quantification of tracer concentrations in small volumes. METHODS: In 9 healthy volunteers, cerebral glucose metabolism was investigated after intravenous injection of 370 MBq of (18)F-FDG, and regional cerebral metabolic rates for glucose (rCMRGlc) were determined in various structures of the brain identified on coregistered MR images using stereotactic and topographic anatomic information. RESULTS: rCMRGlc values (in mumol/100 g/min) were higher in the cerebral cortex (33.5 +/- 2.98), the basal ganglia (32.6 +/- 3.04 in the nucleus caudatus and 40.2 +/- 3.50 in the putamen), the thalamus (36.6 +/- 4.72), and the cerebellum (29.8 +/- 2.20) and were lower in the cerebral white matter (12.3 +/- 1.45) than those reported previously with conventional scanners. This resulted in an increased ratio of cortical values to white-matter values. Various nuclei in the basal frontal lobe (21.4 +/- 3.19 in the basal forebrain and 32.3 +/- 2.39 in the nucleus accumbens), the temporal lobe (22.2 +/- 1.74 in the corpus amygdalae), the hippocampus (25.7 +/- 2.11), the diencephalon (23.1 +/- 3.33 in the corpus geniculatum laterale, 20.2 +/- 2.87 in the corpus geniculatum mediale, and 25.2 +/- 3.29 in the nucleus subthalamicus), and the brain stem (24.4 +/- 2.47 in the colliculus superior, 31.4 +/- 3.63 in the colliculus inferior, 31.0 +/- 3.10 in the nucleus ruber, and 22.8 +/- 2.35 in the substantia nigra) could be identified, and the metabolic rate was assessed in these structures. The effect of improved spatial resolution on quantified metabolic rates could directly be demonstrated in a few cases investigated on scanners of different generations. CONCLUSION: The improved spatial resolution of the HRRT decreased partial-volume effects in the quantification of metabolic rates in the brain and increased the accuracy of rCMRGlc values in large structures. For the first time, this scanner has permitted the determination of metabolic rates in small nuclei that are involved in various neurodegenerative disorders.

Adult↗

PubMed2005

U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice.

UNLABELLED: A major advance in biomedical science and diagnosis was accomplished with the development of in vivo techniques to image radiolabeled molecules, but limited spatial resolution has slowed down applications to small experimental animals. Here, we present a SPECT system (U-SPECT-I) dedicated to radionuclide imaging of murine organs at a submillimeter resolution. METHODS: The high performance of U-SPECT-I is based on a static triangular detector setup, with a cylindric imaging cavity in the center and 75 gold micropinhole apertures in the cavity wall. The pinholes are focused on a small volume of interest such as the mouse heart or spine to maximize the detection yield of gamma-photons. Three-dimensional molecular distributions are iteratively estimated using the detector data and a statistical reconstruction algorithm that takes into account system blurring and data noise to increase resolution and reduce image noise. RESULTS: With 0.6-mm-diameter pinholes, the maximum fraction of detected photons emitted by a point source (peak sensitivity) is 0.22% for a 15%-wide energy window and remains higher than 0.12% in the central 12 mm of the central plane. In a resolution phantom, radioactively filled capillaries as small as 0.5 mm and separated by 0.5 mm can be distinguished clearly in reconstructions. Projection data needed for the reconstruction of cross sections of molecular distributions in mouse organs can readily be obtained without the need for any mechanical movements. Images of a mouse spine show 99mTc-hydroxymethylene diphosphonate uptake down to the level of tiny parts of vertebral processes. These are separated clearly from the vertebral and intervertebral foramina. Using another tracer, one can monitor myocardial perfusion in the left and right ventricular walls, even in structures as small as the papillary muscles. CONCLUSION: U-SPECT-I allows discrimination between molecular concentrations in adjacent volumes of as small as about 0.1 muL, which is significantly smaller than can be imaged by any existing SPECT or PET system. Our initial in vivo images of the mouse heart and spine show that U-SPECT-I can be used for novel applications in the study of dynamic biologic systems with a clear projection to clinical applications. The combination of high resolution and detection efficiency of U-SPECT-I opens up new possibilities for the suborgan-level study of radiotracers in mouse models.

Animals↗