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At least 883 records · Page 49Linked to original sources

Racial disparities in coronary heart disease: a sociological view of the medical literature on physician bias.

PURPOSE: To interpret, within a sociological context, evidence of physician bias in the management and outcomes of coronary heart disease (CHD) treatment for African Americans vs Whites. DATA IDENTIFICATION: Articles addressing race and ethnic disparities in CHD, and gender as an additional risk factor, published since 1980, were searched and reviewed. Source material was identified using the electronic search engines for MEDLINE and Sociological STUDY SELECTION: Articles were included in the review of race or ethnic disparities in heart disease when they provided direct or indirect evidence of potential sources of physician bias and/or differential treatment for CHD. Three types of studies suggest the presence of physician bias, and include those demonstrating: 1) patterned disparities in treatments and interventions; 2) practitioner perceptual bias/stereotyping of patients; and 3) patient perceptions of bias in treatment. RESULTS: A growing body of research supports the presence of physician bias in differential treatment practices for CHD based on patient race/ethnicity, and sometimes patient gender and socioeconomic status, which manifests as additional risk factors in the quality of care, pharmacological therapy, and use of invasive procedures. Access to care and patient preferences/behaviors do not fully account for racial disparities in CHD treatment. CONCLUSION: Socioeconomics, individual racism, and institutional racism represent 3 predominant pathways to differential treatment for CHD that are mediated by the patient-provider relationship. Racial biases are shown to be a part of the social structure of medical practices at both the macro and micro levels. Individual healthcare providers can potentially reduce disparities in Black-White CHD treatment and outcomes by examining the patient-provider relationship for bias. Future studies will require addressing more direct ways of measuring, monitoring, and reducing subtle bias in the healthcare system.

Black or African American↗

Strategies for supporting consumer health information seeking.

Despite a growing number of available Web-based health information resources, consumers continue to face a variety of barriers as they attempt to access these resources. Developing a system that appropriately responds to user queries poses several challenges. Guided by an earlier study that analyzed a large number of queries submitted to ClinicalTrials.gov, we developed a variety of techniques to assist user information seeking. We tested the efficacy of these techniques by submitting the original user queries to our new search engine to determine if these techniques would result in better system performance. Overall, the number of query failures was reduced, but the largest improvement was found in the system's query suggestion capability. For a subset of query failures, the current system was able to cut the earlier failure rate almost in half, in most cases providing a suggestion rather than directly finding records. The techniques described here provide a new approach for responding to user queries. The techniques are tolerant of certain types of errors and provide feedback to assist users in reformulating their queries.

Abstracting and Indexing↗

[Functional consequences and complications of surgery for female stress urinary incontinence].

OBJECTIVE: The functional consequences and complications of surgical treatment offemale stress urinary incontinence (SUI) are not systematically reported in clinical trials. The authors present a practical review of the results of the surgical techniques most frequently used for the treatment of SUI. MATERIALS AND METHODS: An exhaustive literature search concerning the various surgical techniques for female SUI, their results, and their complications, was performed using MEDLINE (1966-2003) and the PUBMED search engine. Some papers presented by expert teams at international congresses were also included. In view of the diversity and weakness of the published results, a specific classification of the consequences of this surgery was adopted, comprising treatment failures, immediate (0 to 48 hours), early (before 6 weeks) and late (after 6 weeks) surgical complications, and impact on quality of life. RESULTS: The best long-term success rate was observed for bladder neck slings. Prolene suburethral sling is a new promising technique, with an objective cure rate of more than 80%, but the publishedfollow-up does not exceed 3 years. Immediate complications included intraoperative bleeding, retropubic haematoma, urinary tract lesions, intestinal lesions, and complications related to the operative position. Early complications consisted of infections, pubic osteomyelitis, urinary fistula, sequelae of nerve lesions, and transient postoperative urinary retention. Late complications were induced voiding disorders, including dysuria, chronic urinary retention and detrusor instability, de novo genital prolapse, sexual disorders, chronic pain, chronic urinary tract infections and complications related to the use of biomaterials, including screws, synthetic tape, and artificial urinary sphincter. The quality of life after SUI surgery, although only rarely studied, was globally and constantly improved. CONCLUSION: This review of the literature shows that no operation presents satisfactory results for all patients. Knowledge of the functional consequences and complications, although interesting, does not have any real value for the choice of a particular operation. Patient information implies mastery of all techniques and the choice of treatment must be determined case by case. This review provides a classified system of validated and detailed information, essentialfor the information of candidates for this functional surgery.

Biocompatible Materials↗

The role of Internet and personal digital assistant in oral and maxillofacial pathology.

Internet usage for dentistry and medicine is growing. Using search engines available on the Internet, websites for oral pathology and oral medicine information resources are explored and evaluated. A framework, whereby the personal digital assistant is used in conjunction with the Internet to enhance the practice and education of oral pathology, is proposed.

Computers, Handheld↗

Web impact factor: a bibliometric criterion applied to medical informatics societies' web sites.

Several methods are available to evaluate and compare medical journals. The most popular is the journal Impact Factor, derived from averaging counts of citations to articles. Ingwersen adapted this method to assess the attractiveness of Web sites, defining the external Web Impact Factor (WIF) to be the number of external pages containing a link to a given Web site. This paper applies the WIF to 43 medical informatics societies' Web sites using advanced search engine queries to obtain the necessary link counts. The WIF was compared to the number of publications available in the Medline bibliographic database in medical informatics in these 43 countries. Between these two metrics, the observed Pearson correlation was 0.952 (p < 0.01) and the Spearman rank correlation was 0.548 (p < 0.01) showing in both cases a positive and strong significant correlation. The WIF of medicalm informatics society's Web site is statistically related to national productivity and discrepancies can be used to indicate countries where there are either weak medical informatics associations, or ones that do not make optimal use of the Web.

Bibliometrics↗

Improving menu categories.

No matter how good a site's navigational tools, site visitors will not use them if the menu categories are ambiguous. Users have to know what to expect when they click on a particular menu item. If the categories are not intuitive, users will have to resort to the site's search engine, ignoring the entire structure. The Pennsylvania Medical Society site (http://www.pamedsoc.org) had been plagued with poor menu labels until it took a step back and improved them.

Consumer Behavior↗

[Nano-ESI-MS/MS identification on differentiation-associated proteins in M1 mouse myeloid leukemia cells induced by IL-6].

OBJECTIVE: To identify two differentiation-associated proteins induced by rhIL-6 in M1 mouse myeloid leukemia cells. METHODS: Protein spots were excised from 2-D gels and digested in-gel with trypsin. The trypsin lysis products were first analyzed by matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) through peptide mass fingerprinting and then performed peptide sequencing by nano-electrospray ionization mass spectrometry/mass spectrometry (nano-ESI-MS/MS). The database search was finished with the Mascot search engine (http://www.matrixscience.co.uk) using the data processed through MaxEnt3 and MasSeq. RESULTS: The two proteins were not revealed by peptide mass fingerprint using MALDI-TOF-MS, while they were respectively identified as Destrin and Putative protein after the sequence of their trypic peptides were obtained by the nano-ESI-MS/MS techniques. CONCLUSION: Nano-ESI-MS/MS technique can successfully identify the two differentiation-associated proteins induced by rhIL-6 and has great advantage in protein analysis.

Actin Depolymerizing Factors↗

Mass processing--an improved technique for protein identification with mass spectrometry data.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis following tryptic digestion of polyacrylamide gel pieces is a common technique used to identify proteins. This approach is rapid, sensitive, and user friendly, and is becoming widely available to scientists in a variety of biological fields. Here we introduce a simple and effective strategy called "mass processing" where the list of masses generated from a mass spectrometer undergoes two stages of data reduction before identification. Mass processing improves the ability to identify in-gel tryptic-digested proteins by reducing the number of nonsample masses submitted to protein identification database search engines. Our results demonstrate that mass processing improves the statistical score and rank of putative protein identifications, especially with low-quantity samples, thus increasing the ability to confidently identify proteins with mass spectrometry data.

Chemistry Techniques, Analytical↗

[The neurobiology of sleep and its influence on memory].

OBJECTIVE: Recent developments in neuroscience have increased our knowledge of the physiology of sleep and dreaming, and thus the number of studies about the influence of sleep on learning and memory have increased rapidly. In this review the objective is to assess the relationship between sleep and memory considering the evidence regarding the neurobiology of sleep and dreaming. METHOD: This is a retrospective literature review and the relevant studies from the last 10 years are included. For this purpose the PubMed search engine and the key words "sleep, neurobiology, synaptic plasticity, memory" were used. RESULTS: Sleep-wake and NREM-REM cycles are accompanied by neuromodulatory influences on forebrain structures that affect behavior, consciousness and cognition. Animal and human studies in which learning paradigms are used to assess the influence of sleep deprivation on memory show the influence of sleep on memory consolidation. Different sleep stages have different effects on memory processes. Some investigators claim that NREM improves declarative memory while REM improves procedural and implicit memory. Other investigators suggest that NREM and REM affect memory in a complementary and sequential way. Molecular and electrophysiological evidence suggests that the influence of sleep on memory is through synaptic plasticity. CONCLUSION: Studies about the physiology of sleep and dreaming will help us to understand consciousness and memory better. The reverse is also true: understanding the contribution of sleep stages to memory will help us to determine the advantages of sleep and dreaming in an evolutionary perspective.

Humans↗

Realizing the potential of the internet for health and medical information.

The latest advances in information technologies have allowed for the development of applications that have had tremendous repercussions in the healthcare field. Along with access, means must be provided to ensure that information is trustworthy and relevant. This article examines some of the problems arising from unprecedented access to vast quantities of health information made possible by the Internet. The role of search engines is explored and some of their associated problems are mentioned. We then presents the most mature of these initiatives to protect the Internet citizen, the HONcode, developed by the Health On the Net Foundation. Finally, we conclude on the concrete result of the Health On the Net Foundation initiatives since 1997.

Health Education↗

[Information explosion in a better light after fifty years].

The phenomenon of "Information explosion" emerged in the professional and later also in the unprofessional community in the middle of the twentieth century. It expresses feeling of an unexpected general congestion with increasing number of published articles and books, which are not possible to go through, process and use in the real time. Unexpected development of the science after the Second World War resulted in unusually high production of new data and information. Their fast release was enabled by modernization of the publication process together with an increase of the number of scientific journals. Despite the relative information isolationism during the totalitarian regiment, this worldwide process soon emerged also in our region. However, the overload in information was not balanced by modernization of methods in the bibliographic and librarian systems, which could bring the new information to the scientific community. The turning point in the transfer of information was the development of worldwide interconnection - the word wide web or the Internet. For the processing of new information it was possible to introduce gradually still more powerful information technologies based on computers with on-line connection to the Internet. To solve the information explosion it was necessary to possess such technology and necessary programs and to master the elements of information and computer know-how. Contemporary modern technology with various user-friendly search engines, catalogues, repositories, and with voluminous bibliographic databases enable the use of full-text sources and give a better view on the formerly catastrophically looking information explosion. Along with that it is necessary to find financial sources to cover the access to the system. Information support of the scientific work based on such possibilities represents in the brim of modern information society the only possibility of effective activity in any field. It is also a good way how to precede the possible next information overload.

Informatics↗

A survey of kidney disease and risk-factor information on the World Wide Web.

BACKGROUND: Chronic kidney disease (CKD) is epidemic, and informing those at risk is a national health priority. However, the discrepancy between the readability of health information and the literacy skills of those it targets is a recognized barrier to communicating health information that may promote good health outcomes. Because the World Wide Web has become one of the most important sources of health information, we sought to assess the readability of commonly available CKD information. METHODS: Twelve highly cited English-language, kidney disease Web sites were identified with 4 popular search engines. Each Web site was reviewed for the availability of 6 domains of information germane to CKD and risk-factor information. We estimated readability scores with the Flesch-Kincaid and Flesch Reading Ease Index methods. The deviation of readability scores for CKD information from readability appropriate to average literacy skills and the limited literacy skills of vulnerable populations (low socioeconomic status, health disparities, and elderly) were calculated. RESULTS: Eleven Web sites met the inclusion criteria. Six of 11 sites provided information on all 6 domains of CKD and risk-factor information. Mean readability scores for all 6 domains of CKD information exceeded national average literacy skills and far exceeded the fifth-grade-level readability desired for informing vulnerable populations. Information about CKD and diabetes consistently had higher readability scores. CONCLUSION: Information on the World Wide Web about CKD and its risk factors may not be readable for comprehension by the general public, especially by underserved minority populations with limited literacy skills. Barriers to health communication may be important contributors to the rising CKD epidemic and disparities in CKD health status experienced by minority populations.

Chronic Disease↗

The battle against the obesity epidemic: is bariatric surgery the perfect weapon?

PURPOSE: Obesity has become a major public health problem worldwide. In developed countries, 10-20% of the adult population are obese with health care costs totalling almost 117 billion dollars each year. Respectively, co-morbidities associated with excess body fat escalate this cost and contribute to social isolation, morbidity and excess mortality. Hence, organizations such as the National Institutes of Health and the Surgeon General of the U.S. are urging development of new strategies to curb this epidemic. SOURCES: A review of the up-to-date published literature reviewing obesity epidemiology, management options and outcomes was performed by two independent reviewers using a combination of hand searching, EMBASE searching and Medline searching using the Pub-Med search engine. PRINCIPAL FINDINGS: The results from conservative therapeutic tools such as dietary intervention, exercise regimens, behavioural modification and even pharmacological adjuncts remain disappointing, with most patients either failing to lose weight or, for those able to lose weight, experiencing total weight regain within a few years. Furthermore, such conservative measures do not sustain improvement in obesity-related co-morbidities. In contrast, bariatric surgery for the severely obese has resulted in an overall 61% weight reduction across all procedures and has been shown to eliminate or significantly ameliorate many of the obesity-related co-morbidities. CONCLUSION: Bariatric surgery appears to be an effective weapon in the battle against the current pandemic of obesity and its devastating complications.

Bariatrics↗

[Investigation of medical journal website construction in Guangdong province].

OBJECTIVE: To investigate the current status of internet-based publication of biomedical journals and website construction in Guangdong province. METHODS: On the platform of the currently available databases for academic science journals (Wanfang Datebase, China Acdemic Journal Network, PubMed and SCI) with the assistance general searching engines, the websites of the medical journals in Guangdong province were evaluated and the editorial offices of the core medical journals in Guangdong province were interviewed. RESULTS: At present, the internet-based publication of the journals was executed predominantly by 3 means, namely utilization of the access to the websites of the direct sponsor, authoritative websites of science and technology, or independent websites. CONCLUSION: Relying on the database system of Wanfang and China Academic Journal Network, for instance, most of the journals can provide access to their full-text resources, but this internet-based publication is somehow delayed in comparison with the print publication. At present, only a few medical journals in Guangdong have built their independent websites, and among those which already have, Journal of First Military Medical University and Cancer are indexed by IM and PubMed, therefore they provide online abstracts of the papers ahead of the print copy publication.

China↗

[The neurobiology of hallucinations].

OBJECTIVE: Although hallucinations are among the cardinal features of schizophrenia, the mechanisms underlying these symptoms have not been fully understood yet. In this review our objective is to summarize the studies about the neurobiology of auditory hallucinations in schizophrenia and discuss their significance for understanding schizophrenia. METHOD: This is a retrospective literature review and the relevant studies within the last 10 years are included. For this purpose Pubmed search engine and 'hallucination, schizophrenia, neurobiology' key words are used. RESULTS: Hallucinations cause sensory modality specific activation in cerebral areas involved in normal sensation. A disturbance in perception of speech seems to have a central role in occurrence of auditory hallucinations. Anatomically, auditory hallucinations appear to involve primary and association cortices, Broca's and Wernicke's areas, subcortical, paralimbic, limbic regions, ventral striatum and thalamus. Furthermore they are suggested to be associated with the dysmodulation of the information flow from ventral striatum to thalamus and cortex caused by increased dopaminergic activity in mesolimbic pathway. CONCLUSION: The validity of the models which are proposed to explain neurobiology of hallucinations in schizophrenia should be tested by new studies. The difficulties regarding the assessment and measurement of subjective mental phenomena are important impacts in studying and understanding the neural correlates of hallucinations. Functional neuroimaging, cognitive and molecular biological studies will hopefully enhance our knowledge about this disease.

Brain↗

Online medical books: their availability and an assessment of how health sciences libraries provide access on their public Websites.

OBJECTIVE: The objective of this study was to determine the number and topical range of available online medical books and to assess how health sciences libraries were providing access to these resources on their public Websites. METHOD: The collection-based evaluative technique of list checking was used to assess the number and topical range of online medical books of the six largest publishers. Publisher inventory lists were downloaded over a two-day period (May 16-17, 2004). Titles were counted and compared with the 2003 Brandon/Hill list. A sample of health sciences libraries was subsequently derived by consulting the 2004 "Top Medical Schools-Research" in U.S. News & World Report. Bibliographic and bibliothecal access methods were evaluated based on an inspection of the publicly available Websites of the sample libraries. RESULTS: Of 318 currently published online medical books, 151 (47%) were Brandon/Hill titles covering 42 of 59 Brandon/Hill topics (71%). These 151 titles represented 22% (N = 672) of the Brandon/Hill list, which further broke down as 52 minimal core, 41 initial purchase, and 58 other recommended Brandon/Hill titles. These numbers represented 50%, 28%, and 12%, respectively, of all Brandon/Hill titles corresponding to those categories. In terms of bibliographic access, 20 of 21 of sampled libraries created catalog records for their online medical books, 1 of which also provided analytical access at the chapter level, and none provided access at the chapter section level. Of the 21 libraries, 19 had library Website search engines that provided title-level access and 4 provided access at the chapter level and none that at the chapter section level. For bibliothecal access, 19 of 21 libraries provided title-level access to medical books, 8 of which provided classified and alphabetic arrangements, 1 provided a classified arrangement only, and 10 provided an alphabetic arrangement only. No library provided a bibliothecal arrangement for medical book chapters or chapter sections. CONCLUSIONS: This study shows that the number and topical range of online medical books is reaching a point where collection-level consideration is warranted to facilitate efficient use and to prevent the problem of split files. However, the results also show that few efforts are underway on the publicly available Websites of the surveyed health sciences libraries to provide the analytical access necessary to meet the structural needs of clinical information seekers.

Access to Information↗

Screening and diagnostic mammograms: why the gold standard does not shine more brightly.

The objective of this article was to evaluate the sensitivity, specificity, positive predictive value, and negative predictive value of both screening and diagnostic mammograms. We looked at twenty seven studies found online with keywords: mammography, positive predictive value, negative predictive value, sensitivity, and specificity using the search engines google.com and botbot.com and placed them into three tables, sorting them first by purpose: either screening or diagnostic studies, and then by study size. We found a wide range of values in the studies reported and a high rate of false positives in many of them as well. Although many clinicians use the mammogram so often and rely on those results, many would benefit by being able to see the wide range of data that is reported worldwide in a format as shown in this article.

Breast Neoplasms↗

[Title, abstract and keywords: essential issues in medical bibliographic research].

UNLABELLED: Medical information, conveyed either by books, journal articles, conference and congress papers or posters, represents the product, the result of the medical research. Note that the informational cycle can be shown schematically as Bibliographic information --> Medical research --> Research results --> Bibliographic information. The result of the scientific research (articles, posters, etc.) re-enters the informational cycle, as bibliographic information for a new medical research. The bibliographic research is still a time, and effort consuming activity, despite the explosive growth of information technology. It requires specific medical, information technology and bibliographic knowledge. AIM: The present work aims to emphasize the importance of title, keywords and abstract terms selection, to article writing and publication in medical journals, and the proper choice of meta-information in web pages. MATERIAL AND METHODS: The bibliographic research was made using two databases with English language information about articles from international medical journals: MEDLINE (PUBMED) and PROQUEST MEDICAL LIBRARY. The results were compared with GOOGLE and YAHOO search. These searching engines are common now in all types of Internet users (including researchers, librarians, etc.). CONCLUSIONS: It is essential for the researchers to know the article registration mechanism in a database and the modalities of bibliographic investigation of online databases, so that the title, keyword and abstract terms are selected properly. The use of words not related to the subject, in title, keywords or abstract, results in ambiguities. The writing and the translation of scientific words must also be accurate, mainly when article authors are non-native English speakers: e.g., chimiotherapy (sic)--20 articles in Medline, 270 articles in Google; morphopathology (sic)-- 78 articles in Medline, and 294 in Google; morphopatology (sic)--2 articles in Medline, and 12 articles in Google.

Abstracting and Indexing↗