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PubMed2006

Localization of estrogen receptor-alpha and -betamRNA in brain areas controlling sexual behavior in Japanese quail.

Two estrogen receptors (ERs), denoted ERalpha and ERbeta, have been identified in humans and various animal species, including the Japanese quail. Estrogens play a key role in sexual differentiation and in activation of sexual behavior in Japanese quail. The distribution of ERalpha in the brain of male and female adult quail has previously been studied using immunohistochemistry, whereas in situ hybridization has been employed to study the distribution of ERbeta mRNA in males only. In this article, we used in situ hybridization to study the distribution of mRNAs for both ERalpha and ERbeta in brain areas controlling sexual behavior of Japanese quail. Our results show that both ERalpha mRNA and ERbeta mRNA are localized in areas important for sexual behavior, such as the preoptic area and associated limbic areas, in both males and females. Moreover, we found differences in distribution of mRNA for the two receptors in these areas. The results of this article support previously reported data and provide novel data on localization of ER mRNAs in adult quail brain of both sexes.

Animals↗

PubMed1983

Sexual behavior of the bull: a review.

Development of sexual behavior, puberty, and social behavior is described in bulls. Normal mating behavior is discussed, including the relative importance of visual and olfactory cues as stimuli. The influence of sexual preparation on quantitative and qualitative seminal characteristics is reviewed. Attention is drawn to the strong genetic influences on libido and mating ability in bulls. The evidence for biostimulation in cattle is examined, with the conclusion that more investigation and exploitation of this phenomenon is warranted.

Animals↗

PubMed1999

The influence of corticosterone on serotonergic stereotypy and sexual behavior in the female rat.

The effects of adrenalectomy and chronic corticosterone treatment on sexual behavior in the ovariectomized female rat were investigated. The serotonergic type 2A (5-HT2A) receptor-mediated behavior 'wet dog shakes' (WDS) was measured concurrently. In Experiment 1, adrenalectomy reduced the frequency of WDS following the administration of the 5-HT(2A/2C) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) but had no effect on spontaneous WDS. In Experiment 2, chronic corticosterone treatment increased DOI-induced WDS in both adrenalectomized and sham-adrenalectomized rats. In Experiment 3, adrenalectomized and sham-adrenalectomized rats were compared on measures of spontaneous WDS and sexual behavior following the administration of estrogen alone, or estrogen in combination with progesterone. Chronic corticosterone and acute progesterone administration increased WDS and facilitated sexual receptivity and proceptivity, while adrenalectomy decreased WDS, facilitated sexual receptivity and inhibited proceptivity. These findings suggest that the behavioral effects seen following hypothalamic-pituitary-adrenal (HPA) axis disruption may, in part, be mediated by altered 5-HT2A receptor responsivity.

Adrenalectomy↗

PubMed1990

Fetal brain transplants induce recovery of male sexual behavior in medial preoptic area-lesioned rats.

Male rats received bilateral lesions within the medial preoptic area which completely abolished sexual behavior. Hypothalamic fetal brain transplants gradually restored sexual behavior to prelesion levels by the 6th week after the transplant. Immunocytochemical analyses revealed tyrosine hydroxylase immunoreactivity neurons within the transplanted tissue. These results demonstrate that fetal brain transplants can restore an innate complex behavior in which no spontaneous recovery is observed.

Animals↗

PubMed1992

The selective 5-HT2 receptor antagonist amperozide attenuates 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-induced inhibition of male rat sexual behavior.

This study was aimed at exploring the role of 5-HT2/5-HT1C neurotransmission in male rat sexual behavior. The administration of the 5-HT2/5-HT1C agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) (1 mg/kg), suppressed sexual activity in most of the animals. The suppressive effect of DOI was antagonized by treatment with amperozide, a selective 5-HT2 receptor antagonist, in doses which did not by themselves affect sexual activity. In addition, several other serotonin antagonists were tested with varying affinity profiles for 5-HT2/5-HT1C receptors, including ketanserin, ritanserin, and mesulergine. All these compounds antagonized the suppressive action of DOI. In contrast, no antagonizing effect was obtained by treatment with (-)-alprenolol, a 5-HT1A antagonist. The present findings suggest that 5-HT2/5-HT1C receptors might be involved in the neural control of male rat sexual behavior, presumably by exerting an inhibitory influence on the behavior.

Alprenolol↗

PubMed1986

Effects of two-stage lesions of the medial preoptic area on sexual behavior of male rats.

The effects of lesions of the medial preoptic area (MPOA) on sexual behavior of adult male rats were examined. Bilateral lesions were performed in either one or two stages. Bilateral, but not unilateral, destruction of the MPOA virtually eliminated mounts, intromissions, and ejaculation. No sparing of the male rats' sexual behavior was observed after two-stage MPOA lesions.

Animals↗

PubMed1990

Sustained influence of previous estradiol or testosterone treatments on sexual behaviors of female pigs.

Two studies were conducted to determine the consequences of extended treatment with estradiol or testosterone on sexual behavior in postpubertal, female pigs. After ovariectomy, either steroid was administered for 6 weeks at dosages sufficient to maintain serum concentrations similar to those observed in mature male pigs. Behavioral evaluations were initiated 2 months after the last steroid treatment. These treatments reduced receptivity (immobile stance when placed with a mature male) and proceptivity (preference to remain near a mature male) in association with an increase in aggressive behavior. In females treated previously with both estradiol and progesterone, sexual behaviors 2 months later were similar to those of control females. When evaluations were repeated 5 months after extended estradiol treatment had ceased, receptivity and proceptivity had returned to that of control pigs and aggressive behavior had diminished greatly. Interpretation of these changes in behavior is that extended periods of estradiol or testosterone treatment sustain activational influences for a considerable amount of time after treatments cease and progesterone antagonizes estradiol's effect on these behaviors. In a companion study, pubertal and post-pubertal females were similar for receptivity but pubertal females spent less time near a mature male. This difference in proceptivity likely reflects a maturational change associated with sexual development in female pigs. Collectively, these observations in postpubertal, female pigs document that prolonged estrogen treatment will activate aggressive behaviors in association with reduced proceptivity and receptivity. Because these behavioral changes are reversible by 5 months after cessation of treatment, they are not the result of sexual differentiation.

Animals↗

PubMed1985

Food conditioning, castration, testosterone administration and sexual behavior in the male rat.

Chronically food-deprived male rats, when paired with a female rat in heat, were rewarded by receiving a food pellet following each intromission. Following castration there was a rapid decline in all aspects of male sexual behavior: after 3 weeks all sex behavior had stopped. There were no differences between the conditioned males and their yoked controls. Substitution with two doses of testosterone (through silastic implants) restored sexual behavior, but equally so in the conditioned and the control animals. Removal of the testosterone implant again caused a very rapid decline in sexual behavior, no differences between experimental and yoked control males. These results suggest that food, as a non-sexual stimulus, does not cause hungry male rats to continue to copulate for prolonged periods following castration. Furthermore, the combination of chronic food deprivation plus castration do summate with each other in the very rapid decline and cessation of male sexual performance.

Animals↗

PubMed1978

Sexual behavior correlates of female orgasm and marital happiness.

The present study was designed to investigate sexual behavior correlates of marital happiness and female orgasm. Forty-eight female students of Baylor University who were 20 to 35 years old and had been married at least 2 years participated in the survey. A specially compiled 131-item marital relations questionnaire provided data for an intercorrelational analysis. Marital happiness, fidelity, and experience of orgasm correlated with certain specific sexual behaviors. These variables were related also to dissatisfaction with marital sex, which is consistent with previous research. However, when dissatisfaction resulting from performing less desired sexual acts was separated from dissatisfaction resulting from not performing desired sexual acts, the correlations differed, often markedly. Thus, the data suggest that unitary measures of dissatisfaction with marital sex may obscure meaningful differences. Also, information was obtained concerning the orgasmic and multiple orgasmic experience of the women, their extramartial experience, and their relative use of and preference for various intercourse positions and noncoital sexual activities.

Adult↗

PubMed1976

Cholinergic mechanisms and sexual behavior in the male rabbit.

The effects of cholinolytic as well as of cholinomimetic agents on sexual behavior in male rabbits were investigated. Castrated animals, injected with a supramaximal testosterone dose, were used. Scopolamine or methylscopolamine, 0.1 mg/kg, inhibited sexual activity. A dose of 0.02 mg had no effects. The muscarinic receptor-stimulating drug, pilocarpine, completely inhibited sexual activity at doses of 2, 10, and 50 mg/kg. A subeffective dose of methylscopolamine completely antagonized the effects of pilocarpine 2 mg/kg, partly the effect of pilocarpine 10 mg/kg, and not at all the effect of pilocarpine 50 mg/kg. Scopolamine completely antagonized the effects of pilocarpine 2 and 10 mg/kg, and not at all the effects of pilocarpine 50 mg/kg. The data indicate that the peripheral effects of both the receptor-blocking and stimulating agents is most important for the effects on sexual behavior, although a central site of action of pilocarpine cannot be ruled out.

Animals↗

PubMed1993

5-HT1A and 5-HT1C/1D receptor agonists produce reciprocal effects on male sexual behavior of rhesus monkeys.

Research has indicated that serotonin (5-HT) is involved in regulating male sexual behavior in rodent, as well as primate species. The present study was designed to further characterize 5-HT influences on male sexual behavior of rhesus monkeys. Experiment 1 examined the effects of 5-HT1A and 5-HT1C/1D receptor stimulation on penile erections and yawning behavior. Administration of the 5-HT1C/1D receptor agonist, m-chlorophenylpiperazine (m-CPP, 0.8 and 3.0 mg/kg), facilitated the occurrence of penile erection, and at doses greater than 0.2 mg/kg stimulated yawning. By contrast, the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 0.01-0.2 mg/kg) did not significantly influence penile erections or yawning behavior. Experiment 2 evaluated the effects of m-CPP and 8-OH-DPAT on the behavior of male monkeys in the presence of a sexually receptive female monkey which the males could see, hear and smell, but not physically contact. Administration of m-CPP along with presentation of a receptive female stimulated penile erections to a greater extent than they were stimulated by either one of these manipulations alone. Administration of 8-OH-DPAT (0.1 and 0.2 mg/kg) produced a decrease in the percent of monkeys exhibiting penile erections in the presence of the female. In this experiment, yawning was affected in opposite directions, with m-CPP stimulating and 8-OH-DPAT decreasing the frequency of yawning. Experiment 3 assessed the effects of m-CPP on male copulatory behavior of rhesus monkeys. Administration of m-CPP (0.8-3.0 mg/kg) produced a dose-dependent decline in the percent of males initiating copulation and achieving ejaculation.(ABSTRACT TRUNCATED AT 250 WORDS)

8-Hydroxy-2-(di-n-propylamino)tetralin↗

PubMed1978

Effects of p-chloroamphetamine and 5,7-dihydroxytryptamine on the sexual behavior of gonadectomized male and female rats.

Treatment with the 5-HT neurotoxins p-chloroamphetamine (PCA, 2 X 10 mg/kg) or 5,7-dihydroxytryptamine (5,7-DHT, 2 X 6 microgram intracerebrally) stimulated the display of all aspects of sexual behavior, including ejaculations, by castrated male rats in the absence of testosterone (T) treatment and increased the behavioral sensitivity to a low level of T stimulation. The reduction of the (3H) 5-HT uptake after PCA treatment was more pronounced in the cortex than in the hypothalamus. 5,7-DHT treatment reduced the (3H) 5-HT uptake in the septum, hippocampus, amygdala, hypothalamus and cortex but the behavioral effects produced by the 5,7-DHT treatment could not be correlated to the biochemical effects in any of these brain areas. Since the behavioral effect of PCA appears to be stronger than that of 5,7-DHT, the 5-HT neurotoxins may exert their effect on sexual behavior in forebrain structures rather than in the hypothalamus. PCA treatment had a very small effect on mounting behavior but 5,7-DHT treatment stimulated the display of mounts and intromission patterns by ovariectomized female rats given no hormone treatment. Neither PCA nor 5,7-DHT had any effect on lordosis behavior tested before and after treatment with estradiol benzoate alone or in combination with progesterone. The observations support the conclusion that 5-HT is involved in the control by T of sexual behavior in male rats, but argue against a role of 5-HT in the neural control of lordosis behavior.

5,7-Dihydroxytryptamine↗

PubMed2003

Recalling sexual behavior: a methodological analysis of memory recall bias via interview using the diary as the gold standard.

This study examined the effect of time lag on the validity of retrospective self-reports of sexual behavior. Seventy-five heterosexual students (44 women, 31 men) made daily recordings of sexual behavior, condom use, and alcohol or substance use for 1 month. Ability of respondents to recall sexual behavior recorded during this period was assessed at 1, 2, and 3 months after diary completion using recall interviews (25 interviewed at each interval). For vaginal intercourse, total recall error was significantly greater at 3 months than at 1 month post-diary. For all other variables assessed, the 2- and 3-month time intervals did not produce significant increase in total recall error. Higher frequency of vaginal intercourse, orgasm, and alcohol use prior to sexual activity were associated with total recall error for some but not all behaviors and outcomes. The results provide a partial validation of the diary-interview recall model as a method for studying recall error.

Adult↗

PubMed2002

[The relationships among self-identity, self-esteem and attitude towards sexual behavior in university students].

PURPOSE: It has been reported that the young people of today tend to engage in sexual behavior at an early age and the abortion rate is high. The purpose of this study was to investigate the attitudes of post-adolescents with regard to sexual behaviors and the relationship to self-identity and self-esteem. METHODS: The subjects were 234 males (mean +/- SD 20.2 +/- 1.1 years) and 460 females (mean +/- SD 19.5 +/- 1.1 years) 4-year university students aged 18 to 23 years in Aichi Prefecture. An anonymous, self-report questionnaire was used to survey the subjects with regard to self-identity ("Establishment of Self" scale), self-esteem (Rosenberg Self-Esteem Scale), and sexual attitude and behavior. The scores on both scales and subscales of the "Establishment of Self" scale, "Foundation of Identity (Foundation)" and "Establishment of Identity (Establishment)", were calculated and intercompared, along with sexual attitude and behavior, controlled for age and school type. RESULTS: The mean total score of the "Establishment of Self" scale for males was 55.3 (SD9.2) and for females 52.2 (SD9.3), while those for the Rosenberg Self-Esteem Scale were 27.2 (SD5.5) and 25.7 (SD5.2), respectively. There was significant positive correlation all scales in both sexes. Both male and female students had positive attitude towards sex and a negative view of "traditional gender roles" particularly females. Of the subjects, 82.4% of males and 69.5% of females were thinking of accepting a request for sexual intercourse from their partners. Many students understood the "need for contraception", that is a component of contraceptive behavior. Most of them, however, didn't acquire the other components. A total of 68.3% of males and 48.2% of females had experienced sexual intercourse during the last year. Of these, 50.6% of males and 58.2% of females consistently used contraception. The score on the "Establishment of Self" scale was higher among both the male and female students who responded positively to having "communication ability," "learning ability," and "acquisition ability." Significant differences were found in total and "Establishment" scales among males, and all scales among females. The score on the Rosenberg Self-Esteem Scale was significantly higher with "learning ability" among males, and with "communication ability" and "learning ability" among females. However, no significant relationship was found between actual contraceptive behavior and any of the scales. CONCLUSION: In dealing with contraception, a gap exists between university students' attitudes and actual behavior. The scores on the "Establishment of Self" scale and the Rosenberg Self-Esteem Scale were found to be significantly higher for those who exhibited higher values for components of contraceptive behavior.

Adolescent↗

PubMed1997

Effects of acute and long-term domperidone treatment on prolactin and gonadal hormone levels and sexual behavior of male and female rats.

Domperidone (DOMP), a dopamine D2 blocker that is unable to cross the blood-brain barrier, is an experimental tool used to induce hyperprolactinemia. Acute and long-term DOMP administration was tested in male and female rats for its effects on sexual behavior and plasma gonadal hormone levels. DOMP (4.0 mg/kg) was injected I.P. either acutely or daily for 30 days. Acute treatment failed to modify any behavioral parameter observed. The 5-day treatment stimulated and the 30-day treatment failed to inhibit sexual behavior of male rats. Serum testosterone levels were significantly reduced after 30 days of treatment in male rats. The 30-day treatment also inhibited sexual behavior and enhanced plasma progesterone levels in ovariectomized and intact female rats, respectively. The present results may be due to DOMP-induced long-term hyperprolactinemia. Alternatively, blockade of dopamine peripheral receptors induced by this treatment may also be responsible for the behavioral changes reported here. Moreover, these data suggest that female rats are more susceptible than males to the behavioral effects of long-term hyperprolactinemia.

Animals↗

PubMed2003

Adolescent oral sex, peer popularity, and perceptions of best friends' sexual behavior.

OBJECTIVE: To provided initial descriptive information regarding adolescents' engagement in oral sex and to investigate adolescents' perceptions of their best friends' sexual behavior and peer-reported popularity as two social mechanisms that may influence engagement in oral sex. METHODS: A total of 212 tenth graders reported their engagement in oral sex and intercourse, number of sexual partners, and use of sexually transmitted infection (STI) protection, as well as perceptions of their best friends' sexual behaviors. Sociometric assessment yielded peer-reported measures of adolescents' preference- and reputation-based popularity. RESULTS: Adolescents were more likely to report engagement in oral sex than intercourse, report more oral sex partners than intercourse partners, and were unlikely to report use of STI protection during oral sex. Perceptions of best friends' behavior were significantly associated with adolescents' own oral sex behavior, but not intercourse. Adolescents who reported sexual activity had high levels of reputation-based popularity, but not likeability among peers; however, sex with more partners was associated with lower levels of popularity. CONCLUSIONS: Implications for prevention programs are discussed.

Adolescent↗

PubMed1987

Postnatal treatment of rats with adrenergic receptor agonists or antagonists influences differentiation of sexual behavior.

The aim of the study was to investigate the possible role of the adrenergic system in development and differentiation of neural centers controlling sexual behavior in adulthood. For this purpose normal and androgenized female rats were treated with the alpha 1-receptor antagonist prazosin, the alpha 2-receptor agonist clonidine, or the alpha 2-receptor antagonist yohimbine-HCl throughout the first week of life. In adulthood all animals were ovariectomized and, after appropriate hormone-priming, they were tested for the capacity to display female and male sexual behavior patterns. Alteration of adrenergic transmission during the critical postnatal period for sexual differentiation of neural centers resulted in significant changes in the capacity to express female lordosis behavior in adulthood. In nonandrogenized animals clonidine significantly reduced the capacity for lordosis behavior. In androgenized animals clonidine had the opposite effect; it attenuated the inhibitory effect of testosterone propionate (TP) on differentiation of lordosis behavior. Prazosin, which was without effect in nonandrogenized animals, also attenuated the inhibitory effect of TP on differentiation of lordosis behavior. Yohimbine was without effect in androgenized and nonandrogenized animals. There was no influence of any of the adrenergic drugs on differentiation of male sexual behavior. In conclusion, differentiation of lordosis behavior seems to be mediated or modulated via adrenergic transmission. The defeminizing effect of testosterone postnatally on the differentiation of lordosis behavior seems to be expressed via alpha 1-adrenergic transmission, and diminished adrenergic activity during the postnatal period seems to protect the developing brain against this effect of testosterone.

Adrenergic alpha-Agonists↗

PubMed2005

Effects of chronic paroxetine pretreatment on (+/-)-8-hydroxy-2-(di-n-propyl-amino)tetralin induced c-fos expression following sexual behavior.

Chronic treatment with the selective serotonin reuptake inhibitor paroxetine impairs the functioning of 5-HT(1A) receptors involved in ejaculation. This could underlie the development of delayed ejaculation often reported by men treated with paroxetine. The neurobiological substrate linking the effects of selective serotonin reuptake inhibitor-treatment and 5-HT(1A) receptor activation with ejaculation was investigated. Male Wistar rats that were pretreated with paroxetine (20 mg/kg/day p.o.) or vehicle for 22 days and had received an additional injection with the 5-HT(1A) receptor agonist 8-OH-DPAT ((+/-)-8-hydroxy-2-(di-n-propyl-amino)tetralin; 0.4 mg/kg s.c.) or saline on day 22, 30 min prior to a sexual behavior test, were perfused 1 h after the sexual behavior test. Brains were processed for Fos-, and oxytocin immunohistochemistry. The drug treatments markedly changed both sexual behavior and the pattern and number of Fos-immunoreactive cells in the brain. Chronic pretreatment with paroxetine caused delayed ejaculation. Acute injection with 8-OH-DPAT facilitated ejaculation in vehicle-pretreated rats, notably evident in a strongly reduced intromission frequency, whereas 8-OH-DPAT had no effects in paroxetine-pretreated rats. Chronic treatment with paroxetine reduced Fos-immunoreactivity in the locus coeruleus, and prevented the increase in Fos-immunoreactive neurons induced by 8-OH-DPAT in the oxytocinergic magnocellular part of the paraventricular nucleus as well as in the locus coeruleus. Since oxytocin and noradrenalin facilitate ejaculation, the alterations in Fos-IR in these areas could connect selective serotonin reuptake inhibitor treatment and 5-HT(1A) receptor activation to ejaculation. Chronic paroxetine treatment and 8-OH-DPAT changed c-fos expression in a number of other brain areas, indicating that Fos-immunohistochemistry is a useful tool to find locations where selective serotonin reuptake inhibitors and 8-OH-DPAT exert their effects.

8-Hydroxy-2-(di-n-propylamino)tetralin↗