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Results for “ABORTION, HABITUAL”

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At least 91 records · Page 5Linked to original sources
PubMed1997

Immunotherapy with husband's leukocytes to primary habitual aborters and autoantibodies in their sera.

OBJECTIVE: This study was performed to determine whether primary habitual aborters have an autoimmunological tendency and whether immunotherapy with leukocytes induces autoantibodies in their sera. METHODS: We measured the levels of antiphospholipid antibodies (APAs) and antinuclear antibodies (ANAs) in the sera of 65 primary habitual aborters. Among them, 8 primary habitual aborters received immunotherapy with their respective husband's leukocytes; these 8 patients were followed up for autoantibodies in their sera before immunotherapy, at the time of pregnancy permission, during the first trimester of pregnancy, at delivery, and postpartum. RESULTS: Sixty-nine percent of the 65 primary habitual aborters were positive for IgG or IgM antibodies to at least 1 of 6 phospholipids, and 29% of them were positive for ANAs. Although the pregnancy outcomes of the 8 primary habitual aborters after immunotherapy were good, their APAs and ANAs converted to positive after the immunotherapy. CONCLUSION: Immunotherapy with leukocytes should be performed after checking and confirming the absence of autoantibodies in the sera of a habitual aborter.

Abortion, Habitual↗
PubMed1987

Anticardiolipin antibodies and complement in ninety-nine women with habitual abortion.

Immunologic investigations were performed on sera from 99 women with habitual abortion (three or more consecutive miscarriages). All were considered healthy and clinical investigations had not revealed any cause for the miscarriages. Sixty-eight were considered to have primary habitual abortion whereas 31 had secondary habitual abortion. Increased anticardiolipin antibody levels were found in 42 patients. None had a primary diagnosis of systemic lupus erythematosus, but at follow-up studies one of them fulfilled the diagnostic criteria of systemic lupus erythematosus. Ten sera, all from patients with primary habitual abortion, showed high anticardiolipin antibody values (greater than or equal to 10 units) concomitant with significantly lower levels of complement factor C4 than those found in sera with moderate or normal anticardiolipin antibody levels. There was no indication of genetic defects explaining the low C4 values, which could be explained at least in part by an activation of complement by the classical pathway.

Abortion, Habitual↗
PubMed1998

[The study of autoantibodies in women with habitual abortion of unknown etiology].

OBJECTIVE: To evaluate the relationship between habitual abortion of unknown etiology and autoantibodies. METHODS: IgG and IgA antibodies against cardiolipin, specific antinuclear double-stranded DNA and single-stranded DNA were measured by enzyme linked immunosorbent assay (ELISA). Antinuclear antibody, smooth muscle antibody, antimitochondrial antibody and antiheart muscle antibody were performed by indirect immunofluorescence assay. Antiextractable nuclear antigen's antibodies were determined by immunodiffusion assay. RESULTS: Most women with habitual abortion of unknown etiology showed higher incidence of antibodies to cardiolipin, nuclear, smooth muscle compared with normal multigravida control (P < 0.05). CONCLUSIONS: These results indicate that most women with habitual abortion of unknown etiology have a higher level of autoreactivity, which may affect the course of pregnancy. The incidence of antismooth muscle antibody in women with habitual abortion of unknown etiology is also increased compared with normal multigravida control.

Abortion, Habitual↗
PubMed2003

[A study of correlation between the change of chromosome centromeric dots and habitual abortions].

To study the correlation between chromosome centromeric dots and habitual abortions, Cd variation, Cd loss,maximum diameter of Cd and Cd-NOR of 38 habitual abortion patients and 42 healthy persons were measured, compared and analysed with Cd-banding technique. It was found that the frequencies of Cd variation and Cd loss were obviously higher and maximum diameter of Cd was smaller in habitual abortion patients than those in healthy persons. The increase of frequencies of Cd variation and Cd loss and the decrease of maximum diameter of Cd might be the causes affecting habitual abortions.

English Abstract↗
PubMed1996

Frequency of factors associated with habitual abortion in 197 couples.

OBJECTIVE: To determine the frequency of factors associated with habitual abortion in 197 couples. DESIGN: Prospective cohort study. SETTING: The British Columbia Recurrent Pregnancy Loss Program, located in a tertiary care academic center. INTERVENTIONS: Diagnostic screening protocol. MAIN OUTCOME MEASURES: Genetic, endocrine, infectious, anatomical, and autoimmune factors associated with habitual abortion. RESULTS: A structural genetic factor was identified in 3.5% of the couples. An endocrine factor, including luteal phase deficiency and hypothyroidism, was identified in 20% and an infectious factor was identified in 0.5% of the couples. An anatomical factor, including various müllerian tract anomalies and severe intrauterine adhesions, was found in 16% and an autoimmune factor, including the antiphospholipid antibody syndrome and the undifferentiated connective tissue syndrome, was identified in 20% of the couples. Eighty-four couples who completed the diagnostic screening protocol were classified as having unexplained habitual abortion. Of these 84 couples, 65% were subclassified as primary, 27% were subclassified as secondary, and 7% had unclassified unexplained habitual abortion. CONCLUSIONS: This large-scale study identified genetic, endocrine, infectious, anatomical, or autoimmune factors in approximately 60% of couples with habitual abortion.

Abortion, Habitual↗