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PubMed1952

Operations on the adrenal glands.

Various conditions of the adrenal gland are amenable to surgical treatment. Removal of a pheochromocytoma is almost always indicated when the tumor is diagnosed. The results of extirpation have been excellent in cases in which patients were operated upon before the onset of chronic hypertension. Removal of the "nerve cell" tumors of the adrenal is indicated if metastasis cannot be demonstrated. Hypofunction of the adrenal cortex may be partially alleviated by the repeated implantation of pellets of desoxycorticosterone acetate. Hyperfunction of the adrenal cortex causes a variety of clinical manifestations depending upon which of the numerous hormones are affected. Removal of a cortical tumor alleviates these symptoms. These tumors are malignant in more than 50 per cent of cases, and recurrence is frequent. Bilateral hyperplasia of the glands rather than a tumor may be present. In such circumstances, resection of 95 per cent of the adrenal tissue is effective in controlling the symptoms of the disease. Total bilateral excision of the adrenals is, at present, under investigation as a means of treatment for a variety of conditions.

Adrenal Cortex Neoplasms↗
PubMed1986

Magnetic resonance imaging of the adrenal glands.

Applications of nuclear magnetic resonance (NMR) to the adrenal gland have received considerable attention in recent years. Using high field strength magnets and surface coil technology, images of normal and abnormal adrenal glands have been obtained that compare favorably, and in some instances excel, computed tomography (CT) with respect to both image quality and, to a greater degree, differentiation of pathology. This article reviews the current state of magnetic resonance (MR) imaging of normal and abnormal adrenal glands, compares MR with CT imaging, and indicates where NMR spectroscopy has been of greatest value to date in the study of adrenal gland disease.

Adenoma↗
PubMedDate not supplied

[Myelolipoma of the adrenal gland].

Adrenal myelolipomas are rare, nonfunctioning, benign neoplasms of the adrenal gland. The authors describe their experience of a case and they report the review of the literature. They illustrate what's etiopathogenetic theories, modern diagnostic technology "of imaging" and different surgical approaches need to be adapted to the excision of the adrenal myelolipomas.

Adrenal Gland Neoplasms↗
PubMed1979

Myelolipoma in adenoma of accessory adrenal gland.

A tumor was incidentally found at autopsy in the vicinity of the right adrenal gland of a 69-year-old man who had died of liver cirrhosis with hepatoma. Microscopic examination disclosed a myelolipoma associated with a cortical adenoma occurring in an accessory adrenal gland. No evidence of hormonal abnormalities was found in the clinical record of the patient. The association of myelolipoma with cortical adenoma occurring in an accessory adrenal gland seems very unusual, and the present case is believed to be the first reported of this type of association.

Adenoma↗
PubMed1988

[Clinical use of magnetic resonance tomography for assessing adrenal function in patients with arterial hypertension].

99 patients with arterial hypertension (AH) were studied: 17 patients with pheochromocytoma, 37 with aldosteronoma, 4 with corticosteroma, 38 with essential hypertension. Control group included 16 healthy subjects. The investigation was performed by means of a NMR-tomograph BMT-1100 ("Brucker", FRG) in axial and frontal planes according to Spin Echo (SE) technique with TR = 2.0 s, TE = 34 ms. Qualitative (visual) as well as quantitative criteria for evaluation of adrenal glands state were developed. Normal size of adrenal glands, relative intensity of their signal and T2 were calculated. The data obtained proved that relative intensity of the signal is a highly informative parameter for differential diagnosis of adrenal gland tumors (its value of less than 1.0 is evidence of cortex lesion, and that of more than 1.4--of medulla lesion). High informative value of MR-tomography for evaluation of adrenal glands state in patients with AH is proved by comparative data obtained by other methods, such as computer tomography aortography and histomorphology.

Adrenal Cortex Neoplasms↗
PubMed1976

Properties of thymidine kinase partially purified from human adrenal glands.

Thymidine kinase was partially purified from human adrenocortical carcinoma, hyperplasia, and normal adrenal glands. For the purpose of clarifying the qualitative and quantitative difference of thymidine kinase between cancer and normal tissue, biochemical properties of partially purified thymidine kinase were compared. Adrenocortical carcinoma and hyperplasia contained greater concentration of thymidine kinase than normal adrenal gland. By the DEAE-cellulose chromatography, adrenocortical carcinoma gave two peaks (Peak I and Peak II) of thymidine kinase, while in hyperplasia and normal adrenal gland, the second peak (Peak II) was only slightly detected or hardly detected. Thymidine kinase in these three glands was identical with respect to pH optimum and inhibition by dTTP, but inhibition by dCTP was quite different. dCTP inhibited the activity of normal adrenal gland and Peak II of adrenocortical carcinoma by 55% and 40% at 0.1 mM, respectively, but the activity of adrenocortical hyperplasia and Peak I of adrenocortical carcinoma was hardly affected. Normal adrenal enzyme was more stable against heat inactivation than adrenocortical carcinoma and hyperplasia. The apparent Km with thymidine for Peak I and Peak II of adrenocortical carcinoma, hyperplasia, and normal adrenal gland was 5.0, 11.1, 5.1 and 25.0 x 10(-6)M, respectively.

Adrenal Cortex Neoplasms↗