SEARCH · PubMed Health

Results for “Bundle of His”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 91 records · Page 5Linked to original sources

PubMed1995

Catheter ablation of the left bundle branch for the treatment of sustained bundle branch reentrant ventricular tachycardia.

Sustained Bundle Branch Reentrant VT. Radiofrequency catheter ablation of the left bundle branch (LBB) was attempted in a patient with sustained bundle branch reentry. During sinus rhythm, the QRS had a complete LBB block pattern, and the LBB was activated retrogradely (transseptal). Ablation of the LBB eliminated inducibility of the tachycardia, while the QRS complex and the duration of the HV interval (70 msec) remained unchanged. Successful ablation of the LBB eliminated bundle branch reentry and yet maintained the anterograde conduction properties of the His-Purkinje system, obviating implantation of a permanent pacemaker.

Aged↗

PubMed2003

Successful radiofrequency catheter ablation of "clockwise" and "counterclockwise" bundle branch re-entrant ventricular tachycardia in the absence of myocardial or valvar dysfunction without detecting bundle branch potentials.

A case is reported of a patient with only isolated conduction abnormalities of the His-Purkinje system with no identifiable myocardial or valvar dysfunction, leading to "clockwise" and "counterclockwise" bundle branch re-entrant ventricular tachycardias (BBRVTs). The electrophysiological study showed infra-Hisian conduction system disease and two different inducible wide QRS complex tachycardias. Neither right bundle branch nor left bundle branch potentials were recorded despite extensive catheter manipulation. However, these tachycardias were diagnosed as BBRVTs by using entrainment manoeuvres and comparing the HV intervals during both sinus rhythm and the tachycardias. These tachycardias were eliminated by catheter ablation of the right bundle branch, using the morphology of the local electrograms and anatomical findings.

Aged↗

PubMed1975

A comparison of His bundle electrograms recorded from the aortic root and from a plaque sutured near the His bundle.

For careful analysis of His bundle electrograms in the dog it is useful to have a stable rather than moving recording site. In this study we have compared the characteristics of His bundle electrograms recorded by two methods in each of ten anesthetized dogs. Records obtained with a Hoffman-type plaque electrode sutured in the vicinity of the His bundlewere not significantly different from ones obtained with a recording catheter wedged in the aortic root. In addition to measurements made during the resting state, comparisons also included those during selectively produced acute but transietn complete A-V block, sinus bradycardia, A-V junctional tachycardia, A-V junctional bradycardia, and various degrees of incomplete A-V block. A stable and accurate His bundle electrogram can be obtained from the aortic root and has the experimental advantage of not having to open the right atrium or place sutures near the A-V node of His bundle.

Acetylcholine↗

PubMed1980

Dissolution of cytoplasmic actin bundles and the induction of nuclear actin bundles by dimethyl sulfoxide.

Within 30 minutes of exposure to medium containing 10% dimethyl sulfoxide, PtK2 cells begin to round up and lose their cytoplasmic actin bundles. At the same time, bundles of actin filaments appear in the nuclei of the cells. One to 2 hours after the dimethyl sulfoxide is removed from the medium, the cells revert to their flattened shape, losing the nuclear actin bundles and regaining the cytoplasmic bundles.

Actins↗

PubMed2000

Parallel actin bundles and their multiple actin-bundling proteins.

Parallel actin bundles are present in a diverse array of structures, where they are critical determinants of cellular shape and physiology. In the past 18 months, new findings have solidified the concept that parallel actin bundles are assembled in cells through the sequential action of multiple actin-bundling proteins and have begun to shed light on the roles played by the individual actin-bundling proteins.

Actins↗

PubMed2005

Toward pi-conjugated molecule bundles: synthesis of a series of B,B',B''-trianthryl-N,N',N''-triarylborazines and the bundle effects on their properties.

As a prototype of a pi-conjugated molecule bundled system, a series of B,B',B''-trianthryl- N,N',N''-triarylborazine derivatives bearing various p-substituted phenyl groups (p-R-C(6)H(4): R = hexyl (1), i-Pr (2), CF(3) (3), Br (5)) as aryl groups was designed and synthesized. The crystal structure analysis of these derivatives confirmed that the three anthryl and three phenyl groups are bundled up alternately in a C(3) symmetrical gear-shaped fashion. On the basis of this structure, the trianthrylborazine derivatives form a unique honeycomblike packing structure consisting of intermolecular pi-stacking of the anthryl moieties. Significant bundle effects were observed in the photophysical and electrochemical properties of these compounds. In their fluorescence spectra, the trianthrylborazine derivatives (1-3) show intense emissions around 390 nm, whose quantum yields (1, Phi(F) = 0.62; 2, Phi(F) = 0.59; 3, Phi(F) = 0.63) are about twice high as that of anthracene (Phi(F) = 0.27). The cyclic voltammetry measurements show that the oxidation peak potential can be tuned by varying the substituents on the phenyl moieties. Theoretical calculations (B3LYP/ 6-31G(d)) suggested that secondary through-bond/through-space interactions in the bundled structure play an important role in the tuning of these properties. Facile structural derivatization at the 10-position of the anthryl moieties of trianthrylborazine was conducted to demonstrate the utility of the borazine skeleton as a core framework for new organic electronic materials.

Boron↗

PubMed1991

Sinoventricular transmission in 10 mM K+ by canine atrioventricular nodal inputs. Superior atrionodal bundle and proximal atrioventricular bundle.

BACKGROUND: This study was done to determine the electrical properties of the superior atrionodal bundle (SAB) and the proximal atrioventricular bundle (PAVB). METHODS AND RESULTS: Extracellular potentials associated with electrical activity in the SAB and PAVB were identified in electrograms using adult canine atrial preparations in which the AV node (AVN) and distal AV (His) bundle (DAVB) had been exposed. Intracellular potentials and/or electrograms of the sinoatrial node (SAN), SAB, PAVB, AVN, DAVB, and atrial contractions from a pectinate muscle bundle in the high right atrial wall were recorded. The electrograms contained deflections representing discharge of the specific tissues and atrial potentials from the adjacent or overlying atrial contractile myocardium. In superfusates containing 2.7 mM K+, sequential discharge of the tissues resulted in brief SAN-SAB, PAVB-DAVB, and AVN-DAVB intervals and a major delay after discharge of the SAB. The delay was attributed to activation of the PAVB, as reflected in extracellular PAVB potentials of long duration. Atrial potentials and the onset of the contractile event followed discharge of the SAN and SAB but preceded activation of the PAVB, AVN, and DAVB. After transection of the PAVB-AVN connections, the AVN exhibited automaticity, but the SAB, PAVB, atrial potentials in all of the electrograms, and atrial contractions persisted at the sinus rate. During exposure to 10 mM K+, atrial potentials in all of the electrograms and atrial contractions ceased, indicating electrical quiescence of the contractile myocardium; however, the unique pattern of discharge of the SAB, PAVB, AVN, and DAVB persisted at the SA nodal rate. CONCLUSIONS: Thus, the SAB and PAVB can be classified as specialized conducting tissues and are intrinsic components of the internodal conductile pathway.

Animals↗

PubMed1997

Drowning of a girl with anomaly of the bundle of His and the right bundle branch.

We report an unusual case of a 17-year-old girl who died in an filled bathtub. There were at least two attacks of unconsciousness in her premortem history. In April 1994, electrocardiography had shown an incomplete right bundle branch block. At autopsy, unspecific signs of drowning and hypoplasia of the terminal part of the atrioventricular bundle of His and the right bundle branch within the cardiac conduction system were found. There were no other obvious autopsy findings related to the sudden death of this girl. In addition, toxicologic examination for illegal drugs and alcohol was completely negative. We conclude that this might be a rare case of death because of acute decompensation of a partial hypoplastic cardiac conduction system with loss of consciousness and consequent drowning in the bathtub. This case illustrates the value of an extensive pathologic examination of the cardiac conduction system in unexpected death of young people.

Adolescent↗

PubMed1998

Predictors of in-hospital bundle branch block reversion after presenting with acute myocardial infarction and bundle branch block. GUSTO-I Investigators. Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries.

Patients with acute myocardial infarction and bundle branch block have a higher mortality rate and more in-hospital complications than patients with normal intraventricular conduction. Patients whose conduction defects revert have an improved prognosis (with outcomes similar to patients who never develop bundle branch block); thus, we analyzed potential predictors of bundle branch block reversion.

Aged↗

PubMed1980

Direct Wenckebach periods in the left bundle branch during bradycardia-dependent left bundle branch block in a patient with sick sinus syndrome.

Direct Wenckebach periods in the left bundle branch with periods of 4:3 and 5:4 conduction alternating with 2:1 left bundle branch block (LBBB) were observed in a patient who was admitted because of congestive heart failure. There was no previous documented LBBB and serial electrocardiographic (ECG) mainfestations afterwards were indicative of sick sinus syndrome. This is probably the first report to describe direct Wenckebach periods in the left bundle branch during bradycardia-dependent (phase-4) LBBB in a patient with sick sinus syndrome.

Aged↗

PubMed2000

Proximal atrioventricular bundle, atrioventricular node, and distal atrioventricular bundle are distinct anatomic structures with unique histological characteristics and innervation.

BACKGROUND: Direct 3D analysis (ie, stereotaxic analysis of 3 planes) has shown that the atrioventricular (AV) node (AVN) is continuous with only specialized myocardium of the proximal AV bundle (PAVB) and distal AV bundle (DAVB) or His bundle. The purpose of the present study was to determine whether the PAVB, AVN, and DAVB possess histological features distinct from each other and from the ordinary myocardium. METHODS AND RESULTS: A protocol that preserves the cytoplasmic and interstitial integrity of the tissue and permits serial sections of the AV junction region to be made in 3 orthogonal planes showed that the PAVB, AVN, and DAVB are characterized by myocardium aggregated into fascicles containing approximately 8 myofibers. Myofibers within the fascicles are coiled or spiraled about each other; and spiraling is most compact in the PAVB. Collagen encases individual fascicles and segregates primary fascicles into secondary fascicles. Fascicles, and not myofibers, are in parallel array in the PAVB, interwoven in the AVN, and parallel in the DAVB. Narrow junctions of parallel fascicles separate the AVN from the PAVB and DAVB. Myocytes, which are largest in DAVB, possess clear perinuclear regions; thin finger-like end processes, which are most numerous in the AVN; uniform, delicate cross-striations; and intercalated disks, which are broader in the PAVB and form short stacks in the AVN. Sheaves of nerve terminals are found, including boutons as in skeletal muscle [corrected]. CONCLUSIONS: The PAVB, AVN, and DAVB have distinct histological features. Collagen septation of primary and secondary fascicles presents natural barriers within the tissues and to surrounding myocardium and structures. These findings confirm that the AV junction region contains a specialized conduction system that is anatomically isolated from ordinary myocardium.

Animals↗

PubMed1990

Right bundle branch block. Echocardiographic study with special reference to the site of block within the right bundle.

One hundred and fifty-seven patients with complete right bundle branch block (CRBBB) were studied with echocardiography (UCG). In 87 of them, both ECG and UCG of good quality were obtained and analyzed to differentiate the site of the block within the right bundle. Their mean age was 53.2 +/- 17.6 (SD) years, and they consisted of 62 males (50.2 +/- 16.8 years) and 25 females (60.8 +/- 17.3 years), suggesting that males were more susceptible to CRBBB than females, with a male to female ratio of 2.48 among our study group. In a normal control group, the time interval from the initial deflection of the QRS complex of the ECG to mitral valve closure (QMC) was 52.3 +/- 11.6 msec, to tricuspid valve closure (QTC) 87.7 +/- 11.5 msec, to the point of full opening of the pulmonary valve (QPO) 124.5 +/- 13.7 msec, from mitral to tricuspid valve closure (MCTC) 35.5 +/- 11.2 msec, and from tricuspid valve closure to the maximum opening of the pulmonary valve (TCPO) 38.0 +/- 13.8 msec, and in patients with CRBBB, QMC 58.7 +/- 13.2 msec, QTC 95.4 +/- 24.2 msec, QPO 169.1 +/- 24.6 msec, MCTC 36.7 +/- 18.2 msec, and TCPO 73.7 +/- 23.7 msec. Although prolonged QMC and QTC are characteristic features in CRBBB as a whole, CRBBB was divided into 4 groups in this study depending on the difference in MCTC and TCPO: Proximal block with prolonged MCTC, peripheral block with prolonged TCPO, diffuse block with both MCTC and TCPO prolonged, and non-specific block without prolongation of either of the two. The incidences were 11.5% (10 patients) for proximal block, 64.4% (56 patients) for peripheral block, 16.1% (14 patients) for diffuse block, and 8.0% (7 patients) for non-specific block. Thus, conduction disturbance in the peripheral portion of the right bundle branch was observed in 80.5% of our cases, suggesting that peripheral block is much more common than proximal block in adults.

Adult↗

PubMed2005

Cardiomyocyte apoptosis in cocaine-induced myocarditis with involvement of bundle of His and left bundle branch.

Cocaine abuse can cause degenerative and inflammatory alterations of the myocardium. Cocaine-induced myocarditis has been previously described, but mostly in chronic cocaine addicts. Among several pathogenetic mechanisms of cocaine-related myocardial damage, the myocardial adrenergic stress and cardiomyocytes apoptosis have been recently proposed. We report an unusual case of myocarditis involving the bundle of His and left bundle branch and cardiac myocytes apoptosis in otherwise healthy occasional cocaine abuser.

Adult↗

PubMed1978

De subitaneis mortibus. XXIX. Randomly distributed focal myocardial lesions causing destruction in the His bundle or a narrow-origin left bundle branch.

Most focally destructive lesions of the heart (e.g., myocarditis) have an essentially random distribution. Any mechanical significance of such diseases depends primarily on there being a very large number of foci. However, single even very small lesions can have profound electrophysiological significance if appropriately located within the cardiac conduction system. Two cases of sudden unexpected death are here reported which had destructive lesions involving the His bundle and a narrow-origin left bundle branch. Not much is known of the electrical or mechanical effects of acute left branch block which is due to complete anatomical transection of that structure in the human heart, and some possible consequences (including sudden unexpected death) are considered. Myocarditis or any other focally destructive disease in the heart may be of little functional importance if it is not widespread, unless some of the lesions happen to damage any of several small but crucially important sites in the cardiac conduction system. Studies to determine the presence or absence of this precise type of damage should be done especially in cases of sudden unexpected death.

Adolescent↗

PubMed1994

[The histopathology of the trabecular section of the right branch of the bundle of His in chronic chagasic patients with a right bundle-branch block].

PURPOSE: To evaluate possible morphological changes in chronic chagasic of the right bundle trabecular branch (RB) with right branch block (RBB) and to draw clinicopathological correlations. METHODS: Eight RBB chronic chagasic septo-marginal trabeculae (SMT) (group A), six left branch block (LBB) chagasic SMT (group B) and six SMT from non-chagasics with no heart disease (group C) were analyzed. Every SMT was completely embedded in paraffin, sub-serially sectioned to the end of the paraffin-block and the sections were processed for pathological study. RESULTS: Right bundle branch trabecular segment mononuclear infiltrate and/or fibrosis were found for 87.5 (7/8) of group A, 50% (3/6) of group B and 16.6% (1/6) of group C. Moderate mononuclear infiltrate and fibrosis were noted respectively for 3 and 1 cases, from group A. For the remaining group A cases and for all the group B and C cases the mononuclear infiltrate and fibrosis were slight. CONCLUSION: The frequency and degree of RB lesions might explain some of RBB. On the other hand, the absence of lesions in one case RBB and the slight degree of RB lesions in chagasics with LBB and in one non-chagasic case indicate that sometimes it is not possible to establish electrocardiographic-pathological correlations after TSM histological examination.

Adult↗

PubMed1990

Medial forebrain bundle of the rat: III. Cytoarchitecture of the rostral (telencephalic) part of the medial forebrain bundle bed nucleus.

The boundaries of the medial forebrain bundle (MFB) of the rat have been presented in previous work on the structure of this fiber system (Nieuwenhuys et al.: J. Comp. Neurol. 206:49-81, '82). Neuronal cell bodies within these outlines constitute the bed nucleus of the MFB. Many fiber components of the MFB appeared to be spatially arranged within the bundle and featured an orderly topography (Veening et al.: J. Comp. Neurol. 206:82-108, '82). As the fibers of the MFB are thought to be a major source of afferents to the bed nucleus (Millhouse: In P.J. Morgane and J. Panksepp (eds): Anatomy of the Hypothalamus, Vol. 1. New York: Marcel Dekker, pp. 221-265, '79), the latter has been subjected in this and the companion study (Geeraedts et al.: J. Comp. Neurol. 294:537-568, '90) to a detailed cytoarchitectonic analysis. This analysis is based on continuous series sectioned in the three conventional planes. On the basis of cytoarchitectonic characteristics, including size and shape, staining intensity, packing density, and spatial orientation of the cell bodies, it was found that the bed nucleus of the MFB as described in the literature is by no means a cytoarchitectonic unit per se. Rather, the neuronal cell population located within the telencephalic stream of the MFB can be parcellated into a number of cellular groups, which partly or entirely belong to more-or-less known basal telencephalic structures. These structures are designated here as the MFB-related areas. They correspond largely to the subcommissural substantia innominata (SIC), the sublenticular substantia innominata (SIL), the nucleus of the diagonal band of Broca, the olfactory tubercle, the magnocellular preoptic nucleus (POMA), the lateral preoptic area (LPOA), and the interstitial nucleus of the stria medullaris (ISM). The complex of the MFB-related areas is surrounded by the following cellular entities: the nucleus accumbens (ACB), the caudatus-putamen region (CPU), the globus pallidus (GP), the bed nucleus of the stria terminalis (BST), the anterior amygdaloid area (AAA), the amygdaloid nuclear complex (A), the medial preoptic area (MPOA) and the anterior hypothalamic area (AHA). Both MFB-related areas and their surroundings have been identified and delimited in this study. This resulted in a new cytoarchitectonic atlas of the rat's basal telencephalon. Our atlas does not only show the relative positions of the above mentioned cellular groups, but also those of their subdivisions.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗

PubMed1983

Comparison of total body surface map depolarization patterns of left bundle branch block and normal axis with left bundle branch block and left-axis deviation.

Total body surface maps from 15 subjects with left bundle branch block and normal axis (LBBB-NA) and 10 subjects with left bundle branch block and left axis (LBBB-LA) were analyzed and compared with maps from normal subjects. In 19 of the 25 subjects with LBBB, the timing of early upper sternal positivity was similar to that of normal subjects, indicative of timely but oppositely directed septal activation. The right ventricular breakthrough was normally located in all, but was earlier after the onset of QRS than expected in some. The initial portion of the positivity produced by left ventricular activation was located in the upper anterior chest in both LBBB-NA and LBBB-LA, but its onset was generally delayed compared with that in normal subjects, presumably because of the time taken by the right-to-left septal activation. Also, the total duration of this positivity was longer than in normal subjects and extended considerably beyond 90 msec, indicating prolonged activation of the anterior free wall of the left ventricle. In LBBB-NA, this upper anterior positivity remained anterior throughout depolarization, but in LBBB-LA it moved toward the left shoulder and the left upper back, presumably due to the posterior orientation of the terminal portion of depolarization. This terminal orientation in patients with LBBB-LA was thought to be due to the additional delay in the activation of the anterobasal portion of the left ventricle caused by selective involvement of the left anterior fascicle.

Aged↗

PubMed1975

HIS bundle electrogram in rheumatic mitral valve disease with special reference to Bachmann's bundle block in P mitrale.

HBEs were recorded from either the right or left ventricle or simultaneously from both in 26 patients with chronic rheumatic mitral stenosis alone or in association with other mild valvular lesions during the diagnostic cardiac catheterization. Eleven of the patients had auricular fibrillation. Of the remaining 15 patients with sinus mechanism and P mitrale in the surface electrocardiogram, 12 were noted to have H potential preceded the termination of P wave and gave P2H interval of negative value- so-called "Bachmann's bundle block". Among these, double atrial activities (A and A' waves) could be identified on the HBE recorded from the left ventricular endocardial surface with catheter electrodes positioned at the subarotic region in 7 patients studied. Interatrial conduction time (P1A' interval) measured in these patients was prolonged in all and ranged from 47 to 82 with an average of 66 msec. Prolongation of intraatrial (or internodal) conduction time was noted in only one patient who also had first degree A-V block and prolonged A-H interval. There was no correlation of either P1P2 or P2H interval to the degree of left atrial enlargement. The P1P2 or P2H interval also had no correlation with hemodynamic parameters. In patients with auricular fibrillation, all impulses unable to conduct to the ventricle were blocked proximal to the His bundle and concealed conduction was not observed distal to it.

Adolescent↗