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PubMed1965

SIGNIFICANCE OF PLATELET ANTIBODIES IN NEONATAL THROMBOCYTOPENIC PURPURA AFFECTING A PAIR OF SIBLINGS.

A pair of siblings, both of whom had neonatal thrombocytopenic purpura, are described. During the first pregnancy, the mother was given chlorothiazide and the implications of this therapy are considered. At the end of the second pregnancy a platelet iso-antibody was detected in the maternal serum. The possible reason for not detecting this antibody in the serum of the second child is considered.

Antibodies↗
PubMed1965

NEWER DRUGS IN THE TREATMENT OF HYPERTENSION.

The treatment of essential hypertension still consists of the judicious combination of two or more agents. The chemical nature, pharmacology, side effects and relative merits of two groups of drugs are reviewed: (1) agents interfering with the synthesis, storage and release of endogenous catecholamines and (2) oral diuretic agents. Rauwolfia compounds, bretylium tosylate, guanethidine, alpha-methyldopa and pargyline hydrochloride comprise the first group; thiazide derivatives, phthalimidine compounds and spironolactones constitute the second. Guanethidine is the most potent and most extensively used agent in the second group. While not yet fully assessed, alpha-methyldopa and pargyline hydrochloride are useful in selected cases. The intrinsic hypotensive properties of oral diuretics, their low incidence of side effects and their ability to potentiate the more potent agents make them useful adjuncts in the long-term treatment of hypertension. Attention is drawn to the potential diabetogenic and hyperuricemic effects of the thiazides and phthalimidine compounds.

Antihypertensive Agents↗
PubMed1964

SULFONAMYL DIURETICS--MECHANISM OF ACTION AND THERAPEUTIC USE.

The mechanism whereby sulfonamyl diuretics are effective is through the blockage of the renal tubular reabsorption of chloride. The excretion of sodium, potassium and water is a passive one to maintain ionic equilibrium. Chlorothiazide has been shown to be almost ineffective as a diuretic agent per se. Although it does block a moiety of the renal tubular reabsorption of bicarbonate, the effect is merely a transient one.

Acetazolamide↗