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[Percutaneous radiotherapy--indications for and differentiation from surgical treatment of metastases].

One third up to half of the patients treated by the radiation oncologist are referred for palliative radiation therapy because of distant metastases, mostly for painful bone or symptomatic brain metastases. As malignant cells are often disseminating long before diagnosis and therapy of the primary tumor, solitary metastases occur very seldom. A single and good resectable brain metastasis is a well-known indication for surgical intervention, especially at infratentorial location. In spherical metastases below a size of 3 cm stereotaxic radio-surgery can be alternatively considered, especially at paramedian location. Bone metastases need more often a surgical therapy, e.g. an impending or already happened fracture of long hollow bones, or radio-resistent tumors of hands and feet. Surgical therapy of metastatic vertebrae are often demanding enormous efforts and skills. Indications for surgery are osteolytical metastases with potential static problems, highly advanced destruction and most of all symptoms of spinal cord compression. The radiation oncologist is well advised to make sure of the surgeon's partnership in regard to the treatment of metastases.

Bone Neoplasms↗

Investigative studies in the diagnosis and treatment of melanoma.

Patients with melanoma have prognostic indicators that can be accurately assessed using standard histopathologic techniques. First-order lymph node disease plays a significant role in determining both the prognosis of the patient and the therapeutic benefit in selected patients. The lymph nodes at risk can be determined by the technique of lymphoscintigraphy, and specificity might be possible using isotopically labeled monoclonal antibodies. Techniques utilizing immunohistology and immunocytology have been developed and applied to the clinical setting. Early diagnosis of recurrent disease is now possible using radioimmunoassays. Specific immunotherapy trials are underway and early results are encouraging.

Antibodies, Monoclonal↗

Retinal vascular changes associated with transpupillary thermotherapy for choroidal melanomas.

PURPOSE: To define retinal vascular changes after transpupillary thermotherapy (TTT) for choroidal melanomas and assess their clinical impact. METHODS: Stereoscopic fluorescein angiogram pairs of 29 patients pre- and post-treatment with TTT were examined for patterns of vascular damage, and the patients were studied for ensuing complications. RESULTS: Widespread retinal capillary loss was confined within the treatment margins except in cases of coexisting large retinal artery or vein occlusions. Artery occlusions occurred in 83%, involving a large artery in 23%. Venous occlusions occurred in 69%, involving large veins in 10%. Subretinal choroidal neovascularization occurred in four cases, in one causing hemorrhage that broke through into the vitreous. No retinal neovascularization occurred. Choroidal vasculature was relatively preserved at the periphery of the treated area. Foveal vascular damage caused visual loss in six cases. Vascular changes beyond the treatment margins did not affect the fovea in any case. Retinal fibrosis affected two cases. Diabetic patients fared no worse than healthy counterparts. CONCLUSIONS: Transpupillary thermotherapy produces characteristic retinal vascular changes that may reduce vision when affecting the fovea. Vascular changes are confined within the treatment margins except in cases of associated large vessel occlusion. There is a small risk of neovascularization, both retinal and choroidal.

Adult↗

Variable outcome of photodynamic therapy for choroidal neovascularization associated with choroidal nevus.

PURPOSE: To report five cases of classic choroidal neovascularization (CNV) associated with choroidal nevus treated with photodynamic therapy (PDT) with verteporfin. METHODS: The patients underwent an ophthalmologic evaluation, including fluorescein angiography and indocyanine green angiography. Clinical and angiographic data were retrospectively analyzed to evaluate visual acuity outcomes and both clinical evolution and angiographic evolution. RESULTS: Two patients presented with subfoveal CNV, and three had juxtafoveal CNV. The mean follow-up was 25.8 months. Visual outcomes were extremely variable. Indeed, best-corrected visual acuity decreased in three eyes, stabilized in one case, and improved in the other case. The number of PDT sessions necessary to obtain CNV stabilization with cessation of fluorescein leakage varied from one to six. CONCLUSION: Bearing in mind that both the natural history and the post-PDT outcome may be extremely variable, further studies are needed to assess the real benefit of PDT for classic CNV secondary to choroidal nevus.

Aged↗

Choroidal neovascular membrane in a series of cases of malignant melanoma of the choroid.

PURPOSE: To examine a series of choroidal melanoma specimens to determine the frequency of overlying choroidal neovascularization (CNV) and to ascertain whether CNV over choroidal malignant melanoma is associated with any particular histological tumour characteristics. METHODS: We carried out a retrospective histological analysis of globes containing choroidal melanomas for evidence of choroidal neovascular membranes. RESULTS: Microscopic evidence of choroidal neovascular membranes was evident in 6% of cases. Choroidal neovascularization was not associated with any particular histological tumour characteristic. CONCLUSION: Choroidal neovascularization over choroidal malignant melanoma is not an infrequent occurrence and possibly appears as frequently as CNV over choroidal naevi. The presence of a choroidal neovascular membrane over a pigmented fundal lesion should not be taken as reassurance that the lesion is benign.

Aged↗