The nature of cognitive dysfunction in school-children with epilepsy.
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Behavioral similarities between antisocial behavior disorders and frontal-lobe cerebral impairment have led to suggestions that conduct disorders are attributable to disinhibition deficit associated with frontal-lobe cerebral functions. This study compared the performance of 21 conduct disorder adolescents on measures of cognitive processes associated with frontal-lobe functions with that of a matched comparison sample. Conduct disorder adolescents performed more poorly on measures sensitive to frontal-lobe dysfunction (conceptual perseveration, poorly sustained attention, impaired sequencing on memory and motor tasks), but not on non-frontal-lobe specific cognitive measures. Although the findings support a neurobehavioral explanation of antisocial behavior as a product of cerebral disinhibition, caution is urged in overinterpreting causal relationships through neurobehavioral data.
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From a prospective study of tardive dyskinesia (TD), psychiatric patients with neuroleptically-induced "persistent" TD were contrasted with controls on a neuropsychological measure of abstracting ability. A significant association is demonstrated between impaired cognitive performance and TD, even when the neuropsychological measure was obtained in advance of TD onset.
We used the Wechsler Adult Intelligence Scale (WAIS) to study a sample of patients with affective disorder (N = 52), schizophrenia (N = 17) and organic brain disease (N = 8). Schizophrenic patients had lower verbal, performance and full-scale IQs than patients with affective disorder, but were no different from those with organic brain disease. An individual WAIS subscale analysis showed that, compared with affectives, schizophrenics had relatively poorer performance on language than non-language tasks. These differences were independent of age, sex, handedness, educational level or drug administration and are consistent with a variety of studies demonstrating significant cerebral dysfunction in carefully diagnosed schizophrenic patients.
A group of 44 bulimic women (DSM-III) as well as 38 women with no indication of an eating disorder, comparable with respect to age, weight and height, were studied by means of the Beck Depression Inventory (BDI), the Dysfunctional Attitude Scale (DAS), the Attributional Style Questionnaire (ASQ), and an Eating Disorder Questionnaire (EDQ). Bulimics showed significantly higher BDI, DAS and ASQ (bad events) scores, respectively. In both groups BDI scores were significantly correlated with DAS and ASQ (bad events) results. BDI was highly predictive of severity of bulimia while no significant prediction was obtained from either DAS or ASQ (bad events) scores. The findings provide first evidence that dysfunctional attitudes and depressive attributional style are predominant in bulimic women but at the same time are not necessarily predictive of the severity of the disorder.
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