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Concordance between women's physiological and subjective sexual arousal is associated with consistency of orgasm during intercourse but not other sexual behavior.

Many studies have found a discordance between women's genital (vaginal pulse amplitude) and subjective sexual arousal responses to erotica. We hypothesized that the association between the physiological and subjective domains would be greater for women with greater orgasmic consistency during penile-vaginal intercourse but not for orgasm consistency during other sexual behaviors. We confirmed this specific hypothesis in a sample (N = 38) of postmenopausal women. In addition, we discovered that the correlation between the domains was unrelated to social desirability responding, that orgasm consistency was not less for intercourse than for other sexual activity, and that orgasm consistency during intercourse was uncorrelated with orgasm consistency during masturbation. We discuss the results in terms of the unique nature of penile-vaginal intercourse, our study's implications for sex therapy, and orgasm consistency during intercourse being an operational measure of functional vaginal sensitivity and sexual pleasure integration and organization.

Arousal↗

PubMed2002

Consistent subtype-specific anti-HIV type 1 T lymphocyte responses in Indian subjects recently infected with HIV type 1.

Anti-HIV-1-specific T cell responses in early HIV-1 infection have been found to be important in deciding the course of disease progression. But there are few data concerning nonsubtype B HIV infection. HIV-1 subtype C is the most prevalent subtype in India. HIV-1 Gag-specific T cell responses in 12 Indian subjects with recent HIV-1 infection were characterized by an ELISpot assay at two consecutive visits and their correlation with plasma viral load and CD4(+) T lymphocyte counts was studied. Ten of the 12 subjects demonstrated T cell responses to either one or both Gag B and C peptides, on at least one visit. Five of 10 responders showed a consistent response (response at both visits): 4 exhibited a Gag C-specific consistent response and 1 showed a consistent response to Gag B. The remaining five patients, showing response at only one of the two visits, were considered inconsistent responders. None of the individuals showed a consistent response to both B and C Gag peptides. Marginally significant correlation was observed between consistency of the response and lower plasma viral load (p = 0.062). The subtype-specific Gag C response was also found to be correlated with lower viral load as compared with the response to Gag B (r = -0.336, p = 0.054 for subtype C and r = -0.234, p = 0.13 for subtype B). The data suggest that the patients exhibiting consistent subtype-specific responses to HIV-1 Gag might have better control of viral replication in early HIV infection.

CD4-Positive T-Lymphocytes↗

PubMed2002

Assessing the significance of consistently mis-regulated genes in cancer associated gene expression matrices.

MOTIVATION: The simplest level of statistical analysis of cancer associated gene expression matrices is aimed at finding consistently up- or down-regulated genes within a given set of tumor samples. Considering the high level of gene expression diversity detected in cancer, one needs to assess the probability that the consistent mis-regulation of a given gene is due to chance. Furthermore, it is important to determine the required sample number that will ensure the meaningful statistical analysis of massively parallel gene expression measurements. RESULTS: The probability of consistent mis-regulation is calculated in this paper for binarized gene expression data, using combinatorial considerations. For practical purposes, we also provide a set of accurate approximate formulas for determining the same probability in a computationally less intensive way. When the pool of mis-regulatable genes is restricted, the probability of consistent mis-regulation can be overestimated. We show, however, that this effect has little practical consequences for cancer associated gene expression measurements published in the literature. Finally, in order to aid experimental design, we have provided estimates on the required sample number that will ensure that the detected consistent mis-regulation is not due to chance. Our results suggest that less than 20 sufficiently diverse tumor samples may be enough to identify consistently mis-regulated genes in a statistically significant manner. AVAILABILITY: An implementation using Mathematica (tm) of the main equation of the paper, (4), is available at www.me.chalmers.se/~mwahde/bioinfo.html.

Algorithms↗

PubMed2005

A procedure for assessing GO annotation consistency.

MOTIVATION: The Gene Ontology (GO) is widely used to annotate molecular attributes of genes and gene products. Multiple groups undertaking functional annotations of genomes contribute their annotation sets to the GO database resource and these data are subsequently used in comparative functional analysis research. Although GO curators adhere to the same protocols and standards while assigning GO annotations, the specific procedure followed by each annotation group can vary. Since differences in application of annotation standards would dilute the effectiveness of comparative analysis, methods for assessing annotation consistency are essential. The development of methodologies that are broadly applicable for the assessment of GO annotation consistency is an important issue for the comparative genomics community. RESULTS: We have developed a methodology for assessing the consistency of GO annotations provided by different annotation groups. The method is completely general and can be applied to compare any two sets of GO annotations. This is the first attempt to assess cross-species GO annotation consistency. Our method compares annotation sets utilizing the hierarchical structure of the GO to compare GO annotations between orthologous gene pairs. The method produces a report on the annotation consistency and inconsistency for each orthologous pair. We present results obtained by comparing GO annotations for mouse and human gene sets. AVAILABILITY: The complete current MGI_GOA GO annotation consistency report is available online at http://www.spatial.maine.edu/~mdolan/

Animals↗

PubMed2006

An iterative refinement algorithm for consistency based multiple structural alignment methods.

MOTIVATION: Multiple STructural Alignment (MSTA) provides valuable information for solving problems such as fold recognition. The consistency-based approach tries to find conflict-free subsets of alignments from a pre-computed all-to-all Pairwise Alignment Library (PAL). If large proportions of conflicts exist in the library, consistency can be hard to get. On the other hand, multiple structural superposition has been used in many MSTA methods to refine alignments. However, multiple structural superposition is dependent on alignments, and a superposition generated based on erroneous alignments is not guaranteed to be the optimal superposition. Correcting errors after making errors is not as good as avoiding errors from the beginning. Hence it is important to refine the pairwise library to reduce the number of conflicts before any consistency-based assembly. RESULTS: We present an algorithm, Iterative Refinement of Induced Structural alignment (IRIS), to refine the PAL. A new measurement for the consistency of a library is also proposed. Experiments show that our algorithm can greatly improve T-COFFEE performance for less consistent pairwise alignment libraries. The final multiple alignment outperforms most state-of-the-art MSTA algorithms at assembling 15 transglycosidases. Results on three other benchmarks showed that the algorithm consistently improves multiple alignment performance. AVAILABILITY: The C++ code of the algorithm is available upon request.

Algorithms↗

PubMed2000

Consistency of swimming performance within and between competitions.

PURPOSE: The consistency of performance between events impacts how athletes should specialize in events, how competitions should be structured, and how changes in performance affect an athlete's placing in an event. We have therefore determined the consistency of swimming performance in events within and between two national-level competitions. METHODS: We used mixed linear modeling to analyze official performance times of 149 male and 162 female swimmers at a junior national championship, and of 117 male and 104 female swimmers at an open national championship 20 d later. The events differed in stroke (backstroke, breaststroke, butterfly, freestyle, and individual medley) or distance (50-1500 m). RESULTS: Swimmers were most consistent in their performance for the same event between the two competitions (typical variation between competitions, 1.4%; 95% likely range of true value, 1.3-1.5%). They were less consistent between distances of a given stroke within each competition (1.7%; 1.5-1.9%) and least consistent between strokes for a given distance (2.7%; 2.3-3.1%). Variation in performance between the longest continuous freestyle distances (400, 800, and 1500 m) in the open competition was half that between widely spaced freestyle distances (50, 200, and 800 m). Faster swimmers were more consistent (1.1%; 0.9-1.4%) for the same event between competitions than slower swimmers (1.5%; 1.3-1.9%). CONCLUSIONS: (a) Swimmers are stroke specialists rather than distance specialists; with the present set of events in competitions, they should concentrate training and competing on a particular stroke rather than a particular distance. (b) More swimmers would have a chance of winning a medal if events of a given stroke differed more widely in distance. (c) Factors that affect performance time by as little as 0.5% will affect the placing of a top junior swimmer.

Adolescent↗

PubMed2000

Consistency conditions and linear reconstruction methods in diffraction tomography.

Because an image can be reconstructed from knowledge of its Radon transform (RT), the task of reconstructing an image is tantamount to that of estimating its RT. Based upon the Fourier diffraction projection (FDP) theorem, from the statistical perspective of unbiased reduction of image variance, we previously proposed an infinite family of estimation methods for obtaining the RT from the scattered data in diffraction tomography (DT). In this work, using the FDP theorem, we define the diffraction Radon transform (DRT), which can be treated as the data function in DT. Subsequently, using strategies similar to those that analyze the consistency conditions on the exponential Radon transform in two-dimensional (2-D) single-photon emission computed tomography with uniform attenuation, we studied the consistency condition on the DRT and we show that there is a hierarchy of estimation methods that actually project the noisy data function onto its consistency space in different ways. In terms of a weighted inner product of the consistency and inconsistency parts of a noisy data function, we further demonstrate that a subset of the family of estimation methods can be interpreted as orthogonal projections onto the consistency space of the DRT. In particular, the statistically suboptimal estimation method in the family corresponds to an orthogonal projection associated with an ordinary inner product of the consistency and inconsistency parts of a noisy data function.

Algorithms↗

PubMed2004

Scene consistency in object and background perception.

Does knowledge about which objects and settings tend to co-occur affect how people interpret an image? The effects of consistency on perception were investigated using manipulated photographs containing a foreground object that was either semantically consistent or inconsistent with its setting. In four experiments, participants reported the foreground object, the setting, or both after seeing each picture for 80 ms followed by a mask. In Experiment 1, objects were identified more accurately in a consistent than an inconsistent setting. In Experiment 2, backgrounds were identified more accurately when they contained a consistent rather than an inconsistent foreground object. In Experiment 3, objects were presented without backgrounds and backgrounds without objects; comparison with the other experiments indicated that objects were identified better in isolation than when presented with a background, but there was no difference in accuracy for backgrounds whether they appeared with a foreground object or not. Finally, in Experiment 4, consistency effects remained when both objects and backgrounds were reported. Semantic consistency information is available when a scene is glimpsed briefly and affects both object and background perception. Objects and their settings are processed interactively and not in isolation.

Humans↗

PubMed1980

Improving recall in retarded persons: consistency of ordering and simultaneity of presentation.

Consistency of ordering (blocked, random) and presentation method (simultaneous, sequential) were investigated in a multi-trial, free recall task with sixty educable mentally retarded adolescents. In a blocked-simultaneous condition, five groups of three stimuli were presented consistently in the same groups from trial-to-trial as well as simultaneously with three words on a slide. The blocked-sequential condition maintained the consistent ordering, but only one item at a time was presented. In a random-simultaneous condition, stimuli were presented not in consistent, but in changing, groups of three. A random-sequential treatment used both inconsistent ordering and sequential presentation. Results showed that consistent ordering led to facilitation of organisation and recall both from recency and other list serial positions. Subjective organisation and clustering were also enhanced by simultaneous presentation. It was concluded that if one instructional strategy had to be chosen in an applied context, it should be consistent ordering accompanied by simultaneous presentation.

Adolescent↗

PubMed1989

Consistency in synesthetic experience to vowels and consonants: five case studies.

The present study attempted to specify the actual degree of consistency in synesthetic experience in two synesthetes and three non-synesthetes. By comparing colour chip selections, and size and density ratings, to the same set of stimulus letters on separate occasions, it was found that the synesthetic subjects showed a high consistency in responding over a short (24 hours) as well as a long (one year) time span. In comparison, the non-synesthetic subjects demonstrated less consistent responding when retested after 24 hours. However, the differences between the two groups were smaller than expected. Consistency to vowels and consonants was compared, and it was found that consistency to consonants was comparable to, or even higher than, vowel consistency in all subjects.

Adult↗

PubMed2000

Consistency of multicenter measurements of heart rate variability in survivors of acute myocardial infarction.

Heart rate variability (HRV) analysis from 24-hour ambulatory ECG has been widely used in risk stratification of patients after myocardial infarction (MI). The accuracy of HRV assessment is known to potentially vary when different commercial systems are used. However, the consistency of HRV measurements has never been fully investigated. Twenty-six post-MI patients (mean age 59 +/- 8 years, 22 men) were studied, of whom 13 succumbed to sudden cardiac death (SCD) within 1 year and 13 remained alive for at least 3 years (MI survivors). Each patient had a 24-hour Holter ECG recorded before hospital discharge. HRV analysis was performed four times from the same recordings using three different Holter tape analysis systems (Marquette, Reynolds, and CardioData) by four independent operators (CardioData system was used twice, once in the United Kingdom and once in the United States). Mean normal-to-normal RR intervals (mNN) and 3 HRV parameters (SDNN, RMSSD, and HRV triangular index [HRVi]) were derived from each recording. The consistency of mNN and HRV measurements was evaluated by coefficient of variance (CV) and by the Bland-Altman method. The results demonstrated that (1) all indices measured by different systems were statistically similar (P = NS) except the measurement of RMSSD (P = 0.01), (2) the measurements of mNN were highly reproducible with a maximum mean difference of 1.8 +/- 13.8 ms and maximum limits of agreement from -14.6 to +15.6 ms. The maximum mean differences were--1.8 +/- 1.4 unit and 4.4 +/- 9.6 ms for HRVi and SDNN, respectively, and RMSSD was less reproducible with a maximum mean difference of--11.1 +/- 11.5 ms, and limits of agreement from -16.2 to +9.6 ms; and (3) the consistency of mNN (CV 0.9% +/- 0.9%) was significantly higher than that of HRVi, SDNN, and RMSSD (P < 0.0001). The consistency of HRVi was similar to that of SDNN (4.8% +/- 2.1% vs 5.7% +/- 4.8%, P = 0.4), and the consistency of RMSSD (26.6% +/- 13.3%) was significantly lower than that of the other measurements (P < 0.00001). In conclusion, the measurements of mNN by different analytical systems are the most consistent among the parameters studied. The global 24-hour measurements of HRV (SDNN and HRVi) are highly reproducible, whereas the measurement of short-term HRV components (RMSSD) is significantly less reproducible.

Adult↗

PubMed1996

Testing the consistency of measurements of the distance between the cemento-enamel junction and the alveolar bone crest on bitewing radiographs.

UNLABELLED: The purpose of the research described in this paper is to test the consistency of measurements of the distance between the cemento-enamel junction and the alveolar bone crest (CJ-AC) on bitewing radiographs. The present paper shows how the consistency tests were organized and which statistical analyses were used. Since the actual characteristic (CJ-AC) could not alter, the variations of the results had to be due to one more of the 5 m-factors (man, material, machine, method and manipulation). To test the consistency of the measurements of CJ-AC, a pretest and an en route test were performed. Both the bitewing radiographs for the pretest and the en route test were sampled at random from the principal material. The principal material consisted of 856 sets of bitewing radiographs from persons born 1930-1949. The pretest of 40 sets of bitewing radiographs were read twice by 2 independent readers. The en route test consisted of 85 sets of bitewing radiographs which were read twice by 1 reader. Neither the results of the pretest nor the results of the en route test showed statistical or clinical differences of significance. IN CONCLUSION: the consistency of this method of measuring is satisfactory for the 2 readers.

Aged↗

PubMed1996

When reprimand consistency may and may not matter.

The present study examined the importance of discipline consistency by varying not only the probability of punishment but also the nature of the discipline agent's response to nonpunished transgressions. Eighteen first through third graders attending a remedial summer school were assigned to one of four feedback conditions in a 2 (Low vs. High Reprimand Consistency) x 2 (Ignore vs. Attend) design. An analysis of the simple effects of reprimand consistency indicated that consistency was important only when the teacher's alternative response was attending. Thus the nature of the adult's response to nonpunished transgressions is important for understanding how discipline consistency affects children's behavior. The importance of conceptualizing discipline consistency as a multivariate construct and of understanding the variables and parameters that may interact with the probability of punishment are discussed.

Attention↗

PubMed1999

Zolmitriptan provides consistent migraine relief when used in the long-term.

Migraine is a chronic disease that significantly reduces quality of life between, as well as during, attacks. Treatments that provide consistent relief may reduce the burden of the disease. In the open-label phase of a two-part study, patients could choose to treat initial, persistent or recurrent migraine headache of any intensity with 2.5 mg or 5 mg zolmitriptan. This novel study design allowed patients to manage and maximise their migraine relief. Headache response rates and pain-free response rates were assessed within two hours of dosing with zolmitriptan, and response rates were compared across migraines with and without a history of aura, and associated or not with menses. Consistency of response was also assessed in those patients treating at least 20 attacks. Of 49,784 attacks treated, 66% (32,737 attacks) were treated with a single dose of zolmitriptan. Two-hour headache response rates to an initial dose of 2.5 mg or 5 mg zolmitriptan were 85% (median 95%) and 79% (median 88%), respectively, across all attacks. Corresponding pain-free response rates were 69% and 59%. Responses were independent of gender and age and were similar in patients with and without aura and in attacks associated or not associated with menses. Consistent response rates were achieved within individual patients; during months 1 to 3, 64% of patients reported a headache response in > 75% of their migraine attacks. In patients treating at least 20 attacks, 2.5 mg and 5 mg zolmitriptan produced consistently high headache response rates (range 84-91% and 76-84%, respectively) and pain-free response rates (range 70-76% and 58-65%, respectively) across attacks. In the minority of attacks requiring a second dose of zolmitriptan for persistent or recurrent headache, response rates to a second dose were also consistent across attacks. In conclusion, zolmitriptan 2.5 mg and 5 mg show consistent effectiveness in the treatment of multiple migraine attacks in individual patients and are unaffected by gender, age and the presence of aura or the relationship to menses.

Adolescent↗

PubMed2005

Ideal suture diameter is critical for consistent middle cerebral artery occlusion in mice.

OBJECTIVE: The use of transgenic and knockout mice has led to a need for a consistent model of mouse transient focal cerebral ischemia. In a great majority of the published mouse middle cerebral artery (MCA) occlusion studies, the methods indicated the type of intraluminal suture used without indicating the actual suture diameter after modification. We attempted to determine the ideal suture diameter to produce consistent occlusion in the MCA of adult male C57BL/6 mice. METHODS: Suture tips were coated to a depth 4 mm with glue, and 6-0 sutures of eight different, precisely measured diameters were produced. The coated 6-0 sutures in different diameters were introduced 10 mm into the internal carotid artery via the external carotid artery of the mice to produce MCA occlusion (n = 40; five animals for each diameter), and the mice (22-24 g) were transaortically perfused with saline. The base of the brain was exposed, and photographs of the vessels were obtained before and after transaortic injection of Evans blue dye to determine the consistency of MCA occlusion for each suture diameter. Cerebral blood flow was measured 10 minutes before occlusion and 20 minutes after reperfusion, and 2,3,5-triphenyltetrazolium chloride staining was performed to demonstrate the ischemic damage in additional animals with 110-microm (n = 5) and 180-microm (n = 8) diameter sutures. RESULTS: Sutures measuring 170 microm and 180 microm in diameter consistently occluded the MCA of C57BL/6 mice. In addition, 2,3,5-triphenyltetrazolium chloride staining demonstrated consistent infarction with 180-microm diameter sutures. The infarct volume was 36.3 +/- 4.2 mm3. CONCLUSION: Small changes in the diameter of the occlusion suture tip affect consistency in the mouse MCA occlusion model.

Animals↗

PubMed1984

[How consistent are personal data? Analysis of statements on the planning status of pregnancies].

The consistency of responses on the planning status of births is analyzed using data from a longitudinal fertility survey being carried out by the Demographic Institute of the Austrian Academy of Sciences. Interviews were conducted in 1978 and 1981 with a sample of two marriage cohorts; in both sets of interviews a question was asked concerning the reaction to a pregnancy at the time the woman heard about it. "After linking the data for the pregnancies leading to first or second births, a consistency index suggested by Ryder and Westoff...was applied which distinguishes between random and nonrandom consistency. For the first births a proportion of 54.4% identical answers yields a consistency index of 38.0...; for second births a proportion of 53.7% identical answers results in [a] consistency index of 30.1...." Differential consistency is also analyzed according to selected socioeconomic and demographic variables as well as a variable measuring the correspondence of husband's and wife's desired family sizes in the opinion of the husband. (summary in ENG)

Attitude↗

PubMed2005

[Consistency analysis in the use of abdominal ultrasonography for diagnosing schistosomiasis japonica-related morbidity].

OBJECTIVE: To explore the consistency among different indices of abdominal ultrasonography for the diagnosis of schistosomiasis japonica related morbidity and the best combination of the indices. METHODS: Six indices of abdominal ultrasonography were selected to investigate schistosomiasis related morbidity in residents in a village of Hunan Province, and the Kappa coefficients of diagnostic consistency among different indices and Cronbach's alpha coefficients of different combinations of indices were computed. RESULTS: The Kappa coefficients of 'liver parenchyma > or = grade II' with 'right midclavicular subcostal' and with 'portal vein diameter' were 0.4131 and 0.4655 respectively, higher than normal level. The degree of their consistency was fair, and others showed poor or almost no consistency. Among the combinations made up of different indices, the Cronbach's alpha coefficient of the combination made up of 'liver parenchyma > or = grade II', 'right midclavicular subcostal' and 'portal vein diameter' was 0.6566 which was the highest, showing the strongest internal consistency. CONCLUSION: The six indices can not be replaced with each other in assessing schistosomiasis related morbidity. Before abdominal ultrasonography is used extensively to assess the morbidity, it is necessary to study the diagnostic consistency of these indices and the best combination of the indices.

Abdomen↗

PubMed2006

Accuracy and consistency of radiographic interpretation among clinical instructors using two viewing systems.

Accurate and consistent radiographic interpretation among clinical instructors is needed for assessment of teaching, student performance, and patient care. The purpose of this investigation was to determine if the method of radiographic viewing affects accuracy and consistency of instructors' determinations of bone loss. Forty-one clinicians who provide instruction in a dental school clinical teaching program (including periodontists, general dentists, periodontal graduate students, and dental hygienists) quantified bone loss for up to twenty-five teeth into four descriptive categories using a view box for plain film viewing or a projection system for digitized image viewing. Ratings were compared to the correct category as determined by direct measurement using the Schei ruler. Agreement with the correct choice for the view box and projection system was 70.2 percent and 64.5 percent, respectively. The mean difference was better for a projection system due to small rater error by graduate students. Projection system ratings were slightly less consistent than view box ratings. Dental hygiene faculty ratings were the most consistent but least accurate. Although the projection system resulted in slightly reduced accuracy and consistency among instructors, training sessions utilizing a single method for projecting digitized radiographic images have their advantages and may positively influence dental education and patient care by enhancing accuracy and consistency of radiographic interpretation among instructors.

Alveolar Bone Loss↗