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PubMed2003

Genetics of phytate phosphorus bioavailability: heritability and genetic correlations with growth and feed utilization traits in a randombred chicken population.

The current study was undertaken to estimate variance components for phytate P bioavailability (PBA) and the genetic correlations among PBA with growth and feed utilization (or intake) traits in an unselected random mating chicken population. Pedigreed data from 901 Athens-Canadian randombred chickens hatched from 26 sires, 71 dams, and 105 grandparents were used for estimation of genetic parameters. Birds were individually housed in metabolic cages at 4 wk of age and fed a 0.35% P diet. After 3 d of acclimatization, excreta produced for 3 consecutive d were collected and feed consumed (FC) was measured. Individual 4-wk BW and BW gain (BWG) during the 3-d excreta collection period were also measured. Feed conversion ratios (FCR) were calculated. Phytate P bioavailability was estimated from the disappearance of phytate during the passage of feed through the gastrointestinal tract. The restricted maximum likelihood method with the average information matrix algorithm was used for the estimation of variance components. The heritability estimate for PBA was about 0.10. Genetic correlations between PBA and BW, BWG, and FC were moderate and negative, indicating that improving PBA utilization would moderately affect growth. The genetic correlation between PBA and FCR was negligible and suggested that selection for PBA will not adversely affect FCR. The economic implications of genetically modifying poultry to improving phytate P utilization and the subsequent elimination or reduction of the amount of phytase used in poultry diets are yet to be determined.

Animal Nutritional Physiological Phenomena↗

PubMed1987

Fecundity and size in the housefly: investigations of some environmental sources and genetic correlates of variation.

Environmental sources and genetic correlates of variation in fecundity and size were studied in field and laboratory housefly populations in central Iowa, U.S.A. Electrophoresis of enzymatic proteins was used to monitor genotypes and heterozygosity. In the field, mean fecundity declined as adult densities increased. Fecundity varied greatly within breeding seasons. Fly body size varied spatially and temporally during summer and winter. Fecundity and size were positively correlated. Size was independent of genotypes at the six loci studied. No relationship was observed between heterozygosity and the magnitude or variability of body size.

Analysis of Variance↗

PubMed2003

Genetic correlations between lean growth and litter traits in U.S. Yorkshire, Duroc, Hampshire, and Landrace pigs.

The objective of this study was to estimate breed-specific genetic correlations between lean growth and litter traits for four U.S. swine breeds. Records for lean growth and litter traits on Yorkshire, Duroc, Hampshire, and Landrace pigs collected between 1990 and April 2000 in herds on the National Swine Registry Swine Testing and Genetic Evaluation System were analyzed. A bivariate animal model and restricted maximum likelihood procedures were used to estimate genetic and environmental correlations between lean growth rate, days to 113.5 kg, backfat, and loin muscle area with litter traits of number born alive, litter weight at 21 d, and number weaned. Most genetic correlation estimates between lean growth and litter traits were small in magnitude and consistent across breeds. Backfat had the largest within-breed genetic correlations with number born alive (0.18 to 0.20) and litter weight at 21 d (-0.27 to -0.30). Estimates of genetic correlations between lean growth traits and number weaned were very small. Estimates of the environmental correlations between lean growth and litter traits also were very small for all traits and for all four breeds. Results indicate that selection for lean growth traits could have a long-term effect on litter traits. Including lean growth traits in a maternal-line evaluation using a multiple-trait model could increase the accuracy of the genetic evaluation for litter traits.

Adipose Tissue↗

PubMed1994

The evolution of dimorphic traits: predicting the genetic correlation between environments.

Many traits vary in a dichotomous manner, although the underlying genetic determination is polygenic. The genetic basis of such dimorphic traits can be analyzed using the threshold model, in which it is assumed that there is a continuously distributed underlying character and the phenotype is determined by whether the character is above or below a threshold. Threshold traits frequently vary with environmental variables such as photoperiod, temperature and density. This effect can be accounted for using a threshold model in which (1) there is a critical value of the environmental variable at which a genotype switches to the alternate morph, and (2) switch (threshold) points are normally distributed in the population. I term this the environmental threshold (ET) model. I show that the ET model predicts that across environments differing in only one factor the genetic correlation will be 1. This prediction is supported by data from three wing dimorphic insects. Evidence is presented that the genetic correlation between environments differing in two components (temperature and photoperiod) is less than 1.

Animals↗

PubMed1997

Genetic correlations between longevity and conformation traits in an upgrading dairy cattle population.

Genetic correlations between longevity and conformation traits were estimated using data on Dutch Black and White cows born in 1978 (11,558 records), 1982 (39,252 records), and 1989 plus 1990 (58,864 records). Longevity traits considered were number of lactations, herd life, and stayabilities until 36 and 48 mo of age and their functional equivalents (i.e., the longevity traits corrected for production). For the 1989 plus 1990 data file, only stayabilities until 36 and 48 mo of age were considered. Conformation traits were rear legs set, front teat placement, udder depth, suspensory ligament, and subjective scores for udder, feet and legs, and type. Also investigated was a possible nonlinear relationship between conformation and longevity traits. Genetic correlations between conformation and longevity traits differed between years of birth, mainly because farmers practiced large-scale upgrading with Holstein-Friesian bulls during the period considered, which caused a change in desired type. Therefore, the predictive value of conformation traits for longevity based on data from an upgrading population, might be limited. Estimates of genetic parameters should be based on the most recent data possible, and these parameters should be reestimated over time. From the 1989 plus 1990 data file, subjective scores for udder and feet and legs had the highest predictive values for functional longevity. Quadratic relationships between conformation and longevity traits did exist, but generally the linear relationships prevailed.

Animals↗

PubMed1984

Genetic correlations between sides and heritability of asymmetry for nonmetric traits in rhesus macaques on Cayo Santiago.

The use of nonmetric traits for estimation of biological distance is a long-standing practice in biological anthropology. Nonmetric traits can be scored using either the individual or the side of the individual as the unit of measure. If sides of the individual are genetically correlated the use of sides would produce redundant genetic information. For this reason, Korey (Am. J. Phys. Anthropol. 53:19-23, 1980) argues for the use of individuals as the unit of measure for nonmetric traits. Ossenberg (Am. J. Phys, Anthropol. 54:471-479, 1981), however, argues that bilateral occurrence of nonmetric traits indicates greater genetic liability for the trait and that therefore the sides are the more biologically correct unit of measure. Genetic correlations for 13 cranial nonmetric traits are estimated for a sample of rhesus macaque skeletons from Cayo Santiago. In addition, heritability of asymmetry is estimated for these 13 traits as a test of Ossenberg's contention that asymmetry is genetically influenced. Significant genetic correlations between sides support Korey's contention that nonmetric traits should be scored by individual. Only two asymmetry heritabilities were significantly different from zero, providing no significant support for Ossenberg's contention that asymmetry is genetically determined. Our results support the theory that asymmetry represents a measure of the ability of an organism to buffer stresses. Therefore, a measure of the heritability of asymmetry is a measure of the heritability of the ability to buffer stresses. This ability does not appear to be heritable in this sample.

Animals↗

PubMed1984

Genetic correlations of abdominal fat with production traits of Leghorn hens based on inbred line averages.

Data from 16 inbred lines derived by three generations of full sib mating from a common outbred base population were used to estimate genetic correlations between body weight, abdominal fat content, follicle number, liver weight, egg weight and egg number using between-line variances and covariances. High genetic correlations were found between body weight, fat content and egg weight. Low genetic correlations were found between follicle number and all traits other than egg weights. Theoretical expectations and low correlations within lines led to the conclusion that environmental correlations among the traits considered were very low.

Abdomen↗

PubMed2005

Genetic correlations between basal and maximum metabolic rates in a wild rodent: consequences for evolution of endothermy.

According to the aerobic capacity model, endothermy in birds and mammals evolved as a correlated response to selection for an ability of sustained locomotor activity, rather than in a response to direct selection for thermoregulatory capabilities. A key assumption of the model is that aerobic capacity is functionally linked to basal metabolic rate (BMR). The assumption has been tested in several studies at the level of phenotypic variation among individuals or species, but none has provided a clear answer whether the traits are genetically correlated. Here we present results of a genetic analysis based on measurements of the basal and the maximum swim- and cold-induced oxygen consumption in about 1000 bank voles from six generations of a laboratory colony, reared from animals captured in the field. Narrow sense heritability (h2) was about 0.5 for body mass, about 0.4 for mass-independent basal and maximum metabolic rates, and about 0.3 for factorial aerobic scopes. Dominance genetic and common environmental (= maternal) effects were not significant. Additive genetic correlation between BMR and the swim-induced aerobic capacity was high and positive, whereas correlation resulting from specific-environmental effects was negative. However, BMR was not genetically correlated with the cold-induced aerobic capacity. The results are consistent with the aerobic capacity model of the evolution of endothermy in birds and mammals.

Analysis of Variance↗

PubMed2004

High genetic correlation between resistance to Haemonchus contortus and to Trichostrongylus colubriformis in INRA 401 sheep.

To compare the protection acquired by infection with Haemonchus contortus or Trichostrongylus colubriformis, successive cross infections with the two species were conducted in two genetically similar groups of 150 ewe lambs from 30 sires of INRA 401 breed. At 6 and 7.5 months of age, each group received two doses of 10000 L3 separated by a treatment of one of the species, followed by a similar infection with the second species at 9 and 11.5 months. Faecal egg counts (FECs) were done 28 and 35 days after each dose. There were very high genetic correlation within and between species suggesting that the environmental conditions were very similar. The heritability of FEC of H. contortus ranged from 0.39 to 0.48 and the genetic correlations between FEC after the first and second infections with the same or different species were all near 1. Selection against this species could be done on the response to only one dose. For T. colubriformis, only the response to challenge infection had a similar heritability (0.47); the genetic correlations within and among species were also near one. These results will assist the selection of sheep resistant to nematode parasites.

Animals↗

PubMed1995

Genetic correlation and heritabilities for purebred and crossbred performance in poultry egg production traits.

Genetic correlations between purebred and crossbred performance and purebred and crossbred heritabilities were estimated for egg production traits of laying chickens using a multivariate sire model accounting for additive relationships between sires. Two sire lines, denoted lines 1 and 2, were crossed to one dam line to produce crossbred progeny. Records for egg weight, egg specific gravity, and egg number were collected on purebred and crossbred hens. In total, 99 sires in line 1 and 292 sires in line 2 were used in the analysis, each sire producing on average 45 purebred and 105 crossbred daughters. Estimates of purebred heritability in lines 1 and 2 were in range of .54 to .74 for egg number traits, .52 to .91 for egg weight traits, and .41 to .83 for egg specific gravity traits. Estimates of crossbred heritability were .04 to .51 for egg numbers, .23 to .45 for egg weight, and .13 to .31 for egg specific gravity. The sire component in crossbreds differed up to 78% from the sire component in purebreds depending on traits. The estimate of genetic correlation (rpc) between purebred and crossbred performance was .56 to .73 for egg number, .69 to .99 for egg weight, and .72 to .82 for egg specific gravity. Although crossbred parameters were strongly affected by environmental factors, the results tend to agree with the theory that traits with a larger dominance variation and a larger difference between sire components in purebreds and crossbreds show a lower rpc.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed2003

Genetics of drought adaptation in Arabidopsis thaliana: I. Pleiotropy contributes to genetic correlations among ecological traits.

We examined patterns of genetic variance and covariance in two traits (i) carbon stable isotope ratio delta13C (dehydration avoidance) and (ii) time to flowering (drought escape), both of which are putative adaptations to local water availability. Greenhouse screening of 39 genotypes of Arabidopsis thaliana native to habitats spanning a wide range of climatic conditions, revealed a highly significant positive genetic correlation between delta13C and flowering time. Studies in a range of C3 annuals have also reported large positive correlations, suggesting the presence of a genetically based trade-off between mechanisms of dehydration avoidance (delta13C) and drought escape (early flowering). We examined the contribution of pleiotropy by using a combination of mutant and near-isogenic lines to test for positive mutational covariance between delta13C and flowering time. Ecophysiological mutants generally showed variation in delta13C but not flowering time. However, flowering time mutants generally demonstrated pleiotropic effects consistent with natural variation. Mutations that caused later flowering also typically resulted in less negative delta13C and thus probably higher water use efficiency. We found strong evidence for pleiotropy using near-isogenic lines of Frigida and Flowering locus C, cloned loci known to be responsible for natural variation in flowering time. These data suggest the correlated evolution of delta13C and flowering time is explained in part by the fixation of pleiotropic alleles that alter both delta13C and time to flowering.

Adaptation, Biological↗

PubMed2004

Genetic correlation between serum insulin-like growth factor-1 concentration and performance and meat quality traits in Duroc pigs.

This study was intended to examine whether serum IGF-I concentration is appropriate for use as a physiological predictor for genetic improvement of meat production and meat quality traits in pigs. Heritabilities and genetic correlations were estimated for these traits. The Duroc breed used in this study was selected for seven generations for average daily BW gain (DG) from 30 to 105 kg of BW, loin-eye muscle area (EM), backfat thickness (BF), and intramuscular fat (IMF) content. Serum IGF-I concentration of boars and gilts at the fourth generation of selection and that of boars, gilts, and barrows from the fifth to seventh generations of selection were measured at 8 wk (IGFI-8W) for 832 animals and again at the time they reached 105 kg of BW (IGFI-105KG) for 834 animals. A multivariate REML procedure was used to estimate genetic parameters with a model incorporating generation of selection, sex, common environmental effect of litter, and individual additive genetic effects. Heritability estimates for IGFI-8W and IGFI-105KG were 0.23 +/- 0.02 and 0.26 +/- 0.03, respectively. The estimates of common environmental effect for IGFI-8W and IGFI-105KG were 0.20 +/- 0.02 and 0.03 +/- 0.01, respectively. Positive genetic correlations were estimated between IGFI-8W and DG (0.26 +/- 0.08), EM (0.22 +/- 0.10), and IMF (0.32 +/- 0.10). Moreover, the positive genetic correlation between IGFI-105KG and EM was 0.42 +/- 0.08. These results indicate that serum IGF-I concentration at an early stage of growth was effective for prediction of IMF, but it was not a reliable physiological predictor of genetic merit of meat production traits.

Adipose Tissue↗

PubMed1989

Genetic correlations between test station and on-farm performance for growth rate and backfat in pigs.

Record of performance data taken on Yorkshire pigs on-farm in 123 breeder herds and at a central test station were used to estimate genetic correlations between measures of backfat depth and days to 90 kg on boars at the test station and boars and gilts on-farm. The data involved records on 3,513 station-tested boars, 13,760 farm-tested boars and 28,203 farm-tested gilts from 838, 2,098 and 2,339 sires, respectively. For backfat depth, estimates of genetic correlations were .85 for test station and on-farm boars and 1.04 for test station boars and on-farm gilts. Estimates of genetic correlations between test station and on-farm measures of days to 90 kg were .80 for boars and .74 for boars and gilts. Based on these results, selection of boars on the basis of test station performance for backfat and growth rate would be expected to result in genetic improvement on-farm in both sexes under North American testing and management conditions.

Adipose Tissue↗

PubMed2000

Genetic correlations for daily gain between ram and ewe lambs fed in feedlot conditions and ram lambs fed in Pinpointer units.

When performance is recorded in automated facilities that measure feed intake of individual lambs that are penned in a group, such as Pinpointer units, a legitimate question is the degree to which daily gain is genetically correlated with daily gain achieved under feedlot conditions. Lambs were from a composite population (1/2 Columbia, 1/4 Suffolk, and 1/4 Hampshire germplasm) and of the F2 or more advanced generations. Data were daily gains of 1,101 rams (PR) fed in Pinpointer units (11 to 17 wk of age) and 2,021 rams (FR) and 3,513 ewes (FE) fed under feedlot conditions (9- or 10-wk period starting at 9 wk of age). The FR and FE lambs were born from 1983 through 1995, whereas the PR lambs were born from 1986 through 1995. Measurements of daily gain in PR, FR, and FE lambs were considered to represent three correlated traits. Unadjusted means were .411, .406, and .326 kg/d for PR, FR, and FE, respectively. Random effects in the model were animal direct genetic, maternal genetic, and maternal permanent environmental. Fixed effects were associated with age of dam (1 to 6 yr), type of rearing (1 to 4), and contemporary group (test date). Variances due to maternal genetic effects with single-trait analyses were near zero, so those effects were eliminated from the three-trait analysis although a random uncorrelated effect due to dam was included in the model. Estimates of heritability were .22, .14, and .23 for PR, FR, and FE, respectively, with fractions of variance due to dam effects ranging from .02 to .05. Estimates of genetic correlations were .86 for PR with FR, .83 for PR with FE, and 1.00 for FR with FE. Estimated phenotypic variances were similar for PR and FR, but one-third less for FE. The similarity of heritability estimates and estimates of genetic correlations all exceeding .83 suggest that daily gain of rams fed in Pinpointer units will reflect genetic expression for daily gain in both ram and ewe lambs fed under feedlot conditions.

Animal Feed↗

PubMed2001

Genetic correlation estimates between ultrasound measurements on yearling bulls and carcass measurements on finished steers.

Carcass and growth measurements of finished crossbred steers (n = 843) and yearling ultrasound and growth measurements of purebred bulls (n = 5,654) of 11 breeds were analyzed to estimate genetic parameters. Multiple-trait restricted maximum likelihood (REML) was used to estimate heritabilities and genetic correlations between finished steer carcass measurements and yearling bull ultrasound measurements. Separate analyses were conducted to examine the effect of adjustment to three different end points: age, backfat thickness, and weight at measurement. Age-constant heritability estimates from finished steer measurements of hot carcass weight, carcass longissimus muscle area, carcass marbling score, carcass backfat, and average daily feedlot gain were 0.47, 0.45, 0.35, 0.41, and 0.30, respectively. Age-constant heritability estimates from yearling bull measurements of ultrasound longissimus muscle area, ultrasound percentage of intramuscular fat, ultrasound backfat, and average daily postweaning gain were 0.48, 0.23, 0.52, and 0.46, respectively. Similar estimates were found for backfat and weight-constant traits. Age-constant genetic correlation estimates between steer carcass longissimus muscle area and bull ultrasound longissimus muscle area, steer carcass backfat and bull ultrasound backfat, steer carcass marbling and bull ultrasound intramuscular fat, and steer average daily gain and bull average daily gain were 0.66, 0.88, 0.80, and 0.72, respectively. The strong, positive genetic correlation estimates between bull ultrasound measurements and corresponding steer carcass measurements suggest that genetic improvement for steer carcass traits can be achieved by using yearling bull ultrasound measurements as selection criteria.

Adipose Tissue↗

PubMed1982

[Genetic-correlation analysis of schizophrenic syndromes].

Two hundred and seven families of patients with schizophrenia were examined. Diagnosis of the disease in probands and relatives was made according to the syndromal forms of schizophrenia. The simple, catatonic, hebephrenic and paranoid forms of the disease were distinguished. Current genetic-correlation analysis demonstrated marked genetic correlation between the disease forms. This makes the above-mentioned classification of schizophrenia inadequate for special genetic studies aimed at the definition of factors that determine the development of different clinical forms of the disease.

Female↗

PubMed1992

Genetic correlations between lifetime production and linearized type in Canadian Holsteins.

Genetic and phenotypic correlations were estimated between 6 lifetime production and 28 linearized type traits using REML. The data set contained 34,322 cows, each with a record for all 34 traits. The analyses accounted for the fixed effects of herd, year-month, classifier, age at first calving, and stage of lactation. Heritabilities were low for lifetime traits and moderate for most type traits except stature, size, capacity, thurl width, and pin setting, which had high heritabilities. Most phenotypic correlations between lifetime production and type were in the range of .15 to .20 except for capacity, rump, and feet and legs, which were around .07. Genetic correlations were strong between lifetime production and angularity (.44 to .55) and dairy character (.53 to .56). Genetic correlations were low to moderate between life-time production and stature (.14 to .25), size (.07 to .18), texture (.19 to .26), style (.11 to .27), head (.15 to .23), pin setting (.10 to .16), rear udder (.19 to .25), and rear attachment (.10 to .22). The only notable negative genetic correlations were lifetime production with rear heel (-.16 to -.27), thurl width (-.18 to -.24), and fore udder (-.05 to -.11).

Animals↗

PubMed2000

Negative genetic correlation between male sexual attractiveness and survival.

Indirect selection of female mating preferences may result from a genetic association between male attractiveness and offspring fitness. The offspring of attractive males may have enhanced growth, fecundity, viability or attractiveness. However, the extent to which attractive males bear genes that reduce other fitness components has remained unexplored. Here I show that sexual attractiveness in male guppies (Poecilia reticulata) is heritable and genetically correlated with ornamentation. Like ornamentation, attractiveness may be substantially Y-linked. The benefit of mating with attractive males, and thus having attractive sons, is opposed by strong negative genetic correlation between attractiveness and both offspring survival and the number of sons maturing. Such correlations suggest either antagonistic pleiotropy between attractiveness and survival or linkage disequilibrium between attractive and deleterious alleles. The presence of many colour pattern genes on or near the non-recombining section of the Y chromosome may facilitate the accumulation of deleterious mutations by genetic hitchhiking. These findings show that genes enhancing sexual attractiveness may be associated with pleiotropic costs or heavy mutational loads.

Animals↗