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Results for “Granuloma, Pyogenic”

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PubMed2003

Midline pyogenic granuloma of the tongue: two case studies.

Characteristically, pyogenic granuloma of the tongue is more common on the lateral side of the tongue. The reasons for this are unclear, but may be related to trauma from adjacent teeth or dentures. This article was prompted by the presentation of two patients with lesions in the midline of the anterior surface of the dorsum of the tongue. Both lesions were successfully removed surgically, and histology revealed them to be pyogenic granulomas. There has been no evidence of recurrence in the 6th month of the follow-up period.

Aged↗

PubMed2001

Laryngeal pyogenic granulomas do not express oestrogen or progesterone receptors.

The objective of this study was to determine the presence of oestrogen and/or progesterone receptors in laryngeal pyogenic granulomas and the impact of these receptors on recurrence of pyogenic granulomas. Twenty-two consecutive patients who underwent microlaryngoscopy and removal of pyogenic granulomas were studied retrospectively. The indications for surgery were airway compromise, failure of medical therapy and suspicion of malignancy. Twelve of these patients' granulomas were analysed for oestrogen and progesterone receptors. Charts were analysed for age, sex, location of the lesion, history of trauma, intubation or gastroesophageal reflux disease (GORD), airway symptoms and recurrence. Oestrogen/progesterone receptors were analysed following deparaffinization of specimens and immunostaining with prediluted anti-oestrogen receptor monoclonal antibody and anti-progesterone receptor monoclonal antibody. No sample expressed oestrogen or progesterone receptors. There were too few recurrences to detect if lack of these receptors played any role in determining outcome in this group. Most of the patients had a history of GORD, intubation or laryngeal surgery. There were 12 recurrences in four patients. All of the recurrences improved on prolonged courses of omeprazole. Pyogenic granulomas do not possess oestrogen or progesterone receptors and are unlikely to respond to hormonal therapy. Patients who have, or are being operated on for, laryngeal pyogenic granulomas should be placed on proton pump inhibitors to decrease the likelihood of recurrence.

Adult↗

PubMed1996

[Pyogenic granuloma of the tongue in chronic graft versus host disease].

INTRODUCTION: The development of pyogenic granuloma of the tongue is rare. We report such a case in a patient with chronic graft-versus-host disease. CASE REPORT: A 5-year-old girl was treated with allogenic bone marrow transplantation for aplastic anemia. Complications consisted in chronic graft-versus-host disease with cutaneous, mucosal and hepatic involvement. Seven months later, a voluminous pyogenic granuloma of the tongue developed on previous erosive lichenoid lesions of chronic graft-versus-host disease while the patient was under cyclosporin. Surgical resection was done. Relapse occurred and treatment was identical. DISCUSSION: Six cases of pyogenic granuloma of the oral cavity in chronic graft-versus-host disease have been reported in the literature. Pyogenic granuloma must be considered in tumoral lesion of the oral cavity of patients with chronic graft-versus-host disease. All patients had erosive lichenoid lesions and were under cyclosporin; its role in the genesis of these lesions is debated. Treatment relies on surgical resection confirming the diagnosis.

Bone Marrow Transplantation↗

PubMedDate not supplied

[Mitomicyn C eye drops as alternative treatment for pyogenic granuloma in anophthalmic socket].

PURPOSE: To evaluate the efficacy of mitomycin C eye drops 0.02% concentration (0.02% MMC) in pyogenic granuloma in anophthalmic socket. METHODS: Six patients who presented pyogenic granuloma were treated with 0.02% MMC four times a day in fifteen-day cycles with intervals of fifteen days between each cycle. The patients were observed every week. RESULTS: Among the six studied patients, one presented a complete resolution of the pyogenic granuloma after a ten-day treatment with 0.02% MMC that is, before the end of the first cycle. In two patients, the treatment was successful after two weeks using 0.02% MMC (one complete cycle). In other two patients, the resolution of the lesion occurred after five weeks that is, at the beginning of the second cycle. 0.02% MMC was not successful in only one patient whose lesion persisted after two cycles of the treatment. None of the patients presented complications after the use of 0.02% MMC. CONCLUSION: The topical use of 0.02% MMC proved efficacy in the treatment of anophthalmic socket pyogenic granuloma. A small number of patients took part in this study, therefore another randomized and comparative research is necessary in order to compare the efficacy of 0.02% MMC with other drugs such as corticosteroids and antimetabolites.

Adolescent↗

PubMed2004

Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma.

Lobular capillary hemangioma is a vascular neoplasm that commonly occurs as a cutaneous tumor. When it involves the skin and mucosal surfaces, ulceration and suppuration may occur, hence the classic term of pyogenic granuloma. Intravenous pyogenic granuloma is a rare solitary form of lobular capillary hemangioma that usually occurs in the veins of the neck and upper extremities. We report the ultrasonographic and magnetic resonance imaging findings of a pyogenic intravenous granuloma localized in the right cephalic vein. The imaging and pathological findings and the differential diagnoses are discussed.

Arm↗

PubMed2002

[Pyogenic granuloma of the lacrimal sac].

BACKGROUND: Pyogenic granulomata belong to the group of inflammatory pseudotumours. They consist of granulation tissue usually following inflammatory processes or trauma. PATIENT: We report on a 86-year old female suffering from chronic dacryocystitis. In the course of the treatment exstirpation of the lacrimal sac was performed. The removed tissue was analysed histologically. RESULTS: Histological examination revealed a dense lymphoplasmacellular infiltration underlying the epithelium of the lacrimal sac. A mushroom-like tumour rising into the lumen of the lacrimal sac could be observed. This tumour consisted of capillaries and a dense inflammatory infiltrate. The findings were consistent with a pyogenic granuloma of the lacrimal sac. CONCLUSION: Pyogenic granulomata usually arise in the conjunctiva as a sequel of chronic lipogranulomatous inflammation. They are very rare in other areas such as the lacrimal drainage system.

Aged↗

PubMed2003

Oral pyogenic granuloma in Jordanians: a retrospective analysis of 108 cases.

PURPOSE: The purpose of the present study was to retrospectively analyze the clinicopathologic features and treatment of oral pyogenic granuloma in Jordanian patients. PATIENTS AND METHODS: Information regarding 108 cases of pyogenic granuloma of the oral cavity that underwent biopsy were retrieved from the records of patients seen at the maxillofacial and periodontology units of the Faculty of Dentistry, Jordan University of Science and Technology, during an 11-year period from 1991 to 2001. Data were reviewed and analyzed for age, gender, site, treatment, and clinical and histopathologic features. RESULTS: Patient ages ranged from 3 to 85 years (mean, 30 years), with the greatest degree of occurrence (26.8%) in the second decade. The male-to-female ratio was 1:1.7. The mean age for females age was higher than that for males. The most frequently involved site was the gingiva (44.4%); other sites were the lips, tongue, buccal mucosa, and palate. Gingival pyogenic granulomas were more prevalent in the maxilla than in the mandible, with the anterior region of both jaws being more commonly affected. The labiobuccal gingiva of both jaws was more commonly affected. The main complaint was bleeding (59.3%), and almost half of the lesions had a pedunculated base, with surface ulceration in 9.2% of cases. The mean greatest granuloma diameter was 10 mm. All lesions were surgically excised, with 5.8% of cases known to have recurred. CONCLUSIONS: The clinicopathologic features of oral pyogenic granuloma in Jordanians are similar to those of other whites. In this series, we found that with surgical excision of pyogenic granuloma, there was a low recurrence rate.

Adolescent↗

PubMed2003

Pyogenic granuloma arising in port-wine stain after cryotherapy.

Pyogenic granuloma is a reactive vascular tumor that rarely arises in association with port-wine stain, either spontaneously or after trauma. A 21-year-old woman, presented here, developed a pyogenic granuloma within a facial port-wine stain after treatment with cryotherapy.

Adult↗

PubMed1989

[Congenital telangiectasic (pyogenic) granuloma of the anus: a rare location of a benign neonatal tumor].

The neonatal anus is an unusual anatomic site for granuloma pyogenicum (GP). Several synonisms exist for GP (at least 16). It is a tumor of soft tissues (benign vascular tumor). Both a maternal variant (the epulis) and a hamartomatous perinatal one are known. The terms teleangiectasic granuloma and pyogenic or infected granuloma have been used to describe respectively the early and late stages of the lesion. In the anal site it appears as a sessile or peduncolated, red-wine, soft little tumor of the size of a millet or barley grain. Histologically it is a capillary haemangioma with inflammatory infiltrates in its soft connective tissue stroma and covered with thinned epidermis. During 1988 we have seen two cases in 2000 consecutive newborns, both in females.

Anus Diseases↗

PubMed1994

Pyogenic granuloma of the cornea induced by "snake oil".

A pyogenic granuloma of the cornea developed on the vascularized cornea of a 79-year-old woman after "snake oil" accidentally dripped in her eye. The snake oil was being used to relieve forehead pain, which may have been referred. The five previously reported examples of corneal pyogenic granuloma are similar to this case in that trauma preceded development of the lesion. However, the chemical trauma induced by the snake oil appears to be a unique mechanism of injury.

Aged↗

PubMedDate not supplied

Pyogenic granuloma stimulates angiogenesis in the chick embryo chorioallantoic membrane.

Ten samples of pyogenic granuloma and 10 of normal skin from age- and sex-matched controls were grafted onto the chick embryo chorioallantoic membrane (CAM) to investigate their possible angiogenic activity. The angiogenic response in pathological and control implants was assessed on histologic sections by a planimetric point-count method 4 days after grafting. The CAM mast cells were also quantified. The vascular counts in the area underlying the pyogenic granuloma were four times higher than those of normal skin. A higher number of mucosa-like mast cells was detected in the intermediate mesenchyme of the CAM in pathological samples in comparison to controls. Pyogenic granuloma may promote angiogenesis leading to release of several angiogenic factors. The role played in angiogenic response by the inflammatory cells, mainly mast cells, forming the perilesional infiltrate was supported by this study.

Adolescent↗

PubMed2006

Treatment of pyogenic granulomas with the Nd-YAG laser.

Pyogenic granuloma is a common vascular tumour that can be treated by various means. However, some large lesions and those located on some difficult-to-treat body sites may represent a difficult challenge to the clinician (residual pain after treatment, difficult to cover with a dressing, or risk of sequelae). We report the successful treatment of such lesions in three patients using the Nd-YAG laser.

Female↗

PubMed1989

[Diagnostic 99mTc-labeled red blood cells scintigraphy in gastrointestinal tract bleeding from an intestinal pyogenic granuloma].

99mTc-labeled red blood cells (RBCs) scintigraphy was useful to detect the site of gastrointestinal (GI) tract bleeding in a 30-year-old woman. Other examinations, double-contrast barium meal study, fiberscopy and conventional contrast arteriography were unsuccessful in diagnosis. A surgical treatment was performed and GI tract bleeding from ileal pyogenic granuloma was proved. In this case the patient had no other obvious hemangioma or pyogenic granuloma. Pyogenic granuloma occurs most commonly on the exposed skin areas and very rare on the intestine.

Adult↗

PubMed2002

Ampullary pyogenic granuloma as a complication of lacrimal plug migration.

We present a patient with ampullary pyogenic granuloma caused by spontaneous migration of a silicone lacrimal plug. A 43-year-old woman with severely dry eyes was treated with non-absorbable silicone punctal plugs insertion in both superior and inferior puncta. Irritation and purulent discharge gradually developed 3 weeks after implantation. A pink, fleshly ampullary lesion over the left superior punctum was noted later. The migrated silicone plug was found close to the common canaliculus during surgery. Histopathologic examination confirmed the diagnosis of pyogenic granuloma. A migrated lacrimal plug resulting in pyogenic granuloma is a rare complication. The treatment of choice is removal of the migrated plug as early as possible. Patients with lacrimal plugs insertions should be informed of possible complications and should be followed up regularly for early detection of plug-related problems.

Adult↗

PubMed1999

Cutaneous metastasis from hepatocellular carcinoma resembling pyogenic granuloma.

A case of skin metastasis from hepatocellular carcinoma (HCC) is reported that resembled pyogenic granuloma. An easily bleeding, cutaneous nodule on the chin of a 62-year-old Japanese male was resected under the diagnosis of pyogenic granuloma. Histology, however, indicated HCC. Cutaneous metastases from HCC are very rare, but the possibility must be considered for unusual nodules resembling pyogenic granuloma.

Carcinoma, Hepatocellular↗

PubMed2002

Pathogenetic roles of angiogenic factors in pyogenic granulomas in pregnancy are modulated by female sex hormones.

BACKGROUND: An abundance of microvessels is the major phenotype of pyogenic granuloma, which has been considered a hormone-related lesion based on clinical observations. Although angiogenic factors and inflammatory cytokines have been implied to play roles in the pathogenesis of pyogenic granuloma, their links to female steroid hormones still remain to be elucidated. Since apoptosis is important in limiting inflammation, we also investigated whether steroid hormones could protect granuloma cells from apoptosis and, therefore, lead to overreactive inflammatory response. METHODS: We employed immunoassays in a series of experiments, including human pyogenic granuloma in pregnancy, mouse air pouch granuloma and U937 (monoblastoid) cells in culture to clarify the relationship among vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and female steroid hormones in granuloma formation. The apoptotic rates were analyzed in vivo and in vitro by terminal deoxynucleotidyl transferase-mediated deoxyuridine 5-triphosphate nick end labeling (TUNEL) and flow cytometry, respectively. RESULTS: Both in human and animal studies, the immunoassays (enzyme-linked immunoabsorbent assay [ELISA] and immunohistochemistry) detected significantly more VEGF and bFGF and less TNF-alpha in hormones than the control group, while TUNEL assay revealed less apoptotic cells in groups with pregnancy levels of hormones. In vitro, progesterone enhanced the expression of VEGF in LPS-treated U937 cells. Both estrogen and progesterone inhibited the apoptosis of U937 cells triggered by exogenous TNF-a CONCLUSIONS: Female steroid hormones may have dual effects on the pathogenesis of pyogenic granuloma in pregnancy. The hormones not only enhance the expression of angiogenic factors in inflamed tissue, but also decrease apoptosis of granuloma cells to extend angiogenic effect.

Adult↗

PubMed2006

Recurrent intraoral pyogenic granuloma with satellitosis treated with corticosteroids.

The development of recurrent pyogenic granulomas as multiple satellite lesions has not been reported in the oral cavity. This report describes an unusual case of intraoral pyogenic granuloma recurring multiple times after surgical excisions with the formation of satellite lesions. Due to failure of surgical management, an alternative approach was taken. We illustrate how the lesions were successfully treated with a series of intralesional corticosteroid injections.

Adult↗

PubMed1989

Recurrent pyogenic granuloma with satellitosis.

The development of recurrent pyogenic granulomas as multiple satellite lesions is rare and often associated with trauma or treatment of the primary lesion. At least 34 cases of such lesions after various treatment modalities have been reported, but none occurred in conjunction with laser therapy. We report a case of recurrent pyogenic granuloma with satellite lesions that developed after carbon-dioxide laser excision of a previously recurrent lesion.

Cephalexin↗