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Results for “HISTAMINE LIBERATION”

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PubMed1989

Cimetidine and ketotifen inhibit stimulated aggregation and histamine liberation from rabbit blood platelets.

The effect of cimetidine and ketotifen was studied on thrombin-stimulated rabbit platelet aggregation as well as on histamine and serotonin liberation. Both drugs inhibited the stimulation of platelets in a dose-dependent way. The effect of ketotifen on stimulated aggregation was about twice that of cimetidine. Stimulated histamine and serotonin liberation was more inhibited by ketotifen than by cimetidine. Both drugs inhibited the liberation of serotonin to a greater extent than that of histamine.

Animals↗
PubMedDate not supplied

[Evaluation of the histamine-liberating property of midazolam].

The variations of plasma histamine levels were studied in two groups of ten patients arriving in the operating room; the first group received midazolam, and the second a saline isotonic solution. The plasma histamine levels were compared, for each patient, to the histamine level measured the day before the operation. An histamine release was found as soon as the patient arrived in the operating room. No variation of the histamine level was found after the injection of midazolam.

Female↗