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PubMed1994

Practical guides. I: Central intravenous additive services.

Centralized intravenous additive services (CIVA) are becoming an essential component of hospital pharmacy services in the U.K. This review explores the background to their development, indicating how aseptic services commenced with total parenteral nutrition, developed further with cytotoxic drug preparation and is now progressing, in an increasing number of hospitals, to a full range of parenteral drug services. The benefits of pharmacy-operated provision of injections in ready-to-administer forms are described. The operation of such services is then considered in detail. A brief discussion of the types of service that can be operated is followed by consideration of staffing, facilities, methods of operation, technical support and documentation. National guidelines in the U.K. and U.S.A. are compared, since these have a major influence of the nature of CIVA service operation. The issues associated with the stability of reconstituted and repackaged injectables are discussed, together with how our knowledge can be used in the assignment of shelf lives to pharmacy-prepared intravenous additives. The review concludes with a brief assessment of future trends and changes likely to affect intravenous services provided under pharmacy control.

Dosage Forms↗
PubMed1999

Clinical pharmacy services and hospital mortality rates.

We evaluated the associations between clinical pharmacy services and mortality rates in 1029 United States hospitals. A data base was constructed from Medicare mortality rates from the Health Care Financing Administration and the National Clinical Pharmacy Services data base. A multivariate regression analysis, controlling for severity of illness, was employed to determine the associations. Four clinical pharmacy services were associated with lower mortality rates: clinical research (p<0.0001), drug information (p=0.043), drug admission histories (p=0.005), and participation on a cardiopulmonary resuscitation (CPR) team (p=0.039). The actual number of deaths (lower) associated with the presence of these four services were clinical research 21,125 deaths in 108 hospitals, drug information 10,463 deaths in 237 hospitals, drug admission histories 3843 deaths in 30 hospitals, and CPR team participation 5047 deaths in 282 hospitals. This is the first study to indicate that both centrally based and patient-specific clinical pharmacy services are associated with reduced hospital mortality rates. This suggests that these services save a significant number of lives in our nation's hospitals.

Data Collection↗
PubMed1984

Preparing and justifying the budget for new or improved services.

The process of preparing and justifying the budget for a new or improved hospital pharmacy service is described. Factors that influence the justification process include the rationale for the new service, facts needed for the decision-making process, the political process within the hospital, timing, and salesmanship. Steps preliminary to preparing the proposal include identifying hospital and departmental goals, relating the proposed service to those goals, assessing the odds of new service approval, and establishing priority for development of the proposal. The components of a formal proposal are discussed, including the budget that describes the financial feasibility of the service. A sample proposal is presented. Prospective pricing does not necessarily eliminate the opportunity for development of new hospital pharmaceutical services. However, the need, cost, revenue, and benefits of such services must be thoroughly justified on a hospital-specific basis.

Budgets↗
PubMed1994

Survey of clinical pharmacy services in United Kingdom National Health Service hospitals.

The extent to which clinical pharmacy services are provided in National Health Service (NHS) hospitals in the United Kingdom was studied by means of a questionnaire. Questionnaires inquiring whether and to what extent certain clinical pharmacy services were provided were mailed to all NHS hospital pharmacies in 1992. The questionnaires also requested information about the hospital and the number and qualifications of pharmacists employed. The results were compared with those of a survey of pharmaceutical services in the United States. Of 508 questionnaires mailed, 416 usable responses were returned. Services commonly provided were inpatient drug therapy monitoring (96%), clinical trials support (92%), formulary management (89%), participation in drug and therapeutic committees (97%), and an on-site drug information center (60%). Services infrequently provided were therapeutic drug monitoring (21%), medication history-taking (16%), and a 24-hour on-site pharmacist (10%). Several services were associated with pharmacies that employed many pharmacists, pharmacists with advanced education, or specialist clinical pharmacists and pharmacies located in medical school teaching hospitals. U.K. hospital pharmacies provided fewer patient-oriented services and more drug information, therapy monitoring, and pharmacist education services than U.S. hospital pharmacies. Provision of clinical pharmacy services in the United Kingdom was associated with employment of many pharmacists, pharmacy clinical specialists, and pharmacists with advanced education.

Clinical Trials as Topic↗