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[Radiation exposure during digital hysterosalpingography: how much is due to fluoroscopy?].

PURPOSE: To determine the proportion of radiation exposure from fluoroscopy during the performance of hysterosalpingography, using a digital image intensifier. MATERIAL AND METHOD: 20 women with primary or secondary sterility were examined. The total radiation dose was measured and the proportion due to fluoroscopy was determined. The use of a computer programme permitted accurate differentiation of the dose obtained by fluoroscopy and radiography. Total mean radiation dose was 256 cGy x cm2; fluoroscopy contributed 187 cGy x cm2. On average, fluoroscopy contributed 69% of total radiation dose. CONCLUSION: During hysterosalpingography with a digital image intensifier, fluoroscopy should be as brief as possible since it contributes most of the radiation dose.

Adult↗

Three-dimensional dynamic MR-hysterosalpingography; a new, low invasive, radiation-free and less painful radiological approach to female infertility.

BACKGROUND: The purpose of this study was to propose a new method for imaging the uterine cavity and Fallopian tube patency by three-dimensional dynamic magnetic resonance hysterosalpingography (3D dMR-HSG) and to analyse if, by using a higher viscosity contrast solution, direct visualization of the Fallopian tubes may be achieved by this new technique. METHODS: 10 consecutive infertile women underwent 3D dMR-HSG and conventional HSG as gold standard. 3D dMR-HSG consisted of injection of 20 ml of a gadolinium-polyvidone solution into the uterine cavity while acquiring five consecutive three-dimensional (3D) T1-weighted MR-sequences. RESULTS: In three patients the catheter became dislodged during 3D dMR-HSG. However, in one of these patients the examination was still partially diagnostic. Imaging findings of 3D dMR-HSG showed good correlation with conventional hysterosalpingography and allowed 3D imaging of the uterine cavity and of Fallopian tube patency in 8/10 patients and direct visualization of the Fallopian tubes in 5/7 patients. CONCLUSION: 3D dMR-HSG represents a new and promising imaging approach to female infertility causing less pain and avoiding exposure of the ovaries to ionizing radiation. By using a higher viscosity MR-contrast agent it allows not only visualization of uterine cavity and Fallopian tube patency but also direct visualization of Fallopian tubes.

Adult↗

Hexabrix as a contrast agent for hysterosalpingography.

Hexabrix, a monoacidic dimeric iodinated contrast material, was compared with Renografin 60 (diatrizoate meglumine) for safety, tolerance, and efficacy in hysterosalpingography, in a double blind study of 52 patients. No serious adverse reactions were noted in either group of patients. Discomfort during and after the procedure was not statistically different in the two groups. No difference in radiographic quality was seen. It was concluded that Hexabrix, despite reduced osmolality and increased viscosity, offers no significant benefit over Renografin 60, but it is a safe and acceptable contrast agent for hysterosalpingography.

Contrast Media↗

Hysterosalpingography with a balloon catheter versus a cannula: evaluation of patient pain.

The amount of procedural and post-procedural pain due to hysterosalpingography performed with a standard cannula (28 patients) versus a balloon catheter (23 patients) was compared. Patients completed questionnaires in which they rated the pain they experienced during insertion of the instrument, during injection of contrast material, immediately after the examination, several hours after the examination, and over the next 6 days. The balloon catheter produced less discomfort during the procedure but significantly more discomfort after the procedure than did the standard cannula. These results indicate that hysterosalpingography with the balloon catheter is not as painless as has been claimed.

Adult↗

MR hysterosalpingography: protocol development and refinement for simulating normal and abnormal fallopian tube patency--feasibility study with a phantom.

PURPOSE: To develop and refine a pulse sequence and protocol for testing the feasibility of magnetic resonance (MR) hysterosalpingography in a phantom model. MATERIALS AND METHODS: A phantom simulating the uterus, fallopian tubes, and surrounding pelvic cavity was constructed. T2-weighted acquisition strategies-breath-hold fast spin-echo, rapid acquisition with relaxation enhancement (RARE), and haff-Fourier RARE-were refined to acquire sequential 70-mm coronal imaging volumes. Contrast agent was injected into the introducing catheter entering the os of the simulated uterus. Interacquisition interval, type of contrast agent (eg, sterile saline solution or water), and quantity of contrast agent (eg, 1-5 mL per acquisition) were varied. Digital image subtraction was used to enhance image quality. Images were qualitatively analyzed and rated good, fair, or poor for temporal resolution, spatial resolution, fallopian tube conspicuity, and free spill conspicuity. Once the technique was refine, the phantom was reconfigured to simulate unilateral and bilateral hydrosalpinx. RESULTS: The RARE sequence with an 8-second interacquisition interval and a 5-mL interacquisition of sterile water produced good images of the simulated fallopian tubes and free spill. Depiction of unilateral and bilateral hydrosalpinx was also reliably demonstrated. CONCLUSION: This study with a phantom model demonstrates the feasibility of MR hysterosalpingography to depict normal and diseased fallopian tubes.

Constriction, Pathologic↗

Dimer X in hysterosalpingography.

The incidence of abdominal pain during hysterosalpingography was assessed from replies to postal questionnaires completed by 42 patients receiving Diaginol Viscous and 23 patients receiving Dimer X: the questionnaires were analysed using a double-blind technique. In the Diaginol Viscous group, 58.5% of patients experienced moderate or severe pain during the injection as compared with an incidence of only 19% in the group receiving Dimer X. In three of tha patients receiving Diaginol Viscous, there was brief loss of consciousness. Radiographic quality was satisfactory with both contrast media. After effects of hysterosalpingography were relatively common and included: lower abdominal pain; vaginal bleeding; temporary difficulty in walking; menstrual disturbances in subsequent periods. No correlation could be demonstrated between the type of medium used and the incidence of these after effects.

Clinical Trials as Topic↗

Hysterosalpingography and sonohysterography: lessons in technique.

OBJECTIVE: The objectives of this article are to review the examination techniques for hysterosalpingography and saline infusion sonohysterography and to present practical tips to enhance physician performance and minimize patient discomfort during these procedures. CONCLUSION: Optimally performed hysterosalpingography and saline infusion sonohysterography can be relatively comfortable procedures for the patient that provide a great deal of useful diagnostic information.

Catheterization↗

Hysterosalpingography and laparoscopy: a comparative study.

Twenty-six women were evaluated with both hysterosalpingography and laparoscopy. The hysterosalpingograms were reviewed independently by two radiologists. Postdrainage films were obtained in 19 of 26 patients. A high false-negative rate (44.9% overall) and low specificity (20.6%) were observed. The postdrainage film contributed to a correct diagnosis in only four of 38 tubes evaluated by the first radiologist and in none evaluated by the second radiologist. Hysterosalpingography is valuable as a screening procedure for identifying abnormals but is not specific in differentiating tubal adhesions from tubal obstructions. It is recommended that preliminary films not be obtained routinely and that postdrainage films be reserved for cases where fluoroscopic and spot-film findings are equivocal.

Evaluation Studies as Topic↗

Organic vs functional obstruction of the fallopian tubes: differentiation with prostaglandin antagonist- and beta 2-agonist-mediated hysterosalpingography and selective ostial salpingography.

In order to determine the prevalence and cause of functional vs organic obstruction of the fallopian tubes, hysterosalpingography was repeated after pharmacologic manipulation with a prostaglandin antagonist (aspirin) and/or a beta 2-agonist (terbutaline) in 100 patients in whom the fallopian tubes did not fill with contrast medium on the initial hysterosalpingogram. Selective ostial salpingography was performed in those in whom the fallopian tubes did not fill on the second hysterosalpingogram. Patients referred from three infertility clinics were included in the study if they could be rescheduled for a second hysterosalpingogram after at least 1 week of preparation with aspirin. Hysterosalpingograms obtained after administration of aspirin showed normal filling in 21 of 100 patients with initially obstructed tubes; the tubes filled in four more patients after administration of terbutaline. Selective ostial salpingography opacified the tubes in another 36 patients in whom the tubes had so far failed to fill. On the basis of the radiographic appearance and sometimes laparoscopic observation, initial nonfilling was attributed to spasma and debris in 49 patients, submucosal fibroids in six, synechiae in three, salpingitis isthmica nodosa in two, and septated uterus in one. Hysterosalpingography, after pharmacologic manipulation with aspirin and/or selective ostial salpingography, revealed false-positive and functional tube obstructions in 61 of 100 patients. Moreover, the radiologic appearance improved categorization of organic obstructions.

Adrenergic beta-Agonists↗

Infertility in women: diagnostic evaluation with hysterosalpingography and other imaging techniques.

This article examines the current roles of hysterosalpingography and other imaging studies used in diagnostic assessment and treatment of infertility in women. The advantages and limitations of hysterosalpingography, transabdominal or transvaginal sonography, and MR imaging in detecting abnormalities of the uterus (congenital anomalies, intrauterine adhesions, myometrial and endometrial derangements) and tubal and peritubal disease are presented. The use of sonography to evaluate cyclical endometrial changes, to assess development of the follicle and corpus luteum, to determine whether ovulation has occurred, and to detect dysfunctional ovulatory dynamics is described, as is the role of this technique in improving the prognostic value of the postcoital test for assessing the quality of cervical mucus. With the development and availability of newer and improved methods for the treatment of infertility disorders in women, comprehensive and detailed evaluation to determine the precise underlying cause or causes of the infertility is important to allow formulation of the most appropriate therapeutic plan. With careful and thorough assessment, the cause of infertility can be identified in 90-95% of couples evaluated.

Adult↗

Comparison between two radiographic contrast media for hysterosalpingography.

Two water-soluble contrast media for hysterosalpingography--one with high viscosity (Perjodal H viscous) and one with low viscosity (Isopaque Amine) were compared with special reference to the development of pain in 61 patients. Patients examined with Isopaque Amine experienced significantly less pain and this contrast medium therefore is suggested as a suitable agent for hysterosalpingography in the investigation of sterility.

Abdomen↗

Hysteroscopy is superior to hysterosalpingography in infertility investigation.

BACKGROUND: The development of advanced endoscopic instrumentation in recent years has demonstrated the superiority of direct visual examination over radiographic demonstration of various body cavities. Just as laparoscopy has gradually taken a primary role in the surgical investigation of the ovulatory infertile patient, the role of intrauterine endoscopy in comparison to hysterosalpingography (HSG) needs to be reevaluated. METHODS: Four hundred and sixty-four infertile women had undergone both hysterosalpingography and a diagnostic hysteroscopy and the findings were analysed. RESULTS: Compared to hysteroscopy the sensitivity of HSG was 98%, but its specificity only 15%, the positive predictive value 45%, and negative predictive value 95%. On hysteroscopy a normal uterine cavity was found in 53% of the cases with a filling defect and in 56% of those with uterine wall irregularity on HSG. CONCLUSIONS: Hysteroscopy, a safe and rapid direct visualisation of the uterine cavity, is superior to HSG in the identification of intrauterine pathology. In view of the low positive predictive value and the low specificity of the HSG, we believe it should be replaced by the diagnostic hysteroscopy as a first line infertility investigation.

Female↗

Is hysterosalpingography an important tool in modern gynecological practice?

OBJECTIVE: To assess the value of hysterosalpingography (HSG) in diagnosing tubal patency and peritubal adhesions. PATIENTS AND METHODS: HSG was followed whenever possible by diagnostic laparoscopy with chromopertubation to give the final prognosis in cases of infertility. RESULTS: Normal HSG findings were obtained in 669 women, and abnormal ones in 306. No significant correlation was found between age of patient, duration, type of infertility, and HSG findings. Tubal blockage was seen in 89.2% and uterine factor in 9.4% of cases. Peritubal adhesions were suggestive in 12.75% of cases. On laparoscopy, done in about half of these women, findings were in agreement with HSG in 59.87% of cases. Follow-up was carried out whether the woman conceived, had a laparotomy, or required further investigations. CONCLUSION: Although somewhat insensitive, the high specificity of hysterosalpingography makes it very helpful for ruling out tubal disease, even where endoscopic evaluation is available.

Adult↗

[Hysterosalpingography in the diagnosis of pelvic endometriosis].

Endometriosis is a common cause of chronic pelvic pain. Laparoscopy is considered the gold standard for definitive diagnosis. This work aims to evaluate whether hysterosalpingography (14SG), a cheaper and more accessible examination, is worth while as a diagnostic tool in this pathology. Thirty patients submitted to laparoscopy for chronic pelvic pain where retrospectively studied. Three different observers evaluated their hysterosalpingographies. The imaging diagnoses were classified as suggestive or not suggestive of external pelvic endometriosis. With laparoscopy, 18 patients had endometriosis, 11 with mild lesions by Acosta classification. Compared to laparoscopy, HSG diagnosis, when made by at least two observers, revealed a sensitivity of 55.5%, a specificity of 75%, a positive predictive value of 77%, and a negative predictive value of 53%. In the presence of clinical pathologic uterosacral--US ligaments and/or sterility, the specificity of HSG may be 100%, but the sensitivity falls below the 40%. We concluded that in a population with chronic pelvic pain, HSG is not a first choice diagnostic tool. This examination only permits the identification of 1/3 of the patients with external endometriosis, being unable to exclude its presence. However, it may be useful in patients with infiltrative endometriosis of the US ligaments.

Adult↗

Radionuclide hysterosalpingography with technetium-99m-pertechnetate: application and radiation dose to the ovaries.

Although radionuclide hysterosalpingography (RNHSG) has been suggested as an efficient procedure for assessing function of fallopian tubes, the radiation dose to the ovaries was addressed as an important issue to be taken into consideration. We describe a modified method of RNHSG, calculating the radiation dose to the ovaries. A small dose of approximately 18.5 MBq (0.5 mCi) of [99mTc]pertechnetate was administered directly into the uterine cavity without overpressure. The accuracy of the method was 84.5% as compared with the contrast hysterosalpingography. The estimated average dose to the ovaries was 0.057 mGy/MBq (0.21 rad/mCi) or 1.08 mGy (108 mrad) per study. RNHSG is an accurate method for functional study of fallopian tube patency with low radiation dose.

Adult↗

Abnormal findings on hysterosalpingography: effects on fecundity in a donor insemination program using frozen semen.

OBJECTIVE: We sought to evaluate the effect of abnormal baseline hysterosalpingography (HSG) on subsequent fecundity during the first six cycles of treatment. METHODS: Hysterosalpingography was performed on 208 asymptomatic ovulatory women with no history of pelvic disease who were referred for donor insemination. The findings were categorized into five groups: 1) normal study, 2) uterine anomaly or filling defect with bilateral tubal patency, 3) normal uterine anatomy with unilateral tubal patency, 4) normal uterine anatomy with bilateral tubal blockage, and 5) normal uterine anatomy with hydrosalpinx. Subjects in groups 4 and 5 received inseminations only if patency of at least one fallopian tube was demonstrated with laparoscopy. Life-table analysis was performed to calculate the average monthly fecundity and cumulative conception rates for each group. The Mantel-Haenszel test was used to compare group fecundities. RESULTS: A total of 1460 donor insemination cycles were performed. The number of cycles in each group were as follows: group 1, 1173 (80%); group 2, 153 (10%); group 3, 90 (6.2%); group 4, 16 (1.1%); and group 5, 28 (1.9%). None of the patients in group 4 or 5 conceived. The cumulative conception rates in the first three groups were 46, 34, and 40%, respectively, and were not significantly different from one another (P greater than .05). Although a high incidence of uterine filling defects and unilateral tubal blockage was observed (19.2%), the incidence of an abnormal HSG finding that significantly decreased fecundity was only 2.8%. CONCLUSION: In women with no history of tubal or uterine disease, routine HSG before initiation of donor insemination is of limited value for identifying decreased treatment fecundity.

Adult↗

[Contrast sono hysterosalpingography in the study of endometrial abnormalities and tubal patency in infertile patients].

The aim of this study was to assess the diagnostic value and the usefulness of sono hysterosalpingography (SHG) in the detection of uterine abnormalities and tubal patency, compared with other diagnostic methods among patient with infertility. In a prospective study, 86 patients in the initial stage of the infertility treatment were examined by SHG using saline NaCl infundibular and Echovist as contrast media. Further status of the tubes and uterine cavity was assessed by the "gold standards", laparoscopy and hysteroscopy. Sensitivity, specificity, positive predictive value and the negative predictive value of SHG using NaCl infundibular for evaluation of the uterine cavity were 98.8%, 92.5%, 91.4% and 92%, respectively. Sensitivity, specificity, positive predictive value and the negative predictive value of SHG for the assessment of the tubal status were 97.6%, 89.2%, 76.3% and 77.4%, respectively. There were no evident complications during or after the procedure. Sono hysterosalpingography is useful in making decisions regarding further procedures for the diagnosis and treatment of infertility. This method is simple, safe and cheap for early assessment of the reproductive status of uterine cavity and fallopian tubes and perspective as a routine, first-line infertility investigation.

Adult↗

[Current role of hysterosalpingography in the assessment of female infertility: review of a series of cases].

The authors reviewed 463 hysterosalpingographies from a series of patients examined for primary infertility. 25.5% of them had been studied with echotomography and 4.1% with therapeutic and explorative laparoscopy. Hysterosalpingographic results were compared with positive findings at clinical examination and with various pathologic associations: the method proved to be extremely valuable in the diagnosis of the primary causes of female infertility, and even showed secondary, sometimes unsuspected, causes--e.g., iatrogenic and inflammatory. Moreover, high agreement (50%) was observed with echotomographic findings. The examination was carried out on an outpatient basis, and proved less dangerous and cheaper than other invasive techniques, its cost being more or less the same as that of US, which however is still the least dangerous and expensive method for the diagnosis of female infertility. Therefore, the authors suggest that diagnostic laparotomy be a second choice and be employed only in the cases where it can have therapeutic purposes. In all the extant cases, combined hysterosalpingography and US are still recommended.

Female↗