PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “INSULIN/effects”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 91 records · Page 5Linked to original sources
PubMed1954

The effect of alloxan diabetes on experimental cholesterol atherosclerosis in the rabbit. IV. The effect of insulin therapy on the inhibition of atherosclerosis in the alloxan-diabetic rabbit.

Experiments were undertaken to ascertain whether the previously demonstrated inhibition of the development of experimental aortic atherosclerosis in alloxan-diabetic rabbits fed cholesterol was due to the injection of alloxan per se or to the existence of the diabetic state produced by alloxan. It was established that, by treating the diabetic state with insulin, the diabetic state could be ameliorated and the inhibitory effect obviated. It was therefore concluded that the inhibitory phenomenon was not due to the injection of alloxan per se but that it was associated with one or more factors that characterize the alloxan diabetic state in the rabbit and that are reversible by insulin therapy. In the course of the experiment it was demonstrated that the inhibitory effect was apparent in cholesterol-fed diabetic rabbits whether or not their diet was supplemented with vegetable oil. The previously reported metabolic abnormalities of the diabetic animals were confirmed. It was established that suitable treatment of the cholesterol-fed diabetic animals with insulin would bring all the metabolic aberrations, including those of the serum lipids, into reasonably close correspondence with those observed in non-diabetic rabbits fed cholesterol.

Alloxan↗
PubMed1959

Action of insulin on sugar permeability in rat diaphragm muscle.

Insulin action upon sugar permeability has been examined in rat diaphragm muscle prepared so that the fibers are either intact or cut. In intact preparations, sucrose and mannitol are largely excluded from the intracellular water while D-galactose, D-xylose, and L-xylose equilibrate in a small fraction of the total cell water; the availability of cell water for D-galactose, D-xylose, and L-xylose is increased by insulin. In cut preparations, in which the cell membrane is not intact, all the sugars studied penetrate into the cell, but intracellular water is not uniformly available for subsequent permeation. Sucrose distributes in a volume of about 40 to 45 per cent of the available cell water; D-xylose, D-galactose, L-xylose, and mannitol are distributed in all or most of the cell water, but these sugars diffuse at different rates. In cut preparations insulin increases the rate of equilibration of D-galactose and D-xylose without significant effect on the other sugars studied; insulin also exerts a "directive" influence on glycogen synthesis from glucose, which cannot be explained solely in terms of accelerated sugar penetration. The significance of these observations in elucidating the locus of insulin action is discussed.

Abscess↗