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At least 91 records · Page 5Linked to original sources

Influence of water immersion, water gymnastics and swimming on cardiac output in patients with heart failure.

BACKGROUND: Whole-body water immersion leads to a significant shift of blood from the periphery to the intrathoracic circulation, followed by an increase in central venous pressure and heart volume. In patients with severely reduced left ventricular function, this hydrostatically induced volume shift might overstrain the cardiovascular adaptive mechanisms and lead to cardiac decompensation. AIM: To assess the haemodynamic response to water immersion, gymnastics and swimming in patients with chronic heart failure (CHF). METHODS: 10 patients with compensated CHF (62.9 (6.3) years, ejection fraction 31.5% (4.1%), peak oxygen consumption (Vo(2)) 19.4 (2.8) ml/kg/min), 10 patients with coronary artery disease (CAD) but preserved left ventricular function (57.2 (5.6) years, ejection fraction 63.9% (5.5%), peak Vo(2) 28 (6.3) ml/kg/min), and 10 healthy controls (32.8 (7.2) years, peak Vo(2) 45.6 (6) ml/kg/min) were examined. Haemodynamic response to thermoneutral (32 degrees C) water immersion and exercise was measured using a non-invasive foreign gas rebreathing method during stepwise water immersion, water gymnastics and swimming. RESULTS: Water immersion up to the chest increased cardiac index by 19% in controls, by 21% in patients with CAD and by 16% in patients with CHF. Although some patients with CHF showed a decrease of stroke volume during immersion, all subjects were able to increase cardiac index (by 87% in healthy subjects, by 77% in patients with CAD and by 53% in patients with CHF). Vo(2) during swimming was 9.7 (3.3) ml/kg/min in patients with CHF, 12.4 (3.5) ml/kg/min in patients with CAD and 13.9 (4) ml/kg/min in controls. CONCLUSIONS: Patients with severely reduced left ventricular function but stable clinical conditions and a minimal peak Vo(2) of at least 15 ml/kg/min during a symptom-limited exercise stress test tolerate water immersion and swimming in thermoneutral water well. Although cardiac index and Vo(2) are lower than in patients with CAD with preserved left ventricular function and controls, these patients are able to increase cardiac index adequately during water immersion and swimming.

Adult↗

Intrapericardial denervation: responses to water immersion in rhesus monkeys.

Eleven anesthetized rhesus monkeys were used to study cardiovascular, renal, and endocrine alterations associated with 120 min of head-out water immersion. Five animals underwent complete intrapericardial denervation using the Randall technique, while the remaining six monkeys served as intact controls. Each animal was chronically instrumented with an electromagnetic flow probe on the ascending aorta, a strain gauge pressure transducer implanted in the apex of the left ventricle (LV), and electrocardiogram leads anchored to the chest wall and LV. During immersion, LV end-diastolic pressure, urine flow, glomerular filtration rate, sodium excretion, and circulating atrial natriuretic peptide (ANP) each increased (P < 0.05) for intact and denervated monkeys. There were no alterations in free water clearance in either group during immersion, yet fractional excretion of free water increased (P < 0.05) in the intact monkeys. Plasma renin activity (PRA) decreased (P < 0.05) during immersion in intact monkeys but not the denervated animals. Plasma vasopressin (PVP) concentration decreased (P < 0.05) during the first 30 min of immersion in both groups but was not distinguishable from control by 60 min of immersion in denervated monkeys. These data demonstrate that complete cardiac denervation does not block the rise in plasma ANP or prevent the natriuresis associated with head-out water immersion. The suppression of PVP during the first minutes of immersion after complete cardiac denervation suggests that extracardiac sensing mechanisms associated with the induced fluid shifts may be responsible for the findings.

Animals↗

Osmoregulation and interstitial fluid pressure changes in humans during water immersion.

The aim of the present study was to determine the magnitude and direction of the shift of body fluids during water immersion of humans to the neck. Five healthy male subjects were studied lying in air for 1.5 h, sitting in 34 degrees C water to the neck for 1 h, and again lying in air for 1.5 h in two sets of experiments. For the first set, vasopressin (0.75 IU, sc) was injected before immersion. Blood and urine samples were drawn every 30 min in air and every 20 min in water. Urinary sodium, potassium, and osmolal clearances were significantly increased during immersion. When the mean maximum change during immersion was calculated for five subjects hematocrit fell by 1.1 U, plasma concentrations of sodium by 3.9 meq/l, chloride by 3.5 meq/l, potassium by 0.2 meq/l, osmolality by 7.9 mosmol/kg H2O, and proteins by 0.25 g/100 ml, whereas total plasma CO2 content increased by 1.33 mmol/l, threonine by 11.6%, proline by 9.0%, methionine by 14.0%, and alanine by 29%. Plasma volume increased 6.1%, and red blood cell volume calculated from hematocrit and hemoglobin increased 3.5%. In the second set of immersion experiments, without vasopressin injection, interstitial fluid pressures were measured with a cotton wick in PE-50 tubing inserted subcutaneously. A mean interstitial fluid pressure of -0.5 cmH2O was observed when the subjects were lying in air. Interstitial fluid pressure had started to decrease by 20 min of immersion, with a maximum decrease during immersion averaging 2.10 cmH2O. We conclude that hyposmotic fluid is mobilized into the blood from interstitial and other extravascular spaces during immersion.

Amino Acids↗

Plasma atrial natriuretic peptide and natriuretic response to water immersion in patients with nephrotic syndrome.

Eight nonnatriuretic (daily Na excretion less than 50 mEq), 4 natriuretic (daily Na excretion greater than 50 mEq), and 4 steroid-responsive nephrotic patients, and 12 normal controls were studied with a 4-hour water immersion with measurements of electrolytes, plasma atrial natriuretic peptide (ANP), plasma renin activity (PRA), and plasma aldosterone (PA) [corrected]. Four nonnatriuretic patients further received 25 g albumin infusion, with a subsequent 2-hour water immersion study. The results are as follows: (1) In the nonnatriuretic patients, the extremely low basal Na excretion rate, high PRA, and PA levels indicated a state of active Na retention. In spite of the water-immersion induced suppression of PRA and PA and a comparable magnitude of plasma ANP increment, the natriuretic response to water immersion was blunted in the nonnatriuretic patients. (2) In the natriuretic patients, water immersion resulted in a similar magnitude of natriuresis but a higher degree of plasma ANP increment in comparison to the normal controls. (3) Natriuretic and plasma ANP responses to water immersion were not different between the steroid-responsive patients and normal controls. (4) The increase in plasma ANP and the suppression of PRA and PA after 25 g albumin infusion did not result in natriuresis until the further suppression of PRA and PA and the further stimulation of plasma ANP by subsequent water immersion. The above results indicate that the natriuretic and plasma ANP responses to water immersion are related to the basal Na status in nephrotic patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Immersion autometallography: histochemical in situ capturing of zinc ions in catalytic zinc-sulfur nanocrystals.

In the mid-1980s, two versions of Timm's original immersion sulfide silver method were published. The authors used immersion of tissue in a sulfide solution as opposed to Timm, who used immersion of tissue blocks in hydrogen sulfide-bubbled alcohol. The autometallography staining resulting from the "sulfide only immersion" was not particularly impressive, but the significance of this return to an old approach became obvious when Wenzel and co-workers presented their approach in connection with introduction by the Palmiter group of zinc transporter 3 (ZnT3). The Wenzel/Palmiter pictures are the first high-resolution, high-quality pictures taken from tissues in which free and loosely bound zinc ions have been captured in zinc-sulfur nanocrystals by immersion. The trick was to place formalin-fixed blocks of mouse brains in a solution containing 3% glutaraldehyde and 0.1% sodium sulfide, ingredients used for transcardial perfusion in the zinc-specific NeoTimm method. That the NeoTimm technique results in silver enhancement of zinc-sulfur nanocrystals has been proved by proton-induced X-ray multielement analyses (PIXE) and in vivo chelation with diethyldithiocarbamate (DEDTC). The aims of the present study were (a) to make the immersion-based capturing of zinc ions in zinc-sulfur nanocrystals work directly on sections and slices of fixed brain tissue, (b) to work out protocols that ensure zinc specificity and optimal quality of the staining, (c) to apply "immersion autometallography" (iZnSAMG) to other tissues that contain zinc-enriched (ZEN) cells, and (d) to make the immersion approach work on unfixed fresh tissue.

Animals↗

Head-out immersion in the non-human primate: a model of cardiovascular deconditioning during microgravity.

BACKGROUND: Orthostatic intolerance is a common complication associated with spaceflight. It has been speculated that this is due to changes in blood volume and alterations in cardiovascular reflexes. The objective of the current study was to develop a model that would allow us to study the cardiovascular system and the regulation of blood volume during short-term microgravity exposure in the primate with the intent of eventually being able to elucidate those factors responsible for the orthostatic intolerance. HYPOTHESIS: Head-out water immersion in the conscious non-human primate simulates the cardiovascular and volume regulatory responses observed in astronauts during exposure to microgravity. METHODS: Four monkeys were chronically instrumented for measuring BP and heart rate and then conditioned to the primate restraint chair. They were then subjected to 72 h of head-out water immersion (two immersions in three monkeys and one immersion in the fourth) in order to simulate the cardiovascular and renal effects of the microgravity environment. RESULTS: During the immersion, there was an increase in arterial BP (ABP) and central venous pressure (CVP) and a reflex decrease in heart rate (HR). Urine flow (UV) increased and water intake decreased, producing a negative water balance. This was not associated with an alteration in food intake. CVP and UV decreased following de-immersion. There was also resetting of the arterial baroreflex control of HR. Significant tachycardia occurred after the immersion that was associated with a decrease in ABP. CONCLUSION: These results are similar to those observed in astronauts during and after spaceflight, suggesting that head-out water immersion of the non-human primate provides a good model for studying cardiovascular and renal adaptations to spaceflight.

Animals↗

Effects of water immersion on pulmonary function in asthmatics.

Immersion induces air trapping in the lungs, as does asthma. Consequently, when using diving apparatus, asthmatics may face greater risk than non-asthmatics of pulmonary barotrauma (PBT) during ascent. We studied the pulmonary airflows and closing capacities (CC = closing volume + residual volume) in subjects with exercise-induced asthma (A, n = 12) and in healthy controls (C, n = 11) under four conditions: dry and immersed, both before and after exercise (treadmill running, non-immersed). Immersed, both C and A had significant and equivalent reductions in vital capacity, FEV1, FEV1/FVC, and FEF25%-75%. Post-exercise and immersed, pulmonary airflows deteriorated further in A but were better in C: FEV1 (A, 3.6 +/- 0.8 liter vs. 3.3 +/- 0.8 liter, P = 0.001; C, 3.9 +/- 0.5 liter vs. 4.1 +/- 0.6 liter, P = 0.006), FEF25-75% (A, 3.5 +/- 1.0 liter x s(-1) vs. 3.0 +/- 0.8 liter x s(-1). P < 0.05; C, 4.0 +/- 0.9 liter x s(-1) vs. 4.3 +/- 0.9 liter x s(-1), P < 0.05). Therefore, in contrast to C, A subjects had reduced pulmonary airflows during immersion after exercise. Furthermore, A subjects more often had no closing volume phase IV when immersed after exercise than C (P = 0.005). Interpreting the absence of phase IV as indicative of more air trapping in the asthmatics during immersion after exercise would be consistent with the reductions in airflow.

Adult↗

Changes in manual dexterity following short-term hand and forearm immersion in 10 degrees C water.

BACKGROUND: Following accidental immersion in cold water, the chance of survival through the initial short-term period may depend on manual dexterity for survival tasks. We aimed to study the time course of impairment of manual dexterity during the initial stages of immersion. METHODS: We investigated gross (manipulating harness buckles) and fine (Purdue Pegboard Assembly) manual dexterity of 11 male and 15 female subjects with either no immersion (Control) or after immersion of right and left hand and forearm in 10 degrees C water for 30, 120, and 300 s. Exposure lengths were presented in a counter-balanced order in a single session. RESULTS: Mean local skin temperature decreased significantly with cold-water immersion, with the amount of cooling proportional to the length of exposure. Buckle test times increased significantly from 9.1 +/- 3.0 s during Control to similar values of 19.5 +/- 11.1 s and 18.14 +/- 12.1 s after 120 and 300 s of immersion. Pegboard scores were significantly lower at 40.2 +/- 7.6 pieces following 300 s of immersion compared with Control and 30 s values of 49.0 +/- 6.4 and 47.2 +/- 6.9 pieces, respectively. CONCLUSIONS: It is concluded that fine and gross manual dexterity were rapidly and progressively impaired with short-term cold-water immersion. Therefore, efforts must be made to protect the hands/forearms from cold and to ensure survival equipment manipulation requires as little dexterity as possible.

Adolescent↗

Protection provided against the initial responses to cold immersion by a partial coverage wet suit.

The protection provided against the initial responses to cold water immersion by a partial coverage wet suit was assessed. Eighteen subjects performed three 2-min immersions into water at 5 degrees C. During each immersion, the subjects wore either: a) cotton overall, b) trunk and arms "wet" immersion suit, or c) "dry" immersion suit. Results showed that the dry suit provided significantly (p less than 0.05) greater protection against the initial cardiac and ventilatory responses to immersion than either the wet suit or cotton overall assemblies. The responses recorded in the wet suit were similar to, and in some cases did not differ from, the cotton overall. We conclude that immersion suit design and tests should consider all of the responses associated with accidental cold water immersion and not just those resulting in a fall in core temperature.

Adolescent↗

[Effect of immersion hypokinesia on the motor unit potentials of human muscles].

Ten test subjects were exposed to water immersion for 3 days. Extraterritorial potentials of low and high threshold motor units (LMU and HMU) of m. biceps brachii were measured using a specially designed multielectrode and an electromyograph. The results revealed substantial changes in LMUs. A significant decrease in the propagation rate of muscle potentials was observed in 9 out of 10 test subjects. The average propagation velocity of LMU potentials was 4.93 +/- 0.16 m/s before exposure, 4.12 +/- 0.07 m/s after a day of immersion and 4.29 +/- 0.09 m/s after three days of immersion, the mean decrease being 20% and 15%, respectively. The total duration of LMU potentials increased significantly during immersion, the increase making 17.5% after a day of immersion and 13% after three days of immersion. The total depolarized zone length diminished by 1.65 mm after a day of immersion and by 1.29 mm after three days of immersion. Conversely, this exposure produced no significant changes in HMU potentials. It can be assumed that the major cause of changes in LMU potentials is reduced muscle activity.

Action Potentials↗

Cardiac output by impedance cardiography during head-out water immersion.

This study was undertaken to ascertain the suitability of impedance cardiography for qualifying cardiac output during water immersion where the electrodes were wet. The cardiac output was compared during wet and dry immersion with the head above water by breath holding briefly at 3 lung volumes. For dry immersion, the subjects were protected from contacting water during immersion by enveloping the whole body in a thin plastic bag. For wet immersion, the subject went into the water wearing only trunks. Eleven healthy males served as subjects. Both basal thoracic impedance and the minimum rate of impedance change decreased during wet immersion. These changes were specific, which insignificantly influenced the computation of stroke volume as compared to dry immersion. Our results showed no statistical differences between wet and dry immersions, and between measurements made at total lung capacity functional residual capacity, or residual volume. It is concluded that impedance cardiography is applicable directly in wet conditions without having to protect the subject from getting wet.

Adult↗

[Adaptive effects of repeated immersion exposure on the human body].

The effect of intermittent immersion on orthostatic tolerance, fluid-electrolyte metabolism and neuromuscular system was investigated. Control and experimental immersions were used. Experimental immersion was preceded by 12-hour exposure to immersion at night for three times. Experimental immersion was accompanied by reduced renal excretion of fluid, sodium and potassium and normalization of the muscle tone. After experimental immersion orthostatic tolerance approached the control level. The difference in the physiological effects of control and experimental immersions seem to be associated with the capacity of the human body to adapt to immersion, if it is applied intermittently.

Adaptation, Physiological↗

Effects of short-term and prolonged immersion on the cardiovascular responses to exercise.

The primary purpose of this investigation was to examine the effects of water immersion in 35 degrees C water, per se, and the effects of 3 h of water immersion on the physiological responses to exercise. Experiments in air were conducted after 15 min of water immersion and after 3 h of water immersion. After each condition, exercises of 20%, 40%, 60%, 80%, and 100% of the subject's maximum oxygen consumption were performed on a cycle ergometer. Oxygen consumption (VO2), cardiac output, heart rate (HR), stroke volume, and blood pressure were determined. At submaximal workloads, no significant differences in the data were observed. The VO2 at the maximal workload after 3 h of immersion (3.32 +/- 0.15 L.min-1) was significantly higher than the value after 15 min of immersion (3.03 +/- 0.20 L.min-1). Both of these values were significantly lower than the value in air (3.83 +/- 0.30 L.min-1). The peak HR's were significantly higher after 3 h of immersion (167 +/- 2 b.min-1). These observations suggest that 3 h of immersion can cause alterations in the cardiovascular responses to maximal exercise; however, submaximal responses were unaffected.

Adult↗

Antigen uptake and immune responses after immersion vaccination.

Immersion vaccination is an effective and practical method for mass vaccination of fish and most commercial bacterins are currently administered by this method, even though the exact mechanisms of antigen uptake and protection still remain unknown. Immersion vaccination includes several delivery techniques including spray, direct immersion, hyperosmotic dip and flush exposure. Various factors have been shown to influence the uptake of antigen from a vaccine bath, such as the concentration of vaccine, the length of immersion time, size of the fish, stress, pH and salt concentration of the vaccine solution, the water temperature, anaesthetics, the use of adjuvants, and the physical state (particulate or soluble) of the antigen. Among these, the antigen concentration is the most important factor for antigen uptake and protection. Recently we found that the amount of antigen taken up is correlated with the length of immersion time in dilute vaccine solutions. Most authors have suggested the gills as the main site of antigen entry, but skin, lateral line and the gut have also been suggested. Our quantitative study has shown that the skin is the main site of antigen uptake and that there are no differences in rate of uptake between the lateral line and the remaining skin of the body surface. Not only phagocytes but also several types of epithelial cells are involved in antigen uptake. Cells involved in antigen uptake can be different depending on the physical state of the antigen and the site of antigen entry. In most trials with immersion vaccination, antibodies against pathogens are not detectable in the serum by micro-titration and, even when antibodies are found, the titre does not always correlate with protection. However, some authors have reported elevated specific antibody levels in the serum of fish vaccinated by immersion, and even that protection can be successfully conferred by transferring immune plasma. Thus, the role of humoral immunity on protection mechanisms after immersion vaccination has been controversial and potentially important roles for cell-mediated immunity or local immunity have been implicated.

Animals↗

Prevention of heat strain by immersing the hands and forearms in water.

The effectiveness of hand immersion in water at 10 degrees C, 20 degrees C and 30 degrees C as a technique for reducing heat strain in Royal Navy (RN) personnel has been investigated at the Institute of Naval Medicine (INM). Four subjects exercised at a moderate work rate, whilst wearing fire fighting clothing in an environmental chamber at 40 degrees C. The subjects reached heat strain safety limits within 45 minutes of commencing work at which point they rested in the heat for 30 minutes whilst they underwent one of four experimental conditions: without intervention (control); or with their hands immersed in water at 10 degrees C, 20 degrees C or 30 degrees C. The experiment was repeated on a further three days so that the subjects undertook each experimental condition in a balanced randomised order. During the control condition without hand immersion the subjects were unable to cool. Immersion of the hands in water (at 10 degrees C, 20 degrees C or 30 degrees C) significantly (P < 0.05) lowered body core (auditory canal) temperature within ten minutes. Assessing the effectiveness of this technique by the initial rates of core temperature reduction, revealed that immersion of the hands was more effective the colder the water. Following 20 minutes of hand immersion mean core temperature had dropped from 38.5C to: 36.9(standard deviation 0.19) degrees C, 37.3(0.18) degrees C, and 37.8(0.10) degrees C, in 10 degrees C, 20 degrees C and 30 degrees C water respectively. Cooling powers estimated from changes in mean body temperature were 334, 307 and 113 watts using 10 degrees C, 20 degrees C and 30 degrees C water respectively. These results indicate that hand immersion in water at a temperature of between 10 degrees C and 30 degrees C is an efficient means of cooling heat stressed personnel who have been exercising. This simple and effective technique may be applied to many industrial and military tasks to reduce heat strain, lower the risk of heat injury, and increase safe total work times in the heat. For the RN, hand immersion could be used in fire fighting, damage control and NBC operations where personnel alternately work and rest.

Adult↗

Linguistic status subsequent to childhood immersion injury.

The linguistic abilities of two groups of children who had been involved in immersion incidents are reported--one group at 12 months after the immersion incident (n = 25), and the second group at five years after the immersion incident (n = 9). The performances of the two experimental groups on standardized language tests were compared with the performances of appropriate control groups that were matched for age, sex and socioeconomic status. The speech and language skills of the 12-months post-immersion group and the matched control group were assessed by means of the sequenced inventory of communication development. Subjects who were assessed 12 months after the immersion injury scored significantly lower results than did control subjects on receptive and expressive language ages that were calculated as percentages of the chronological age. No differences in language scores were evident between the subjects who were at five years after the immersion incident and their control subjects as assessed by the test of language development--primary. The language abilities of the victims of an immersion incident were correlated with their neurological status at presentation to hospital. The results suggest a need to monitor the linguistic development of all children who present initially in a coma after an immersion incident. The need for a longitudinal study of the linguistic abilities of these children is indicated.

Child, Preschool↗

Radiological tele-immersion for next generation networks.

Since the acquisition of high-resolution three-dimensional patient images has become widespread, medical volumetric datasets (CT or MR) larger than 100 MB and encompassing more than 250 slices are common. It is important to make this patient-specific data quickly available and usable to many specialists at different geographical sites. Web-based systems have been developed to provide volume or surface rendering of medical data over networks with low fidelity, but these cannot adequately handle stereoscopic visualization or huge datasets. State-of-the-art virtual reality techniques and high speed networks have made it possible to create an environment for clinicians geographically distributed to immersively share these massive datasets in real-time. An object-oriented method for instantaneously importing medical volumetric data into Tele-Immersive environments has been developed at the Virtual Reality in Medicine Laboratory (VRMedLab) at the University of Illinois at Chicago (UIC). This networked-VR setup is based on LIMBO, an application framework or template that provides the basic capabilities of Tele-Immersion. We have developed a modular general purpose Tele-Immersion program that automatically combines 3D medical data with the methods for handling the data. For this purpose a DICOM loader for IRIS Performer has been developed. The loader was designed for SGI machines as a shared object, which is executed at LIMBO's runtime. The loader loads not only the selected DICOM dataset, but also methods for rendering, handling, and interacting with the data, bringing networked, real-time, stereoscopic interaction with radiological data to reality. Collaborative, interactive methods currently implemented in the loader include cutting planes and windowing. The Tele-Immersive environment has been tested on the UIC campus over an ATM network. We tested the environment with 3 nodes; one ImmersaDesk at the VRMedLab, one CAVE at the Electronic Visualization Laboratory (EVL) on east campus, and a CT scan machine in UIC Hospital. CT data was pulled directly from the scan machine to the Tele-Immersion server in our Laboratory, and then the data was synchronously distributed by our Onyx2 Rack server to all the VR setups. Instead of permitting medical volume visualization at one VR device, by combining teleconferencing, tele-presence, and virtual reality, the Tele-Immersive environment will enable geographically distributed clinicians to intuitively interact with the same medical volumetric models, point, gesture, converse, and see each other. This environment will bring together clinicians at different geographic locations to participate in Tele-Immersive consultation and collaboration.

Humans↗

The effect of hand immersion on body temperature when wearing impermeable clothing.

The effects of hand immersion on body temperature have been investigated in men wearing impermeable NBC clothing. Six men worked continuously at a rate of approximately 490 J. sec-1 in an environmental temperature of 30 degrees C. Each subject was permitted to rest for a period of 20 minutes when their aural temperature reached 37.5 degrees C, and again on reaching 38 degrees C, and for a third time on reaching 38.5 degrees C (three rest periods in total). Each subject completed three experimental conditions whereby, during the rest periods they either: a. Did not immerse their hands (control). b. Immersed both hands in a water bath set at 25 degrees C. c. Immersed both hands in water at 10 degrees C. Physiological measures of core temperature, skin temperature and heart rate were recorded at intervals throughout the experiment. Measures of mean aural temperature and mean skin temperature were significantly (P less than 0.05) reduced if hands were immersed during these rest periods, compared to non immersion. As a result, the total work time of subjects was extended when in the immersed conditions by some 10-20 minutes within the confines of the protocol. It is concluded that this technique of simple hand immersion may be effective in reducing heat stress where normal routes to heat loss are compromised.

Adult↗