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At least 91 records · Page 5Linked to original sources
PubMed2026

Genetic insights into the relationship between age at menarche and mental health-related phenotypes.

BACKGROUND: Multiple observational studies have reported associations between age at menarche (AAM) and mental health problems, yet their shared genetic architecture remains poorly characterized. METHODS: We leveraged genome-wide association study summary statistics for AAM and 15 mental health-related phenotypes. We conducted a multi-method integrative analysis encompassing linkage disequilibrium score regression, pleiotropic analysis under the composite null hypothesis, functional mapping and annotation, multi-marker analysis of genomic annotation, pathway enrichment, and bidirectional two-sample Mendelian randomization (MR) to explore shared genetic architecture and potential causal relationships. RESULTS: Our study identified significant genetic correlations between AAM and eight mental health-related phenotypes (miserableness, fed-up feelings, nervous feelings, ever thought that life is not worth living, ever self-harmed, depression, ever smoker, and age started smoking in former smokers). A total of 155 pleiotropic loci, 18 colocalized loci (e.g., 6q16.3), and 203 pleiotropic genes (e.g., LIN28B) were identified. These genes are expressed in multiple regions, including the cerebral cortex and hypothalamus, and are involved in various biological processes and signaling pathways. Additionally, MR analysis revealed causal associations between AAM and 5 mental health-related phenotypes (mood swings, miserableness, fed-up feelings, and age at which smokers started smoking in former/current smokers). CONCLUSIONS: Our study revealed extensive genetic associations between AAM and mental health-related phenotypes, and further explored the potential causal relationships between them. These findings enhance our understanding of the relationship from a genetic perspective and establish a foundation for future research to explore the biological pathways and environmental interactions contributing to these associations.

Genome-Wide Association Study↗
PubMed1977

Internal-external expectancy, maladjustment and psychotherapeutic intervention.

This paper reviewed research on the relationship between internal-external expectancy, maladjustment and psychotherapeutic intervention. The implications drawn from the studies reviewed were: (a) externality is related to poor psychological adjustment and (b) psychotherapy can be effectively utilized to modify expectancy.

Anxiety↗
PubMed1979

Locus of control and biofeedback: a review of the literature.

This paper first reviews studies which have investigated the efficacy of using locus of control orientation to predict performance in various modes of biofeedback. However, contradictory evidence and methodological problems make it impossible to draw any conclusions regarding the connection between internality-externality and biofeedback performance. Second, various attempts to modify externality through biofeedback treatment are reviewed. Although EMG feedback can apparently be used to shift locus of control in an internal direction, there are some major issues that need to be resolved. Of primary importance is the fact that the rationale for modifying externality is based on an unproven assumption that externality has a role in the causation of various undesirable behaviors. Also, as no follow-up testing has been done, there is no evidence that the EMG biofeedback causes relatively permanent, stable locus of control changes. If the shifts are only temporary, then its use as a modifier of externality is questionable.

Behavior↗
PubMed1979

A cognitive-behavioral versus nondirective group treatment program for opioid-addicted persons: an adjunct to methadone maintenance.

Fourteen methadone maintenance individuals participated in a 10-week program comparing the relative effectiveness of a cognitive-behavioral (CB) versus discussion-type (DISC) group in developing adaptive behavioral skills and self-evaluations. Posttreatment and follow-up results indicated that the CB group was significantly more successful than the DISC group in lowering reported levels of anxiety, depression, and situational non-assertiveness. These data are discussed in terms of a comprehensive, social rehabilitation program that involves multiple treatment techniques and measurement criteria.

Adult↗
PubMed1977

Gains and losses of vascular surgery patients.

Understanding the gains and losses experienced by the patient and his family aids in assessing the psychologic sequela of peripheral vascular surgery. Placing the patients' individual responses into the categories of: function, self-directiveness, self-definition, and future orientation offers a way to conceptualize the meaning of the illness to the patient. Factors such as physical mobility and integrity, self-concept and body image greatly influence the adaption process. Conceptually, these elements provide a framework upon which to base nursing intervention. Careful observation, skillful interviewing, and interpersonal support are appropriate nursing considerations when caring for the patient with peripheral vascular disease. The goal of adaption is a successful reintegration of the whole person,which comes from an acceptance of both gains and losses experienced in surviving peripheral vascular surgery.

Activities of Daily Living↗
PubMed1979

Assertiveness, locus of control and coping behaviors used to diminish tension.

To investigate how coping behaviors may be preconditioned by assertiveness and locus of control, a questionnaire was given to 133 undergraduates of whom 87% reported recent tension attributed mainly to academic pressures. From a list of 22 common coping reactions, the students were asked to check those they use to deal with their tensions. The coping responses were also correlated with scores on an assertiveness inventory (AES) and Rotter's Internal-External Locus of Control (I-E) Scale. Reliance on one's own initiatives and turning to significant others were the responses most frequently reported as reactions to tension while seeking professional help was ranked last. Male students more frequently reported using marijuana or seeking sexual comfort than females, while females more frequently reported dysfunctional reactions such as spending endless hours thinking about the problem. The AES correlated significantly with problem-solving approaches. The IE Scale showed internals more inclined to meditate; externals indicated a greater likelihood to seek professional help, fantasize, or drink alcohol.

Adaptation, Psychological↗