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At least 91 records · Page 5Linked to original sources
PubMed1992

[Effect of immunosuppressants FK506 and rapamycin on the function of progesterone receptor: protein "p59-HBI", intersection between immunology and endocrinology?].

In the absence of hormonal ligand, inactive, heterooligomeric, 8-10S steroid receptor complexes include a p59 protein (apparent M(r) approximately 59 kDa) bound to th heat shock protein hsp90 (apparent M(r) approximately 90 kDa), which itself binds to the ligand binding domain LBD of the receptor molecule, p59 is thus an hsp binding immunophilin HBI, which, through its interaction with a chaperone, may intervene in several cellular functions. We report that, in cell-free experiments at 0 degrees C, FK506 and rapamycin do not release p59 nor hsp90 from the 9.5S rabbit uterus progesterone receptor, suggesting that the binding of p59 to hsp90 does not interfere with the rotamase site of HBI. There is no "transformation/activation" of the receptor, but an up to 2 fold increase in progesterone agonist and antagonist binding to the receptor is observed. It is suggested that a functional interaction between HBI and receptor activity may be mediated by hsp90.

Animals↗
PubMed1991

[Dental treatment concepts on a point of intersection].

Dentists appear to plan the treatment of one and the same patient very differently. Each dentist uses both professional and relational concepts, but the differences in treatment plans are in this article just partially explained.

Dental Care↗
PubMedDate not supplied

Attention, the intersection of cost and quality in health care.

A method for assessing health care technology that models the demand on the clinician's attention exerted by patients' data (diagnostic and therapeutic) can provide a means for simultaneously reducing the cost and improving the quality of health care. The attentional demand exerted by patients' data can be measured by the amount of uncertainty in the data. Uncertainty can be expressed mathematically by the concept of entropy in information theory.

Health Services Needs and Demand↗
PubMed1990

[Fatal accidents at train intersections in Denmark].

Material was collected concerning fatal level-crossing accidents in Denmark during the period 1.1.1980 to 31.12.1987. The epidemiological and traumatic circumstances are illustrated. A total of 51 fatal level-crossing accidents occurred which corresponds to 1% of all the annual traffic deaths in Denmark. The majority of the accidents occurred in good weather conditions and between 12 noon and 3.59 pm. Single-person accidents constituted 75%. The majority of the persons killed belonged to the local population and were familiar with the local conditions. The majority of the accidents were the local conditions. The majority of the accidents were due to poor visual conditions and lack of attention. In level-crossings with a keeper, the commonest causes were blinding by the sun and fog. The majority of the accidents occurred in level-crossings marked by light and sound signals. The risk for accidents in these crossings is six times as great as in crossings with half barriers. Private cars were most frequently involved and the persons killed in these died of head and cerebral injuries because the train buffers hit them at head height. Derailing of the trains was only seen on three occasions where the obstructing vehicles were heavy lorries. The fact that more derailings did not occur must be due to the low rate of the trains in the railway sidings where the majority of accidents occurred. A few proposals are made for prophylactic measures.

Accidents, Traffic↗
PubMedDate not supplied

[Diagnostic usefulness of Ca 19-9 antigen in cancer of the pancreas and neoplasms of the pancreato-biliary intersection].

Antigen CA 19-9 was measured in the serum of a group of 16 patients with pancreatic cancer, in 19 patients with non-pancreatic gastrointestinal malignancies, and in 19 others with benign pancreatobiliary disease. The test showed a high sensitivity with a low specificity and a positive predictive value for diagnosis of pancreatic cancer when confronted with a group of controls that included both benign and malignant gastrointestinal disease. The low specificity was due to high CA 19-9 values in other gastrointestinal cancers, especially in carcinoma of the ampulla and the biliary tract. When the latter were added to the group of patients with pancreatic cancer, and the diagnostic accuracy of the test was re-evaluated, sensitivity, specificity and both positive and negative predictive values increased. Values of CA 19-9 over 100 U/ml are highly predictive of malignancy in patients with pancreato-biliary disease.

Adult↗
PubMedDate not supplied

[Clinico-angiographic indications for surgical intersection of the superficial temporal artery in patients with central chorioretinal dystrophy].

Clinical and angiographic assessment of the status of 28 patients with sclerotic central chorioretinal dystrophy, carried out before and after surgery, has revealed a discrepancy between the improved hemodynamics in the orbital artery and vascular coating and the clinical results of the operation. Analysis of the fluorescent angiograms of the fundus oculi has helped detect the patients with the 'dry' and pseudotumorous forms of the disease, for whom crossing the superficial temporal artery is indicated.

Adult↗