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At least 91 records · Page 5Linked to original sources
PubMed1997

Automatic construction of knowledge base from biological papers.

We designed a system that acquires domain specific knowledge from human written biological papers, and we call this system IFBP (Information Finding from Biological Papers). IFBP is divided into three phases, Information Retrieval (IR), Information Extraction (IE) and Dictionary Construction (DC). We propose a query modification method using automatically constructed thesaurus for IR and a statistical keyword prediction method for IE. A dictionary of domain specific terms, which is one of the central knowledge sources for the task of knowledge acquisition, is also constructed automatically in the DC phase. IFBP is currently used for constructing the Transcription Factor DataBase (TFDB) and shows good performance. Since the model of knowledge base construction that is adopted into IFBP is carried out entirely automatically, this system can be easily ported across domains.

Algorithms↗
PubMed2001

ARIANE: a mediation framework with health information sources.

OBJECTIVES: to design and implement mediators dedicated to access heterogeneous information sources in a homogeneous way. METHOD: processes translate a query into the syntax of a target source built thanks to the UMLS knowledge sources and a catalog of information sources. Communication services connect users with information sources at the point they deliver results. RESULTS: examples show the benefits healthcare professionals may found in searching information in this way. DISCUSSION: improvements on the current developments may be done according to the current architecture of ARIANE. Specially, the user interface should be easier to use than the present one.

Information Services↗
PubMed2000

Clinical effectiveness in the post-anaesthesia care unit: how nursing knowledge contributes to achieving intended patient outcomes.

Clinical effectiveness in the post-anaesthesia care unit: how nursing knowledge contributes to achieving intended patient outcomes This paper reports part of an ongoing study on how nursing knowledge develops in practice and influences patient outcomes. The practice focus is post-anaesthesia nursing, an area which has been under-represented in nursing research. A qualitative approach was used to explore narrative data, collected by in-depth interviews, with 32 experienced post-anaesthesia nurses. Data analysis and interpretation were informed by a phenomenological perspective consistent with a research focus on individual experiences. Interpretation of the narratives gave rise to a description of knowledge development which occurred as nurses gained experience, drew on the available knowledge base, and used knowledge in practice. This led to the identification and description of 'referential' and 'effective' types of knowledge. Referential knowledge comprises the variety of external knowledge sources available to inform practice. When referential knowledge was incorporated into the personal knowledge of the individual nurse in everyday practice, it was transformed into effective knowledge which was used by nurses to achieve desired patient outcomes. The study findings indicate that nurses used effective knowledge as evidence for decision making and interventions in everyday practice. The key finding of the study is that effective nursing knowledge requires practice for its development.

Anesthesia↗
PubMed2001

Integration of clinical practice guidelines into a distributed regional electronic patient record for tumour-patients using XML: a means for standardization of the treatment processes.

With the rising efforts to guarantee a high quality treatment in medicine and to reduce the costs in the health care system, Clinical Practice Guidelines (CPG) have developed into a very important reference in medicine. CPGs are especially useful for the standardization of multi-professional treatment processes like the care for patients with malignant diseases. The Tumour-Centre Heidelberg/Mannheim (Germany) leads a project to build up a regional, virtual distributed Electronic Patient Record (EPR) for patients with malignant diseases in the Rhein-Neckar-Area. Aims of the first stages of the project are the introduction of the distributed EPR to two co-operating pilot-clinics. In this context we intend to provide access for medical professionals not only to the data of the jointly treated patients, but also to relevant existing CPGs and other medical knowledge sources like Medline and Cochrane-Library. Knowledge and Patient data should be interlinked to offer patient-specific views on the CPG-information. As all professions have different information needs, this views should be presented individualized according to the demands of the users. We analysed three relevant CPGs and defined a meta-structure that will be refined to a common meta-structure for CPGs in Oncology. CPGs as well as structured patient-documents will be implemented in the Extensible Markup Language (XML), as this platform-independent technology seems to suit our needs for data exchange and presentation purposes best. The implementation process will be accompanied tightly with evaluations to gain experience for further expansions of the EPR. The vision of the project is, that by integrating CPGs in a shared distributed EPR, the way towards standardized treatment processes in a local, but multi-professional setting, and the efforts to guarantee a high quality treatment in Oncology can sufficiently be supported.

Computer Communication Networks↗
PubMed1999

Anatomy atlases.

Anatomy atlases are unlike other knowledge sources in the health sciences in that they communicate knowledge through annotated images without the support of narrative text. An analysis of the knowledge component represented by images and the history of anatomy atlases suggest some distinctions that should be made between atlas and textbook illustrations. Textbook and atlas should synergistically promote the generation of a mental model of anatomy. The objective of such a model is to support anatomical reasoning and thereby replace memorization of anatomical facts. Criteria are suggested for selecting anatomy texts and atlases that complement one another, and the advantages and disadvantages of hard copy and computer-based anatomy atlases are considered.

Anatomy↗
PubMed1995

HIV-related knowledge and risk behaviors of street youth in Belo Horizonte, Brazil. The Street Youth Study Group.

Individual interviews were conducted with 379 youth who work and/or live on the streets of a large Brazilian city to assess HIV-related knowledge, sources of information, risk behaviors, and prevention beliefs and strategies. Respondents demonstrated high levels of factual knowledge about HIV transmission (84% correct) coupled with high levels of misconceptions about casual transmission (53% correct) and intermediate levels of knowledge about prevention (64% correct). Only 54% of the respondents had heard about AIDS recently, and 37.5% said they talked to someone about AIDS. The most common sources of information about HIV/AIDS were the mass-media and friends. Over half the sample reported taking precautions to reduce their risk of HIV infection; however, the proportion of youth taking effective precautions was low. Among the 247 youth (65% of the sample) who had initiated sexual activity, lifetime condom use was reported by 18%, and condom use at last intercourse by 10%. Youth with higher levels of knowledge were more likely to report behavior changes to avoid HIV infection. These findings underscore the urgent need for prevention programs tailored to street youth in developing countries.

Acquired Immunodeficiency Syndrome↗
PubMed1993

Funding for research.

With the exception of pharmaceutical companies, all the funding organisations have a standard application and information form outlining the areas of research they wish to encourage and fund. Many of the organisations advertise nationally, indicating closing dates and contact numbers for further information. It is important to contact fund administrations to gain feedback on the direction of your project while it is still being drafted. This article has nominated just a few of the funding sources available to general practice related researchers. It is simply a matter of becoming familiar with the variety of sources and the types of projects that they fund. By applying only to common knowledge sources such as GPEP, researchers are ignoring the availability of alternate funding sources that may be even more appropriate to their project.

Australia↗
PubMed2000

Mediation services with health information sources.

OBJECTIVES: To design and implement mediators dedicated to access various kinds of information sources in the framework of the project ARIANE. METHOD: Mediators are dynamically built thanks to three components: pieces of knowledge issued from the UMLS knowledge sources and from a catalog of information sources, processes that translate a query into the syntax of a target source, and communication services provided by operating systems. RESULTS: A scenario details the complete mediation process with an indexed web site. CONCLUSION: This approach mixes knowledge and software engineering. It benefits from services provided by operating systems and allows scalability and reusability of software components.

Computer Communication Networks↗
PubMed1996

An expert system for the detection of cervical cancer cells using knowledge-based image analyzer.

Analyzing for abnormalities of cell images in the cervix uteri provides a basis for reducing deaths and morbidity from cervical cancer through detection of potentially cancerous cells, provision of prompt advice and opportunities for follow-up and treatments. However, cytopathology is usually based on subjective interpretation of morphological features. Arbitrary criteria have to be devised for their classifications. Subjective interpretations of such criteria are likely to result in diagnostic shifts and consequently disagreement occurs between different interpreters. This article presents a novel approach to the composition of segmentation and diagnosis processes for biomedical image analysis. A prototype expert system has been developed to provide an objective and reliable tool to gynaecologists. Special image analyzing techniques are used and a set of knowledge sources is designed. The expert system employs a robust control strategy which minimizes the amount of domain-specific control knowledge. It has been proved to work effectively in the detection of cervical cancer.

Artificial Intelligence↗
PubMed1998

A pragmatic implementation of medical temporal reasoning for clinical medicine.

In most development tools for knowledge-based systems object-property-value-triples are the basic ontological representation. We have extended this approach for temporal reasoning by replacing the values with time-objects. A time-object is a combination of a value with a time-point or a time-interval. By preserving the object-property-value-triples basic artificial intelligence techniques can be applied without modifications in the temporal case. The greater complexity of temporal inferences is compensated by a blackboard control architecture enabling small knowledge-sources. The control of the strategic reasoning is in accordance with the select and test model. A prototype of a knowledge-based advisor for the acute radiation syndrome has been implemented and partially evaluated. Due to the affected proliferative tissues it is a strongly time-oriented medical domain.

Acute Disease↗
PubMed1998

Towards interoperability of information sources within a hospital Intranet.

Information is usually available in heterogeneous data format and various legacy sources. Interoperability appears to be a major approach for applications to access information. The project ARIANE is devoted to provide end-users with an easy to use and natural access to information databases. In this frame we defined actors able to operate the mediation between end-users and information servers: a "broker" which selects appropriate resources and "mediators" which access data suppliers. We have implemented a web-oriented stand-alone prototype accessing three types of information sources: a bibliographical server, a SQL database server and a hypertext server. Both broker and mediators exploit the Unified Medical Language System knowledge sources, especially the Information Sources Map which allows a way to identify information servers.

Computer Communication Networks↗
PubMed1999

Demographic and attitudinal variables related to high-risk behaviors in Asian males who have sex with other men.

Although AIDS is spreading rapidly in minority communities, little is known about attitudes, knowledge, and behavior related to AIDS and HIV in the Asian community. The purpose of this study was to examine these variables in a sample of gay Asian males, as well as to investigate the relationship between knowledge, sources of information, culturally influenced attitudes and high-risk behaviors in this population. Results from a sample of 60 young Asian men who self-identified as "having sex with other men" indicated they were generally knowledgeable about methods of transmission and prevention, and appeared linked to a large information network that included informal sources such as peers and formal sources. However, significant percentages held culturally biased views of AIDS, such as believing race of partner or one's own gender role in the sexual encounter determined level of risk; and one third of the sample did not use condoms regularly. Having been tested for HIV was associated with holding less traditional cultural beliefs and a higher sexual activity level. Open communication about safer sexual practices was associated with monogamous as opposed to multiple relationships and with decreased tendency to engage in alcohol-related unprotected sex. Variance in overall risk was predicted by demographic variables such as education, age, and level of sexual activity, rather than by the attitudinal factors measured. Limitations of this exploratory study include a time-limited subject recruitment period and consequent small sample size, a homogeneous sample weighted toward young, well-educated, and middle-class respondents, and the exclusion of non-English speaking individuals. Nevertheless, study findings suggest that educational outreach targeting Asians who have sex with other men needs to address inaccurate cultural beliefs about HIV/AIDS, emphasize consistent condom use, and encourage models of open communication with partners about safer sexual practices.

Adolescent↗
PubMed1994

Indexing guidelines: applications in use of pulmonary artery catheters and pressure ulcer prevention.

In a busy clinical environment, access to knowledge must be rapid and specific to the clinical query at hand. This requires indices which support easy navigation within a knowledge source. We have developed a computer-based tool for trouble-shooting pulmonary artery waveforms using a graphical index. Preliminary results of domain knowledge tests for a group of clinicians exposed to the system (N = 33) show a mean improvement on a 30-point test of 5.33 (p < 0.001) compared to a control group (N = 19) improvement of 0.47 (p = 0.61). Survey of the experimental group (N = 25) showed 84% (p = 0.001) found the system easy to use. We discuss lessons learned in indexing this domain area to computer-based indexing of guidelines for pressure ulcer prevention.

Abstracting and Indexing↗
PubMed2000

Using bioinformatics in gene and drug discovery.

Bioinformatics has, out of necessity, become a key aspect of drug discovery in the genomic revolution, contributing to both target discovery and target validation. The author describes the role that bioinformatics has played and will continue to play in response to the waves of genome-wide data sources that have become available to the industry, including expressed sequence tags, microbial genome sequences, model organism sequences, polymorphisms, gene expression data and proteomics. However, these knowledge sources must be intelligently integrated.

Journal Article↗
PubMed2001

Integrating local and scientific knowledge: an example in fisheries science.

Attempting to predict the spatial dynamics fish stocks, as required for management, is an ominous task given our incomplete understanding of biological and ecological mechanisms underpinning behavioral responses of fish. Large gaps still exist in our basic scientific knowledge. Nonetheless, the knowledge of fishers and fishery managers is not incorporated into our scientific analyses, even though such information is rich in observation since knowledge of fish behavior and distribution is a prerequisite for their profession. Combining such observations with more conventional scientific studies and theoretical interpretations provides a means by which we may bridge some gaps in our knowledge. Presented here is an example of how both local and scientific knowledge can be integrated in a heuristic model. The model, CLUPEX, is developed in the framework of a fuzzy logic expert system and uses linguistic statements written in natural language to capture and combine knowledge sources in the form of IF... THEN rules. The rules are inferred from interviews with experts and fishery professionals including fishers, fishery managers, scientists, and First Nations people. The knowledge base, comprised of the set of rules, is flexible in the sense that it can easily be modified to add additional information or change current information. Using input pertaining to biotic and abiotic environmental conditions, CLUPEX uses the rules to provide quantitative and qualitative predictions on the structure, dynamics and mesoscale distribution of shoals of migratory adult herring during different life stages of their annual life cycle.

Animals↗
PubMed2000

Comparison of two knowledge bases on the detection of drug-drug interactions.

This paper describes a drug ordering decision support system that helps with the prevention of adverse drug events by detecting drug-drug interactions in drug orders. The architecture of the system was devised in order to facilitate its use attached to physician order entry systems. The described model focuses in issues related to knowledge base maintenance and integration with external systems. Finally, a retrospective study was performed. Two knowledge bases, developed by different academic centers, were used to detect drug-drug interactions in a dataset with 37,237 drug prescriptions. The study concludes that the proposed knowledge base architecture enables content from other knowledge sources to be easily transferred and adapted to its structure. The study also suggests a method that can be used on the evaluation and refinement of the content of drug knowledge bases.

Artificial Intelligence↗
PubMed2001

Long-term working memory in text production.

In reading and other high-level cognitive tasks, Ericsson and Kintsch (1995) proposed that the limited capacity of short-term working memory (STWM) is supplemented by long- term working memory (LTWM) for individuals with a high degree of domain-specific knowledge. In Experiment 1, college students (N = 80) wrote persuasive and narrative texts concerning baseball; domain-specific knowledge about baseball and verbal ability was assessed. The results showed that verbal ability and domain-specific knowledge independently affected writing skill, supporting the view that literacy depends on both knowledge sources and refuting one argument raised in support of the LTWM hypothesis. Experiment 2 (N = 42) replicated this outcome and tested the prediction that a high degree of domain-specific knowledge would lessen interference on a secondary task. The data supported the interference prediction, offering evidence that LTWM plays a role in the production of text.

Adult↗