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[The molecular genetic and biological aspects of the ecology of pathogenic Leptospira (Leptospira interrogans)].

The results of recent investigations on the application of some genotyping methods (genomic fingerprinting, analysis of restriction length fragment polymorphism of DNA, etc.), made in order to study the population structure of pathogenic leptospires and to evaluate their intraspecies heterogeneity with regard to their main ecological features, are reviewed. New data on the use of PRC-based amplification test systems for the study of specific features of host persistence of leptospires are presented. The relative role of the parasitic and saprophytic phases of existence for populations of pathogenic leptospires belonging to different intraspecies taxa is discussed.

Animals↗
PubMed2006

Development of species-specific PCR primer sets for the detection of Leptospira.

Spirochetes of the genus Leptospira infect animals and humans and are the causative agents for the emerging infectious disease leptospirosis. Rapid and simple assays for the identification of individual Leptospira species are currently not available. For identification of individual Leptospira species, PCR primers that detect the ompL1 gene sequence for the majority of pathogenic leptospires were developed in this study. The primer pairs detect Leptospira interrogans, Leptospira borgpetersenii, Leptospira kirschneri, Leptospira santarosai, Leptospira weilii and Leptospira noguchii, without cross-reacting with other Leptospira species. The development of the primers revealed a divergence of the ompL1 gene within L. interrogans, splitting this species into two separate groups. The species-specific primers will be especially useful in epidemiological studies and disease outbreak investigations for the detection of Leptospira species in human, animal and environmental samples.

Bacterial Outer Membrane Proteins↗