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Results for “LIPID METABOLISM”

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At least 91 records · Page 5Linked to original sources
PubMed2004

Effects of soybean beta-conglycinin on hepatic lipid metabolism and fecal lipid excretion in normal adult rats.

beta-Conglycinin decreased blood triacylglycerol (TAG) levels in male Wistar adult rats. Liver mitochondrial carnitine palmitoyltransferase activity in the beta-conglycinin-fed group significantly increased as against the casein-fed group. Hepatic fatty acid synthase activity in the beta-conglycinin group significantly decreased as against that of the casein-fed group. Fecal fatty acid excretion in the beta-conglycinin group was significantly higher than in the casein group.

Animals↗
PubMed1995

Lipid metabolism.

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Lipid Metabolism↗
PubMed1994

Lipid metabolism.

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Lipid Metabolism↗
PubMedDate not supplied

[Effect of pregnancy on maternal carbohydrate and lipid metabolism. II: Changes in lipid and carbohydrate metabolism as well as hormonal changes following intravenous glucose administration].

The following parameters of glucose biokinetics in pregnancy, in which the behavior of the glucose in the steady state is described, were investigated mathematically following short-term disturbance of the steady state of the maternal metabolism by intravenous administration of glucose. The glucose assimilation coefficient (KG) is unchanged in pregnancy. However, both during pregnancy and post partum (2.30; 2.20; 2.36; 1.79 [%/min]), the values are higher than in the non-pregnant control group (1.2%/min). Analogously to these findings, the glucose distribution space increases during pregnancy from 13 liters to 16.3 liters, decreasing post partum to 13.4 liters. The easily exchangeable glucose pool, i.e., the quantity available for assimilation in the distribution space, is unchanged during pregnancy; nor is there any change as compared to the non-pregnant and postpartal control groups. Glucose transfer, i.e., the glucose quantity which enters or leaves the pool per unit of time, is increased during pregnancy (0.45; 0.444; 0.47 [g/kg/h]) as compared to the non-pregnant and postpartal controls (0.25; 0.35 [g/kg/h]). The findings above indicate that the maternal glucose metabolism is increased during pregnancy. Owing to the lipolytic effect of HPL, the mother is obliged to meet a portion of her energy requirements from the lipid metabolism, so that there is enough glucose available for the fetus. HPL appears to develop this glucose-saving effect doubly.(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Glucose↗
PubMed2006

[Peculiarities of lipid metabolism during pregnancy].

More than 200 mln women become pregnant every year. In most cases outcome of labor is successful. The hormonal status changes during pregnancy initiate various adaptive mechanisms. Among them is "switch" of the energetic metabolism to lipid metabolism. It undergoes essential changes. The aim of our investigation was to study the peculiarities of lipid metabolism during pregnancy. 30 pregnant patients have been investigated based on 2 stage dynamics: I stage--pregnancy period=13.0+/-1.4 weeks; II stage--pregnancy period=35.7+/-0.5 weeks. Total cholesterol, HDL, LDL, triglycerides, VLDL and Index of atherogenic risk have been measured by biochemical analysis. The parameters of lipid metabolism became significantly impaired, except HDL (40.0+/-5.8 vs. 57.5+/-9.4 mg/dl), which increased significantly. They revealed significant both direct and inverse correlations with sex hormones. Obtained results point to the body's adaptive mechanisms expressed in the increase of antiatherogenic fraction of total cholesterol; and the influence of sex hormones as well. With the increase of period of pregnancy physiological dyslipidemia became worse, which might be metabolic basis for the development of "prestage" of gall-stone--cholestasis of gall-bladder.

Cholesterol, VLDL↗
PubMed1981

[Biochemical changes in vinyl chloride poisoning. I. Effect of different conditions of vinyl chloride exposure on lipid metabolism in rats].

Lipids metabolism was evaluated in rats chronically exposed to vinyl chloride concentrations of 50, 500 and 20 000 ppm. The studies involved: 1) estimation of lipids content in serum; 2) estimation of cholesterol and triglycerides content in some tissues (liver, muscles, connective tissue, aortic wall), 3) evaluation of the rate of incorporating 14C-acetate into 14C-cholesterol in liver and the rate of its transition into blood. The studies were carried out after 1, 3, 6 and 10 months of vinyl chloride exposure. The results prove that under effects of vinyl chloride exposure some tendencies of an increase in the total and esterified cholesterol in serum vary with the magnitude of exposure (vinyl chloride airborne concentration, intoxication time). As to triglycerides and phospholipids at the final phase of intoxication (after 10 months) a significant increase in their serum content is found at the 20 000 ppm. concentration, whereas there are no changes in the free fatty acids level. As to the examined tissue only in liver some tendencies are found of a decrease in cholesterol content and much greater decrease in triglycerides level, which is progressing with intoxication time and exposure magnitude. No effect of vinyl chloride on the level of lipids in muscles, aortic wall and connective tissue were found. Studies of cholesterol synthesis in liver showed some increase in the rate of building 14C-acetate into cholesterol only in two highest vinyl chloride concentrations (500 and 20 000 ppm) after 10 months of exposure. The results demonstrate that chronic vinyl chloride exposure only slightly affects lipid metabolism. The most significant changes occur only after 10 months of exposure at the concentration of 20 000 ppm. It is supposed that the disturbances in lipid metabolism have no important contribution to vinyl chloride poisonings pathology.

Animals↗
PubMedDate not supplied

The cornea and disorders of lipid metabolism.

Disorders of lipid metabolism, either hyperlipidemia or hypolipidemia, are associated with the formation of corneal opacities. Corneal arcus, the most commonly encountered peripheral corneal opacity, is frequently associated with abnormal serum lipid levels, but may occur without any predisposing factors. Reports also have linked corneal arcus with alcoholism, diabetes mellitus and atherosclerotic heart disease. Unilateral arcus is a rare entity that is associated with carotid artery disease or ocular hypotony. Diffuse corneal opacities associated with hypolipidemic disorders such as LCAT deficiency, fish eye disease and Tangier disease, may be the initial manifestation of these disorders and puts the ophthalmologist in a position to make an early diagnosis. Corneal arcus, along with a central corneal opacity, is seen in Schnyder's crystalline stromal distrophy. The association of the disorder with a dyslipidemia remains controversial. A review of lipid metabolism, corneal arcus and several disorders of lipid metabolism that affect the cornea are presented.

Alcoholism↗
PubMed2006

Hepatic gene expression profile of lipid metabolism in rats: Impact of caloric restriction and growth hormone/insulin-like growth factor-1 suppression.

We investigated the role of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis on caloric restriction (CR) using male wild-type and transgenic homozygous dwarf rats bearing an antisense GH transgene and their F1 heterozygous progeny fed either ad libitum or subjected to 30% CR. CR predominantly altered expression of hepatic genes involved in the stress response, xenobiotic metabolism, and lipid metabolism. Most gene expressions involved in stress response and xenobiotic metabolism were regulated in a GH/IGF-1-dependent manner, and those involved in lipid metabolism were regulated in a GH/IGF-1-independent manner. Moreover, CR enhanced the gene expression involved in fatty acid synthesis after feeding and those encoding mitochondrial beta-oxidation enzymes during food shortage, probably via transcriptional regulation by peroxisome proliferator-activated receptor alpha. These results, taken together with serum biochemical measures and hepatic triglyceride content, suggest that CR promotes lipid utilization through hepatic transcriptional alteration and prevents hepatic steatosis in a GH/IGF-1-independent manner.

Animals↗
PubMed2003

Cellular lipid metabolism and the role of lipids in progressive renal disease.

Dyslipidemia contributes to the rate of progression of atherosclerosis and chronic kidney disease. Also, chronic kidney disease leads to the development of secondary abnormalities in lipid metabolism that contribute to increased cardiovascular morbidity and mortality. This review presents the mechanisms that underlie this risk. The mechanisms of normal cellular lipid metabolism and the abnormalities that develop in association with inflammation are reviewed. There is a special emphasis on foam cells in the kidney and on lipid-mediated changes in intrinsic kidney cells that lead to glomerulosclerosis and interstitial fibrosis. Correlates to studies performed in whole animals and humans are included.

Animals↗
PubMedDate not supplied

The hair levels of unsaturated fatty acids (oleic, linoleic, and linolenic) indicators of the lipid metabolic balance.

The lipid metabolism was evaluated using a new method for assay of the hair contents in unsaturated fatty acids. Determinations in various hair segments and in the blood serum were performed before and after a hypolipemic diet and drug therapy in hypercholesterolemic patients in comparison with a control group. The correlation factors between the levels of the oleic, linoleic and linolenic acids in the serum and those in the hair were +0.967, +0.987 and +0.992, respectively. The method provides information on the therapy influence on the lipid metabolism variations within several weeks or months.

Adult↗