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At least 91 records · Page 5Linked to original sources
PubMed1984

Effects of desipramine on clinical liver function tests.

Results of liver function tests in 46 depressed patients changed little during treatment with desipramine and were uncorrelated with drug plasma levels. The findings suggest that tricyclic-associated hepatitis, rather than being dose dependent, is an uncommon, idiosyncratic phenomenon.

Adult↗
PubMed1999

[Importance of determination of monoethylglycinexylidide (MEGX)--as a liver function test in hepatology and liver transplantation].

Intravenously administered lidocaine is rapidly metabolised in the liver biotransformation enzyme system through oxidative N-deethylation with cytochrome P-450, accompanied by production of monoethylglycinexylide (MEGX). Changes of the activity and capacity of this sensitive system in liver diseases are expressed in disturbed metabolism of substances predominantly metabolised by this enzymatic system. Serum concentration of MEGX--a lidocaine metabolite--reflects the disturbance of liver function. The degree of liver function disturbance correlates with the rate of MEGX concentration fall. Utilization of MEGX test in clinical practice is multiple. In patients with chronic liver diseases is the MEGX test an appropriate complementary test enabling the evaluation of liver functional state with prognostic value. In the field of transplantology it may be used in pretransplantation period for donor liver functional state evaluation and in posttransplantation term for monitoring the graft functional state. The test was used in similar manner in paediatric patients. MEGX test is an appropriate method for rapid estimation of functional liver capacity in actual period. It is a rapid, simple test, which represents a complementary method in hepatology and liver transplantation. MEGX is worldwide used in detection of the functional liver state in patients with various forms of liver diseases and in patients prior to and after liver transplantation. (Ref. 46.)

Animals↗
PubMedDate not supplied

Biochemical studies of apparently 'healthy' blood donors with reference to liver function tests and immunoglobulins.

Liver function tests and immunoglobulin features of apparently 'healthy' blood donors were studied. Twenty-one (9.5%) subjects with HBsAg were observed. These subjects were found to have significantly higher mean and standard deviation of total serum bilirubin, alanine and aspartate aminotransferase levels than those of a randomly selected HBsAg-negative group. Serum urea was significantly lower (p less than 0.01) in the HBsAg-positive cases. Total serum IgE (IU/ml) was significantly higher in the HBsAg-positive cases (p less than 0.01). Comparison of laboratory findings of these cases and active hepatitis HBsAg-positive subjects showed that there were more elevated abnormalities in the latter.

Adult↗
PubMed2004

Use of lidocaine metabolism to test liver function during the long-term follow-up of liver transplant recipients.

BACKGROUND/AIMS: The aim of this study was to assess the usefulness of the monoethylglycinexylidide (MEGX) test to monitoring the long-term function of liver allografts. METHODS: MEGX production was measured prospectively in 60 consecutive liver transplant recipients undergoing their annual review. RESULTS: Median MEGX values in liver recipients (54 ng/mL; range 10-146) were lower than those found in healthy controls (78 ng/mL; range 44-118). MEGX values correlated negatively with alanine aminotransferase (ALT) activity (p = 0.004) and with the overall histological score (p = 0.01), and positively with sulfobromophthalein (BSP) and indocyanine green (ICG) clearances (p = 0.0002 and p = 0.002, respectively). A stepwise decline was observed with worsening liver fibrosis, from 71 +/- 5 microg/L in patients with no fibrosis to 27 +/- 9 microg/L in patients with bridging fibrosis (p = 0.002). BSP and ICG clearances correlated more closely than the MEGX test with the overall histological score (p = 0.001 and p = 0.001, respectively) and portal fibrosis (p = 0.002 and p = 0.001). CONCLUSIONS: The measurement of MEGX formation is a simple and non-invasive method to monitor liver graft function. It may constitute a valuable tool for assessing the degree of fibrosis.

Adolescent↗
PubMed1986

Orthotopic liver transplantation in pigs without cold perfusion of the donor liver. Evaluation by quantitative liver function tests.

Orthotopic liver transplantation (OLT) was performed in 12 pigs and liver function assessed before and after transplantation. In 6 pigs OLT was carried out without cold perfusion of the donor liver, whereas in the other 6 animals the donor organ was perfused in situ. 5/6 animals without perfusion and 4/6 with cold perfusion survived for more than 10 days. Significantly better liver function was revealed by the aminopyrine breath test (ABT) and the indocyanine green (ICG) disappearance in the group with the cold perfusion of the liver, whereas no differences in routine liver function tests were seen between the two groups. Although OLT without cold perfusion of the donor liver is feasible and prolonged survival of animals is possible, the function of these organs is markedly reduced compared to the cold perfused organs. This method can, therefore, not be recommended. ABT and ICG disappearance are sensitive tests for the evaluation of the liver function in the post-transplant period.

Aminopyrine↗
PubMedDate not supplied

Correlation between cytochrome P-450 system and liver function tests during experimental liver transplantation.

The aims of this investigation are: 1) to assess the function of the hepatocyte in transplanted porcine liver, immediately after reperfusion, by monitoring both LFTs and the MEGX levels; 2) to search for correlation between MEGX and LFTS, in an effort to evaluate the metabolic mechanisms occurring in the early liver transplantation revascularization phase. The MEGX test was found to be less than 50 micrograms/ml in all the recipients and all the LFTS tested have been reported to be out the normal range. Furthermore our data has shown a statistically significant correlationship between the MEGX values and those of alkaline phosphatase and prothrombin and a highly significant correlationship with cholinesterase.

Animals↗
PubMed1990

Use of quantitative liver function tests--caffeine clearance and galactose elimination capacity--after orthotopic liver transplantation.

To establish the potential value of quantitative tests of liver function following orthotopic liver transplantation (OLT), a total of 100 determinations of caffeine clearance (CafCl) and galactose elimination capacity (GEC) were made in ten OLT recipients early in the post-operative course (days 2, 4, 6, 8 and 12) and later when clinically stable (3-12 months). Values were compared with a reference range in six normal volunteers in whom it was shown that the standard doses of caffeine (125 mg) and galactose (0.5 g per kg body weight) could be given together without interference. In orthotopic liver transplantation recipients initial GEC and CafCl measurements showed no correlation with peri-operative blood loss, donor ischaemia time, initial bile flow or survival. Throughout the early post-operative period, there were wide inter- and intra-individual variations in both CafCl (17-fold range from 0.16 to 2.7 ml.min-1.kg-1) and GEC (2.4-fold range from 5.1 to 12 mg.min-1.kg-1), but the only correlation of test values with standard liver function tests results was between GEC and gamma-glutamyltranspeptidase. However, GEC values fell by 19% during periods of acute rejection and there was an inverse correlation of GEC with white cell count probably related to sepsis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗