SEARCH · PubMed Health

Results for “Mainstreaming”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 91 records · Page 5Linked to original sources

PubMed2006

Gas chromatography/mass spectrometry versus liquid chromatography/fluorescence detection in the analysis of phenols in mainstream cigarette smoke.

A new gas chromatographic/mass spectrometric (GC/MS) technique for the analysis of hydroxybenzenes (phenols) in mainstream cigarette smoke has been developed. The technique allows the measurement of 24 individual compounds, and the sum of a few other alkyl-dihydroxybenzenes. A critical evaluation is done for the new technique and for an established high-performance liquid chromatographic (HPLC) technique reported in the literature for the analysis of hydroxybenzenes in cigarette smoke, which uses fluorescence detection. Compared with the HPLC procedure, the new technique has similar accuracy, precision, and robustness. However, the GC/MS procedure allows for a larger number of phenols to be analyzed simultaneously, and eliminates any potential interference that may appear in the HPLC method. Using the GC/MS analysis, it was found that besides the main phenols typically measured in mainstream cigarette smoke such as phenol, catechol, hydroquinone, and cresols, many other phenols that are present at lower levels can be quantitated in mainstream cigarette smoke.

Ascorbic Acid↗

PubMed2006

Uncovering differences across the cancer control continuum: a comparison of ethnic and mainstream cancer newspaper stories.

OBJECTIVE: The use of the news media to disseminate control research could play a pivotal role in reducing the cancer burden. An important first step is to understand how newspapers cover cancer and if differences exist between mainstream and ethnic newspapers. METHODS: Cancer news in the major U.S. (MAJN) (N=5327) and ethnic (ENW) newspapers (N=565) appearing in 2003 were content analyzed. Comparisons of mainstream and ethnic newspapers utilized Pearson x(2) tests of two-sided statistical significance and independent samples t tests for interval-level variables. RESULTS: Breast cancer dominated coverage: 27% of MAJN and 35% of ENW stories mentioned breast cancer. Coverage focused primarily on cancer treatment (MAJN: 60%; ENW: 52%) rather than on primary or secondary prevention. Compared to mainstream newspapers, the ethnic newspapers required lower literacy levels for understanding news stories, were substantially more likely to cover primary and secondary cancer prevention, and paid more attention to cancer awareness and education. CONCLUSIONS: The ethnic media are a promising vehicle for dissemination of cancer control messages. However, the successful utilization of any U.S. newspaper as a dissemination mechanism requires a greater understanding of the root causes for imbalances in cancer coverage and work with journalists to reframe cancer news coverage.

Awareness↗

PubMed2004

Mainstream smoke constituent yields and predicting relationships from a worldwide market sample of cigarette brands: ISO smoking conditions.

The study objective is evaluation of a benchmark approach for predicting mainstream smoke constituent machine-yields for conventional cigarette brands from worldwide markets. Results for ISO smoke yields support the validity of benchmarking when brands, for which yields are to be predicted, have design characteristics within boundaries established by the exploratory brands. Yields of ISO-method mainstream smoke constituents were generally well described by weighted least squares regression relationships with ISO tar (R2>0.80 and coefficient p values <0.05). The impact of the varied chemical composition of cigarette tobaccos from different regions on smoke constituent yields was recognized. Mainstream smoke nitrogen oxides and tobacco-specific nitrosamine (TSNA) yield prediction relationships improved by including tobacco nitrate or TSNA concentration factors in respective independent parameters. For carbon-filter brands, inclusion of a carbon factor improved the predicting relationships for several vapor-phase constituents. Relationships were validated with a subset of additional validation brands. Greater than 90% of the validation brands' smoke chemistry yields were within the 95% prediction intervals. Average differences between measured and predicted yields were generally within the range of one to two measurement standard deviations. The estimation methods proposed relate to machine-smoking conditions and are not intended to reflect the actual exposure of any given consumer to smoke constituents.

Benchmarking↗

PubMed2005

Language use of older Italian-background persons with dementia in mainstream and ethno-specific residential care.

BACKGROUND: Australia has a growing aging migrant population and rates of dementia in residential care are high. The communication of persons with dementia and limited English language proficiency in residential care is an area that has received little attention in the research literature. METHOD: Thirty-nine Italian-background older persons with severe dementia residing in either mainstream (n = 20) or Italian-specific (n = 19) aged care facilities were observed and language use was recorded. Medication regime and language proficiency information was obtained. RESULTS: Participants in mainstream facilities engaged in less communication with co-residents and were prescribed daytime benzodiazepines at a higher rate than those in Italian-specific facilities. CONCLUSIONS: Older persons in mainstream facilities with dementia and lower levels of English proficiency may benefit from additional language-relevant resources. The finding of higher prescription rate of daytime benzodiazepines requires further investigation.

Aged↗

PubMed2005

Development of a quantitative method for the analysis of tobacco-specific nitrosamines in mainstream cigarette smoke using isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry.

An improved method has been developed for the determination of the four major tobacco-specific nitrosamines (TSNA) in mainstream cigarette smoke. The new method offers decreased sample preparation and analysis time as compared to traditional methodologies. This method uses isotope dilution liquid chromatography coupled to a tandem mass spectrometer with electrospray ionization and is significantly more sensitive than traditional methods. It also shows no evidence of artifactual formation of TSNA. Sample concentrations were determined for four TSNA in mainstream smoke using two isotopically labeled TSNA analogues as internal standards. Mainstream smoke was collected on an industry standard 44-mm Cambridge filter pad, extracted with an aqueous buffer solution, and analyzed without further sample cleanup. This method has been validated through intra- and interlaboratory studies and has shown excellent recoveries, sensitivity, and repeatability. The limits of detection of each TSNA varied from 0.01 to 0.1 ng/mL, and the linear calibration range of the instrument in sample matrix spanned 0.5-200 ng/ mL, which allowed for the determination of the TSNA levels in cigarettes with a wide range of deliveries. Data are also reported from two commercially available industry reference cigarettes and show excellent agreement and reproducibility over a six-month time period (n > 50).

Artifacts↗

PubMed2004

Solid-phase microextraction-based approach to determine free-base nicotine in trapped mainstream cigarette smoke total particulate matter.

Characterizing nicotine delivery from tobacco products is important in the understanding of their addictive potential. Most previous studies report total nicotine and have not differentiated between nicotine in its protonated or free-base form. Rather than simply determining total nicotine, the method described in this paper determines the amount of free-base nicotine associated with trapped mainstream smoke particulate matter generated using a standardized smoking machine protocol. This method quantitatively determines volatile free-base nicotine associated with the particulate phase portion of mainstream cigarette smoke using solid-phase microextraction combined with gas chromatography-mass spectrometry. The headspace above total particulate matter from mainstream cigarette smoke trapped on a Cambridge filter pad (CFP) was analyzed for free-base nicotine in 26 cigarette brands. The selected cigarette brands were chosen to cover a wide range of tar and nicotine deliveries as measured under Federal Trade Commission machine smoking conditions. In the CFP's headspace the free-base nicotine levels ranged from 0.01 to 0.08 mg/cigarette. The measured ranges of free-base nicotine were remarkably similar over the different tar and nicotine delivery categories of full-flavored, light, and ultralight cigarette brands.

Gas Chromatography-Mass Spectrometry↗

PubMed2001

Does "mainstreaming" guarantee access to care for medicaid recipients with asthma?

OBJECTIVE: Recent reforms in the federal Medicaid program have attempted to integrate beneficiaries into the mainstream by providing them with managed care options. However, the effects of mainstreaming have not been systematically evaluated. DESIGN: Cross-sectional survey. SETTING/PARTICIPANTS: A sample of 478 adult, nonelderly asthmatics followed by a large Northern California medical group. MEASUREMENTS AND MAIN RESULTS: We examined differences in self-reported access by insurance status. Compared to patients with other forms of insurance, patients covered by the state's Medicaid program (Medi-Cal) were more likely to report access problems for asthma-related care, including difficulties in reaching a health care provider by telephone, obtaining a clinic appointment, and obtaining asthma medication. Adjusting for relevant clinical and sociodemographic variables, Medi-Cal patients were more likely to report at least one access problem compared to non-Medi-Cal patients (adjusted odds ratio [AOR], 3.34; 95% confidence interval [CI], 1.43 to 7.80). Patients reporting at least one access problem were also more likely to have made at least one asthma-related emergency department visit within the past year (AOR, 4.84; 95% CI, 2.41 to 9.72). Reported barriers to care did not translate into reduced patient satisfaction. CONCLUSIONS: Within this population of Medicaid patients, the provision of health insurance and care within the mainstream of an integrated health system was no guarantee of equal access as perceived by the patients themselves.

Adult↗

PubMed1977

Reentry: a study of the movement of young drug users toward mainstream society.

In the middle 1960s hundreds of thousands of young people dramatically left American mainstream society to join the hippie movement. Almost ten years after the height of the hippie phenomenon, there has been little longitudinal investigation of the predictions by social scientists that these young people would be lost from future mainstream involvement. In the late 1960s, through a study of young drug users in the Haight-Ashbury neighborhood of San Francisco, my colleagues and I began to assess the degree of movement taken by hippie drug users toward mainstream society. This research focused on the differential outcome of three groups of young drug users, approximately two and a half years after they were initially studied.

Adult↗

PubMed2007

Cellular mechanisms of mainstream cigarette smoke-induced lung epithelial tight junction permeability changes in vitro.

Mainstream cigarette smoke increases the permeability of human airways; however, the mechanism for this increased permeability is poorly defined. Tight junctions between adjacent epithelial cells constitute the physiological barrier to fluid and macromolecules in epithelium. These structures are highly regulated by phosphorylation and their association with the cytoskeleton. The goal of these studies was to identify the signal transduction pathways that regulate smoke-induced permeability. Using a physiologically relevant air-liquid interface exposure system, electrically tight monolayers of the human bronchial epithelial cell-line Calu-3 were exposed to fresh, whole mainstream cigarette smoke. This exposure results in a regulated, dose-dependent loss of epithelial barrier function in the lung epithelial monolayers. With cigarette smoke exposure, transepithelial electrical resistance (TER) is decreased and albumin flux is increased, indicating a loss in barrier function to ions and macromolecules, respectively; however, both largely recover in 30 min. Smoke-induced losses of macromolecular barrier function are the result of multicellular junctional reorganization, resulting in increased leak volume rather than leak frequency. Inhibiting Rho kinase (ROCK) significantly reduces the smoke-induced permeability to both ions and macromolecules, while inhibiting protein tyrosine kinases (PTK) only reduces smoke-induced macromolecular permeability. Interestingly, inhibiting myosin light chain kinase (MLCK) exacerbates smoke-induced permeability, indicating that MLCK and ROCK have opposing regulatory roles. Our results demonstrate that the smoke-induced loss of epithelial barrier function in human bronchial epithelium is a regulated process rather than a cytotoxic response. Additionally, our results indicate that activation of PTK and ROCK and inactivation of MLCK contribute to the increased airway permeability caused by mainstream cigarette smoke.

Amides↗

PubMed2003

Assessment of tobacco-specific nitrosamines in the tobacco and mainstream smoke of Bidi cigarettes.

Bidi cigarettes, or bidis, are a tobacco product that originated in India and have been gaining popularity in the USA during the past few years, particularly with adolescents. As with conventional cigarettes, tobacco and smoke from bidis contain chemical constituents including carcinogenic chemicals such as the tobacco-specific nitrosamines (TSNAs). To help better assess the potential public health risk associated with bidi cigarettes, we developed modern high throughput methods to accurately quantify TSNA levels in tobacco and mainstream cigarette smoke particulate. We determined the TSNA levels in the tobacco filler and mainstream smoke from 14 bidi cigarette brands. In the bidi tobacco filler, the 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) levels ranged from 0.09 to 0.85 microg/g, while N'-nitrosonornicotine (NNN) levels ranged from 0.15 to 1.44 microg/g. These amounts are comparable with those in typical American blended cigarettes. The levels of NNK in mainstream smoke from bidis ranged from 2.13 to 25.9 ng/cigarette, and NNN levels ranged from 8.56 to 62.3 ng/cigarette. The wide variation in the TSNA levels most probably reflects the hand-rolled nature of the bidi cigarettes, resulting in a product with less homogenous tobacco amount and a wider variation in overall cigarette construction quality. TSNA levels of bidis were comparable with those of conventional cigarettes, and bidis should not be considered a lower-risk alternative tobacco product. Our analytical findings concur with the previous biologic and biochemical evidence supporting epidemiologic studies linking bidi use with various cancers, especially oral cavity and lung cancers.

Nitrosamines↗

PubMed1996

The social adjustment of deaf adolescents in segregated parially integrated and mainstreamed settings.

This study examined the social adjustment of deaf adolescents enrolled in segregated (&egr; = 39), partially integrated (&egr; = 15), and mainstreamed (&egr; = 17) settings, comparing them with a control group of hearing students (&egr; = 88). Segregated students showed the lowest levels of adjustment overall. Partially integrated students reported better adjustment overall. Partially integrated students reported better adjustment than mainstreamed students with deaf peers; mainstreamed students reported better adjustment than partially integrated students with hearing peers, showing the same levels of adjustment with hearing peers as hearing students. Regardless of placement, deaf students reported better or equal adjustment with deaf than with hearing peers. Social adjustment with deaf peers was related to American Sign Language (ASL) skill and adjustment with hearing peers to spoken English. These findings suggest tht deaf students can benefit from both segregated and integrated placements as complememtary forms of social experience that each contribute to overal adjustment.

Journal Article↗

PubMed2005

Viewpoint: what is the best and most ethical model for the relationship between mainstream and alternative medicine: opposition, integration, or pluralism?

Despite radical improvements in medicine over the past 60 years, patients maintain multiple health care pathways that include high utilization of unconventional treatments. The authors examine three possible relationships between mainstream and alternative medicine: opposition, integration, and pluralism. Opposition, the traditional ethical position that the medical profession must eradicate unconventional medicine for the good of the patient, has withered away. Integration of mainstream and alternative medicine is increasingly advocated in tandem with hospital-based programs that amalgamate the use of conventional and alternative therapies. While advocates of integrative medicine often speak of "evidence-based" complementary and alternative medicine (CAM), integration fosters double standards for validating conventional and unconventional treatments. Integration also ignores unbridgeable epistemological beliefs and practices between mainstream and alternative medicine. Pluralism, which has been relatively ignored, calls for cooperation between the different medical systems rather than their integration. By recognizing the value of freedom of choice in medical options, pluralism is compatible with the principle of patient autonomy. Nonetheless, the pluralistic model does not amount to a relativistic stance according in which there would be no objective standards for comparing the therapeutic merit of conventional and CAM treatments. As an ethical model, pluralism realizes that physicians must be prepared to disagree with patient choices to pursue alternative therapies, and urge patients not to forgo medically indicated treatment. Pluralism encourages cooperation, research, and open communication and respect between practitioners despite the possible existence of honest disagreement, and preserves the integrity of each of the treatment systems involved.

Clinical Medicine↗

PubMed2004

Can mainstream services learn from male only sexual health pilot projects?

Over the past decade a number of community based sexual health projects aimed solely at young men have proved to be very successful at attracting young men into genitourinary medicine services. These projects are often short term funded and under evaluated so it isn't clear exactly how successful they are and why this might be so. These projects should be carefully evaluated and examined to elicit factors, either unique or common in nature, which could be utilised by mainstream sexual health services wishing to develop work with young men. There are many barriers to this happening in mainstream services, some being resource and time problems and others to do with values of staff and lack of quality training. The article looks at practical ways that working with men and the skills and confidence of staff can be improved in mainstream settings while recognising that much of what needs to be done to support the needs of young men must take place in the planning and commissioning stage of services.

Age Factors↗

PubMed2006

A comparison of the application of the self-regulation model of the relapse process for mainstream and special needs sexual offenders.

The self-regulation model of the relapse process (Ward & Hudson, 2000) has been developed and empirically validated on general sexual offender populations (Bickley & Beech, 2002), but not on specific sexual offender populations. This paper aims to investigate whether special needs offenders, as compared to mainstream sexual offenders, can be categorized into the offense pathways described in the model. In addition, this paper aims to evaluate the application of the self-regulation model in highlighting the treatment needs of the special needs group. Special needs sexual offenders are defined as a treatment population that includes individuals with lower functioning, limited social and communication skills, and literacy deficits. Participants were classified into the self-regulation model using a method developed by Bickley and Beech (2002). Demographic and offense information were collected and comparisons made between the special needs and mainstream groups. The results showed that the sexual offenders with special needs could be reliably classified into the offense pathways of the self-regulation model. The largest group of special needs offenders was in the approach-automatic group, followed by the approach-explicit group. The results indicated no significant differences in representation in the offense pathways between the special needs and mainstream sexual offenders. The results also indicate that the special needs group would benefit from a responsive approach to treatment, which incorporates appropriate treatment targets identified by the self-regulation model.

Adult↗

PubMed1983

Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar.

Radicals in the gas phase of both mainstream and sidestream cigarette smoke have been studied using electron-spin resonance ESR spin-trapping techniques with alpha-phenyl-N-tert-butyl nitrone (PBN) as the spin trap. The principal radicals we trap appear to be alkoxyl radicals. Mainstream and sidestream gas-phase smoke each have about the same concentration of radicals, about 1 X 10(16) radicals per cigarette (or 5 X 10(14) per puff). These radicals are reactive, yet they appear to be remarkably long-lived: they are still spin trapped from gas-phase smoke after more than 5 min. We propose that a steady-state concentration of reactive radicals exists in gas phase cigarette smoke. We suggest that this steady state is produced by the slow oxidation of nitric oxide (present in high concentrations in smoke and relatively unreactive) to the more reactive nitrogen dioxide, followed by the reaction of nitrogen dioxide with reactive organic molecules in smoke (such as olefins and dienes). Preliminary experiments reported here support this hypothesis. Tar from both mainstream and sidestream smoke contains persistent free radicals that exhibit broad, single-line ESR spectra with g values of 2.003. The tar radical can be extracted into tert-butylbenzene and other organic solvents, and we have applied a variety of fractionation procedures to these solutions. Most of the radicals occur in the fractions that contain the phenolic tobacco leaf pigments. Treatment of alcoholic solutions of tar with base generates a new group of radicals that appear to be semiquinone radicals derived from the oxidation of the phenolic and polyphenolic species in tar.

Chemical Phenomena↗

PubMed2006

A comparison of mainstream and special education for teenagers with Down syndrome: implications for parents and teachers.

This article presents data from a research study designed to compare the achievements of teenagers with Down syndrome educated in mainstream classrooms or in special education classrooms throughout their full-time education. Progress is reported for speech and language, literacy, socialisation, daily living skills and behaviour. For all the teenagers, there is evidence of progress with age on all the measures except for communication. Communication continued to improve through teenage years for the included children but not for those in special education classrooms. There were no significant differences in overall outcomes for daily living skills or socialisation. However, there were large significant gains in expressive language and literacy skills for those educated in mainstream classrooms. Teenagers educated in mainstream classrooms showed fewer behavioural difficulties. Further, comparison with data published by these authors in an earlier study, showed no improvements in school achievements in special education over a 13 year period in the UK (1986-1999).

Activities of Daily Living↗

PubMed1986

Effect of sidestream and mainstream smoke exposure on in vitro interferon-alpha/beta production by L-929 cells.

A peristaltic pump smoking machine that allows simultaneous generation of mainstream (active) and sidestream (passive) smoke from a cigarette was used to expose cultures of murine L-929 cells, a potent producer of interferon, to smoke. The cigarette used was the University of Kentucky 2R1 reference cigarette. The dosages of smoke used for exposure were the highest doses possible that generated a minimum toxic effect, and they were serially diluted to lower doses. Dosages were determined by the number of smoke puffs generated, the volume of smoke puffs generated, and the total particulate matter deposited on Cambridge filters in the smoke machine. Viability of exposed cells was equivalent to control cell cultures. Interferon-alpha/beta was induced by addition of polyriboinosinic-polyribocytidylic acid to the cells. Interferon production was substantially reduced in viable cells exposed to mainstream or sidestream smoke. Aging of smoke by delaying time of exposure of the cells to the smoke, or filtration of smoke through activated charcoal substantially decreased the alteration of interferon production by smoke exposure. These results suggest that actual exposure of cells to mainstream or sidestream smoke can inhibit in vitro interferon-alpha/beta induction, but the cells can be protected from these effects by smoke manipulation.

Animals↗

PubMed1980

Medicaid and the Mainstream: Reassessment in the Context of the Taxpayer Revolt.

California's Medicaid program-Medi-Cal-attempted to implement the ideal of mainstream medical care for the poor by giving program beneficiaries a "credit card" for use in the private health care marketplace. This exposed the program to the perverse economic incentives of the fee-for-service, costplus health care system, and contributed to a high rate of increase in program costs. Attempts to control costs have been equally perverse, resulting in low payment rates, the second-guessing of physician professional judgments, the probing of medical and fiscal records, and the use of computerized surveillance systems. Attempts to shift to the use of more efficient delivery systems have had small success. Attempts to attain cost containment through restructuring the Medi-Cal program have been rejected in the name of the mainstream ideal. Costs have continued to escalate, with annual increases as high as 20 percent in some years. Medi-Cal now costs $4 billion per year, the largest single program in California state government. The taxpayer revolt in California is creating a fiscal crisis that will force rethinking of the premises of publicly funded health care for the poor, and a restructuring of strategies for reaching that objective. In the short run, it appears that the issue may not be whether the indigent will have access to mainstream medical care, but whether they will have access to any medical care. In the longer run, the crisis should represent an opportunity for building a system of health care that can serve the financially disadvantaged at a cost tolerable to our society.

California↗