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Results for “Microcirculation”

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At least 91 records · Page 5Linked to original sources

PubMed1992

Gastric microcirculation and acute gastric mucosal lesions in patients with hepatic cirrhosis.

We endoscopically investigated gastric microcirculation using a laser-Doppler flowmeter and acute gastric mucosal lesions (AGML) during a 3-year follow-up period in patients with hepatic cirrhosis. Gastric microcirculation tends to decrease in patients with hepatic cirrhosis, especially when gastric mucosal hemorrhage or mucosal petechiae are observed endoscopically. Total gastric resection was performed for gastric hemorrhage due to AGML in three patients, two of whom had good liver function--Child's grade A--and survived more than 5 years with a good quality of life, but one patient with Child's grade C experienced poor quality of life and died within 2 years after surgery. We conclude that decreased gastric microcirculation plays a role in the occurrence of AGML in patients with hepatic cirrhosis. Total gastric resection should be carefully considered for hemorrhagic gastritis in patients with Child's grade C hepatic cirrhosis.

Acute Disease↗

PubMed1992

[The effect of hyperbaric oxygenation on the secretory, motor function and microcirculation of the stomach and duodenal walls in patients with duodenal ulcers].

A total of 22 patients with duodenal ulcer were examined for secretory and motor functions, microcirculation of the gastroduodenal wall and changes in the stomach-duodenum interrelations under the influence of hyperbaric oxygenation. Of these, group I included 9 patients with active ulcer; group II 13 persons with a healing ulcer. To assess gastric and duodenal functions, use was made of pH-metry combined with the measurement of intraluminal pressure by "open catheters". Microcirculation of the gastroduodenal wall was estimated by the radiation method. The studies have shown that the patients with active ulcer treated by hyperbaric oxygenation manifested a decrease of motor activity of both stomach and duodenum, an improvement of acid-neutralizing function of the stomach, a reduction of the duration of duodenum acidification, a greater normalization of microcirculation in the duodenal wall than in the gastric wall. In the patients with healing ulcers, the duodenal motility returned to normal, the initially elevated gastric motility fell to normal, the acidification of the duodenal bulb declined, and the regional blood flow returned to normal. It may thus be concluded that the positive impact of hyperbaric oxygenation on gastroduodenal function was more pronounced in the patients with healing ulcers where a more considerable decrease of motor activity was not accompanied by duodenal motility suppression.

Adult↗

PubMed1992

[Microcirculation during inhalation of 100% oxygen in rabbits].

Using a rabbit ear chamber (REC), the author compared the effect of air inhalation and that of 100% oxygen inhalation on microcirculation of rabbits. Eight rabbits, weighing 3-4 kg, were used for this study. After observing the microcirculation under air inhalation, the inspired gas was changed to 100% oxygen and the microcirculation was again observed. This procedure was repeated twice to confirm any changes that had been observed. No significant changes were observed in the blood pressure, heart rate and pulse pressure by inhaling either O2 concentration. During the inhalation of 100% oxygen, the diameter, blood-flow velocity and blood-flow rate of the arterioles were markedly reduced (P less than 0.01). All these parameters observed in the venules during air inhalation showed no significant differences compared with the values taken during 100% oxygen inhalation. This study using REC has shown that inhalation of 100% oxygen causes microcirculatory changes especially affecting the arterioles.

Administration, Inhalation↗

PubMedDate not supplied

[Disorders of physiological parameters of the body (lipid peroxidation and microcirculation) after naso-orbital injuries and the methods of their correction].

A naso-orbital injury is often associated with a craniocerebral injury due to the close anatomical localization of the facial and cerebral compartments of the skull. Patients with such injuries showed enhancement of free-radical lipid oxidation and microcirculation disorders. They were controlled by traditional therapeutic methods in combination with antioxidants of direct and indirect action (ascorbic acid, flacumin, alpha-tocopherol acetate, pentoxifylline ) that were given in standard doses. Improvement of microcirculation and decrease of free-radical oxidation of lipids were followed by faster normalization of bioelectric activity and hemodynamics of the brain and earlier clinical recovery. Microcirculation parameters recorded during biomicroscopy of vessels of the bulbar conjunctiva can be used for evaluating cerebral circulation because vessel responses of the eyeball and the brain are similar.

Adult↗

PubMed1991

[Effect of 654-2 on the cerebral blood flow in patients with ischemic cerebrovascular disease by measurement of 133Xe rCBF and the microcirculation of bulbar conjunctiva].

Eighteen patients with cerebrovascular disorder were observed comparatively using 133Xe rCBF measurement and microcirculation test of bulbar conjunctiva before and after treatment with 654-2. Remarkable decreasing of blood flow in the brain and improving of bulbar conjunctiva microcirculation were found after treatment. We consider that the same drug caused the different change of blood flow in and out brain may due to the reaction of micrangium tissue construction, nerve regulation and different organ's micrangium to Ach. We recommend 133Xe as a objective measurement to estimate brain blood flow. The value of treatment of ischemic cerebrovascular disorder by 654-2 and raising microcirculation test as a objective measurement remains to discussed.

Adult↗

PubMed1991

[Effect of ulinastatin on microcirculation under excessive hemorrhage and fluid therapy].

Microcirculation during excessive hemorrhage and fluid therapy under anesthesia with or without associated treatment by ulinastatin (urinary trypsin inhibitor) was studied by using the rabbit ear chamber. Sixteen rabbits were divided into 2 groups; 8 rabbits without ulinastatin treatment (C group) and rabbits treated with ulinastatin (U group). After blood withdrawal, hemodynamic disturbance appeared in both groups. But the catecholamine concentration showed no increase in either groups. Significant differences between the groups were found only in urinary output and microcirculation. These were well maintained during hemorrhage in the ulinastatin treated group. It is concluded that ulinastatin is effective in maintaining microcirculation during excessive hemorrhage and fluid therapy.

Animals↗

PubMed1990

[Vascular permeability, microcirculation and biologically active substances in patients with hemorrhagic fever with renal syndrome].

As many as 56 patients with associated hemorrhagic fever and the renal syndrome were examined for vascular permeability, microcirculation and blood plasma histamine, serotonin, kallikrein and prekallikrein. In all the disease periods, the majority of the patients (n-52) demonstrated a rise of vascular permeability for protein and liquid part of the plasma, with this being marked in particular in the oligoanuric period. Besides, significant perivascular and intravascular changes in microcirculation were noted in the oligoanuric and polyuric disease periods. It was established during examination of biologically active substances that the greatest shifts were experienced by the kinin system. Sometimes the content of kallikrein surpassed the control values more than 7-fold. Less pronounced changes were seen in blood plasma serotonin and histamine. A direct correlation was established between vascular permeability, microcirculation and the content of all biologically active substances explored by the authors. The strongest correlation was found to exist between the above parameters and the kinin system of blood plasma.

Acute Disease↗

PubMed1991

[Cochlear microcirculation in living guinea pigs following explosion].

The cochlear microcirculation in living guinea pigs was observed, explosion was then imposed on the left ear and the velocity of blood cell flow and vessel diameters were measured within one hour. The results showed that: 1. there was an orderly stable movement of blood cells in all vascular beds under normal conditions; 2. the flow rate in both spiral ligament and stria vascularis increased promptly after explosion, that in the spiral ligament might return to normal within 30 minutes with vasodilatation, indicating increased blood supply early after explosion; 3. there was no relationship between changes in microcirculation and hearing loss and hair cell damage. The cause of hair cell damage and hearing loss were discussed and the techniques of vital microscopic studies of cochlear microcirculation assessed.

Animals↗

PubMed1990

[The influence of electric needling "Juci" on nail-bed microcirculation of apoplectic patients].

UNLABELLED: "Juci" is one kind of acupuncture methods. It is that acupoints of the one side are used to treat the disease of the another side. In order to prove this theory and the difference from puncturing paralytic side (Tanci) 30 patients with hemiplegia due to cerebral infarction were observed under the same condition and stimulative parameter. Selecting points: Hegu and Quchi acupoint were electrified for 15 minutes. The changes of Nail-bed microcirculation were observed for half an hour and recorded after pulling out needles. CONCLUSION: Through the observation of outline of blood vessel, colour of blood vessel ansa, ansa's top blood-stasis of blood vessel, condition of blood flow and the rate of blood flow before and after Juci (puncturing healthy side) they were different or quite different on the hemiplegic side (p less than 0.05 or p less than 0.01). however, only the colour of blood-vessel ansa and rate of blood flow were different, others had no statistical significance on healthy side. Though puncturing paralytic side can make the nail-bed microcirculation improved, only rate of blood flow was different. Others had no statistical significance. In short both Juci and Tanci improve the nail-bed microcirculation of hemiplegic side, but the former is much better than the latter.

Acupuncture Therapy↗

PubMed1990

[Tongue tip microcirculation in patients with different symptoms].

Observations of tongue tip microcirculation were made on 104 patients with different symptom-complex [5 groups: Yin deficiency, Yang deficiency, Qi.blood deficiency, Qi stagnation-blood stasis, damp-heat] in view of TCM, and on 100 healthy persons. 10 indicators including the transverse diameter of the fungiform papillae, morphology of microvascular clumps in the tongue papillae, congestion of the top of microvascular loop, loop dilation, blood color, hemodynamics in microvascular loop, exudation, hemorrhage and loop morphology were observed. The results were: patients of each group were found to have to different degree microcirculation dysfunction; every group differed with Qi stagnation-blood stasis group of being most different. The numbers of abnormal indicators: Qi stagnation-blood stasis group had all 10; Yang deficiency group 9; Yin deficiency and Qi-blood deficiency group 8, 8 respectively; damp-heat group 7. This study discussed the relationship between tongue tip microcirculation of each group and the changes of tongue picture and typing of differentiation of symptoms and signs in view of TCM.

Adolescent↗

PubMed1989

[State of microcirculation homeostasis in children with rheumatism].

Microcirculatory homeostasis was studied in 107 children suffering from rheumatic fever. Conjunctival microcirculation and platelet aggregation were examined. The content of circulating immune complexes and medium-size molecules was measured in the blood. Microcirculation was investigated in 137 healthy children aged 3 to 15 years, making up a control group. Comprehensive investigation of microcirculation in children suffering from rheumatic fever enables one to define the activity of the rheumatic process at the early times of the illness and to ensure timely administration of adequate antirheumatic therapy.

Adolescent↗

PubMed1989

[State of the blood platelet link of hemostasis and microcirculation in patients with ischemic heart disease during plasmapheresis treatment].

The paper provides the results of studies into plasmapheresis-induced changes in the thrombocytic link of hemostasis and microcirculation in 40 patients with coronary heart disease (CHD). Repeated sessions of plasmapheresis (P) were found to produce an inhibitory effect on platelet aggregation and to improve microcirculation in CHD patients with signs of increased platelet functional activity. In CHD patients with low platelet functional activity, the first P session was demonstrated to cause an increase in platelet functional activity whereas the subsequent sessions inhibited platelet aggregation. No significant microcirculatory improvement was seen in this group of patients. Heparin and rheopolyglucin given to control patients exerted no substantial effect on the thrombocytic link of hemostasis and microcirculation.

Adult↗

PubMed1989

Hypoperfusion of the intestinal microcirculation without decreased cardiac output during live Escherichia coli sepsis in rats.

In order to determine the intestinal microvascular responses to normotensive, high cardiac output (CO) bacteremia, we measured vascular diameters and blood flow at different levels of the intestinal microcirculation during live E. coli bacteremia in male Sprague-Dawley rats (n = 16). Precollicular brainstem transection was used to allow study free of drug anesthesia. The microcirculation of a loop of small intestine (with intact neurovascular connections) was observed by in vivo video microscopy and optical Doppler velocimetry at a magnification of x1,500. Intraluminal microvessel diameters and red cell velocity were measured in successive branches until the vessel entered a villus. CO was measured by transpulmonary thermodilution. Intravenous infusion of 1 x 10(9) live E. coli caused a 20% increase in CO at 50 min and a 14% decrease in systemic vascular resistance. However, microvascular blood flow to the small intestine decreased by 27% at 1 hr and by 56% at 2 hr. Progressive arteriolar constriction (25-50%, P less than .05) occurred at all levels of the intestinal microcirculation. These data indicate that intestinal hypoperfusion caused by arteriolar constriction occurs during high CO bacteremia. This hypoperfusion could contribute to mucosal injury and intestinal mucosal barrier dysfunction during sepsis.

Animals↗

PubMed1989

The defensive role played by the gastric microcirculation.

Microcirculation plays an important role in the maintenance of functional integrity of the stomach and in the provision of its defense mechanisms against damage. Changes in blood flow in the gastro-duodenal mucosa, brought about by the local release of vasoactive or cytotoxic mediators, including free-radicals, the eicosanoids thromboxanes and leukotrienes, and the related phospholipid, PAF, have been implicated in the pathogenesis of various forms of peptic ulceration and erosive gastritis. Damage to microvessels and vascular endothelium leading to disruption of microcirculation is considered to be an initial event in the development of such lesions. Furthermore, preservation of microcirculation by prostaglandins is likely to make an important contribution to the overall protection of the gastric mucosa by these agents. Studies on the hemostatic mechanisms in the gastric mucosa indicate that bleeding is initially arrested by a coagulation process that is independent of platelet aggregation. Thus, the identification and characterization of microcirculatory events is of major importance in the understanding of pathophysiological processes in the gastric mucosa.

Humans↗

PubMed1989

A comparison of the effects of photodynamic therapy on normal and tumor blood vessels in the rat microcirculation.

The effects of light activation of the tumor photosensitizer dihematoporphyrin ether (DHE) were studied in the microcirculation of the rat cremaster muscle. Arterioles and venules in an implanted chondrosarcoma were studied by in vivo television microscopy and were compared to normal vessels of the same size elsewhere in the preparation and in control preparations. Activation with green light (530-560 nm, 200 mW/cm2, 120 J/cm2) 48 h after intraperitoneal injection of DHE (10 mg/kg body wt) resulted in significant narrowing of diameters of red blood cell columns in tumor arterioles and venules. The response in normal and control arterioles and venules was not significantly different from that seen in the tumor vessels except that the control arterioles did not remain significantly constricted during the treatment period. Treatment resulted in stasis of blood flow in 90% of tumor and normal arterioles at the completion of light activation. In venules, stasis of blood flow was observed in 75% of tumor and 70% of normal vessels. Vasoconstriction was the primary response in arterioles, while thrombosis predominated in venules. Morphologic assessment of light-activated vessels in the cremaster preparation by transmission electron microscopy revealed platelet aggregation with damage to endothelial cells and smooth muscle cells. Perivascular effects observed included interstitial edema and damage to skeletal muscle cells. In the tumor-bearing preparation, no direct cytotoxic effect on the tumor cells was shown. The surrounding vessels exhibited similar vascular stasis, but the lining cells appeared minimally affected. Photoactivation of DHE results in significant changes in the microcirculation which lead to stasis of blood flow. In this model, the response was similar for the normal microvasculature and for the microcirculation of an implanted chondrosarcoma. These effects may account, in part, for the mechanism of action of photodynamic therapy.

Animals↗

PubMed1988

New aspects of the theory of microcirculation.

New aspects and details of the mechanism of the microcirculation in the tissues are discussed in the paper. Particular attention is payed to the role of the blood pressure amplitude for the filtration and resorption processes through the capillary wall. A new model of the microcirculation is discribed in which the interstitial space is considered as a functional unit determining the intensity of the transcapillary exchange processes. The components of the hydraulic interstitial pressure are characterized as well as the process of formation and transport of limphatic fluid. The proposed model is a base for the better understanding of the theory of microcirculation.

Humans↗

PubMed1988

[Renal microcirculation in experimental acute pancreatitis of dogs--the effect of pancreatic protease inhibitor and dopamine].

To understand the renal microcirculation in acute pancreatitis is important to know the pathophysiology of renal insufficiency frequently observed as one of multiple organ failures in severe acute pancreatitis. In mongrel dogs acute pancreatitis was experimentally introduced by autologous bile added trypsin injection into the pancreatic duct. The effect of new synthesized pancreatic protease inhibitor (PATM) and dopamine in a dose of 3mg/kg/hr and 10 micrograms/kg/min were investigated, respectively. In acute pancreatitis dogs, renal arterial blood flow and renal tissue blood flow immediately fell and gradually decreased in time course of experiment and renal vascular resistance increased from 2 hours after onset of pancreatitis. When pancreatic protease inhibitor (PATM) was infused in acute pancreatitis dogs, blood pressure and pulse pressure relatively preserved during the experiment. Renal blood flow and renal tissue blood flow were maintained during the first 1 hour and thereafter slightly decreased, however which was less than that of no PATM treated dogs. When dopamine was infused in acute pancreatitis dogs, blood pressure was maintained during the first 90 minutes thereafter remarkably decreased. Renal blood flow was maintained within 60 minutes, however it remarkably decreased at the end of the experiment. This study suggested that renal microcirculation was disturbed from early period of acute pancreatitis in dogs and pancreatic protease inhibitor (PATM) had a beneficial effect of maintain the renal microcirculation.

Acute Disease↗

PubMed1988

[Disorders of microcirculation in subarachnoid hemorrhage and intracerebral hemorrhage].

The pathophysiological notions of hemodilution treatment of ischemic seizures with plasma expanders indicates the significance of microcirculation. Microcirculation disorders arise from the interrelations of hemodynamic, vascular, and hemorrheologic factors. It seems that hemodilution with hydroxyethyl starch reduces peripheral microcirculation disorders, thus inhibiting the development of cerebral edema. In the case of subarachnoid hemorrhage, the hemorrheologic factors deteriorate less severely when given antifibrinolytic treatment with Aprotinin. Simultaneous hemodilution with hydroxyethyl starch can counterbalance the already existing changes.

Blood Coagulation Tests↗