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At least 91 records · Page 5Linked to original sources
PubMed1986

[Complications of the treatment of cervix neoplasms by radiotherapy].

Of 939 patients treated by radiotherapy for carcinoma of the cervix at the hôpital Notre-Dame in Montreal, between 1979 and 1981, 275 (29.3%) had digestive, urologic, gynecologic, vascular, osseous and cutaneous complications. Surgery was necessary to treat 73 complications in 55 patients (5.9%): 42 digestive (25 occlusions, 13 fistulas and 4 perforations); 22 urologic (16 occlusions, 5 fistulas, 1 hemorrhage); 6 gynecologic (3 hemorrhage and 3 uterine necrosis); 1 cutaneous, 1 vascular and 1 osseous necrosis. No direct correlation was found between the incidence of the complications and certain predisposing factors such as the type of radiotherapy, patients' age, stage of the disease and gynecologic surgery before radiotherapy. However, there was a strong correlation between the incidence of complications and the dose of radiotherapy and the need for gynecologic surgery after radiotherapy. High morbidity was observed in the 55 patients treated surgically: they had to undergo a mean of 2.36 operations each, 2.98 general anesthetics, 1.81 hospitalizations (mean duration 75.7 days); 21 had one or more definitive stomas. The death rate was 5.45%. Surgical treatment was individualized. Limited resections were performed for occlusions, fistulas and perforations whenever it was technically feasible to treat digestive and urologic complications. A bypass procedure was used when resection would have been too extensive or dangerous. The majority of rectal lesions were treated by colostomy and a Hartmann procedure.

Adolescent↗
PubMed1981

[Possibilities and limitations of radiotherapy in neoplasms of the anterior cranial fossa].

Primary and secondary tumors of the anterior cranial fossa are discussed in clinic-therapeutical survey and mainly the role of radiation therapy of some of these tumors is stressed. The possibilities of additional use of radiosensitizing substances and possible combinations with chemotherapeutic agents are related. Statistical results of our own concerning malignant glioma and retinoblastoma are shown; the last mentioned tumors are a grateful and demanding indication area of radiation therapy. Casuistic experiences with malignant melanoma of the orbital region are discussed; detailed recommendations as to radiotherapeutic management of intraorbital tumors are given.

Brain Neoplasms↗
PubMed1998

[Diagnostic imaging of the salivary glands in patients undergoing radiotherapy of head and neck neoplasms].

INTRODUCTION: Radiotherapy of head and neck cancers changes the shape and function of the salivary glands included in the treated region. We investigated the morphological and functional alterations in the major salivary glands in 15 patients treated with radiotherapy for head and neck cancers (total dose: 55-66 Gy). MATERIAL AND METHODS: All the patients underwent B-mode and power Doppler US, CT and 99mTC salivary scintigraphy, before, at the end, and 60-80 days after radiotherapy. RESULTS: At the end of treatment, US showed irregular margins and inhomogeneous parenchymal echogenicity in 13 parotid and in eight submandibular glands. Doppler US showed of focal hyperemia and focally decreased or no intraparenchymal flow in nine parotid and in two submandibular glands. CT demonstrated parenchymal inhomogeneity with increased and decreased density areas, cancers irregular margins, and gland atrophy in 15 parotid and in eight submandibular glands. Salivary scintigraphy depicted injuries of the major salivary glands detecting their reduced pertechnetate uptake in 12 parotid and in eight submandibular glands, with a decreased drug excretion in 12 parotid and in 12 submandibular glands. DISCUSSION AND CONCLUSION: Our findings confirm that the major salivary glands are affected by radiotherapy, which makes their morphological and structural monitoring of vital importance. US is the technique of choice for its low cost and easy execution, and it is well accepted by the patients because it requires no exposure to ionizing radiations. Power Doppler provided no relevant information, but it confirmed the high resistance of small and middle caliber vessels after radiotherapy. Scintigraphy clearly showed the glands involvement demonstrating decreased uptake technetium secretion and excretion. In conclusion, US and CT are both extremely useful in the study of the morphological changes of the major salivary glands.

Adult↗