PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “NEOPLASMS, EXPERIMENTAL”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 91 records · Page 5Linked to original sources
PubMed1981

Tocopherol in irradiation of experimental neoplasms. Influence of dose and administration.

The influence of tocopherol, administered intramuscularly in different single doses, on the effect of local irradiation of a transplanted rat sarcoma was investigated. Tocopherol in doses of 5, 25 or 50 mg/100 g body weight enhanced significantly the tumour growth retardation induced by irradiation. Tocopherol in a dose of 100 mg/100 g body weight as a placebo preparation had no similar effect. The influence of tocopherol administered intramuscularly or orally in identical doses was similar.

Administration, Oral↗
PubMed1981

[Usefulness of serum pseudocholinesterase isoenzymes in acute and chronic liver diseases and neoplasms (experimental and clinical study)].

This paper was designed to study experimentally in rats hepatic and serum pseudocholinesterase, (CHE), and its isoenzyme activity, and also to analyze its behavior in acute hepatitis, cirrhosis and primary and secondary hepatic tumours. Five isoenzymes in rat liver homogenates and 4 to 5 in rat serum were found. In normal human serum 4 to 5 CHE-isoenzymes were recognized. Cuali and quantitative decreases in all serum CHE isoenzymes were found in all patients with severe liver disease. Isoenzyme No. 1 decreased significatively in cirrhotics, showing a double peak inscription. Isoenzyme No. 5 was elevated in the three patients with hepatoma.

Adenoma↗
PubMed1984

[A short term test suitable for in vitro prediction of the drug sensitivity of human leukemias: a preliminary study on murine experimental neoplasms].

The present report provides information on the optimal assay conditions for evaluating chemosensitivity in vitro, as assessed by using murine leukemias and by correlating the in vitro results with the known chemosensitivity in vivo. The experiments were carried out with lymphocytic leukemias of DBA/2 origin, i.e.L1210 Cr and P388, maintained by weekly i.p. inoculation of 10(6) cells in histocompatible hybrid CD2F1 mice. Briefly, the assay involves in vitro incubation of leukemic cells with antitumor drugs for 1h at 37 degrees C and evaluation of drug-induced cell damage by adding to the cultured cells 125I-deoxyuridine at different times (3, 24, 48 and 72 hrs) after drug exposure. The results, expressed as percent inhibition of the isotope incorporation with respect to untreated controls, indicate that this assay may reflect the differential chemosensitivities exhibited in vivo by murine leukemias only on a 48-hr interval between drug treatment and 125IUdR uptake evaluation. These results suggest that a similar assay could be employed for predicting the chemosensitivity of human leukemias.

Animals↗