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PubMed1984

Hypereosinophilic syndrome and plasmocytoma. Report of a case and review of the literature.

The 4th case of plasma cell neoplasm associated with a hypereosinophilic syndrome is described and compared with the previous reports. Hypereosinophilia in the present patient displayed some borderline traits with eosinophilic leukemia. Myeloproliferative disorders of the eosinophilic line often present as a precancerous state, but sometimes they seem to acquire malignant independence. In our patient the occurrence of a plasmocytoma with a dramatic course leads to suspect an underlying complex genetic aberration.

Eosinophilia↗
PubMed1976

Plasmocytoma with IgM paraproteinemia. A case report.

A case of typical diffuse plasmocytoma with IgM paraproteinemia is described. The patient presented with systemic and monomorphic proliferation of atypical and immature plasma cells. osteolytic lesions, retinal venous thrombosis and hemorrhagic diathesis. The therapy with steroids and alkeran produced clinical and hematological remission for 11/2 year with a decrease of macroglobulins in the serum. Cell and paraprotein type remained unchanged during the course of the disease. This case, and similar ones already reported in the literature, suggest that neoplastic plasma cell proliferation is accompanied by synthesis of paraproteins including the IgM type. However, this is not characteristic for Waldenström's macroglobulinemia. The author concludes that differential diagnosis in these cases can only be made by cytologic examination.

Humans↗
PubMed2000

[Solitary plasmocytoma of the calvarium].

We report a case of 54 year old patient harboring a solitary painless mass of the calvarium. There was a well-defined biparietal lytic lesion on plain skull radiographics. Computed tomography showed a large hyperdense lesion. This lesion was extraaxial and nearly isointense with gray matter on T1 and T2-weighted MR images, and diffusely enhanced after gadolinium injection. Angiography showed hyperovascularity supplied by middle meningeal and superficial temporal arteries. Imaging study bore some similarities to meningioma. A large extra-axial mass with an important lytic lesion should have led to the diagnosis of plasmocytoma.

Humans↗
PubMed2001

[Extramedullary plasmocytoma. Report of 5 cases].

The extramedullary plasmacytoma account for 1-2% of the total number of plasma-cell growths. 80 percent are originated on head and neck, beginning on submucous layer of the upper airways. Male are more frequent affected at sixth-seventh decade. Roentgentherapy chemotherapy is only worldwide accepted in cases of scattered disease, but when the cases are localizated the method is under assessment. Long tern follow up of patients is recommended, because there are cases which after many years of calm can evolve into a multiple myeloma. We report 5 cases: 3 women and 2 men, diagnosed as extramedullary plasmocytoma. In one of them, considered as nasal plasmacytoma, three years later was discovered an other plasmacytoma on a tibial epiphysis. The whole group was surgically treated with complementary röntgentherapy 4 of them. Afterwards no one showed multiple myeloma.

Adult↗
PubMed1975

[Plasmocytoma of the orbit (author's transl)].

After a survey of the clinical picture of plasmcytoma including histological, internal and radiological findings the special aspects of affections of the orbit are described and demonstrated by four own cases since 1955. The authors propose the differentiation between plasmocytomas with bony erosive changes, solitary or multiple, and extrameudllary myeloma for theapeutical and prognostical reasons. The extramedullary myeloma of the orbit has a better prognosis and should be treated by local excision of the tumor with following radiation (CO-60). In case of bony erosive changes the extension of the tumor has to be considered, in case of multiple involvement of the body the radiation should be prefered as a palliative treatment in combination with chemotherapy.

Aged↗
PubMed1975

Microheterogeneity of Immunoglobulin G from plasmocytomas. Identification of two types of IgG by isoelectric focusing.

Isoelectric focusing of serum immunoglobulin G (IgG) revealed that the microheterogeneity, which is expressed in the isoelectric points (IEP), partly is caused by differences in the content of N-acetyl-neuraminic acid (NANA), partly by other effects, probably including deamidation. Two different types of Plasmocytoma-IgG, which differ in IEF-pattern, i.e. population distribution, in sensitivity towards neuraminidase and in carbohydrate content, are described. The contents of carbohydrates in these 2 IgG-types are up to 30% greater and 50% less, respectively, than that of normal IgG. A precise correlation was found between the total content of NANA in moles per mole IgG-monomer and the shift in band-IEP on hydrolysis catalyzed by neuraminidase. This may be used for a rapid estimate of NANA in IgG. The results do not permit a discrimination between an anabolic and a catabolic origin of the heterogeneity in the carbohydrate moiety of IgG.

Antibodies, Heterophile↗
PubMed2004

Surgical treatment of solitary plasmocytoma of the spine: case series.

The mean survival of patients with skeletal solitary plasmocytoma is 75% at 5-year follow-up. This highly osteolytic tumor may compromise spinal stability. Radiotherapy is effective in local control of the disease, however, it is not effective in restoring spinal stability. Fracture risk and progressive vertebral collapse persist. For this reason, we must consider the need to establish the probability of progressive vertebral collapse, based on the degree of involvement of the vertebral body at the time of diagnosis. We used parameters described by Taneishi and Kaneda, as well as those of Heller and Boden to predict progressive vertebral collapse. Three cases are presented and their treatment is described.

Decompression, Surgical↗
PubMed1992

[Plasmocytoma with asynchronous metastasis. Immunohistological and ultrastructural contribution].

The case of a 37-year-old male who developed multiple asynchronous extramedullary plasmocytoma localizations is reported. The first site involved was the cecum. Other tumors successively arose in the chest wall, testis, buttock, nasal cavity, skin, and mediastinum. The patient died 59 months after initial diagnosis. Light microscopy and ultrastructural studies disclosed a substantial proportion of immature plasmocytes in the different tumors, explaining in part the poor activity of radiotherapy and chemotherapy. Although in many cases this clinical pattern indicates multiple myeloma, investigations failed to detect this condition in the patient reported here. Shortly before the fatal outcome, a peak of IgA kappa globulin was detected in the serum. This immunoglobulin was also identified on tumor cells using immunoperoxidase labeling.

Adult↗
PubMed2006

Solitary plasmocytoma of frontal bone presenting as an asymptomatic forehead lump.

Solitary plasmocytoma of bone is a rare type of plasma cell tumor. We present a case of a solitary extramedullary plasmacytoma of the frontal bone presenting as an asymptomatic forehead lump with clinically benign characteristics. This case highlights the need for a high index of suspicion when dealing with enlarging subcutaneous lumps of the forehead and scalp. The significance of this lies in the appropriate sequencing of investigations and the implementation of the necessary treatment regimen.

Aged↗
PubMedDate not supplied

[Extramedullary plasmocytoma of the nasopharynx].

A case of extramedullary plasmacytoma sited in the nasopharynx in a 25 years old women is presented. The first symptomatology was otology; no evidence of plasmocytoma after clinical study were found in another site. We also do a revision of diagnostic and therapeutic management. We ind this case interesting because his site of origin and the patient's sex.

Adult↗
PubMed1975

[Selection of cell lines resistant to cyclic AMP and theophylline from murine plasmocytoma MOPC 173. Cross resistance to ouabain and concanavalin A].

Using cAMP or theophyllin as selective agents, we obtained from contact inhibited and non contact inhibited cell lines, derived from the same plasmocytoma, different resistant cell lines. All of them were cAMP and theophyllin resistant and also ouabain and con A resistant as judged by the growth curves in presence of the different drugs.

Cell Division↗
PubMed1991

Non-excretory plasmocytoma--value of imaging procedures.

We report a case of a 84-year old patient with a non-excretory plasmocytoma. Lacking pathological laboratory values, first diagnostic hints on this rare disease were provided by imaging procedures. Computed tomography and plain radiography surpassed bone scan with 99mTc-diphosphonate compounds in detecting bone associated lesions. According to data in the literature, magnetic resonance imaging and bone marrow scintigraphy seem to be useful in quantifying bone marrow involvement, whereas computed tomography and plain radiography appear to be good tools in detecting localized cortical or spongious lesions in multiple myeloma.

Aged↗
PubMed1990

[Solitary plasmocytoma of the mandible: study of a case].

The isolated plasmocytoma of the maxilla is an extremely rare tumor. It is classified in the group of low-grade B lymphomas. Its clinical and even radiological diagnosis remains difficult. Some authors, such as H.S. LOH in 1983, have attempted to regroup all reported cases in the literature, but many are incomplete, especially those which were first published. Most of the time, it is the pathological examination that rectifies the diagnosis and, currently, the immuno-chemical examination that confirms this diagnosis; this was demonstrated in the case reported here.

Female↗
PubMed1989

Role of cytostasis in antitumor immunity against syngeneic X5563 plasmocytoma: comparative study of cytostasis and cytolysis using variant tumors and neonatally thymectomized mice.

The mechanism of antitumor immunity against syngeneic X5563 plasmocytoma was investigated with cytostasis and cytolysis assays by changing the host-tumor interrelationship using neonatally thymectomized (NTx) mice and spontaneous variant tumors. Immunization with mitomycin C-treated X5563 cells (MCC-X5563) in complete Freund's adjuvant (CFA) induced an effective anti-X5563 immunoprophylaxis in vivo. Such immunized mice and X5563 tumor-bearing mice showed cytostatic, but not cytolytic, activity in their peritoneal exudate cells (PEC) in vitro. Both cytostatic and cytolytic activities were induced in PEC of regressor (R1 and R2) variant tumor-bearing mice. But NTx mice, which could exert cytostatic activity and no cytolytic activity, could reject about one-half of R1 variant tumors. Immunizations using a progressor P1 variant tumor, obtained from R1 tumor after nearly complete rejection, did not give a prophylactic effect in vivo, nor did they induce in vitro cytolytic activity although a low degree of cytostatic activity was detected. These results suggest that cytostasis is the common and basic effector mechanism of antitumor resistance against syngeneic original or variant X5563 tumors, and that the collaboration of cytolysis and cytostasis exerts strong resistance against regressor variants.

Animals↗
PubMed1989

[Solitary extramedullary plasmocytoma of the small intestine].

A case is presented of PES of the small intestine debuting with subocclusive crises. After the preoperative study the patient was diagnosed as probable neoplasm of the small intestine. In the operation was confirmed an annular stenosing ileal tumor that respected the serosa. Ample intestinal resection was practiced with a normal postoperative recovery. The pathology report indicated plasmocytoma, the immunoperoxidase technique being negative. The existence of multiple myeloma and other lesions at a distance was excluded. Almost a year after the operation the patient remains asymptomatic and free of recurrence. A review of the literature is offered.

Humans↗