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PubMed1975

Epidemiologic characteristics of patients with prostatic neoplasms.

A case-control study was conducted between 1957 and 1965 on 128 patients with benign prostatic hyperplasia (BPH), 256 age-matched controls, 290 prostate cancer patients and 290 age-matched controls for the prostate cancer patients, all of whom had completed the Roswell Park Memorial Institute epidemiology questionnaire and were interviewed on admission to the Institute. Compared to the control groups a higher proportion of both case groups were Protestants and residents of smaller towns. The major finding in this case-control study was a significantly higher risk for prostate cancer in fertile males compared to both married and non-married, but infertile males. This finding was confirmed when fertility was used as a variable for the classification of study groups in an earlier prospective study reporting the follow-up of patients with BPH and non-neoplastic controls. In this study, patients with children were found to have a relative risk of 2.69 for prostate cancer compared to the married patients with no children. Fertility may be a manifestation of constitutional-hormonal factors that increase the risk of prostate cancer.

Adult↗
PubMed1978

[Testosterone, FSH and LH level in the serum of patients with prostatic neoplasms, treated with female hormones].

Testosterone, FSH and LH were measured in serum of patients suffering from prostatic carcinoma. The efficacy of treatment with 1 mg diethylstilbestrol/d (Cyren A) was shown by suppressed serum levels of testosterone, FSH and LH comparable to castration in a follow-up until 560 weeks after beginning of therapy. Prolactin was raised in all patients under treatment.

Diethylstilbestrol↗
PubMed1980

[Bone metastases of prostatic neoplasms with reference to the histological type and local tumor stage].

In prostatic cancer the frequency of osseous metastases - detected earliest by bone scintigraphy - amounts to 21.8% at the time of histological verification of the primary tumour. This frequency depends on the histological type of the prostatic carcinoma and yields 10.5% in uniform adenocarcinomas and 40.4% in pluriform carcinomas. The rate of metastases in the uniform adenocarcinomas rises with increasing histological dedifferentiation. The percentage of prostatic carcinomas with pluriform pattern in comparison with uniform adenocarcinomas rises markedly, corresponding to the local tumour extent (T2 = 36.4%, T3 = 52.2%, T4 = 61.1%). For the purpose of stage-related therapy of prostatic cancer, histological grading and clinical staging, including bone scanning, are absolutely essential.

Adenocarcinoma↗
PubMedDate not supplied

[Comparative assessment of the WHO and Gilson histological classifications of prostatic neoplasms (taking into account data of ploidy studies)].

We estimated ploidometric nuclear parameters of predominating cell population in various prostatic adenocarcinomas in using WHO vs Glison classification to define advantages of the above classifications. Ploidometry provides information on cell composition and proliferative activity of cells. We observed greater ploidity in different grades of cell atypia. WHO histological classification by differentiation grade corresponds to ploidometric characterization of tumor cell populations but fails to reflect the presence of different histological types of the tumor. Currently introduced classification by Glison is more effective both diagnostically and prognostically as it reveals a dominant histological type of the tumor and shows other variants of tumor growth progression.

Adenocarcinoma↗
PubMed1979

[Chemotherapy of bladder and prostatic neoplasms in children].

The basic informations concerning pathology and clinical stagging of malignant tumours localized in urinary bladder and prostatic gland are introduction to proper presentation of own material collected and treated in the years 1962-1977. The material consists of 23 cases of rhabdomyosarcoma localized in minor basin. Formerly in the years 1962-1975, the basic form of treatment was surgery with/or radiotherapy. Chemotherapy that was given accidently in special indications as single dose or for a short time. Since 1975, we have started with systematic multidrug chemotherapy (VAC) used as an important part of complex therapy. Finally the authors discuss the place of chemotherapy in complementary treatment on the base of the literature and their own experience.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed2001

[Prostate neoplasm prevalence in Talca, VII Region of Chile].

BACKGROUND: In 1998, there were 1,218 deaths in Chile caused by prostate cancer. This figure results in a death rate of 16.6 per 100,000 males for this disease. AIM: To assess the prevalence of prostate cancer in the Seventh Region of Chile. MATERIAL AND METHODS: A probabilistic sample of 327 males aged 40 to 59 years old was studied. In all, a codified questionnaire was applied, a digital rectal examination was performed and a blood sample was drawn to measure prostate specific antigen. All digital rectal examinations were performed by the same observer. Patients with an abnormal rectal examination or prostate specific antigen were subjected to a prostatic biopsy under ultrasound guidance. RESULTS: In 14 subjects, the digital rectal examination was considered abnormal and in seven, prostate specific antigen was over 4 ng/ml. All subjects with elevated prostate specific antigen had an abnormal rectal examination. In three of the 14 subjects, the biopsy showed a well differentiated adenocarcinoma. All three were aged over 50 years old. The resulting calculated prevalence of prostate cancer was 9.2 per 1,000 males (CI 4.2-14.1). CONCLUSIONS: The cost effectiveness of screening for early diagnosis of prostate cancer must be calculated, to decide its incorporation in preventive medical examinations.

Adult↗