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Results for “Pyometra”

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PubMed1995

Pyometra after endometrial resection and ablation.

BACKGROUND: Hysteroscopic endometrial ablation is increasingly accepted as a safe means of controlling excessive uterine bleeding. CASE: A 47-year-old woman underwent endometrial resection and ablation for menorrhagia and subsequently developed pyometra and bacteremia. Placement of an intrauterine drain and intravenous antibiotic therapy led to full recovery. CONCLUSION: Postoperative pyometra occurred after endometrial resection and ablation, a procedure reported to have few complications. To our knowledge, this has not been reported before.

Anti-Bacterial Agents↗

PubMed1989

Prostaglandin F(2)alpha usage in a dairy reproduction program for treatment of unobserved estrus, pyometra and ovarian luteal cysts.

A retrospective study was conducted to evaluate the outcome of 223 prostaglandin F(2)alpha (PGF) treatments given to lactating Holstein and Jersey cows over a 44-mo period. The cows were part of a commercial dairy herd. Treated cows were given PGF (25 mg i.m.) because they had not been observed in estrus or because they had been diagnosed as having a luteal cyst or pyometra. Outcome of treatments was assessed for frequency of response to treatment (the detection of estrus), time interval to detection and pregnancy outcome of breedings at PGF induced estrus. Of the 223 administrations of PGF, 70% (156 223 ) were given for unobserved estrus, 12.1% (27 223 ) were given for cystic ovarian disease and 15.2% (34 223 ) were given for pyometra. Estrus was detected in 55.3% (120 217 ) of cows over a period of 36 to 130 hours after PGF administration. Interval to estrus and response rates were not influenced by the reason for treatment. Mean time interval to response was 79.1 h. Time interval for response was affected by season (P < 0.01) housing location (P < 0.01) and lactation number (P < 0.05). Insemination was performed following 157 of the treatments. For cows treated for unobserved estrus, insemination was performed in response to estrus or at 80 h if no estrus had been previously seen. Of this group, 39.7% (58 146 ) failed to show estrus and were inseminated at 80 h. Reinsemination was required for 22.7% (20 88 ) of the cows that manifested estrus following insemination at 80 h. Overall conception rate was 41.4% (65 157 ). Cows inseminated in response to estrus had a 53.4% (47 88 ) conception rate, and appointment bred (80 h) cows had a 20.7% (12 58 ) conception rate. Factors significantly influencing conception were response to PGF administration (P < 0.05), season (P < 0.01) and lactation number (P < 0.01). It was concluded that estrus detection efficiency affects the outcome of PGF administration and that conception rates resulting from 80 h breeding when no estrus is observed may be unacceptably low.

Journal Article↗

PubMed1991

Progesterone profiles in postpartum Holstein dairy cows as an aid in the study of retained fetal membranes, pyometra and anestrus.

This study was carried out to investigate the utility of enzymeimmunoassay (EIA) - derived progesterone profiles in the investigation of postpartum reproductive abnormalities and the effect of their use on reproductive performance in Holstein cows. Whole milk samples, collected twice weekly from parturition until confirmation of pregnancy or removal from the herd, were assayed for progesterone (P4) concentration using a commercially available microtitre plate EIA. The sensitivity, specificity, precision and accuracy were satisfactory to distinguish cyclic changes of P4 reflecting ovarian activity. The P4 profiles indicated that retained fetal membranes and anestrus were associated with increased mean intervals to first ovulation and first estrus (P < 0.05). The first luteal phase of cows with pyometra was prolonged compared with that of normal herdmates (P < 0.05). Anestrus cows had an increased number of ovulations before first service and before pregnancy (3.9 and 5.9) in comparison with normal herdmates (2.1 and 3.5; P < 0.05). Calving to pregnancy interval was increased above normal (74.8) for pyometra (125.0) and anestrus (152.7) (P < 0.05). Pregnancy rate for anestrus cows (82%) was lower than for normal cows (100%) and more anestrous cows were culled (27%) than normal cows (5%) (P < 0.5). The P4 profiles indicated that the major problem in the herd studied, anestrus (32% incidence rate), was most likely due to the failure to observe estrus rather than acyclicity.

Journal Article↗

PubMed2006

Combination dopamine agonist and prostaglandin agonist treatment of cystic endometrial hyperplasia-pyometra complex in the bitch.

Cystic endometrial hyperplasia-pyometra (CEH-P) complex is a progesterone-dependent disease that requires medical treatment in bitches intended for breeding. To test the efficacy and safety of a combined protocol and to assess the effect of age, stage of cycle, previous steroid hormone administration and parity on treatment, 29 bitches diagnosed with CEH-P complex were treated daily with cabergoline 5 microg/kg PO and cloprostenol 1 microg/kg SC for 7-14 days, along with supportive antibiotic and hydration therapies. Before treatment, and on Days 3, 7 and 14, all bitches were evaluated clinically and uterine horn diameter measured during trans-abdominal ultrasonography. Twenty-four of 29 bitches were cured by either Day 7 or 14. Nine bitches had mild digestive side effects. Clinical signs related to pyometra began to improve markedly as early as Day 2 of treatment. Uterine diameters decreased (P < 0.05) by Day 3 of treatment, and continued to gradually decrease, reaching normal size by Day 14. Relapses occurred in 6 of 29 cases. Pregnancy was achieved in one of the two young bitches bred after treatment. No significant relationships were found between success rate and age, stage of the estrous cycle, previous hormone administration or parity. Although no variables affecting treatment results could be identified, this combination of compounds was found to be an efficient and safe for treatment of CEH-P.

Animals↗

PubMed2006

Changes in CRP, SAA and haptoglobin produced in response to ovariohysterectomy in healthy bitches and those with pyometra.

The aim of the study was to assess changes in serum C-reactive protein (CRP), serum amyloid A component (SAA) and haptoglobin (Hp) concentrations in healthy bitches and in those with pyometra undergoing ovariohysterectomy, and to establish the usefulness of such determinations for monitoring the postoperative period. Our results indicate that CRP and SAA determinations serve to evaluate the severity of the inflammatory process in pyometra since the concentrations of these acute phase proteins were increased immediately after surgery and diminished thereafter. The CRP and SAA response was rapidly produced while Hp concentrations increased in a more gradual manner. Thus, postoperative concentrations of CRP and SAA provide valuable information on the subsidence of the inflammatory response during the uneventful postoperative period. Our findings also suggest that acute phase proteins might be useful diagnostic markers of early postoperative complications.

Animals↗

PubMed2006

Computed tomography features of spontaneously perforated pyometra: a case report.

Spontaneous perforation of pyometra is an extremely rare emergent gynecologic disease. We report a 73-year-old woman with a spontaneously perforated pyometra presenting with acute abdomen in the emergency department. A dedicated computed tomography examination of the abdominal and pelvic regions revealed the diagnosis. The patient recovered well after surgical intervention and antibiotic treatment.

Abdomen, Acute↗

PubMed1985

Benign senile pyometra, endometrial cholesterol granulomas and adenosquamous carcinoma.

Endometrial curettage of a 78-year-old patient with benign senile pyometra revealed endometrial cholesterol granulomas. Five years later cytological studies were suspicious of malignancy. Hysterectomy disclosed an endometrial adenosquamous carcinoma associated with cholesterol granulomas. We speculate that endometrial cholesterol granuloma, like endometrial xanthogranuloma, represents a rare morphologic variant of benign senile pyometra. Consequently a strong association with carcinoma is to be expected.

Adenocarcinoma↗

PubMed1989

Generalized peritonitis due to spontaneous rupture of pyometra.

Spontaneous rupture of pyometra is a rare cause of generalized peritonitis. Only a few cases have been recorded in the English medical literature, most of which were associated with gynaecological malignancy. We have recently treated a patient with generalized peritonitis due to ruptured pyometra, in which there was no evidence of malignancy or other cervical disease. From comparison with the other published case reports, several features deserve emphasis.

Aged↗

PubMedDate not supplied

Emphysematous pyometra in a dog.

An 8-year-old intact female West Highland White Terrier was examined for anorexia, vomiting, abdominal distension, and mild purulent vulvar discharge. The results of physical examination, laboratory testing, and radiography are presented. Emphysematous pyometra was suspected and confirmed at surgery. Clostridium perfringens was isolated from the uterine lumen. A brief discussion of emphysematous pyometra is presented.

Animals↗

PubMed1983

Pyometra and pyovagina in koalas.

Four female koalas were found to have pyometra and pyovagina at autopsy. All had soiling of fur around the cloaca and were in poor condition. One koala had cystic ovaries in addition to the pyometra while another had extensive peritonitis due to rupture of one of the uterine horns. Chronic cystitis was present in all koalas while one also had pyelonephritis. Microbiological examination revealed a mixed flora of both aerobes and anaerobes.

Animals↗

PubMedDate not supplied

Therapeutic effects of cefozopran on polymicrobial infections associated with Enterococcus faecalis in a Rat pyometra model.

Enterococcus faecalis plays an important role as a pathogen in polymicrobial infections. We evaluated the efficacy of cefozopran (CZOP) using polymicrobial pyometra rats. Rats were infected with a mixed intrauterine inoculation of E. faecalis plus either Bacteroides fragilis or Prevotella bivia (minimal inhibitory concentration of CZOP; E. faecalis: 6.25 micrograms/ml, B. fragilis: 12.5 micrograms/ml, P. bivia: 12.5 micrograms/ml). Immediately after inoculating 10(5) CFU of each organism/rat, CZOP (either 40 mg/kg, i.v., q.i.d., for 5 days or 80 mg/kg, i.v., b.i.d., for 5 days) was administered. The intrauterine inflammatory change and bacterial counts in the CZOP-treated group were compared with those in the nontreated control group. CZOP significantly (p < 0.01) decreased the bacterial counts except for B. fragilis in the regimen of 80 mg/kg b.i.d. However, the 40 mg/kg, q.i.d., regimen significantly (p < 0.05) reduced bacterial counts compared to 80 mg/kg, b.i.d. These results suggest that CZOP in a more divided dose is efficacious for the treatment of polymicrobial infections associated with E. faecalis in pyometra.

Animals↗

PubMed1999

Endoscopic management of a case of complete septate uterus with unilateral pyometra.

We report a case with an unusual müllerian anomaly: complete uterine septum and pyometra in the right hemicavity and pyocolpos along with a longitudinal vaginal septum. A patient with recurrent low-grade fever and lower abdominal pain was admitted. Pyometra and pyocolpos were detected in the right uterine hemicavity and in the right hemivagina. The septa were resected, the cavities were irrigated, and the patient was treated with antibiotics. The patient conceived 8 months later. Patients with abnormal vaginal findings should be approached with caution; precise knowledge of urogenital anatomy and urogenital anomalies is necessary in the management of these patients.

Abdominal Pain↗

PubMed1997

Successful laparoscopy assisted ovariohysterectomy in two dogs with pyometra.

Two dogs with pyometra were treated by laparoscopy assisted ovariohysterectomy. Hemostasis of the mesovarium was achieved with an ultrasonic scalpel and hemoclips. Both ovaries and the uterus were exposed via a 10-mm caudal port that was enlarged to 3 cm and the uterine cervix was excised after ligation of the uterine arteries. These cases were the first report on ovariohysterectomy for pyometra by laparoscopy assisted surgery in the veterinary field.

Animals↗

PubMed1998

Relationship of the blood endotoxin concentration and prognosis in dogs with pyometra.

The blood concentrations of endotoxin in dogs with pyometra (n = 45) were compared with those in healthy dogs (n = 17). The blood endotoxin concentrations in the healthy dogs (n = 17), in those with good prognosis (n = 41) and those with poor prognosis (n = 4) were 3.4 +/- 2.8 pg/ml, 9.5 +/- 11.3 pg/ml and 74.2 +/- 18.3 pg/ml, respectively. The concentrations in the dogs with good prognosis and poor prognosis were significantly (p < 0.01) higher than those in the healthy dogs. The dogs with poor prognosis had significantly (p < 0.01) higher endotoxin concentrations than those with good prognosis. Blood endotoxin concentrations were measured in 9 dogs after surgery, and were found to be decreased. These results suggest the possible involvement of endotoxin in the pathophysiological changes due to pyometra in dogs, and also that the blood endotoxin concentration could be used as a marker to determine prognosis.

Animals↗

PubMed2005

Use of aglepristone and aglepristone + intrauterine antibiotic for the treatment of pyometra in bitches.

In this study, the efficacy of aglepristone and/or intrauterine antibiotic administration for the treatment of bitches with cystic endometrial hyperplasia/pyometra complex was investigated. Twenty-four bitches (5-12 years old) with the diagnosis of pyometra were treated at the University of Kafkas and at Istanbul University. The diagnosis of pyometra was established on the basis of the results of clinical, ultrasonographic and vaginal examinations, the haematological and biochemical findings and the history data. In Group I (n = 13), aglepristone (Antiprogestin, Alizine, Virbac, France; 0.33 ml/kg, s.c.) was administered on days 1, 2, 7, and 14 (day 1: diagnosis). In Group II (n = 11), intrauterine antibiotic treatment was performed according to the antibiogram on days 1, 2, 4, 6, 8 in addition to aglepristone given as in Group I. Clinical and ultrasonographic examinations, haematological results and occurrence of oestrous cycles revealed that the ratio of effectively treated bitches was 6/13 and 9/11 in Groups I and II, respectively.

Animals↗

PubMed2001

Pyometra and uterine adenocarcinoma in a melengestrol acetate-implanted captive coati (Nasua nasua).

A 9-yr and 3-mo-old captive female coati (Nasua nasua) was implanted with melengestrol acetate for contraception for 4.5 yr prior to presentation. During her annual examination, purulent vaginal discharge and a palpably prominent uterus were identified. Ancillary diagnostic tests including hematology, cystocentesis, radiographs, and abdominal ultrasound were consistent with pyometra. An ovariohysterectomy was performed and histologic examination revealed pyometra and uterine adenocarcinoma, similar to pathology that has been associated with melengestrol acetate contraception in felids, canids, and primates. Given the potential association between melengestrol acetate and uterine pathology in this case, we recommend caution with melengestrol acetate use in procyonids.

Adenocarcinoma↗

PubMed2006

A hermaphrodite dog with bilateral ovotestes and pyometra.

Hermaphroditism was identified in a 3-year-old American Cocker spaniel with an enlarged os clitoridis that was shown as reddish finger-like structure protruding from the vulva. The urethral orifice was located cranially to the base of the os clitoridis. The gonads were situated caudal to the kidneys at the cranial tips of the uterine horns, and were composed mainly of seminiferous tubules and interstitial cells and had ovarian follicles in the cortices. The uterus was enlarged and revealed pyometra. Gross and histopathological findings of the dog suggested hermaphroditism with bilateral ovotestes and pyometra.

Animals↗

PubMed1992

[A case of urinary retention due to tuberculous pyometra].

A rare case of urinary retention due to tuberculous pyometra is presented. A 70-year-old woman visited our hospital complaining of dysuria and pollakisuria on January 26, 1990. In spite of medication of cholinergic agents, urinary retention developed on April 6, 1990. Cystoscopy revealed elevation of the urethra and bladder neck. Physical examinations disclosed a child-head-sized tumor in the lower abdomen, which persisted following catheterization. Excretory urogram showed a large retrovesical mass. Chain urethrocystogram revealed anterior dislocation of the bladder neck and the proximal portion of the urethra. CT scan and MRI demonstrated a fluid-filled pelvic mass, which positioned above the vagina and compressed the urinary bladder anteriorly. Total hysterectomy was performed on August 6, 1990. Pathological diagnosis was tuberculous endometritis. Urinary symptoms disappeared immediately after the operation. Postoperative chain urethrocystography revealed complete cure of the dislocation of the bladder neck and urethra. We collected 34 cases of urinary retention due to gynecological disease in Japan, and 110 cases in English literature. Among the frequent diseases were retroverted gravid uterus, prolapse uteri, uterine leiomyomas, ovarian cyst, imperforated hymen and vaginal atresia. The mechanisms of urinary retention in gynecological disease are discussed. No case of urinary retention due to tuberculous pyometra was found in the literature.

Aged↗