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At least 91 records · Page 5Linked to original sources
PubMed2003

Comparative trial between sodium tetradecyl sulfate and glycerin in the treatment of telangiectatic leg veins.

BACKGROUND: Thirteen patients were treated with either sodium tetradecyl sulfate (STS) or glycerin to compare the efficacy and adverse sequelae of each agent. OBJECTIVE: To determine the relative safety and efficacy of two sclerosant solutions. METHODS: Each patient's leg veins that were from 0.2 to 0.4 mm in diameter and that did not have incompetence from the saphenofemoral junction and whose feeding reticular veins had been already treated in a prior sclerotherapy session were randomly treated with either 0.25% STS or 72% glycerin solution. Patients were evaluated from 2 to 6 months postsclerotherapy for overall clinical improvement and incidence of adverse sequelae. RESULTS: Glycerin was comparable to STS in discomfort of injection but demonstrated a significant decrease in bruising, swelling, and postprocedural hyperpigmentation. Glycerin also demonstrated a better, more rapid clearance of treated telangiectasias. CONCLUSIONS: Seventy-two percent glycerin is a safe and effective sclerosant with fewer side effects and more rapid clearance of telangiectatic leg veins than STS.

Adult↗
PubMed1983

The use of sclerotherapy for treatment of postmastectomy wound seromas.

Five patients who developed seromas following mastectomy with lymph node dissection were treated with aspiration of the seromas and instillation of a sclerosant solution containing tetracycline. All seromas resolved promptly without infection, flap necrosis, or recurrence. The technique is recommended for treatment of this postoperative complication.

Adenocarcinoma↗
PubMedDate not supplied

[Arterial complications of the treatment of varices].

Surgical accidents (wounding, the inept mutilation of the fork of the femoral artery) are serious only when they are not recognized, and are treated late. If they are treated immediately, or soon after their occurrence, by an able team, recovery is usually straight-forward and successful. However, if a sclerosant solution is injected by accident intra-arterially, it causes irreparable damage to the area concerned, even if diagnosis is immediate and a strongly active treatment administered. Examples are cited.

Adult↗
PubMed1989

Morphological and hemodynamic changes of the lung after injection of 5% ethanolamine oleate into dogs.

We examined the pulmonary hemodynamics and morphology after injection of a sclerosing solution of 5% ethanolamine oleate (EO) into 24 normal dogs. EO of 0.5 ml/kg (n = 5), 1.0 ml/kg (n = 6), and 3.0 ml/kg (n = 7) was injected through the jugular vein into the right atrium for pathological examination and gravimetric study of the lung, while monitoring the pulmonary hemodynamics for 12 h. Normal saline of 3.0 ml/kg was injected into the remaining 6 control dogs, using the same method. Cardiac output significantly decreased immediately after injection of the sclerosant in all dogs given 0.5 ml/kg, 1.0 ml/kg and 3.0 ml/kg injections of EO; however, there was a tendency toward recovery from 6 h after injection in dogs given 0.5 ml/kg and from 9 h in dogs given 1.0 ml/kg. Pulmonary hypertension just after injection and hypoxia at 9-12 h occurred only when 3.0 ml/kg was injected. Irreversible pulmonary hemorrhage was present in the excised lungs in 4 of 7 dogs given 3.0 ml/kg, while there were no significant lesions in the other dogs. The lung water content in cases of 1.0 and 3.0 ml/kg injections was significantly higher than that in the controls, while there was no significant difference between those given 0.5 ml/kg and of the controls. The findings obtained in this study suggest that EO less than 0.5 ml/kg used for sclerosing esophageal varices seems to have little untoward influence on pulmonary hemodynamics and morphology.

Animals↗
PubMed1979

[The surgical treatment cavernous haemangioma of the soft tissues in the orofaciale region (author's transl)].

The experience gathered in therapy of 85 cavernous haemangioma allows to make the following conclusions: -The therapy of canernous haemangioma is very flexible. Localisation, expansion, increasing, aesthetical and functional troubles determine the indication for the therapeutical way. -Cavernous haemangioma must be operated in early infancy. The complete excision is the best method. The conservative control only with the outlook of a spontanremission is unsafe. -Big haemangioma will be treated by a combined treatment (destroying of blood vessels + surgical therapy). After injection of sclerosing solutions it is possible to exstirpate the haemangioma completely. -Extensive plastic and reconstructive operations will be done first after age of twenty years. The use of adjacent flaps shows suitable results.

Adolescent↗
PubMedDate not supplied

Treatment of recalcitrant intermetatarsal neuroma with 4% sclerosing alcohol injection: a pilot study.

The purpose of this investigation was to conduct a prospective trial to assess the effectiveness of a 4% sclerosing alcohol injection in a small group of patients with intermetatarsal neuromas who had failed previous conservative therapies including corticosteroid injections. Six patients with 8 neuromas were followed for a mean 346 days. A weekly series of 3-9 injections containing 1 mL of the 4% alcohol sclerosing solution were given based on patient response to treatment. Pre- and posttreatment surveys consisting of both objective and subjective findings including a visual analog pain scale were collected. The average pretreatment visual analog pain rating was 7.5 +/- 1.14. The average posttreatment visual analog pain rating was 1.38 +/- 2.39 with an average reduction of 6.13. The average reported improvement in symptoms was 73%. Five of the 6 patients would recommend the treatment to a friend or family member. No complications were encountered. Two neuromas in 2 patients failed the sclerosing injection course: 1 ultimately responded to antiinflammatory use and the other underwent excision.

Aged↗
PubMed1988

Endoscopic sclerotherapy of oesophageal varices.

The authors present their experience with the outcome of gastrofibroscopic sclerotherapy of oesophageal varices, performed in a total of 70 patients with portal hypertension. All patients were classified in classes B and C according to Child's criteria, and 68 of them had variceal bleeding before receiving sclerotherapy. Acute bleeding was successfully arrested in seven cases, and elective sclerotherapy in between bleeding episodes was carried out in 60 cases. To date, complete obliteration has been noted in 34 patients. An effect of previous sclerotherapy was observed during the next therapeutic session in 18, and eight patients died from progressive hepatic insufficiency. In the discussion section, the authors analyse current concepts on the technique of sclerotherapy related to complications, on instrumentarium and sclerosing solutions, and on the significance of prophylactic, acute and elective sclerotherapy, with the importance of endoscopic sclerotherapy of oesophageal varices perceived mainly in comparison with the results of surgery from the point of view of long-term patient survival.

Adolescent↗
PubMed1981

[Morphology of the lower esophagus after endoscopic varicosclerosation (author's transl)].

Submucous injection of 5 p.c. phenol in arachis oil in the lower esophagus can stop a bleeding from esophageal piles without considerable complications. Microscopical examinations on 14 human esophageal specimens demonstrate that phenol in oil as opposed to other sclerosing solutions produces only a mild, bland running inflammation in the tissue. Deep mucosal ulcerations, perforations of the wall, phlegmonous inflammations or mediastinitis could be observed. Nevertheless, under the intact esophageal mucosa a sufficient production of collagen fibres develops, which is effecting a varicosclerosation.

Adult↗
PubMed1992

Treatment of hydrocele testis with aspiration and injection of polidocanol.

Hydroceles of the testis were treated by aspiration and injection of the sclerosant solution polidocanol in 20 patients. Three patients had recurrences but otherwise the complication rate was nil. Injection of polidocanol is a promising treatment that should be investigated further for primary therapy of hydrocele of the testis. In contrast to some other agents this drug does not cause pain during or after the injection.

Aged↗
PubMed2000

[The use of an alcohol gel of ethyl cellulose in the treatment of venous malformations].

Absolute alcohol is the most effective treatment of venous malformations. We created an alcoholic sclerosing solution less diffusible and we report a preliminary study on 6 patients. The viscosity of the alcohol was enhanced with ethylcellulose and we treated 7 patients with VM. Two benign skin ulcerations were observed and one patient with a large VM of the face could be treated around the eyes in a dangerous area. The results are encouraging and a larger study is being performed.

Cellulose↗
PubMed2004

Microfoam ultrasound-guided sclerotherapy of varicose veins in 100 legs.

OBJECTIVE: To demonstrate the efficacy of duplex-guided foam sclerotherapy measured against patient symptom relief and quality of life. METHODS: An analysis was performed of 100 randomly chosen legs with varicose veins treated with ultrasound-guided foam sclerotherapy with a mean follow-up of 22.5 months. RESULTS: An average number of 2.1 treatments using an average of 8.7 mL of foam sclerosing solution were required to close incompetent varicose veins. Thirty-one percent of leg varicose veins required a second treatment at 3 months; 100% of patients felt that their legs were successfully treated with resolution of all symptoms in 85% and resolution in all varicose veins in 92%. CONCLUSION: Ultrasound-guided foam sclerotherapy is effective in treating varicose veins with high patient satisfaction with results and improvement in quality of life.

Female↗
PubMed1984

[Alternative sclerosing technic for the wall of the esophagus in esophageal varices. Experiences with 103 cases of sclerotherapy].

Haemorrhage caused by oesophageal varices, will produce the highest complication rate of portal hypertension. Fiberendoscopic sclerotherapy has been widely introduced for treating those oesophageal varices. Two methods which are technically different are applied: intravariceal injection of the sclerosing solution and paravariceal injection inducing subepithelial fibrosis of the oesophageal wall. Twenty-five patients with oesophageal varices were subjected to 103 fiberendoscopic sclerotherapy sessions. Before every session a Sengstaken-Blakemore tube was inserted in the oesophagus. Sclerotherapy took place along this tube. This modified technique of paravariceal sclerotherapy of the oesophageal wall provides the possibility of secure sclerotherapy by using no specially adapted fiberoptic endoscopes.

Adult↗
PubMedDate not supplied

Endoscopic sclerosis of the gastric cardia for prevention of experimental gastroesophageal reflux.

Surgical anti-reflux therapy appears to involve the muscles of the proximal gastric cardia and those of the lower esophageal sphincter. In an experimental canine reflux model, we injected sclerosant solution into the submucosa of the proximal gastric cardia, hypothesizing that the subsequent fibrotic reaction might exert an anti-reflux effect. Reflux was induced by atropine infusion, and the amount of reflux was quantitated by pH monitoring. Endoscopic sclerosis was effective in preventing reflux induced by high-dose atropine. Because the length and pressure of the lower esophageal sphincter were unaffected by endoscopic treatment, reflux prevention was possibly related to enhancement of the gastric component of the reflux barrier.

Animals↗
PubMed1987

The role of sclerotherapy in the treatment of esophageal varices: personal experience and a review of randomized trials.

Although many more randomized trials will be required to define the role of prophylactic EVS and other therapies (95-99) in the treatment of varices, EVS appears to have a place in the management of varices before they bleed. However, in view of studies recently presented in abstract form (98, 99), it must be stressed that at least in the United States, prophylactic EVS should be restricted to patients in randomized trials. Results from a VA cooperative study (98) led to the conclusion that prophylactic EVS should not be done in male patients with alcoholic cirrhosis and esophageal varices due to excess mortality in the active EVS group (p = 0.009). Although a large number of patients (n = 282) were included into this trial, on the average each of the 12 VA centers treated only 12 patients with EVS. Thus, although investigators were experienced with EVS, a single unforseen problem occurring at each VA center only once could dramatically alter the results of the study. For example, a relatively potent sclerosant solution (45) used in this study may be effective in treating variceal bleeders, but be too toxic and damaging to the esophagus for prophylactic EVS. Also, even though to enter the VA cooperative study, patients were required to have at least three variceal channels, and 89% in the study actually had "large" varices, these "large" varices may not be the same as the "ominous-looking" varices required of the patients in Paquet's study (88, 89, 99). Exactly which subgroups will benefit from each of the various treatments available will be defined as further studies of patients with a high risk of variceal bleeding are completed (95, 99).

Clinical Trials as Topic↗
PubMed1987

Sclerotherapy for superficial venules and telangiectasias of the lower extremities.

Sclerotherapy remains the best single treatment for telangiectasias and superficial venules of the lower extremities. It has been used successfully for decades. It is, however, a somewhat tedious and time-consuming procedure and requires great patience on the part of the physician. With careful attention to the details of the procedure and with necessary practice and experience on the part of the physician, a good result will be obtained. To summarize: Use one of the safe, modern sclerosing solutions: hypertonic sodium chloride 18 to 25 per cent, Aethoxysklerol 0.25 to 1.0 per cent, or Sclerodex. Good illumination, liberal use of alcohol on the skin, and 2 to 3 X magnification will increase the visibility of the tiny vessels. Use 3-ml Luer-Lok syringes and 30-gauge needles and thread the needle carefully into the vessel while using slow and steady injection with light pressure. Always provide post-treatment compression with cotton balls, tape, and compression hosiery. Because the majority of patients are most gratified, serious risks are minimal, and most side effects are of a transitory nature, sclerotherapy is a most worthwhile technique to master and include in one's armamentarium of simple, office-based cosmetic dermatologic procedures.

Humans↗
PubMed2002

Sclerosis of gross cysts of the breast: a three-year study.

Breast cysts can be separated into two types: Type I cyst with a lining epithelium which shows apocrine metaplasia, and Type II cyst with an epithelium which is markedly attenuated or absent. The risk of subsequent breast cancer among patients with Type I cysts can be up to 4. The standard treatment is fine needle aspiration, but 20% of the cysts recur. Pharmacological treatment has been tried, which reduces size and volume, but has side-effects and a high recurrence rate post-treatment occurs. The objectives of this prospective study were to sclerose the cyst, induce its regression and prevent or reduce recurrence rate, with the administration of a sclerosing solution (Sclerovein) within the cyst post-aspiration. Fifty-seven patients were followed in the study, 37 with Type I cysts and 20 with Type II cysts. At the end of six months all patients with Type II cysts had no detectable cyst. On the other hand, two patients still had a residual Type I cyst. At the end of three years our recurrence rate appears to be less than 2%, with one patient with a possible recurrence. No significant side-effects were observed. The use of Sclerovein is a simple and safe alternative in the treatment of recurring cysts.

Adolescent↗
PubMedDate not supplied

A comparative evaluation of sclerosants for esophageal varices: a prospective randomized controlled study.

The aim of this prospective randomized controlled study was to find a safe and effective sclerosing solution for endoscopic injection sclerotherapy in the treatment of esophageal variceal bleeding. Ninety consecutive patients with portal hypertension and variceal bleeding were randomized to receive sclerotherapy with 5% ethanolamine oleate, 3% sodium tetradecyl sulfate, or absolute alcohol at an interval of 3 weeks. Sixty-four patients who received more than three sessions were analyzed. All three agents were found to have similar success and complication rates (p greater than 0.05). However, absolute alcohol required fewer sessions (p less than 0.01) and lesser amounts (p less than 0.01) to produce successful variceal sclerosis and had the added advantage of low cost and easy availability.

Adult↗