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PubMed1980

[Neutron activation analysis of selenium using a coincidence counting method (author's transl)].

Neutron activation analysis of selenium using 75Se has been investigated by means of a coincidence counting of gamma-rays in the cascade decay series by a NaI(TI) detector and a Ge(Li) detector. Using this method, the background around the photopeak of 75Se-265 keV could be reduced to one twentieth, and thus the detection limit of selenium could be improved four times higher than the usual method. For examining the accuracy of this measuring method, selenium contained in Bovine Liver (NBS) was determined and the content of selenium was found to be 1.02 micrograms/g (the certified value is 1.1 +/- 0.01 micrograms/g). Selenium content in Orchard Leaves (NBS) was determined to be 0.081 +/- 0.006 micrograms/g (the certified value is 0.08 +/- 0.01 micrograms/g), though its non-destructive determination was difficult because of its very low content. The results obtained here indicate that the accuracy, the precision and the reproducibility for selenium determination are thought to be adequate. As an example of a sample containing many interference nuclides, selenium in a soot was determined on the basis of these results.

Activation Analysis↗
PubMedDate not supplied

Uptake and localization of selenium-75 in mammary epithelial cell lines in vitro.

The uptake and subcellular localization of selenium-75 was examined in 3 established mammary cell lines in vitro. Previous studies had demonstrated that cell line YN-4 exhibited a biphasic growth response to selenium, whereas cell lines CL-S1 and WAZ-2t exhibited only an inhibition of growth. All 3 cell lines incorporated selenium-75 readily over a 48-h incubation period and the concentration of selenium-dependent glutathione peroxidase was correlated with the level of selenium-75 uptake. However, neither of these 2 parameters could be related to the unique biphasic growth response exhibited by cell line YN-4. The intracellular localization of selenium-75 was similar in lines CL-S1 and YN-4 with the label incorporated primarily in the cytosol and secondarily in the mitochondria. Although the unique growth response of line YN-4 could not be attributed to the incorporation parameters examined herein, the stable incorporation of selenium-75 at high levels should make these lines useful for further studies on the subcellular localization of selenium into organelles and macromolecules.

Animals↗