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PubMed2004

Analytical procedure for the in-vial derivatization--extraction of phenolic acids and flavonoids in methanolic and aqueous plant extracts followed by gas chromatography with mass-selective detection.

An in-vial simple method for the combined derivatization and extraction of phenolic acids and flavonoids from plant extracts and their direct determination with GC-MS, is described. The method is taking advantage of the beneficial potentials of phase transfer catalysis (PTC). Catalysts in soluble and polymer-bound form were tested with the latter being the format of choice due to its high reaction yield and facile separation from the rest of the reaction system. Optimization of experimental conditions was established. Chromatographic separation of eight phenolic acids and four flavonoids methylated via the PTC derivatization step was achieved in 45 min. The detection limits for the described GC-MS(SIM) method of analysis ranged between 2 and 40 ng/ml whereas limits of quantitation fall in the range 5-118 ng/ml, with flavonoids accounting for the lowest sensitivity due to their multiple reaction behavior. Four methanolic extracts from Tilia europea, Urtica dioica, Mentha spicata and Hypericum perforatum grown wild in north-western Greece and four aquatic infusions from commercially available Mentha spicata, Origanum dictamnus, Rosemarinus officinalis and Sideritis cretica were analyzed. Good trueness of the method was demonstrated as no matrix effects were found for the analytes concerned.

Flavonoids↗
PubMed2005

Plants known as té in Spain: an ethno-pharmaco-botanical review.

Although the word té (tea) in Spanish is derived from the Chinese tscha and refers to the oriental plant Camellia sinensis, it is popularly used throughout Spain to refer to at least 70 different plant species. These are usually collected in the countryside, boiled dry or fresh, and drunk after meals. The drinking of té is a social habit that encourages conversation in a relaxed atmosphere. Tés are also commonly used as digestifs and stomachics, and in some cases as laxatives, antidiarrhoeics, and to reduce the blood pressure. They are not used as stimulants. It appears that the habit of drinking Camellia sinensis afforded the cognitive context for drinking other infusions with no specific medicinal purpose. Some té species are very common in Spain (and their use is quite extended), others are endemic, and others still are allochthonous that now live in the wild. The majority of these species belong to the families Asteraceae and Lamiaceae. The most important and widely distributed are Jasonia glutinosa, Sideritis hyssopifolia, Lithospermum officinale, Chenopodium ambrosioides and Bidens aurea. Other remarkable but more locally used tés include Cruciata glabra (only in the Pyrenees), Inula salicina and Mentha arvensis (in the Central Mountain Range of Madrid), and Potentilla caulescens (in Tarragona).

Beverages↗
PubMed2005

Anti-ulcerogenic activity of some plants used in folk medicine of Pinarbasi (Kayseri, Turkey).

Several ethnomedicinal plant remedies used in Pinarbasi, Kayseri, in particular those which are used for the treatment of several peptic ulcer symptoms such as stomach ache, heartburn, etc. were selected for evaluation of their anti-ulcerogenic potential. In order to confirm the claimed activities, decoctions were prepared from aerial parts of Malva neglecta Wallr. (Malvaceae), leaves of Potentilla reptans L. (Rosaceae), fruits of Rumex patientia L. (Polygonaceae), aerial parts of Sanguisorba minor Scop. ssp. muricata (Spach) Briq. (Rosaceae), aerial parts of Sideritis caesarea Duman, Aytac&Baser (Lamiaceae), and flowers of Verbascum cheiranthifolium Boiss var. cheiranthifolium (Scrophulariaceae) according to their described folkloric applications. Pharmacological experiments clearly demonstrated that the extracts of all plants given orally showed significant gastric protection against the ethanol-induced gastric ulcer model in rats. Furthermore, healing effects were also confirmed through histopathological examination.

Animals↗
PubMed2005

Traditional phytotherapy and trans-cultural pharmacy among Turkish migrants living in Cologne, Germany.

This article reports on an ethnopharmaceutical field study carried out among Turkish migrants in Cologne, western Germany, which recorded 79 botanical taxa and 115 plant-based preparations, encompassing 167 folk phytotherapeutical uses, as well as a few other biological (animal and mineral derived) remedies. One-fourth of the recorded remedies were represented by food-medicines. Half of the ingredients quoted came originally from Turkey; only a few plants were gathered from the wild or cultivated in the Cologne area. This article discusses the Turkish migrants' frequent use of aerial parts of Sideritis species, the fruits of Pistacia terebinthus and the seeds of Peganum harmala from the perspective of modern phytopharmacology, phytotherapy and toxicology. It considers cultural adaptation related to the use of folk pharmaceuticals by analysing the ingredients of the Turkish folk pharmacopoeia and comparing them with those of the Turkish medical ethnobotany and of the phytotherapy of the host country (Germany). Only one third of the remedies mentioned by Turkish migrants living in Cologne are also known in German evidence-based phytotherapy, and less than 10% of the recorded phytotherapeutic uses are common to both pharmacopoeias. This article concludes by suggesting hypotheses on future changes affecting the knowledge and use of medicinal plants within the Turkish community of Cologne.

Culture↗
PubMed2006

[Post-traumatic psychosis: the contribution of an acute post-immediate trauma to a dynamic theorization].

SUMMARY: In his recent publication (2004), in which he favors the psycho-dynamic approach, M. Bertrand underlines the importance of traumatic matter at the heart of new clinical, methodological and epistemological challenges of psychopathology. TRAUMATIC PSYCHOSIS CONCEPT: Our contribution ("post-traumatic psychosis") comes within that prospect in reference to the semiology of traumas generated by extreme situations, such as the tsunami in South Asia (December 2004), the terrorist attacks in Madrid (March 2004) or the hostage taking in North Ossetia (September 2004). Four principle sets of themes lead us to suggest a traumatic psychosis when the person shows symptoms of a neurotic psychic structure: 1. There's no traumatic representation or psychic inscription of the event. Sideration (and its stupor-like confusion symptoms) or panic flight (together with hallucinations or acute delirious fits) often illustrate this first clinical aspect. 2. According to the psychodynamic frame of reference, psychic processes tend to ignore the pleasure/displeasure principle. They are governed by the "invasion" of affects of pain and compulsion to repeat. 3. The models of neurosis and psychic conflict are not efficient in the management of the "quota of affect" and the drive influence. 4. It would be necessary to add, from a psychopathological point of view, the appearance of temporary fits of mental confusion, self-destructive and autolysis behavior. CLINICAL FEATURES: The frame of reference of a DSM IV type "descriptive" psychopathology (ie acute Stress Disorder) seems to de inadequate to convey the implemented post traumatic stakes. If trying to soothe the symptoms is undeniably important, psychic disorganizations that generate a semiology that is essentially present in the symptomatology of the psychoses cannot be ignored. A first clinical approach makes it possible to specify the argumentation of our proposal: "a post-traumatic psychosis". It is supported by five main syndromic classes: 1) the symptoms are often more or less temporary delirious fits (delirious ideas or perceptions of a persecutory, cenesthetic or hypochondriac nature), mental confusion (oneiroid state, anxiety and stupor), phases of depersonalization and derealization, severe death pangs, serious physical disorders, divides close to schizophrenic-type dual personalities; 2) the adhesiveness marks the impossibility for the victims to keep away from a trauma. The objects are bound, persecuting and adhesive; 3) traumatic temporality imposes a factual and current omnipresence of the trauma. It destroys the temporal projections of the patient as well as an anamnesic reconstruction; 4) the "traumatic body" is not that of hysterical neurosis conversions. The somatic semiology marks operational-type functioning (P. Marty); 5) traumatic compliance doesn't work on the level of facilitations that lead to the formation of symptoms. The identity structure appears disorganized by the dismantling of the primary psychic envelopments. PSYCHOPATHOLOGICAL ASPECTS: A second theoretical approach makes it possible to promote this immediate psychotic-type post-traumatic psychopathology. Four considerations of fundamental psychopathology support our contribution: 1) Pictogramic inscription. The severe traumatism does not produce the polarity required for the process of "self-fathering" described by P. Aulagnier in connecting with original processes. Traumatic adhesiveness does not separate the victim from the trauma. It splits the necessary mediation spaces and distance for the emergence of representation processes. 2) Pain affect. The pain affect generated recalls the first experiences of the newborn, primitive agony and anaclitical collapse; the "narcissistic contract" is broken and the patient lives without a secure base or a sufficiently good and supporting psychic container (D.W. Winnicott). 3) Anxiety status. The anxiety is not of neurotic nature but truly annihilating. It is often similar to anxieties caused by disasters, psychoses due melancholy (H. Ey) or more "archaic" anxieties that have been observed in hebephrenic pathologies. 4) Body dismantling. The trauma results in "mute somatizations that cannot be symbolized" (M. Bertrand). They appear in sensory outward signs such as dermatosis, pruritus, diarrhea, hemorrhagic periods or persistent headaches for example. These two clinical and theoretical aspects of the severe forms of trauma confirm the unconscious traumatolytic aim of the victim's psychological destruction. The semiological forms most impervious to therapeutic processes seem to be, in reference to hostage-takings or terrorists acts, those where the patient was conformed with a trauma "that was not carried out" like mock hangings or executions. Suicidal dimension seems to be the ultimate recourse so as not to sink into insanity and to keep a subjective position when faced with barbarian figures.

Affect↗
PubMed1997

Relative validity of clinical techniques for measuring the body composition of persons with amyotrophic lateral sclerosis.

Tracking body composition is necessary to understand how amyotrophic lateral sclerosis (ALS) is affecting a patient's morphology and to provide a basis for appropriate nutritional advice throughout disease progression. Dual X-ray absorptiometry (DEXA) has been shown to reliably detect body composition changes in persons with ALS. However, this procedure is expensive and available primarily for research. The purpose of this study was to determine the relative validity of two common clinical techniques, anthropometry and bioelectrical impedance analysis (BIA), for measuring the body composition of persons with ALS. Twenty-three persons with ALS volunteered for the study; seven with primarily bulbar symptoms, five with primarily arm weakness, five with primarily leg weakness, and six with significant weakness in all extremities. On a single day subjects underwent body composition analysis by the three techniques, with DEXA serving as the criterion method. Anthropometry and BIA results were converted to lean and fat mass using eight prediction equations commonly cited in the literature. Anthropometry measures were also converted to estimates of muscle mass using two additional equations. Both BIA and anthropometry tended to overestimate lean mass and underestimate fat mass compared to DEXA. However, the BIA prediction equations had smaller mean differences, larger correlations, and smaller standard errors of estimate than the anthropometry equations. The Lukaski et al. BIA equation (Lukaski, H.C., Bolonchuk, W.W., Hall, C.B., Siders, W.A., 1986. Validation of tetrapolar bioelectrical impedance method to assess human body composition. J. Appl. Physiol. 60, 1327-1332) most closely matched the values derived by DEXA and is probably the best method for measuring the lean and fat mass of persons with ALS, as long as they maintain adequate hydration levels. The Heymsfield et al. equation (Heymsfield, S.B., McManus, C., Smith, J., Stevens, V., Nixon, D.W., 1982. Anthropometric measurement of muscle mass: revised equations for calculating bone-free arm muscle area. Am. J. Clin. Nutr. 36, 680-690) for estimating muscle mass may also be a useful clinical tool for this population. Further longitudinal studies are needed to determine whether the equations that correlated best with DEXA at a single point in time are also sensitive enough to detect changes in body composition over a period of time.

Absorptiometry, Photon↗
PubMed2001

Effect of aqueous extracts of some plants of Lamiaceae family on the growth of Yarrowia lipolytica.

Aqueous extracts of some plants belonging to the Lamiaceae family (Sideritis montana, Origanum dictamnus, Mentha piperita, Rosmarinus officinallis and Origanum marjorana) caused an important increase of the lag time of Yarrowia lipolytica. Especially, Origanum dictamnus and Rosmarinus officinallis extracts enhanced the lag time considerably and influenced negatively the specific growth rate of this yeast. In culture media having low C/N ratio, all plant extracts caused an increase of the biomass produced in relation to glucose and nitrogen consumed, while, in high C/N ratio media the effect of the extracts on biomass production was negative. In the presence of aqueous plant extracts, in low C/N ratio culture media, the ratio sigma unsaturated/sigma saturated fatty acids in the cellular lipids increased, whereas in high C/N ratio media it decreased.

Antibiosis↗
PubMed1997

Low-temperature interactions of NO with the S1 and S2 states of the water-oxidizing complex of photosystem II. A novel Mn-multiline EPR signal derived from the S1 state.

The spin-1/2-carrying NO molecule interacts with both the S1 and S2 states of the water oxidizing complex. The intermediates of the interaction can be resolved and trapped by NO treatment at subzero temperatures. At -30 degrees C and in the presence of approx. 500-700 microM NO, S1 loses the ability to yield by illumination an EPR active S2-state with an approximate half-time of 40-60 min. At longer incubation times (t1/2 = 4-5 h), an intense new multiline signal develops. The new signal has a hyperfine splitting similar to the S2 multiline [Dismukes, G. C., & Siderer, Y. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 274-278], but a modified shape with intense lines on the high field side. The NO modified S1 state can act as a low-temperature electron donor yielding an EPR silent state upon illumination at 200 K. NO interacts also with the S2 state of the water oxidizing complex rapidly at temperatures as low as -75 degrees C, to yield an EPR silent state. The rates of the latter interaction show analogies to the ammonia binding to the S2 state. It is possible, however, that NO, unlike ammonia, destabilizes the S2 state. On the basis of preliminary experiments with varying chloride concentrations in the range 0.1-50 mM, the S1 multiline state is attributed to binding of NO at a chloride sensitive site on the Mn cluster. The rapid interactions with the S2 state as well as the intermediate binding to the S1 state are less well understood at present, but they are tentatively assigned to the chloride-insensitive site of ammonia binding in the Mn cluster.

Cold Temperature↗
PubMed1999

Inhibition of NOS-2 expression in macrophages through the inactivation of NF-kappaB by andalusol.

1. Andalusol, ent-6alpha,8alpha,18-trihydroxy-13(16),14-labdadiene, is a naturally occurring diterpene, isolated from Sideritis foetens (Lamiaceae). This compound exhibited therapeutic activity when evaluated in in vivo models of paw and ear inflammation (Navarro et al., 1997: Z. Naturforsch., 52, 844-849). The pharmacological effects of this diterpene have been analysed on the activation of the macrophage cell line J774 with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma). 2. Incubation of J774 macrophages with andalusol (0.1 - 100 microM) inhibited the synthesis of nitrite caused by LPS (1 microg ml-1) in concentration and time-dependent manners. The maximal inhibition was observed when andalusol was added 30 min before LPS stimulation and decreased progressively as the interval between andalusol and LPS challenge increased up to 14 h. 3. Incubation of J774 cells with LPS resulted in the expression of NOS-2 protein (130 kDa) as identified by Western blot analysis. The levels of this enzyme decreased significantly in the presence of andalusol (IC50=10.5 microM), suggesting that this diterpene inhibited NOS-2 expression. 4. Andalusol inhibited nuclear factor kappaB activation, a transcription factor necessary for NOS-2 expression in response to LPS and IFN-gamma. This compound also inhibited the degradation of IkappaBalpha favouring the retention of the inactive NF-kappaB complexes in the cytosol. 5. Related compounds to andalusol but lacking the polyol groups were less effective inhibiting NOS-2 expression in LPS-activated macrophages. The present findings provide a mechanism by which the anti-inflammatory properties of this diterpene could be mediated.

Animals↗
PubMed2002

Primary hepatic carcinoid tumor with metachronous lymph node metastasis after long-term follow up.

A case of hepatic carcinoid tumor occurring in a 71-year-old man is reported. The tumor was diagnosed initially as a hepatocellular carcinoma, and was then shown after resection histologically to be a carcinoid tumor. The tumor cells formed small nests and trabeculae separated by fibrous septa and were positive for Grimelius staining. Immunohistochemically, most of the tumor cells stained positive with chromogranin A and neuron-specific enolase. After a follow up for 5 years and 7 months, the patient developed tumors in lymph nodes between the remnant liver and the lesser curvature of the stomach with no tumors in other organs. Histologically, the tumor cells in the lymph nodes demonstrated a pattern of the immunostainings consistent with carcinoid tumor. After lymphadenectomy, the patient is free from recurrence in the regional lymph nodes for more than 1 year. This case is con-sidered to be a primary hepatic carcinoid tumor with metachronous lymph node metastasis.

Aged↗
PubMed2000

Immunomodulating properties of the diterpene andalusol.

Andalusol [ent-13(16),14-labdadiene-6 alpha,8 alpha,18-triol], a labdane diterpene isolated from an anti-inflammatory extract of the medicinal plant Sideritis foetens Clem. was evaluated for immunomodulating properties. It exhibited a dose-dependent inhibitory effect on the hemolytic activity of the classical complement pathway and also inhibited lymphocyte proliferation induced by concanavalin A at non-cytotoxic concentrations (1-100 microM). No effect on the alternative pathway was observed. These results indicate that andalusol has immunosuppressive effects in vitro in addition to its anti-inflammatory activity.

Adjuvants, Immunologic↗
PubMed1990

Cytostatic and antibacterial activity of some compounds isolated from several lamiaceae species from the canary islands.

A chemotherapeutic study has been carried out on thirteen products Eeleven diterpenes, one lignan, (+)-sesamin, and a coumarin, siderin] isolated from SALVIA and SIDERITIS species considered endemic to the Canarian flora. The data obtained suggest that some diterpenoid compounds show an interesting cytostatic activity, specially galdosol ( 6) with an ID (50) value of 0.5 microg/ml. These compounds also evidence a moderate antibacterial activity against Gram positive bacteria.

Journal Article↗
PubMed1981

Seismology and geodesy of the sun: Solar geodesy.

Measurements of the elliptical figure of the sun made in 1966 are analyzed on an hourly basis. This analysis yields an improved measure of the previously found solar distortion, rotating rigidly with a sidereal period of 12.38+/-0.10 days. It also yields a set of residùals used to search for signals due to low-frequency solar oscillations.

Journal Article↗
PubMed2001

Orbital amputation neuroma causing failure of prosthesis wear.

PURPOSE. To describe an orbital amputation neuroma that developed following enucleation and led to the patient 's inability to wear an oc- ular prosthesis. METHODS. This is a retrospective case report in a private practice setting. An elderly woman underwent enucleation of the right eye,and subsequently developed orbital pain and inflammation. Systemic and local steroids proved of no benefit, and the socket became increasingly painful,contracted and frozen. She was unable to wear her prosthesis. An orbital mass was noted,and subsequently biopsied. RESULTS. The biopsy specimen demonstrated orbital amputation neuroma. Her pain was relieved. CONCLUSION. Orbital amputation neuroma should be a diagnostic con- sideration when a patient develops a painful orbital mass following enucleation.

Journal Article↗
PubMed2002

A prospective comparison of the two main indications of efavirenz in 2001 highly active antiretroviral therapy (HAART) regimens: first-line versus salvage use.

OBJECTIVE: To determine the efficacy of efavirenz introduction in first-line HAART compared with salvage multidrug regimens. PATIENTS AND METHODS: Prospective 15 month comparison of 107 consecutive HIV-infected patients starting efavirenz, according to laboratory and clinical outcome of first-line versus rescue drug use, therapeutic history and association of selected antimicrobial agents: naive patients were compared with nucleoside reverse transcriptase inhibitor (NRTI)-experienced patients in the first group, and patients in the second group who had one or more NRTI changed when starting a rescue treatment containing one or more novel protease inhibitors (PIs) were compared with those who did not. RESULTS: Efavirenz was administered with one or more novel NRTIs to 55 patients (27 antiretroviral-naive and 28 patients experienced with NRTIs only), compared with 52 patients who needed a multidrug salvage regimen after two or more failures of a 15-40 month PI-containing regimen. In an intention-to-treat analysis, con-sidering early interruption or an unsatisfactory virological course as a failure, only one patient on salvage therapy completed a favourable 15 month follow-up, compared with 31 patients experiencing first-line efavirenz-based HAART (P < 0.0001). The immunological response was less affected in both intensity and duration in patients undergoing rescue therapy. While no significant outcome difference was detected in the first group between naive and NRTI-experienced patients, among the salvage subjects the change of one or more NRTIs seemed to significantly improve virological and immunological outcome. Viral genotyping detected at least the K103N mutation in 41% of the 78 evaluable patients, despite lack of exposure to efavirenz and related compounds. Salvage patients had a significantly greater frequency of non-nucleoside RTI (NNRTI) resistance compared with the first-line group (P < 0.0001), in proportion to the extent of mutations affecting other drug classes (P < 0.0001). CONCLUSION: An efavirenz-based initial triple drug HAART proved significantly more effective than efavirenz adjunct to a rescue treatment performed after repeated failures of PI-based regimens. The unsatisfactory response of the salvage group was probably due to diffuse cross-resistance descending from previous therapy, even when NNRTIs were never administered.

Alkynes↗
PubMed1995

Parents' contributions to children's knowledge and attitudes regarding AIDS: another look.

Attempted to determine, using a sample of students in Grades 3, 5, and 7, whether parent-child communication about AIDS and parent knowledge of AIDS predict children's knowledge, social attitudes, and worry regarding AIDS, partially replicating tests by Sigelman, Derenowski, Mullaney, and Siders (1993) of main effects, interaction, and potentiation models of parent-child socialization. Most parents had talked to their children about AIDS but many were susceptible to myths about HIV transmission. Child age was the strongest predictor of accurate knowledge and positive attitudes, but gender, ethnicity, and parent education also made modest contributions. Consistent with the potentiation model, parent knowledge of common transmission myths predicted child knowledge of those same myths (and willingness to interact with individuals who have AIDS as well) only when parent-child communication about AIDS was relatively extensively (and only when child rather than parent reported it). Findings suggest that both the quantity and quality of parental messages must be considered by socialization researchers but that parents may not be the primary socializers of knowledge and attitudes regarding AIDS and other health issues.

Acquired Immunodeficiency Syndrome↗
PubMed2003

Water flows in the parasitic association Rhinanthus minor/Hordeum vulgare.

Using the facultative root hemiparasite Rhinanthus minor and its host Hordeum vulgare several aspects of water relations have been measured in this parasitic association. Extraction of xylem sap by the parasite from the host's roots is facilitated by con siderably higher transpiration per leaf area in the parasite than in the host and by the fact that stomata of attached Rhinanthus were open all day and night despite extremely high ABA concentrations in the leaves. By comparison, another root hemiparasite, Melampyrum arvense, parasitizing various grasses in the field, showed normal diurnal stomatal behaviour. The abnormal behaviour of Rhinanthus stomata was not due to anatomical reasons as closure could be induced by applying high external ABA concentrations. Remarkable differences have been detected between the hydraulic conductance of barley seminal roots showing relatively low values and that of Rhinanthus seminal roots showing very high values. The latter could be related to the observed high ABA concentrations in these roots. Whole plant water uptake, transpirational losses, growth-dependent deposition, and the flows of water within the plants have been measured in singly growing Rhinanthus and Hordeum plants and in the parasitic association between the two. Water uptake, deposition and transpiration in Rhinanthus were dramatically increased after attachment to the barley host; most of the water used by the parasite was extracted as xylem sap from the host, thereby scavenging 20% of the total water taken up by the host's roots. This water uptake by the parasitized host, however, due to a parasite-induced reduction in the host's growth, was decreased by 22% as compared to non-parasitized barley. The overall changes in growth-related water deposition in the host and parasite pointed to decreased shoot growth and relatively favoured root growth in the host and to strongly favoured shoot growth in the parasite. These changes in the host became more severe, when more than one Rhinanthus was parasitizing one barley plant.

Abscisic Acid↗