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Benign soft-tissue neoplasm simulating sarcoma of spermatic cord.

A large, painless, slow-growing mass arising in the scrotum of a twenty-three-year-old man, which proved to be benign myxoma, simulated a primary sarcoma of the spermatic cord. Only 1 case of myxoma involving the spermatic cord has been reported previously. It is extremely important that multiple microscopic sections of the specimen be examined carefully so that the proper tissue diagnosis can be made. A false diagnosis of malignancy may lead to treatment that is not indicated and that has a high morbidity.

Adult↗

The efficacy of gallium scintigraphy in detecting malignant soft tissue neoplasms.

A prospective study was conducted on 55 consecutive patients to evaluate the efficacy of gallium scintigraphy in detecting malignancy in any soft tissue mass. It was determined that gallium scintigraphy could detect malignancy with a sensitivity of 96% and a specificity of 87%. Large and small sarcomas, irrespective of their fascial location, were identifiable by gallium imaging. Occult, nonpulmonary sites of disseminated disease were detected in 13%. Gallium scintigraphy proved to be a reliable predictor of malignancy for all soft tissue masses, but because of its cost, it must be used judiciously.

Adolescent↗

[Principles of the treatment of soft tissue neoplasms of the locomotor system].

Although chemotherapy and radiotherapy is widely used in oncological treatment, surgical treatment still plays the main role in orthopaedic oncology. Surgical radicalism on which depends the time of a patient's survival cannot justify any operations needlessly mutilating patients and in this way destroying motor function. The principle of surgical radicalism may have special exceptions in the case of elderly persons.

Amputation, Surgical↗

Phenoxyacetic acid herbicides and chlorophenols and the etiology of lymphoma and soft-tissue neoplasms.

The phenoxyacetic acid herbicides and the chlorophenols are compounds of economic importance. The herbicide 2,4-D is widely used in agriculture, industry, and the home. Recently, concern has arisen over their safety as a result of studies linking these compounds with soft-tissue sarcomas and non-Hodgkin's lymphomas. We reviewed the available literature in order to advise a provincial government regulatory body and investigated methodologic issues by examining the pattern of reported cases in Alberta. We conclude that, taking into account the serious limitations on methodology in the available data, the evidence for a causal association is strongest for non-Hodgkin's lymphomas and probably reflects either a weak effect or, possibly, a confounding exposure associated with the use of 2,4-D. Given the worst-case assumptions, however, the potency of 2,4-D as a carcinogen is probably weak. Its intrinsic toxicity is less than that of alternative herbicides and the hazard posed by its use is probably much less than either the use of chemical alternatives or manual cleaning of vegetation, which carry a high risk of occupational injuries.

Chlorophenols↗

Imaging methods for assessment of pedal soft-tissue neoplasms.

The advent of cross-sectional, tissue-specific, noninvasive multiplanar imaging methods has enabled the radiologist to probe the etiopathogenesis of soft-tissue lesions of the foot to greater advantage than in the past. High-resolution, high-contrast images are now available so that a wide variety of conditions may be explored, resulting in accurate compartmental localization and assessment of both adjacent tissue as well as vascular invasion and distant metastasis.

Diagnostic Imaging↗

The Radiologic Features of Non-Neoplastic Tumors of Soft Tissue.

Neoplasms of the soft tissues cause localized swelling and a variable degree of tissue response on the part of the host; these features they share with many non-neoplastic disorders. A spectrum of lesions that may simulate soft tissue neoplasms are described, with their radiologic appearances. The cellular nature of the matrix of a lesion cannot be identified absolutely as neoplastic by current imaging methods. Although sonography and magnetic resonance imaging can each produce valuable diagnostic information hitherto not provided by imaging the soft tissues, they do not per se show evidence of neoplasia. The differentiation of the two types of tumor, neoplastic and non-neoplastic, can only be achieved by a combination of clinical, radiologic and histologic information. Ultimately, biopsy with histologic examination may be required for the definitive diagnosis.

Journal Article↗

Hyaline cartilage-origin bone and soft-tissue neoplasms: MR appearance and histologic correlation.

Magnetic resonance (MR) images and histologic studies of 16 chondroid-matrix lesions were reviewed to determine if any distinctive morphologic or signal features might be discerned. Ten biopsy-proved nonchondroid bone lesions were compared in terms of configuration and signal characteristics. The tumor matrix had a distinctive appearance of homogeneous high signal intensity in a defined lobular configuration on images of all hyaline cartilage lesions obtained with a long repetition time and a long echo time. The areas of hyperintensity relative to muscle corresponded to areas of hyaline cartilage matrix with its uniform composition, low cellularity, and high water content; the lobular morphologic characteristic had an identical histologic correlate. The chondroblastomas, clear-cell chondrosarcoma, and synovial chondromatosis demonstrated a much more cellular stroma, with only scattered islands of chondroid matrix, and were isointense or hypointense compared with muscle on all MR sequences. The distinctive lobular, high-intensity MR appearance was not seen in the ten nonchondroid bone lesions.

Adolescent↗

[Soft tissue neoplasms arising from myofibroblasts].

A group of 14 mainly spindle-cell tumours caused some uncertainly during bioptic classification with diagnosis oscillating between proliferating fibroma, fasciitis, fibrosarcoma, mesenchymal tumour, leimyoma, fibromesothelioma or even polymorphocellular sarcoma. A common feature was seen in the presence of different proportions of myofibroblasts of largely variable appearance. The only justification for the term "tumours arising from myofibroblasts" is in the predominance of well defined myofibroblasts. In all other cases the presence of such elements is at least a prospective contribution to the assessment of histogenetic connections.

Adolescent↗