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Quantifying the disease impact of cigarette smoking with SAMMEC II software.

Smoking-Attributable Mortality, Morbidity, and Economic Costs Software, Release II (SAMMEC II) has been developed for the Office on Smoking and Health, Public Health Service, to permit rapid calculation of deaths, years of potential life lost, direct health-care costs, indirect mortality costs, and disability costs associated with cigarette smoking. For the mortality-related measures, age-specific and age-adjusted rates are also calculated. The pivotal epidemiologic measure in these calculations is the smoking-attributable fraction, and attributal risk measure. A multiple-measure approach (attributable mortality and economic costs) to quantifying a health problem is termed "disease impact estimation." Previously, national and State-specific estimates of smoking-attributable mortality and economic costs were calculated using SAMMEC software, the predecessor of SAMMEC II. SAMMEC II is completely menu-driven and operates within the Lotus 1-2-3 software as a set of linked spreadsheets. SAMMEC II adapts national epidemiologic methods for use by State and local health departments. Increased exposure of public health professionals to disease impact estimation techniques, as demonstrated by SAMMEC II, will lead to improvements in both methodology and the quality of smoking-related health data. The primary purpose of SAMMEC II, however, is to provide State or locality-specific data on the health consequences of smoking to policymakers and public health professionals in these jurisdictions.

Cost Allocation

[Convenient and useful computer software for the anesthesiologist].

Convenient and useful computer software for the anesthesiologist to draw figures for presentation, or to perform statistical analysis were presented. Each software is selected in the condition that it does not need special optional hardware, and processes the data quickly even with an old type computer, and also that even a computer beginner can easily operate it. The presented software are as follows: 1) Silhouette (drawing figures), 2) NEO (drawing figures), 3) Graph note (drawing figures), 4) Chart up science (drawing figures), 5) Z's word JG (making slide manuscripts) and 6) Biostat (doing statistical analysis).

Anesthesiology

Computer system and software of POSITOLOGICA II: a whole body positron emission tomograph.

Since a whole body PET-scanner POSITOLOGICA II was installed at the National Institute of Radiological Sciences (NIRS) in 1982, improvements of the computer system and developments of new software have been continuously made to correspond to clinical requirements. As the result, POSITOLOGICA II possesses one of the most powerful systems and sophisticated software in Japan. This report describes the present status of the computer system and software of POSITOLOGICA II. It also discusses problems which still exist and proposes a future computer system for the PET study.

Brain

Protein databases and software on BIONET.

BIONET provides databases, software, and networking/communications tools to over 2500 molecular biologists worldwide. Software for the analysis of nucleic acid and protein sequence data is provided by both IntelliGenetics and academic contributors. BIONET is currently implementing dedicated high speed servers for searching protein databases, as well as providing more flexible tools for protein structure recognition and prediction. In this review, protein databases and analysis software available on the BIONET resource are described, and progress in providing new tools for structure prediction, comparative sequence analysis, and pattern recognition using Artificial Intelligence (AI) techniques are summarized.

Amino Acid Sequence

Software review: Dioptimum.

UNLABELLED: BEST FEATURES: The software screens all preoperative measurements to detect those likely to be in error. This data screening function is based on statistical analysis of the distribution of eye measurements within the human population. If measurements are input that are far from the average value, the program will identify those cases with a message on the screen and a large warning sign. Nevertheless, the program will perform the requested lens power calculations. The program will also compare measurements between right and left eyes, if both are entered, and a test is performed on the asymmetry between the eyes. WORST FEATURES: The lack of a written owner's manual is probably the most glaring defect of the program, even though most of the important information is present on a disk. Only users familiar with running software programs will be able to easily obtain the data. The program can be installed on a hard disk only two times. For physicians with multiple offices or multiple computers that are not on-line, this is a significant handicap. HARDWARE REQUIREMENTS: Two floppy disk drives, 256K RAM and printer, DOS 3.0 or higher are required. One floppy drive plus a hard drive can also be used. The program will run a TTL monochrome or color monitor but the type of color monitor is not specified. LIST PRICE: $495 COPY PROTECTION: Yes USER SUPPORT: 800 number available EASE OF USE: Good ON SCREEN HELP: Yes CONSUMER VALUE: Very expensive PERFORMANCE: Excellent PUBLISHED BY: Storz Ophthalmics, Inc. 1365 Hamlet Avenue Clearwater, FL 34616 (818)-443-2606 or (800)-237-5906 A defective disk can be returned for replacement at no charge within 1 year of the date of purchase. Beyond that date, disks can be replaced at a cost of $10.00. In summary, this is a very well thought out software program for calculating and printing IOL powers using a second-generation lens implant power formula. With appropriate written documentation, the program will become extremely easy to use, even for novices. Because it is so simple to use, surgeons will continually update their personalized surgeon factors and patient data in order to provide patients with the best possible refractive results. A discussion of the use of the Holladay formula in comparison to other formulas is found in reference 2.

Humans

[Structuring and use in clinical research of a software for the diagnosis and features of polypoid lesions of the colorectum].

Double contrast enema and endoscopy are very important in the diagnosis of adenomas and early cancer of the colon and rectum. These exams can not only detect the presence, but also suggest the histologic diagnosis, of polypoid lesions of the colon. An Olivetti M24 Personal Computer was used to create a software to study the results obtained by double contrast enema, and to compare them with endoscopy and pathology. The data base is formed by 7 files: one anagraphic, 3 collecting the characteristics of the diagnosis--namely the radiologic, the endoscopic and the pathologic one-- and 3 multiple files featuring each lesion, as defined by the three diagnostic techniques. The software allows to evaluate the different lesions that can be detected by the three techniques in the same patient and to compare the diagnosis of presence to the morphologic features of each lesion. False negatives and false positives of each technique are easily recognized. It is also possible to characterize the single morphologic feature leading the radiologist and/or the endoscopist to express an opinion about the histologic diagnosis of each lesion and to compare them with pathological features. The first experience in clinical use of the software, in the analysis of the characters of 336 lesions in 218 patients, is described.

Colonic Neoplasms

Microcomputer software and interface for control of a microscope scanning stage.

Motorized scanning stages are valuable in microscopy systems that employ digital image analysis and for the development of semiautomatic computer-assisted microscope systems; the development of standard software "tools" to control such stages will facilitate their integration into a variety of computer-based systems. A set of Microsoft BASIC and Turbo PASCAL programs that interfaces a microprocessor-controlled stepper motor microscope stage (MDACE 1000) to an IBM PC or PC-AT or compatible microcomputer via a serial interface (RS-232) is described. These programs can be integrated into other software written in either BASIC or PASCAL, or used via a menu program that directs the routines to control scanning patterns and to locate the microscope stage to a selected area of the slide. Coordinates of significant events on a slide can be stored on a disk file to allow future examination. The software and interface also provide control of a filter wheel in the microscope for use in multicolor fluorescence assays.

Computers

Computerized accounting for the dental office. Using horizontal applications general ledger software.

Remember that computer software is designed for accrual accounting, whereas your business operates and reports income on a cash basis. The rules of tax law stipulate that professional practices may use the cash method of accounting, but if accrual accounting is ever used to report taxable income the government may not permit a switch back to cash accounting. Therefore, always consider the computer as a bookkeeper, not a substitute for a qualified accountant. (Your accountant will have readily accessible payroll and general ledger data available for analysis and tax reports, thanks to the magic of computer processing.) Accounts Payable reports are interfaced with the general ledger and are of interest for transaction detail, open invoice and cash flow analysis, and for a record of payments by vendor. Payroll reports, including check register and withholding detail are provided and interfaced with the general ledger. The use of accounting software expands the use of in-office computers to areas beyond professional billing and insurance form generation. It simplifies payroll recordkeeping; maintains payables details; integrates payables, receivables, and payroll with general ledger files; provides instantaneous information on all aspects of the business office; and creates a continuous "audit-trail" following the entering of data. The availability of packaged accounting software allows the professional business office an array of choices. The person(s) responsible for bookkeeping and accounting should choose carefully, ensuring that any system is easy to use, has been thoroughly tested, and provides at least as much control over office records as has been outlined in this article.

Accounting

Software design for an inexpensive, practical, microcomputer-based DNA cytometry system.

Recent advances in digital electronics have made it possible to put together videophotometry systems capable of practical DNA ploidy measurements at a relatively modest cost. Such a system, based upon the IBM PC microcomputer and other "off-the-shelf" components, is now operational in our laboratory. This paper discusses the design considerations that went into the development of the software for this system. It examines the choices, constraints and tradeoffs involved in such a software engineering project and considers the practical implementation of image processing algorithms and a user-friendly interface. An overview is given of the modular, menu-driven software through which the system is controlled, along with a description of normal operational flow.

Cell Nucleus

Software development of the EMI head scanner.

A method has been developed to run the general purpose operating system RDOS on the same disc of the head scanner computer as is used for scanner software and data. This made it possible to develop additional software in high level programming language for image processing, based on original image data on the disc. All new images produced by the program are stored on the disc in the same format as the original images. This makes it possible to handle processed images exactly as the original ones and to do multiple operations. The following processing has been included in the program so far: subtraction, smoothing, density profiles, vertical reconstructions, magnification and labelling. A set of operator commands has been developed which are very similar to the ordinary commands for the scanner, which makes the program to appear being a direct extension of the standard scanner software.

Computers

Characteristics of the software for computer applications in medicine.

The requirements of clinical medicine which have tended to make the design and implementation of software for hospital computer systems more difficult than that elsewhere, are discussed in this paper. Specific constraints on the software for selected computer-assisted activities in a hospital environment are examined in considerable depth. It is shown that since some of these activities have counterparts elsewhere, hospital computing can benefit from the accumulated experience in dealing with similiar problems in business and scientific environments. The argument is put forward that developing countries, with their characteristic problem of acute shortage of skilled manpower in both medicine and computing, should initially concentrate on applying computers to these activities alone. Furthermore, medical education in such countries should incorporate programmes relating to computer technology in general and the software aspects in particular.

Computers

[Comparison of fingerprints using a personal computer and graphic software sold on market].

We compared the fingerprint images using a personal computer and a graphic software sold on market. The fingerprints of thumb of left hand recorded by pressing and rolling on paper were input in computer using image scanner. These two fingerprint images were overlapped by moving and rotation on the computer screen, and were fitted well. This result showed that the fingerprints recorded by any way from one person were fitted. Latent and accused's fingerprints were also input in computer using image scanner. These images were analyzed by the same procedure. These two fingerprints were part by unfitting. It was decided these two fingerprints were not derived from one person. We also considered the possibility that the latent fingerprint was the reversed one. Then, the image was reversed of its color on the screen of computer (black to white and white to black) and compared by the same procedure. In this experiment, two fingerprint images were not fitted in a part. This showed that the reversed fingerprint was also able to be analyzed by this procedure. For the comparison of fingerprints, this report showed the ability of the personal computer and software which can be obtained easily from market. Following the improvement of the hardware and software used in this examination in near future, the computerized identification of fingerprints like this study will become more accurate and convenient.

Computer Graphics

[Guide to a new data base system of literatures on dental materials and devices. Off-line retrieval system using commercially available software for data base management].

This article describes the off-line retrieval systems for the data base file of literatures on dental materials and devices which was constructed by the Japanese Society for Dental Materials and Devices. The off-line systems employed two kinds of commercially available softwares for data base management on a personal computer. The data base file was stored in the large-scale computer and downloaded into MS-DOS text files. They were supplied through floppy disks. A program was developed for converting the text files into coded data format which could be transmitted to the applied software. The converted data base files could be successfully processed with two commercial softwares for data base management on a personal computer.

Databases, Bibliographic

Experience with gated cardiac software phantoms for quality control of applications programmes.

Ten gated cardiac software phantoms, representing normal and abnormal clinical conditions, were transferred to 9 different computer systems and tested with 11 cardiac programmes. Problems of inappropriate data format were encountered when analysing the phantoms on other systems. The global left ventricular ejection fraction (LVEF) values resulting from the different programmes were compared. Significant programme differences were found, the programmes falling generally into two groups. Few LVEF outlier values were identified. Full functional assessment of cardiac phantoms requires a set of different views which together form the phantom. Application of software phantoms for programme assessment and training requires prudence and attention to the acquired data format, frame time, and gating method for the appropriate use of phantoms.

Computer Simulation

A parallel software architecture for building intelligent medical monitors.

Intensive care units become more complicated each day as the number of devices developed to monitor various aspects of a patient's status continues to increase. Intelligent monitors attempt to reduce this complexity by interpreting the data and presenting a high level summary to the clinician. We propose an innovative parallel software architecture for constructing intelligent medical monitors: the process trellis. The process trellis is an explicitly parallel structure, and therefore can take advantage of the performance gains available from parallel computing hardware. It does not, however, presuppose any expertise in parallel programming on the part of the application programmer. A prototype cardiovascular monitor has been built using this parallel software architecture. Preliminary testing of the monitor has shown that real-time cardiovascular monitoring, including data calculations, symbolic classification, and interpretation can be accomplished in real-time.

Expert Systems

Development of software for pulse oximeter and investigation of its realtime response in clinical environment.

We developed a pulse oximeter software at Thorax Centre, Erasmus University as a joint project with an industry and evaluated it in the clinical environment of thorax anaesthesia using a computerized protocol for realtime data collection during routine clinical procedures. This paper gives an account of the results we obtained from the development project and the clinical study. The paper consists of two parts. First part describes different components of the software module and their influence on different aspects of the clinical behaviour of the oximeter. The second part describes the results of realtime response investigation. The investigation was carried out using a personal computer to collect the data continuously during anaesthesia, surgery and post-operative periods. Two other industry standard oximeters, Nellcor and Ohmeda were also included in our study. We collected data on more than fifty patients on an average of eight hours per patient over a period of four months with major emphasis on low-saturation occurrences. The interpretation of the data was focused more on the realtime response anomalies on random cases than on ensemble statistical data evaluation. We found, that there are few factors in clinical environment which often influences the measurement of a pulse oximeter very strongly. Most often the anomalies were found during low saturation measurement. The main objective of this paper is to make the results available to practising clinicians so that it may be useful to identify these occurrences during routine clinical usage.

Evaluation Studies as Topic

Development of stereological analysis software for the calculation of volume, number and surface density.

COSAS, an acronym for COmputerized Stereological Analysis System, is software designed to facilitate the process of quantitative morphological analysis. It is a flexible, reliable, and easy to use software system which provides the biologist with a simple means for performing stereological analysis. It provides for estimation of volume and surface density and allows for direct calculation of diameter information from planimetric data. The latter capability is unique to COSAS and provides the ability to calculate longest and shortest diameters for convex profiles, enabling calculation of number density. Access to all intermediate calculations is possible, so the process of transformation of raw data into the stereological descriptors can be completely exposed. This serves two purposes: (1) it provides a means for tracing results; (2) the intermediate values can be utilized independently. This system was used to analyze peroxisomes in tissues from patients with Zellweger's disease and neonatal-onset adrenoleukodystrophy. The system was also used to facilitate an immunocytochemical analysis of cytochrome P450 topology in the endoplasmic reticulum membrane.

Algorithms

MACSPEC--a software system for fully automatic processing and analysis of large series of NMR spectra.

In vivo NMR spectroscopy often accumulates a large number of spectra (typically 100 individual files or even more) to follow metabolic changes with high time-resolution. The analysis of these spectra is very time-consuming for the spectroscopist and, furthermore, it requires the spectrometer's computer, needed for control of experiments. Here we report the software system MACSPEC developed for automatic processing and analysis of large series of individual NMR spectra on a peripheral personal computer. With this software the spectrometer's computer is kept available for experiments, and the necessary interaction of the spectroscopist is limited to a definition of the processing conditions at the beginning of the data analysis.

Electronic Data Processing