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Results for “THYROCALCITONIN”

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PubMedDate not supplied

[Dynamics of the changes in thyroid gland parenchyma on thyrocalcitonin administration].

Experiments were conducted on rats; a study was made of the effect of thyrocalcitonin (TCT) administration--5 Units a day--on thyroid gland. TCT administration during the first 5 days led to structural-functional reconstruction of the gland and activation of the synthesis and elimination of the iodine-containing hormones. Prolonged action of the iodine-containing hormones. Prolonged action of TCT (for 20 days) caused hypofunction of the gland, suppression of endogenous TCT production; it also intensified connective tissue proliferation, and destructive focal changes of the thyroid parenchyma.

Animals↗
PubMedDate not supplied

[State of protein and mineral metabolism following thyrocalcitonin administration during experimental osteogenesis].

Prolonged administration of thyrocalcitonine (TC) into rats (at a dose 5 un per animal) led to some alterations in protein and mineral metabolism: decrease in content of calcium and phosphorus in blood, activation of alkaline phosphatase in blood, decrease in excretion of hydroxyproline, increase in excretion of aminonitrogen with urine. Distinct correlation was observed between the metabolic activity and definite steps in reparative osteogenesis. Exogenous TC activated the cellular structures, which participated in the regenerative processes, promoted the rapid turnover of bone generation and decreased the periods of tracture healing.

Alkaline Phosphatase↗
PubMed1981

[Effect of thyrocalcitonin on the contraction and relaxation of the isolated myocardium in metabolic blockade and acidosis].

Thyrocalcitonine did not produce any effect on the contraction and relaxation of the thin papillary muscles of guinea-pigs, but restored reduced indices of the thick muscles function. The effect of the hormone was most expressed at a high contraction rate. The hormone also stopped reduction in the amplitude of the contractions or partly restored it under the action of metabolic inhibitors--2.4-dinitrophenol or 2-deoxyglucose as well as under the action of acidosis (pH-6.9). A positive inotropic effect of the hormone, that manifest itself under the conditions of a reduced amplitude of contractions is evidently realized through the influence on the Ca++--Na+ metabolism in cells and physiologically grounded, since it favours the stabilization of the myocardial contractility under hypocalcemia.

Acidosis↗
PubMed1978

[The treatment of Paget's disease using salmon thyrocalcitonin. 8 cases (author's transl)].

An open trial of synthetic salmon thyrocalcitonin was carried out in 8 cases of progressive and multifocal Paget's disease over a period of three months and at a dose of 80 MRC.U twice daily. A clinical improvement was seen in half the cases. The action was also marked upon laboratory parameters with, in particular, an average decrease in alkaline phosphatase of 51% and in urinary hydroxyproline levels of 29.4%.

Alkaline Phosphatase↗
PubMed1978

The effect of thyrocalcitonin therapy and phosphate deprivation on tumoral calcinosis.

Six siblings were screened for clinical and biochemical evidence of tumoral calcinosis. The 3 brothers showed all the characteristic manifestations of this entity. Two of them were treated for an initial period of 6 months with large doses of thyrocalcitonin, with virtually no response. After a 9-month equilibration period they were treated by phosphate depletion, and at the end of 6 months they were re-investigated. There was no appreciable objective or radiological difference in the extent of the masses. It was concluded that, in these 2 patients, surgical excision of the tumours was the only feasible form of therapy.

Adult↗
PubMed1976

[The effect of single and long-term thyrocalcitonin administration on glucose tolerance and insulin secretion].

In male rats, i. m. administration of thyrocalcitonin (TCT)--2 and 10 units/kg for 1, 5, 10 and 15 days, reduced calcium level in the blood serum. In the TCT-treated rats the glucose-tolerance curves after i. p. injection of glucose became diabetoid-like. TCT inhibited the increase of insulin-like activity of the serum after glucose injection. The data suggest that TCT, lowering the calcium content of blood serum, inhibited the glucose-induced secretion of insulin.

Animals↗
PubMed1977

[Morphofunctional reaction of the cortical lamina of the adrenal gland to reparative osteogenesis and administration of thyrocalcitonin].

A complex of morphofunctional changes of the adrenal cortex was studied on 150 albino male rats in case of thyrocalcitonin (TCT) administration and experimental fracture. There proved to be an increase of functional activity of the gland under conditions of reparative osteogenesis. The state of hyperfunction developed the first five days of TCT administration in a dose of 5 Units daily. The following saturation of the organism with TCT caused depression of the adrenal gland, particularly of its glucocorticoid function. It is supposed that the inhibitory effect of TCT on the adrenal cortex served as one of the mechanisms accelerating the repair processes in the bone tissue.

Adrenal Cortex↗
PubMed1977

[Role of exogenous thyrocalcitonin in post-traumatic skin regeneration].

The character and completeness of posttraumatic skin regeneration, as well as the role of fibroblastic cells were studied under the effect of thyrocalcitonine (TCT). By means of cytological, morphological, histochemical autoradiographic, electron microscopic and some biochemical methods, stimulating effect of TCT on the cell proliferation and differentiation in the host regeneration was demonstrated. Application of TCT enhanced the main stages of collagenogenesis that, in its turn, promoted earlier transformation of granulous tissue into connective tissue and stimulated healing of experimental wounds.

Animals↗
PubMed1976

Transplacental effects of thyrocalcitonin on intestinal calcium-binding protein, alkaline phosphatase activity and ossification of long bones in rat fetuses.

Pregnant rats were treated with 44, 88 and 176 Medical Research Council munits of thyrocalcitonin (TCT) twice daily during days 10 to 21 of gestation. Nonpregnant rats received the same treatment for 12 days. Administration of TCT to the pregnant rats increased the ash and calcium content of fetal bones and decreased the phosphorus content. The diaphyses were short and contained many persisting enchondral trabeculae and a reduced number of osteoclasts. TCT reduced the fetal intestinal alkaline phosphatase activity but elevated the intestinal calcium-binding protein content. In the pregnant and nonpregnant rats, treatment with TCT resulted in hypocalcemia and hypophosphatemia, and increased the calcium-binding protein content of the duodenal mucosa. In the fetuses, the calcium-binding protein content and alkaline phosphatase activity were higher in the jejunum and ileum than in the duodenum, and were much higher than the values found in adult animals. Our findings indicate that TCT passes through the rat placenta and affects the fetal skeleton and calcium metabolism directly, resulting primarily in decreased bone resorption.

Alkaline Phosphatase↗